戚炜

1. Zhao, Jiaqi*; Qian, Hui; An, Yang; Chu, Liping; Tan, Dongxia; Qin, Chenyang; Sun, Qianying; Wang, Yunpeng; Qi, Wei^#; .PPARγ and C/EBPα enable adipocyte differentiation upon inhibition of histone methyltransferase PRC2 in malignant tumors.JOURNAL OF BIOLOGICAL CHEMISTRY. Oct 2024. 300(10).

2. Liu, Dongdong*; Li, Zhen; Tan, Dongxia; An, Yang; Chu, Liping; Chen, Tiancheng; Li, Weijia; Zhou, Ailin; Xiang, Ruijie; Zhang, Liye; Qu, Yuxiu; Qi, Wei^#; .BMP-ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B-Cell Lymphoma.ADVANCED SCIENCE. 2024. 11(12).

3. Shi, Yulei*; Qi, Wei^#; .Histone Modifications in NAFLD: Mechanisms and Potential Therapy.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 01 Oct 2023. 24(19).

4. Chu, Liping*; Tan, Dongxia; Zhu, Meimei; Qu, Yuxiu; Ma, Xin; Song, Bao-Liang^#; Qi, Wei^#; .EZH2 W113C is a gain-of-function mutation in B-cell lymphoma enabling both PRC2 methyltransferase activation and tazemetostat resistance.JOURNAL OF BIOLOGICAL CHEMISTRY. Feb 2023. 299(4).

5. Chu, Liping*; Qu, Yuxiu*; An, Yang*; Hou, Linjun; Li, Juewan; Li, Weijia; Fan, Gaofeng; Song, Bao-Liang; Li, En; Zhang, Liye; Qi, Wei^#; .Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer.CELL DEATH & DISEASE. 15 Feb 2022. 13(2).

6. Jiang, Shi-You*; Yang, Xinglin; Yang, Zimo; Li, Jue-Wan; Xu, Meng-Qiang; Qu, Yu-Xiu; Tang, Jing-Jie; Li, Yun-Feng; Wang, Liguo; Shao, Yi-Wen; Meng, Xin-Yuan; Hu, Huili; Song, Bao-Liang^#; Rao, Yu^#; Qi, Wei^#; .Discovery of an insulin-induced gene binding compound that ameliorates nonalcoholic steatohepatitis by inhibiting sterol regulatory element-binding protein-mediated lipogenesis.HEPATOLOGY. Apr 2022.

7. Zhao, Jiaqi*; Zhou, Ailin; Qi, Wei^#; .The Potential to Fight Obesity with Adipogenesis Modulating Compounds.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Feb 2022. 23(4).

8. Hui Qian*; Zhao JQ(赵佳琦)*; Xinyi Yang; Sujuan Wu; Yang An; Yuxiu Qu; Zhen Li; Hui Ge; En Li; Wei Qi^#; .TET1 promotes RXRα expression and adipogenesis through DNA demethylation.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. Jun 2021. 1866(6).

9. Zhou, Zhang-Sen*; Li, Mei-Xin; Liu, Jie; Jiao, Hengwu; Xia, Jing-Ming; Shi, Xiong-Jie; Zhao, Huabin; Chu, Liping; Liu, Jingrong; Qi, Wei; Luo, Jie; Song, Bao-Liang^#; .Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2.NATURE COMMUNICATIONS. 17 Jan 2020. 11(1).

10. Gong, Xue-Min*; Li, Yun-Feng*; Luo, Jie*; Wang, Ji-Qiu*; Wei, Jian*; Wang, Ju-Qiong; Xiao, Ting; Xie, Chang; Hong, Jie; Ning, Guang; Shi, Xiong-Jie; Li, Bo-Liang; Qi, Wei^#; Song, Bao-Liang^#; .Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance.NATURE METABOLISM. May 2019. 1(5):570-583.

11. Qi, Wei*; Zhao, Kehao*; Gu, Justin*; Huang, Ying*; Wang, Youzhen; Zhang, Hailong; Zhang, Man; Zhang, Jeff; Yu, Zhengtian; Li, Ling; Teng, Lin; Chuai, Shannon; Zhang, Chao; Zhao, Mengxi; Chan, Homan; Chen, Zijun; Fang, Douglas; Fei, Qi; Feng, Leying; Feng, Lijian; Gao, Yuan; Ge, Hui; Ge, Xinjian; Li, Guobin; Lingel, Andreas; Lin, Ying; Liu, Yueqin; Luo, Fangjun; Shi, Minlong; Wang, Long; Wang, Zhaofu; Yu, Yanyan; Zeng, Jue; Zeng, Chenhui; Zhang, Lijun; Zhang, Qiong; Zhou, Shaolian; Oyang, Counde; Atadja, Peter; Li, En^#; .An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.NATURE CHEMICAL BIOLOGY. 2017. 13(4):3810.

12. Chen, Yan*; Kim, Jeesun; Zhang, Ruipeng; Yang, Xiaoqin; Zhang, Yong; Fang, Jianwu; Chen, Zhui; Teng, Lin; Chen, Xiaowei; Ge, Hui; Atadja, Peter; Li, En; Chen, Taiping; Qi, Wei^#; .Histone Demethylase LSD1 Promotes Adipocyte Differentiation through Repressing Wnt Signaling.CELL CHEMICAL BIOLOGY. 2016. 23(10):1228-1240.

13. Qi, Wei*; Chan, HoMan*; Teng, Lin; Li, Ling; Chuai, Shannon; Zhang, Ruipeng; Zeng, Jue; Li, Min; Fan, Hong; Lin, Ying; Gu, Justin; Ardayfio, Ophelia; Zhang, Ji-Hu; Yan, Xiaoxia; Fang, Jialuo; Mi, Yuan; Zhang, Man; Zhou, Tao; Feng, Grace; Chen, Zijun; Li, Guobin; Yang, Teddy; Zhao, Kehao; Liu, Xianghui; Yu, Zhengtian; Lu, Chris X.; Atadja, Peter; Li, En^#; .Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012. 109(52):21360-21365.

14. Jiang, Shi-You*; Tang, Jing-Jie; Xiao, Xu; Qi, Wei; Wu, Suqian; Jiang, Chao; Hong, Jiaxu; Xu, Jianjiang^#; Song, Bao-Liang^#; Luo, Jie^#; .Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase.PLOS GENETICS. Jul 2019. 15(7).

15. Jiang, Shi-You*; Li, Hui; Tang, Jing-Jie; Wang, Jie; Luo, Jie; Liu, Bing; Wang, Jin-Kai; Shi, Xiong-Jie; Cui, Hai-Wei; Tang, Jie; Yang, Fan; Qi, Wei; Qiu, Wen-Wei^#; Song, Bao-Liang^#; .Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol.NATURE COMMUNICATIONS. 03 Dec 2018. 9.