课题组长
姓名:
曾嵘中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务:
所在院所:
生命科学与技术学院、中国科学院分子细胞科学卓越创新中心
荣誉称号:
课题组简介
研究内容:
研究组致力于发展蛋白质组研究技术和建立大规模蛋白质组研究平台。近年来,在高通量蛋白质鉴定及修饰分析,蛋白质定量,亚细胞蛋白质分析和蛋白质相互作用等蛋白质组研究方法和技术上进行探索。采用定量化研究手段研究细胞分子网络,疾病动物模型等系统中的蛋白质动态行为,并采用计算生物学手段构建蛋白质动态行为及其调控模型。目前研究的细胞模型主要为3T3L1脂肪细胞分化等系统,动物模型主要为糖尿病大鼠等系统。 |
代表性论文(*第一作者,#通讯作者)
- 1. Li, Qing-Run*; Xing, Xiao-Bin; Chen, Tao-Tao; Li, Rong-Xia; Dai, Jie; Sheng, Quan-Hu; Xin, Shun-Mei; Zhu, Li-Li; Jin, Ying; Pei, Gang; Kang, Jiu-Hong#; Li, Yi-Xue#; Zeng, Rong#.Large Scale Phosphoproteome Profiles Comprehensive Features of Mouse Embryonic Stem Cells.MOLECULAR & CELLULAR PROTEOMICS. 2011. 10(4).
- 2. Deng, Wen-Jun*; Nie, Song; Dai, Jie; Wu, Jia-Rui; Zeng, Rong#.Proteome, Phosphoproteome, and Hydroxyproteome of Liver Mitochondria in Diabetic Rats at Early Pathogenic Stages.MOLECULAR & CELLULAR PROTEOMICS. 2010. 9(1):1-116.
- 3. Wang, Qijun*; Zhang, Yakun; Yang, Chen; Xiong, Hui; Lin, Yan; Yao, Jun; Li, Hong; Xie, Lu; Zhao, Wei; Yao, Yufeng; Ning, Zhi-Bin; Zeng, Rong; Xiong, Yue; Guan, Kun-Liang; Zhao, Shimin#; Zhao, Guo-Ping#.Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux.SCIENCE. 2010. 327(5968):14-17.
- 4. Wu, Yi-Bo*; Dai, Jie; Yang, Xing-Lin; Li, Su-Jun; Zhao, Shi-Lin; Sheng, Quan-Hu; Tang, Jia-Shu; Zheng, Guang-Yong; Li, Yi-Xue; Wu, Jia-Rui; Zeng, Rong#.Concurrent Quantification of Proteome and Phosphoproteome to Reveal System-wide Association of Protein Phosphorylation and Gene Expression.MOLECULAR & CELLULAR PROTEOMICS. 2009. 8(12):289-2826.
- 5. Li, Qing-run*; Ning, Zhi-bin; Tang, Jia-shu; Nie, Song; Zeng, Rong#.Effect of Peptide-to-TiO2 Beads Ratio on Phosphopeptide Enrichment Selectivity.JOURNAL OF PROTEOME RESEARCH. 2009. 8(11):5375-5381.
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