2015年科研成果

1.    CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH.

Kang Y, Zheng B, Shen B, Chen Y, Wang L, Wang J, Niu Y, Cui Y, Zhou J, Wang H, Guo X, Hu B, Zhou Q, Sha J, Ji W, Huang X. Hum Mol Genet. 2015 Dec 20;24(25):7255-64.

2.     T7 replisome directly overcomes DNA damage.

Sun B, Pandey M, Inman JT, Yang Y, Kashlev M, Patel SS, Wang MD.Nat Commun. 2015 Dec 17;6:10260.

3.    Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling.

Yang R, Wang M, Wang J, Huang X, Yang R, Gao WQ.Stem Cell Reports. 2015 Nov 10;5(5):816-828.

4.    LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP.Nat Commun. 2015 Oct 8;6:8325.

5.    Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system.

Wang X, Yu H, Lei A, Zhou J, Zeng W, Zhu H, Dong Z, Niu Y, Shi B, Cai B, Liu J, Huang S, Yan H, Zhao X, Zhou G, He X, Chen X, Yang Y, Jiang Y, Shi L, Tian X, Wang Y, Ma B, Huang X, Qu L, Chen Y.Sci Rep. 2015 Sep 10;5:13878.

6.    Breaking bad: The mutagenic effect of DNA repair.

Chen J, Furano AV.DNA Repair (Amst). 2015 Aug;32:43-51.

7.    CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse.

Zi Z, Zhang Z, Li Q, An W, Zeng L, Gao D, Yang Y, Zhu X, Zeng R, Shum WW, Wu J.CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse.PLoS Genet. 2015 Aug 25;11(8):e1005485.

8.    Functional annotation of cis-regulatory elements in human cells by dCas9/sgRNA.

Du Y, Meng Q, Zhang J, Sun M, Shen B, Jiang H, Kang N, Gao J, Huang X, Liu J.Functional annotation of cis-regulatory elements in human cells by dCas9/sgRNA.Cell Res. 2015 Jul;25(7):877-80.

9.    The Role of Stroma in Tumor Development.

Werb Z, Lu P.The Role of Stroma in Tumor Development.Cancer J. 2015 Jul-Aug;21(4):250-3.

10.  TP53 loss creates therapeutic vulnerability in colorectal cancer.

Liu Y, Zhang X, Han C, Wan G, Huang X, Ivan C, Jiang D, Rodriguez-Aguayo C, Lopez-Berestein G, Rao PH, Maru DM, Pahl A, He X, Sood AK, Ellis LM, Anderl J, Lu X.TP53 loss creates therapeutic vulnerability in colorectal cancer.Nature. 2015 Apr 30;520(7549):697-701.

11.  The importance of ligands for G protein-coupled receptor stability.

Zhang X, Stevens RC, Xu F.Trends Biochem Sci. 2015 Feb;40(2):79-87.