2014年科研成果

1.       Crystal structure of the N-terminal methyltransferase-like domain of anamorsin.

Song G, Cheng C, Li Y, Shaw N, Xiao ZC, Liu ZJ. Proteins. 2014 Jun;82(6):1066-71. doi: 10.1002/prot.24443. Epub 2013 Nov 22.

2.       NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan JA, Ting JP. Immunity. 2014 Mar 20;40(3):329-41. doi: 10.1016/j.immuni.2014.01.010. Epub 2014 Feb 20.

3.       Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a re versible intermediate maturation stage.

Zhao L, Hua T, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Qu L, Hung LW, Huang W, Liu L, Ye K, Ouyang S, Cheng G, Liu ZJ. Cell Res. 2014 Mar;24(3):344-58. doi: 10.1038/cr.2014.4. Epub 2014 Jan 10.

4.       Crystal structures of the F88Y obelin mutant before and after bioluminescence provide molecular insight into spectral tuning among hydromedusan photoproteins.

Natashin PV, Markova SV, Lee J, Vysotski ES, Liu ZJ.  FEBS J. 2014 Mar;281(5):1432-45. doi: 10.1111/febs.12715. Epub 2014 Jan 29.

5.       Structures of the Ca2+-regulated photoprotein obelin Y138F mutant before and after bioluminescence support the catalytic function of a water molecule in the reaction.

Natashin PV, Ding W, Eremeeva EV, Markova SV, Lee J, Vysotski ES, Liu ZJ.  Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):720-32. doi: 10.1107/S1399004713032434. Epub 2014 Feb 15.