The major mission of Gao-lab is to use Drosophila and mammalian cell systems to achieve a comprehensive understanding of the mechanisms of chromatin and (epi-)genetic factors, particularly with a focus on long non-coding RNAs and histone epigenetic codes in development, reproduction, innate immunology, aging and cancer disease. Towards achieving this mission, Gao-lab bridges the new genetic methods and biochemistry approaches into investigation of the mechanisms of those (epi-)genetics factors involved in fundamental biological processes. Their research will define not only epigenetic molecules and pathways but also many fundamental biological processes that impact human health.