杨贝

1. Zhang, Ruiwen*; He, Zhou; Shi, Yajing; Sun, Xiangkun; Chen, Xinyu; Wang, Guoquan; Zhang, Yizhou; Gao, Pan; Wu, Ying; Lu, Shuhan; Duan, Junyi; Sun, Shangwu; Yang, Na; Fan, Wei; Zhao, Kaitao; Yang, Bei; Xia, Yuchen; Zhang, Yan; Zhang, Ying; Yin, Hao^#; .Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale.CELL. 25 Jul 2024. 187(15).

2. Luo, Yaxin*; Hou, Yaofeng; Zhao, Wenwen; Yang, Bei^#; .Recent progress in gene therapy for familial hypercholesterolemia treatment.ISCIENCE. 20 Sep 2024. 27(9).

3. Han, Wenyan*; Qiu, Hou-Yuan*; Sun, Shangwu*; Fu, Zhi-Can*; Wang, Guo-Quan*; Qian, Xiaowen*; Wang, Lijie; Zhai, Xiaowen; Wei, Jia; Wang, Yichuan; Guo, Yi-Lin; Cao, Guo-Hua; Ji, Rui-Jin; Zhang, Yi-Zhou; Ma, Hongxia; Wang, Hongsheng; Zhao, Mingli; Wu, Jing; Bi, Lili; Chen, Qiu-Bing; Li, Zifeng; Yu, Ling; Mou, Xiaodun; Yin, Hao; Yang, Li^#; Chen, Jia^#; Yang, Bei^#; Zhang, Ying^#; .Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs.CELL STEM CELL. Nov 2023.

4. Niu, Jun*; Wang, Qi; Zhao, Wenwen; Meng, Bing; Xu, Youwei; Zhang, Xianfang; Feng, Yi; Qi, Qilian; Hao, Yanling; Zhang, Xuan; Liu, Ying; Xiang, Jiangchao; Shao, Yiming^#; Yang, Bei^#; .Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs.NATURE COMMUNICATIONS. 04 Aug 2023. 14(1).

5. Jia, Xinshuo*; Li, Yanan*; Wang, Teng; Bi, Lulu; Guo, Lijuan; Chen, Ziting; Zhang, Xia; Ye, Shasha; Chen, Jia; Yang, Bei; Sun, Bo^#; .Discrete RNA–DNA hybrid cleavage by the EXD2 exonuclease pinpoints two rate-limiting steps.THE EMBO JOURNAL. 04 Jan 2023. 42:e111703.

6. Li, Xiaosa^#*; Zhou, Lina*; Gao, Bao-Qing*; Li, Guangye; Wang, Xiao; Wang, Ying; Wei, Jia; Han, Wenyan; Wang, Zixian; Li, Jifang; Gao, Runze; Zhu, Junjie; Xu, Wenchao; Wu, Jing; Yang, Bei; Sun, Xiaodong^#; Yang, Li^#; Chen, Jia^#; .Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure.NATURE COMMUNICATIONS. 29 Mar 2022. 13(1):1669.

7. Wang, Lijie*; Xue, Wei*; Zhang, Hongxia*; Gao, Runze*; Qiu, Houyuan*; Wei, Jia; Zhou, Lina; Lei, Yun-Ni; Wu, Xiaocheng; Li, Xiao; Liu, Chengfang; Wu, Jing; Chen, Qiubing; Ma, Hanhui; Huang, Xingxu; Cai, Cheguo; Zhang, Ying; Yang, Bei^#; Yin, Hao^#; Yang, Li^#; Chen, Jia^#; .Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations.NATURE CELL BIOLOGY. May 2021. 23(5):552-563.

8. Xiaojie Shi*; Yue Wan*; Nan Wang*; Jiangchao Xiang*; Tao Wang; Xiaofeng Yang; Ju Wang; Xuxue Dong; Liang Dong; Lei Yan; Yu Li; Lili Liu; Shinchen Hou; Zhenwei Zhong; Ian A. Wilson; Bei Yang; Guang Yang^#; Richard A. Lerner^#; .Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.NATURE COMMUNICATIONS. 05 May 2021.

9. Meng, Bing*; Lan, Keke; Xie, Jia; Lerner, Richard A.; Wilson, Ian A.^#; Yang, Bei^#; .Inhibitory antibodies identify unique sites of therapeutic vulnerability in rhinovirus and other enteroviruses.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 16 Jun 2020. 117(24):13499-13508.

10. Wang, Xiao*; Ding, Chengfeng*; Yu, Wenxia*; Wang, Ying*; He, Siting*; Yang, Bei*; Xiong, Yi-Chun; Wei, Jia; Li, Jifang; Liang, Jiayi; Lu, Zongyang; Zhu, Wei; Wu, Jing; Zhou, Zhi; Huang, Xingxu; Liu, Zhen^#; Yang, Li^#; Chen, Jia^#; .Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response.CELL REPORTS. 02 Jun 2020. 31(9).

11. Cui, Yan-ru*; Wang, Shao-jie*; Chen, Jun; Li, Jie; Chen, Wenzhang; Wang, Shuyue; Meng, Bing; Zhu, Wei; Zhang, Zhuhong; Yang, Bei; Jiang, Biao; Yang, Guang; Ma, Peixiang^#; Liu, Jia^#; .Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides.GENOME BIOLOGY. 26 Feb 2020. 21(1).

12. Xu, Juncao*; Cui, Kaijie*; Shen, Liqiang; Shi, Jing; Li, Lingting; You, Linlin; Fang, Chengli; Zhao, Guoping^#; Feng, Yu^#; Yang, Bei^#; Zhang, Yu^#; .Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor.ELIFE. 17 Dec 2019. 8.

13. Yang, Li^#*; Yang, Bei^#; Chen, Jia^#; .One Prime for All Editing.CELL. Dec 2019. 179(7):1448-1450.

14. Zhao, Quanju*; Ren, Chaowei*; Liu, Linyi*; Chen, Jinju; Shao, Yubao; Sun, Ning; Sun, Renhong; Kong, Ying; Ding, Xinyu; Zhang, Xianfang; Xu, Youwei; Yang, Bei; Yin, Qianqian^#; Yang, Xiaobao^#; Jiang, Biao^#; .Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.JOURNAL OF MEDICINAL CHEMISTRY. 24 Oct 2019. 62(20):9281-9298.

15. Wang, Ying*; Gao, Runze*; Wu, Jing*; Xiong, Yi-Chun; Wei, Jia; Zhang, Sipin; Yang, Bei; Chen, Jia^#; Yang, Li^#; .Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs.GENOME BIOLOGY. Oct 2019. 20(1).

16. Chen, Jia^#*; Yang, Bei^#; Yang, Li^#; .To BE or not to BE, that is the question.NATURE BIOTECHNOLOGY. May 2019. 37(5):520-521.

17. Xia, Shuai*; Yan, Lei*; Xu, Wei*; Agrawal, Anurodh Shankar; Algaissi, Abdullah; Tseng, Chien-Te K.; Wang, Qian; Du, Lanying; Tan, Wenjie; Wilson, Ian A.^#; Jiang, Shibo^#; Yang, Bei^#; Lu, Lu^#; .A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.SCIENCE ADVANCES. Apr 2019. 5(4).

18. Yang, Bei^#*; Yang, Li^#; Chen, Jia^#; .Development and Application of Base Editors.CRISPR JOURNAL. Apr 2019. 2(2):91-104.

19. Wang, Xiao*; Li, Jianan*; Wang, Ying*; Yang, Bei*; Wei, Jia*; Wu, Jing; Wang, Ruixuan; Huang, Xingxu^#; Chen, Jia^#; Yang, Li^#; .Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion.NATURE BIOTECHNOLOGY. Oct 2018. 36(10):946-949.

20. Yan, Lei*; Meng, Bing; Xiang, Jiangchao; Wilson, Ian A.^#; Yang, Bei^#; .Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 angstrom resolution.ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY. Sep 2018. 74:841-851.

21. Qiang, Min*; Dong, Xue*; Zha, Zhao; Zuo, Xiao-Kun; Song, Xing-Lei; Zhao, Lixia; Yuan, Chao; Huang, Chen; Tao, Pingdong; Hu, Qin; Li, Wei-Guang; Hu, Wanhui; Li, Jie; Nie, Yan; Buratto, Damiano; Zonta, Francesco; Ma, Peixiang; Yu, Zheng; Liu, Lili; Zhang, Yi; Yang, Bei; Xie, Jia; Xu, Tian-Le; Qu, Zhihu^#; Yang, Guang^#; Lerner, Richard A.^#; .Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 07 Aug 2018. 115(32):E7469-E7477.

22. Li, Xiaosa*; Wang, Ying*; Liu, Yajing*; Yang, Bei*; Wang, Xiao; Wei, Jia; Lu, Zongyang; Zhang, Yuxi; Wu, Jing; Huang, Xingxu^#; Yang, Li^#; Chen, Jia^#; .Base editing with a Cpf1-cytidine deaminase fusion.NATURE BIOTECHNOLOGY. Apr 2018. 36(4):324-327.

23. Lei, Liqun*; Chen, Hongquan*; Xue, Wei*; Yang, Bei*; Hu, Bian*; Wei, Jia; Wang, Lijie; Cui, Yiqiang; Li, Wei; Wang, Jianying; Yan, Lei; Shang, Wanjing; Gao, Jimin; Sha, Jiahao; Zhuang, Min; Huang, Xingxu; Shen, Bin^#; Yang, Li^#; Chen, Jia^#; .APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks.NATURE STRUCTURAL & MOLECULAR BIOLOGY. Jan 2018. 25(1):45-52.

24. Wang, Lijie*; Xue, Wei*; Yan, Lei*; Li, Xiaosa; Wei, Jia; Chen, Miaomiao; Wu, Jing; Yang, Bei^#; Yang, Li^#; Chen, Jia^#; .Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor.CELL RESEARCH. Oct 2017. 27(10):1289-1292.

25. Yang, Bei^#*; Li, Xiaosa; Lei, Liqun; Chen, Jia^#; .APOBEC: From mutator to editor.JOURNAL OF GENETICS AND GENOMICS. Sep 2017. 44(9):423-437.

26. Xiang, Jiangchao*; Su, Jie; Lan, Qiaoshuai; Zhao, Wenwen; Zhou, Yu; Xu, Youwei; Niu, Jun; Xia, Shuai; Qi, Qilian; Sidhu, Sachdev; Lu, Lu^#; Miersch, Shane^#; Yang, Bei^#; .Antigenic mapping reveals sites of vulnerability on alpha-HCoV spike protein.COMMUNICATIONS BIOLOGY. 04 Nov 2022. 5(1).

27. Shangwu Sun*; Rui Zhu*; Mengyao Zhu; Qi Wang; Na Li^#; Bei Yang^#; .Visualization of conformational transition of GRP94 in solution.LIFE SCIENCE ALLIANCE. Nov 2023. 7(2).

28. Zhao, Wenwen*; Li, Jifang*; Wang, Xiao*; Xu, Wei*; Gao, Bao-Qing*; Xiang, Jiangchao; Hou, Yaofeng; Liu, Wei; Wu, Jing; Qi, Qilian; Wei, Jia; Yang, Xiaoyu; Lu, Lu^#; Yang, Li^#; Chen, Jia^#; Yang, Bei^#; .Prime editor-mediated functional reshaping of ACE2 prevents the entry of multiple human coronaviruses, including SARS-CoV-2 variants.MEDCOMM. 2023.