2023年科研成果

12月

144.Computer-Aided Prediction of the Interactions of Viral Proteases with Antiviral Drugs: Antiviral Potential of Broad-Spectrum Drugs.

Pengxuan Ren, Shiwei Li, Shihang Wang, Xianglei Zhang, Fang Bai.

Molecules. 2023 Dec 31;29(1):225. doi: 10.3390/molecules29010225.

143.Joint Efforts of Replicative Helicase and SSB Ensure Inherent Replicative Tolerance of G-Quadruplex.

Lijuan Guo, Yanling Bao, Yilin Zhao, Zhiyun Ren, Lulu Bi,Xia Zhang, Cong Liu, Xi-Miao Hou , Michelle D Wang,Bo Sun.

Adv Sci (Weinh). 2023 Dec 21:e2307696. doi: 10.1002/advs.202307696. Online ahead of print.

142.Murine trophoblast organoids as a model for trophoblast development and CRISPR-Cas9 screening.

Qian Mao, Qinying Ye, Yiwen Xu, Jingwei Jiang, Yunhao Fan, Lili Zhuang, Guohui Liu, Tengfei Wang, Zhenwu Zhang, Teng Feng, Shuangbo Kong, Jinhua Lu, Hui Zhang, Haopeng Wang, Chao-Po Lin.

Dev Cell. 2023 Dec 18;58(24):2992-3008.e7. doi: 10.1016/j.devcel.2023.11.007. Epub 2023 Dec 5

141.Expanding genome editing scopes with artificial intelligence.

Li Yang,Jia Chen.

Sci Bull (Beijing). 2023 Dec 15;68(23):2881-2883. doi: 10.1016/j.scib.2023.10.025. Epub 2023 Oct 28.

140.Cryo-EM structure of cannabinoid receptor CB1-β-arrestin complex.

Yuxia Wang, Lijie Wu, Tian Wang, Junlin Liu, Fei Li, Longquan Jiang, Zhongbo Fan, Yanan Yu, Na Chen, Qianqian Sun, Qiwen Tan, Tian Hua, Zhi-Jie Liu.

Protein Cell. 2023 Dec 15:pwad055. doi: 10.1093/procel/pwad055. Online ahead of print.

139.Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma.

Yunfan Sun, Pin Wu, Zefan Zhang, Zejian Wang, Kaiqian Zhou, Minfang Song, Yuan Ji, Fenglin Zang, Limu Lou, Keqiang Rao, Pengxiang Wang, Yutong Gu, Jie Gu, Binbin Lu, Limeng Chen, Xiuqi Pan, Xiaojing Zhao, Lihua Peng, Dongbing Liu, Xiaofang Chen, Kui Wu, Penghui Lin, Liang Wu, Yulin Su, Min Du,Yingyong Hou, Xinrong Yang, Shuangjian Qiu, Yinghong Shi, Huichuan Sun, Jian Zhou, Xingxu Huang, David H Peng,Liye Zhang,Jia Fan.

Cancer Cell. 2023 Dec 12:S1535-6108(23)00401-4. doi: 10.1016/j.ccell.2023.11.010. Online ahead of print. 

138.Oxytocin neurons mediate stress-induced social memory impairment.

Shulu Zhan, Zhenhua Qi, Fang Cai, Zilong Gao, Jingdun Xie, Ji Hu.

Curr Biol. 2023 Dec 9:S0960-9822(23)01587-7. doi: 10.1016/j.cub.2023.11.037. Online ahead of print

137.Esketamine accelerates emergence from isoflurane general anaesthesia by activating the paraventricular thalamus glutamatergic neurones in mice.

Wen-Ying Duan , Kang Peng , Hui-Min Qin , Bai-Ming Li , Yun-Xin Xu , Dan-Jun Wang , Le Yu , Hui Wang,Ji Hu, Qing-Xiu Wang .

Br J Anaesth. 2023 Dec 2:S0007-0912(23)00619-0. doi: 10.1016/j.bja.2023.10.038. Online ahead of print.

136.Expression analysis of plvap in mouse heart development, homeostasis and injury.

Yu Sui, Shan Kou, Kaixin Ge, Jinjun Cao, Chen Liu,Hui Zhang.

Gene Expr Patterns. 2023 Dec:50:119343. doi: 10.1016/j.gep.2023.119343. Epub 2023 Sep 28.

135.Post-translational modifications in stress granule and their implications in neurodegenerative diseases.

Zhangshun Wang, Chen'ang Zhang, Chengyu Fan,Yanfen Liu.

Biochim Biophys Acta Gene Regul Mech. 2023 Dec;1866(4):194989. doi: 10.1016/j.bbagrm.2023.194989. Epub 2023 Sep 24.

11月

134.Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants.

Wenwen Duan, Dongmei Cao, Sheng Wang, Jianjun Cheng.

Chem Rev. 2023 Nov 30. doi: 10.1021/acs.chemrev.3c00375. Online ahead of print.

133.Time-resolved proteomic profiling reveals compositional and functional transitions across the stress granule life cycle.

Shuyao Hu, Yufeng Zhang, Qianqian Yi, Cuiwei Yang, Yanfen Liu, Yun Bai.

Nat Commun. 2023 Nov 27;14(1):7782. doi: 10.1038/s41467-023-43470-1.

132.Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry.

Haofeng Wang #, Qi Yang #, Xiaoce Liu #, Zili Xu #, Maolin Shao #, Dongxu Li, Yinkai Duan, Jielin Tang, Xianqiang Yu, Yumin Zhang, Aihua Hao, Yajie Wang, Jie Chen, Chenghao Zhu, Luke Guddat, Hongli Chen, Leike Zhang, Xinwen Chen, Biao Jiang, Lei Sun, Zihe Rao, Haitao Yang.

Nat Commun. 2023 Nov 21;14(1):7574. doi: 10.1038/s41467-023-42527-5.

131.Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs.

Wenyan Han, Hou-Yuan Qiu, Shangwu Sun, Zhi-Can Fu, Guo-Quan Wang, Xiaowen Qian, Lijie Wang, Xiaowen Zhai, Jia Wei, Yichuan Wang, Yi-Lin Guo, Guo-Hua Cao, Rui-Jin Ji, Yi-Zhou Zhang, Hongxia Ma, Hongsheng Wang, Mingli Zhao, Jing Wu, Lili Bi, Qiu-Bing Chen, Zifeng Li, Ling Yu, Xiaodun Mou, Hao Yin, Li Yang,Jia Chen, Bei Yang,Ying Zhang.

Cell Stem Cell. 2023 Nov 17:S1934-5909(23)00369-7. doi: 10.1016/j.stem.2023.10.007. Online ahead of print.

130.Visualization of conformational transition of GRP94 in solution.

Shangwu Sun, Rui Zhu, Mengyao Zhu, Qi Wang, Na Li,Bei Yang.

Life Sci Alliance. 2023 Nov 10;7(2):e202302051. doi: 10.26508/lsa.202302051. Print 2024 Feb.

129.Recognition of methamphetamine and other amines by trace amine receptor TAAR1.

Heng Liu #, You Zheng #, Yue Wang #, Yumeng Wang #, Xinheng He, Peiyu Xu, Sijie Huang, Qingning Yuan, Xinyue Zhang, Ling Wang, Kexin Jiang, Hong Chen, Zhen Li, Wenbin Liu, Sheng Wang, H Eric Xu, Fei Xu.

Nature. 2023 Nov 7. doi: 10.1038/s41586-023-06775-1. Online ahead of print.

128.CaMKII mediates sexually dimorphic synaptic transmission at neuromuscular junctions in C. elegans.

Wan-Xin Zeng #, Haowen Liu #, Yue Hao #, Kang-Ying Qian, Fu-Min Tian, Lei Li, Bin Yu, Xian-Ting Zeng, Shangbang Gao, Zhitao Hu,Xia-Jing Tong.

J Cell Biol. 2023 Nov 6;222(11):e202301117.doi: 10.1083/jcb.202301117. Epub 2023 Aug 25.

127.DeepSA: a deep-learning driven predictor of compound synthesis accessibility.

Shihang Wang #, Lin Wang #, Fenglei Li,Fang Bai.

J Cheminform. 2023 Nov 2;15(1):103. doi: 10.1186/s13321-023-00771-3.

126.Advances and Applications of Brain Organoids.

Yang Li #, Peng-Ming Zeng #, Jian Wu #, Zhen-Ge Luo.

Neurosci Bull. 2023 Nov;39(11):1703-1716. doi: 10.1007/s12264-023-01065-2. Epub 2023 May 24.

125.Design and application of the transformer base editor in mammalian cells and mice.

Wenyan Han #, Bao-Qing Gao #, Junjie Zhu #, Zongxing He #,Jianfeng Li, Li Yang, Jia Chen.

Nat Protoc. 2023 Nov;18(11):3194-3228. doi: 10.1038/s41596-023-00877-w. Epub 2023 Oct 4.

124.In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome.

Xiao-Cui Yang #, Anthony Desotell #, Min-Han Lin #, Andrew S Paige #, Agata Malinowska, Yadong Sun, Wei Shen Aik, Michał Dadlez, Liang Tong, Zbigniew Dominski .

RNA. 2023 Nov;29(11):1673-1690. doi: 10.1261/rna.079709.123. Epub 2023 Aug 10.

10月

123.Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness.

Shengmiao Chen, Yiran Wu, Yang Gao, Chenxu Wu, Yuetong Wang, Chun Hou, Miao Ren, Shuyuan Zhang, Qi Zhu, Jiali Zhang, Yufeng Yao, Mei Huang, Yingchuan B Qi, Xue-Song Liu,Tiffany Horng,Haopeng Wang,Dan Ye,Zhengjiang Zhu,Suwen Zhao,Gaofeng Fan.

Cell Rep. 2023 Oct 31;42(10):113246. doi: 10.1016/j.celrep.2023.113246. Epub 2023 Oct 12.

122.A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses, including all major Omicron strains.

Hebang Yao, Hongyang Wang, Zhaoyong Zhang, Yuchi Lu, Zhiying Zhang, Yu Zhang, Xinyi Xiong, Yanqun Wang, Zhizhi Wang, Haitao Yang, Jincun Zhao,Wenqing Xu.

MedComm (2020). 2023 Oct 26;4(6):e397. doi: 10.1002/mco2.397. eCollection 2023 Dec.

121.Design and Synthesis of Novel GPR139 Agonists with Therapeutic Effects in Mouse Models of Social Interaction and Cognitive Impairment.

Jianhang Mao, Yilong Cui, Huan Wang, Wenwen Duan, Zhi-Jie Liu, Tian Hua, Ning Zhou, Jianjun Cheng.

J Med Chem. 2023 Oct 26;66(20):14011-14028. doi: 10.1021/acs.jmedchem.3c01034. Epub 2023 Oct 13.

120.Structural basis for activation and filamentation of glutaminase.

Chen-Jun Guo, Zi-Xuan Wang,Ji-Long Liu.

Cell Res. 2023 Oct 13. doi: 10.1038/s41422-023-00886-0. Online ahead of print.

119.Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC.

Jingxi Liang, Xiuna Yang, Tianyu Hu, Yan Gao, Qi Yang, Haitao Yang, Wei Peng, Xiaoting Zhou, Luke W Guddat, Bing Zhang, Zihe Rao, Fengjiang Liu.

Structure. 2023 Oct 5;31(10):1158-1165.e3. doi: 10.1016/j.str.2023.07.014. Epub 2023 Aug 23.

118.Dynamic elementomics of single-cell ICP-MS-derived signals in normal and calcium pump PMCA4-deficient mouse epididymal sperm during capacitation.

Bao Li Zhang, Ze Peng Zhang, Su Meng Shi, Hui Juan Shi, Patricia A DeLeon, Winnie Shum.

Metallomics. 2023 Oct 4;15(10):mfad059. doi: 10.1093/mtomcs/mfad059.

117.Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir.

Yinkai Duan #, Hao Zhou #, Xiang Liu #, Sho Iketani #, Mengmeng Lin #, Xiaoyu Zhang, Qucheng Bian, Haofeng Wang, Haoran Sun, Seo Jung Hong, Bruce Culbertson, Hiroshi Mohri, Maria I Luck, Yan Zhu, Xiaoce Liu, Yuchi Lu, Xiuna Yang, Kailin Yang, Yosef Sabo, Alejandro Chavez, Stephen P Goff,Zihe Rao, David D Ho,Haitao Yang.

Nature. 2023 Oct;622(7982):376-382. doi: 10.1038/s41586-023-06609-0. Epub 2023 Sep 11.

116.Base editing of organellar DNA with programmable deaminases.

Jin-Soo Kim,Jia Chen.

Nat Rev Mol Cell Biol.2023 Oct 4. doi: 10.1038/s41580-023-00663-2. Online ahead of print.

115.Design and application of the transformer base editor in mammalian cells and mice.

Wenyan Han #, Bao-Qing Gao #, Junjie Zhu #, Zongxing He #,Jianfeng Li, Li Yang,Jia Chen.

Nat Protoc. 2023 Oct 4. doi: 10.1038/s41596-023-00877-w. Online ahead of print.

114.Structural biology and inhibition of the Mtb cell wall glycoconjugates biosynthesis on the membrane.

Lu Zhang, Zihe Rao.

Curr Opin Struct Biol.2023 Oct:82:102670. doi: 10.1016/j.sbi.2023.102670. Epub 2023 Aug 4.

9月

113.Recognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex.

Ling Yuan, Yaoyao Han, Jiazheng Zhao, Yixiao Zhang,Yadong Sun.

Nat Commun.2023 Sep 28;14(1):6071. doi: 10.1038/s41467-023-41845-y.

112.Intrathecal delivery of AAV-NDNF ameliorates disease progression of ALS mice.

Wei Cheng,Jing Huang,Xiu-Qing Fu, Wei-Ya Tian,Peng-Ming Zeng,Yang Li,Zhen-Ge Luo.

Mol Ther.2023 Sep 27:S1525-0016(23)00505-1. doi: 10.1016/j.ymthe.2023.09.018. Online ahead of print. 

111.Ash1L ameliorates psoriasis via limiting neuronal activity-dependent release of miR-let-7b.

Wan-Jie Du, Huan Yang, Fang Tong, Shuai Liu, Chen Zhang, Yeying Chen, Yuze Yan, Yan-Wei Xiang, Ling-Yang Hua, Ye Gong,Zhi-Xiang Xu, Xiaoyan Liu, Xingyu Jiang, Mingfang Lu,Ji-Song Guan, Qingjian Han.

Br J Pharmacol. 2023 Sep 27. doi: 10.1111/bph.16254. Online ahead of print.

110.Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group.

Pengxuan Ren, Hui Li, Tianqing Nie, Xiaoqin Jian, Changyue Yu, Jian Li, Haixia Su, Xianglei Zhang, Shiwei Li, Xin Yang, Chao Peng, Yue Yin, Leike Zhang, Yechun Xu, Hong Liu,Fang Bai.

J Med Chem.2023 Sep 14;66(17):12266-12283. doi: 10.1021/acs.jmedchem.3c00818. Epub 2023 Aug 18. 

109.Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7.

Cuixia Li, Yiran Wu, Wenli Wang, Lu Xu, Yan Zhou, Yang Yue, Tingting Wu, Meifang Yang, Yanli Qiu, Minhao Huang, Fangfang Zhou, Yiqing Zhou, Piliang Hao, Zhixiong Lin, Ming-Wei Wang,Suwen Zhao, Dehua Yang,Fei Xu, Houchao Tao.

J Med Chem.2023 Sep 14;66(17):11855-11868. doi: 10.1021/acs.jmedchem.2c01795. Epub 2023 Sep 5. 

108.Fat body-specific reduction of CTPS alleviates HFD-induced obesity.

Jingnan Liu #, Yuanbing Zhang #, Qiao-Qi Wang #, Youfang Zhou, Ji-Long Liu .

Elife.2023 Sep 11:12:e85293. doi: 10.7554/eLife.85293.

107.Prime editor-mediated functional reshaping of ACE2 prevents the entry of multiple human coronaviruses, including SARS-CoV-2 variants.

Wenwen Zhao, Jifang Li, Xiao Wang, Wei Xu, Bao-Qing Gao, Jiangchao Xiang , Yaofeng Hou, Wei Liu, Jing Wu, Qilian Qi, Jia Wei, Xiaoyu Yang, Lu Lu, Li Yang, Jia Chen, Bei Yang .

MedComm (2020).2023 Sep 10;4(5):e356. doi: 10.1002/mco2.356. eCollection 2023 Oct.

106.Chemical-induced phase transition and global conformational reorganization of chromatin.

Tengfei Wang #, Shuxiang Shi #, Yuanyuan Shi #, Peipei Jiang #, Ganlu Hu #, Qinying Ye, Zhan Shi, Kexin Yu, Chenguang Wang, Guoping Fan,Suwen Zhao,Hanhui Ma,Alex C Y Chang, Zhi Li, Qian Bian, Chao-Po Lin.

Nat Commun.2023 Sep 9;14(1):5556. doi: 10.1038/s41467-023-41340-4.

105.GPCRana: A web server for quantitative analysis of GPCR structures.

Yu Guo, Qingtong Zhou, Bin Wei, Ming-Wei Wang, Suwen Zhao.

Structure. 2023 Sep 7;31(9):1132-1142.e2. doi: 10.1016/j.str.2023.06.008. Epub 2023 Jun 30.

104.Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of RORγ antagonists.

Lianghe Mei, Lansong Xu, Sanan Wu, Yafang Wang, Chao Xu, Lin Wang, Xingyu Zhang, Chengcheng Yu, Hualiang Jiang, Xianglei Zhang,Fang Bai, Chengying Xie.

Eur J Med Chem.2023 Sep 5;257:115472. doi: 10.1016/j.ejmech.2023.115472. Epub 2023 May18.

103.Effect on cell survival and cytoophidium assembly of the adRP-10-related IMPDH1 missense mutation Asp226Asn.

Gerson Dierley Keppeke, Chia-Chun Chang, Ziheng Zhang, Ji-Long Liu.

Front Cell Dev Biol.2023 Sep 4:11:1234592. doi: 10.3389/fcell.2023.1234592. eCollection 2023.

102.Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years.

Mauro Maccarrone, Vincenzo Di Marzo, Jürg Gertsch, Uwe Grether, Allyn C Howlett,Tian Hua, Alexandros Makriyannis, Daniele Piomelli, Natsuo Ueda, Mario van der Stelt.

Pharmacol Rev.2023 Sep;75(5):885-958. doi: 10.1124/pharmrev.122.000600. Epub 2023 May 10.

8月

101.A new regulator of autophagy initiation in glia.

Linfang Wang, Shiping Zhang, Shuanglong Yi,Margaret S Ho.

Autophagy.2023 Aug 29:1-3. doi: 10.1080/15548627.2023.2251821. Online ahead of print

100.Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis.

Fenyong Yao #, Shisheng Huang # , Jiahui Liu #, Chunhua Tan #, Mengqi Xu, Dengkui Wang, Maoqing Huang, Yiyao Zhu,Xingxu Huang,Shuijin He.

Cell Death Dis.2023 Aug 23;14(8):543. doi: 10.1038/s41419-023-06071-w.

99.Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group.

Pengxuan Ren, Hui Li, Tianqing Nie, Xiaoqin Jian, Changyue Yu, Jian Li, Haixia Su, Xianglei Zhang,Shiwei Li, Xin Yang,Chao Peng,Yue Yin,Leike Zhang,Yechun Xu,Hong Liu,Fang Bai.

J Med Chem.2023 Aug 18. doi: 10.1021/acs.jmedchem.3c00818. Online ahead of print.

98.Enlarged DNA unwinding by Nme2Cas9 permits a broadened base editing window beyond the protospacer.

Ziting Chen #,Xiangyang Li #,Qian Zhang,Wenjun Sun,Xiaoxuan Song,Xia Zhang,Xingxu Huang, Bo Sun.

Sci China Life Sci.2023 Aug 18. doi: 10.1007/s11427-023-2384-9. Online ahead of print.

97.A parabrachial-hypothalamic parallel circuit governs cold defense in mice.

Wen Z Yang #, Hengchang Xie #, Xiaosa Du #, Qian Zhou #,Yan Xiao,Zhengdong Zhao,Xiaoning Jia, Jianhui Xu,Wen Zhang,Shuang Cai,Zhangjie Li,Xin Fu,Rong Hua,Junhao Cai,Shuang Chang, Jing Sun,Hongbin Sun,Qingqing Xu,Xinyan Ni,Hongqing Tu,Ruimao Zheng,Xiaohong Xu,Hong Wang,Yu Fu,Liming Wang,Xi Li,Haitao Yang,Qiyuan Yao,Tian Yu Qiwei Shen,Wei L Shen.

Nat Commun.2023 Aug 15;14(1):4924. doi: 10.1038/s41467-023-40504-6.

96.HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation.

Erpeng Wu #,Wenyan He #,Chenlu Wu,Zhangcheng Chen,Shijie Zhou,Xialian Wu, Zhiheng Hu,Kelong Jia,Jiasong Pan,Limin Wang,Jie Qin,Dan Liu,Junxia Lu,Huayi Wang,Jixi Li,Sheng Wang, Liming Sun .

Cell Res.2023 Aug 14. doi: 10.1038/s41422-023-00859-3. Online ahead of print.

95.Profiling neurotransmitter-evoked glial responses by RNA-sequencing analysis .

Mengxiao Wang, Margaret S Ho.

Front Neural Circuits.2023 Aug 14:17:1252759. doi: 10.3389/fncir.2023.1252759. eCollection 2023.

94.Orthogonally Engineered Albumin with Attenuated Macrophage Phagocytosis for the Targeted Visualization and Phototherapy of Liver Cancer.

Wei-Tao Dou, Peng Qiu,Yuanyuan Shi,Ling Zhu,Chen Guo, Na Li,Yi Zang,Tingting Liu,Suwen Zhao,Yufei Pan,Liwei Dong,Jonathan L Sessler,Yexiong Tan,Jia Li,Hongyang Wang,He Tian, Xiao-Peng He.

J Am Chem Soc.2023 Aug 9;145(31):17377-17388. doi: 10.1021/jacs.3c05052. Epub 2023 Jul 27.

93.Structural biology of SARS-CoV-2 Mpro and drug discovery.

Yinkai Duan, Haofeng Wang,Zhenghong Yuan,Haitao Yang.

Curr Opin Struct Biol.2023 Aug 4;82:102667. doi: 10.1016/j.sbi.2023.102667. Online ahead of print.

92.Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs.

Jun Niu #, Qi Wang #, Wenwen Zhao #, Bing Meng #, Youwei Xu #, Xianfang Zhang,Yi Feng, Qilian Qi, Yanling Hao, Xuan Zhang,Ying Liu, Jiangchao Xiang,Yiming Shao,Bei Yang.

Nat Commun.2023 Aug 4;14(1):4676. doi: 10.1038/s41467-023-40321-x.

91.Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs.

Jun Niu #, Qi Wang #, Wenwen Zhao #, Bing Meng #, Youwei Xu #, Xianfang Zhang, Yi Feng, Qilian Qi, Yanling Hao, Xuan Zhang, Ying Liu, Jiangchao Xiang, Yiming Shao,Bei Yang.

Nat Commun.2023 Aug 4;14(1):4676. doi: 10.1038/s41467-023-40321-x.

90.Automated phenotyping of postoperative delirium-like behaviour in mice reveals the therapeutic efficacy of dexmedetomidine.

Silu Cao #, Yiling Wu #, Zilong Gao #, Jinxuan Tang, Lize Xiong,Ji Hu,Cheng Li.

Commun Biol.2023 Aug 2;6(1):807. doi: 10.1038/s42003-023-05149-7.

89.An erythrocyte membrane-modified biomimetic synergistic nanosystem for cancer anti-vascular therapy and initial efficacy monitoring.

Jieying Zhang,Fang Li,Lili Su,Qian Hu,Jianfeng Li,Xingjun Zhu.

J Mater Chem B.2023 Aug 2;11(30):7160-7168. doi: 10.1039/d3tb00807j.

88.Progress and Prospects of Gene Editing in Pluripotent Stem Cells.

Zhenwu Zhang, Xinyu Bao,Chao-Po Lin.

Biomedicines.2023 Aug 1;11(8):2168. doi: 10.3390/biomedicines11082168.

87.Immunometabolism at the basis of health and disease; an editorial.

Jan Van den Bossche,Tiffany Horng,Dylan G Ryan.

Biochim Biophys Acta Mol Basis Dis.2023 Aug;1869(6):166715. doi: 10.1016/j.bbadis.2023.166715. Epub 2023 Apr 6.

7月

86.Adenosine A2A Receptor (A2AAR) Ligand Screening Using the 19F-NMR Probe FPPA.

Jinfeng Zhang, Dandan Feng,Jianjun Cheng,Kurt Wüthrich.

J Am Chem Soc.2023 Jul 19;145(28):15061-15064. doi: 10.1021/jacs.3c04218. Epub 2023 Jun 5.

85.Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia.

Shiping Zhang,Shuanglong Yi,Linfang Wang,Shuhua Li,Honglei Wang,Li Song, Jiayao Ou, Min Zhang,Ruiqi Wang,Mengxiao Wang,Yuchen Zheng, Kai Yang,Tong Liu,Margaret S Ho.

Proc Natl Acad Sci U S A.2023 Jul 18;120(29):e2301002120. doi: 10.1073/pnas.2301002120. Epub 2023 Jul 10.

84.Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.

Chengsong Yan, Lin Zheng,Shutan Jiang, Haochen Yang, Jun Guo, Lu-Yi Jiang, Tongzhou Li, Haosong Zhang,Yibing Bai,Yu Lou, Qi Zhang,Tingbo Liang,Wolfgang Schamel,Haopeng Wang, Weiwei Yang,Guangchuan Wang,Zheng-Jiang Zhu,Bao-Liang Song,Chenqi Xu.

Cancer Cell.2023 Jul 10;41(7):1276-1293.e11. doi: 10.1016/j.ccell.2023.04.016. Epub 2023 May 26.

83.Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing.

Shiheng Liu #, Hong Wang #, Xiaorun Li,Fan Zhang,Jane K J Lee,Zihang Li,Clinton Yu,Jason J Hu, Xiaojing Zhao,Takuma Suematsu, Ana L Alvarez-Cabrera,Qiushi Liu,Liye Zhang,Lan Huang, Inna Aphasizheva,Ruslan Aphasizhev,Z Hong Zhou.

Science. 2023 Jul 7;381(6653):eadg4725. doi: 10.1126/science.adg4725. Epub 2023 Jul 7.

82.Molecular mechanism of ensitrelvir inhibiting SARS-CoV-2 main protease and its variants.

Mengmeng Lin,Xudong Zeng,Yinkai Duan, Zinan Yang,Yuanyuan Ma,Haitao Yang,Xiuna Yang, Xiang Liu.

Commun Biol.2023 Jul 5;6(1):694. doi: 10.1038/s42003-023-05071-y.

81.The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility.

Xin Wang #, Di-Hang Lin #, Yue Yan #, An-Hui Wang #, Jiaoyang Liao #, Qian Meng #, Wen-Qing Yang #, Heng Zuo, Min-Min Hua, Fengjuan Zhang, Hongwen Zhu, Hu Zhou, Tian-Yu Huang, Rui He, Guangyong Li, Yue-Qiu Tan, Hui-Juan Shi, Lan-Tao Gou, Dangsheng Li, Ligang Wu, Yonggang Zheng, Xiang-Dong Fu, Jinsong Li,Rujuan Liu, Guo-Hui Li, Mo-Fang Liu.

Sci China Life Sci.2023 Jul;66(7):1459-1481. doi: 10.1007/s11427-023-2390-5. Epub 2023 Jun 15.

80.Alternative Z-genome biosynthesis pathway shows evolutionary progression from Archaea to phage.

Yang Tong #, Xinying Wu #, Yang Liu #, Huiyu Chen, Yan Zhou, Li Jiang, Meng Li,Suwen Zhao, Yan Zhang.

Nat Microbiol.2023 Jul;8(7):1330-1338. doi: 10.1038/s41564-023-01410-1. Epub 2023 Jun 12.

6月

79.Cytoophidia and filaments: you must unlearn what you have learned.

Chen-Jun Guo, Ji-Long Liu.

Biochem Soc Trans.2023 Jun 28;51(3):1245-1256. doi: 10.1042/BST20221410.

78.RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis.

Chao Liu, Liying Wang, Yanan Li, Mengmeng Guo, Jun Hu, Teng Wang, Mengjing Li, Zhuo Yang, Ruoyao Lin, Wei Xu, Yinghong Chen, Mengcheng Luo, Fei Gao, Jia-Yu Chen, Qianwen Sun, Hongbin Liu, Bo Sun, Wei Li.

Nucleic Acids Res.2023 Jun 28;gkad524. doi: 10.1093/nar/gkad524. Online ahead of print.

77.Charging CAR by electrostatic power.

Haopeng Wang, Yuwei Huang, Chenqi Xu.

Immunol Rev.2023 Jun 27. doi: 10.1111/imr.13232. Online ahead of print.

76.Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome.

Hongyang Wang, Mariann Bienz, Xiao-Xue Yan,Wenqing Xu.

Nat Commun.2023 Jun 22;14(1):3702. doi: 10.1038/s41467-023-39439-9.

75.Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.

Yu Guo #, Guangshun Zhang #, Qi Yang #, Xiaowei Xie #, Yang Lu #, Xuelian Cheng #, Hui Wang #, Jingxi Liang #, Jielin Tang #, Yuxin Gao #, Hang Shang, Jun Dai, Yongxia Shi, Jiaxi Zhou, Jun Zhou, Hangtian Guo, Haitao Yang, Jianwei Qi, Lijun Liu, Shihui Ma, Biao Zhang, Qianyu Huo, Yi Xie, Junping Wu, Fang Dong,Song Zhang, Zhiyong Lou, Yan Gao, Zidan Song, Wenming Wang, Zixian Sun, Xiaoming Yang , Dongsheng Xiong, Fengjiang Liu, Xinwen Chen, Ping Zhu, Ximo Wang,Tao Cheng,Zihe Rao.

Nat Commun.2023 Jun 15;14(1):3537. doi: 10.1038/s41467-023-39267-x.

74.Identification of mesenchymal-to-epithelial transition during heart regeneration through genetic lineage tracing.

Zibei Gao #, Zhengkai Lu #, Jinyan Meng, Chao-Po Lin, Hui Zhang,Juan Tang.

Stem Cell Res Ther.2023 Jun 14;14(1):161. doi: 10.1186/s13287-023-03391-8. 

73.Neodb: a comprehensive neoantigen database and discovery platform for cancer immunotherapy.

Tao Wu, Jing Chen, Kaixuan Diao, Guangshuai Wang, Jinyu Wang, Huizi Yao,Xue-Song Liu.

Database (Oxford).2023 Jun 13;2023:baad041. doi: 10.1093/database/baad041. 

72.Mechanism of an RBM-targeted rabbit monoclonal antibody 9H1 neutralizing SARS-CoV-2.

Xiaoyu Chu, Xinyu Ding, Yixuan Yang, Yuchi Lu, Tinghan Li, Yan Gao, Le Zheng, Hang Xiao, Tingting Yang, Hao Cheng, Haibin Huang, Yang Liu, Yang Lou, Chao Wu, Yuxin Chen,Haitao Yang, Xiaoyun Ji, Hangtian Guo.

Biochem Biophys Res Commun.2023 Jun 11;660:43-49. doi: 10.1016/j.bbrc.2023.04.002. Epub 2023 Apr 5.

71.Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.

Shengjie Fan #, Yingxuan Yan #, Ying Xia #, Zhenyu Zhou #, Lingling Luo #, Mengnan Zhu #, Yongli Han, Deqiang Yao, Lijun Zhang, Minglv Fang, Lina Peng, Jing Yu 1, Ying Liu, Xiaoyan Gao, Huida Guan, Hongli Li, Changhong Wang, Xiaojun Wu,Huanhu Zhu, Yu Cao, Cheng Huang.

Nat Commun.2023 Jun 8;14(1):3368. doi: 10.1038/s41467-023-39118-9.

70.Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A.

Yuxiang Chen, Bo Chen, Tingting Wu, Fangfang Zhou, Fei Xu .

Protein Cell.2023 Jun 7;14(6):464-468. doi: 10.1093/procel/pwac033.

69.Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans.

Jing-Yi Peng, Xuqing Liu, Xian-Ting Zeng, Yue Hao, Jia-Hui Zhang, Qian Li,Xia-Jing Tong.

Cell Rep.2023 Jun 7;42(6):112598. doi: 10.1016/j.celrep.2023.112598. Online ahead of print.

68.Sustained remission of type 2 diabetes in rodents by centrally administered fibroblast growth factor 4.

Hongbin Sun, Wei Lin, Yu Tang, Hongqing Tu, Ting Chen, Jie Zhou, Dezhong Wang, Qingqing Xu, Jianlou Niu, Wenliya Dong, Sidan Liu, Xinyan Ni, Wen Yang, Yingzheng Zhao, Lei Ying, Jie Zhang, Xiaokun Li, Moosa Mohammadi,Wei L Shen, Zhifeng Huang.

Cell Metab. 2023 Jun 6;35(6):1022-1037.e6. doi: 10.1016/j.cmet.2023.04.018. Epub 2023 May 10.

67.Structure of the priming arabinosyltransferase AftA required for AG biosynthesis of Mycobacterium tuberculosis.

Yicheng Gong, Chuancun Wei, Jun Wang, Nengjiang Mu, Qinhong Lu, Chengyao Wu, Ning Yan, Huifang Yang, Yao Zhao, Xiuna Yang, Sudagar S Gurcha, Natacha Veerapen, Sarah M Batt, Zhiqiang Hao, Lintai Da, Gurdyal S Besra,Zihe Rao, Lu Zhang.

Proc Natl Acad Sci U S A.2023 Jun 6;120(23):e2302858120. doi: 10.1073/pnas.2302858120. Epub 2023 May 30.

66.Establishment of an induced pluripotent stem cell (SIAISi016-A) line from a 62-years old Chinese Han patient with Alzheimer's disease.

Juan Huang, Ying Wang,Jian Zhao, Yulei Deng, Wenshi Wei.

Stem Cell Res.2023 Jun;69:103091. doi: 10.1016/j.scr.2023.103091. Epub 2023 Apr 8.

65.Development of the nonreceptor tyrosine kinase FER-targeting PROTACs as a potential strategy for antagonizing ovarian cancer cell motility and invasiveness

Yanchun Zhang, Xuexue Xiong, Renhong Sun, Xiaotong Zhu, Chen Wang, Biao Jiang, Xiaobao Yang, Dake Li,Gaofeng Fan.

J Biol Chem.2023 Jun;299(6):104825. doi: 10.1016/j.jbc.2023.104825. Epub 2023 May 16.

5月

64.Structural basis of human PRPS2 filaments.

Guang-Ming Lu #, Huan-Huan Hu #, Chia-Chun Chang,Jiale Zhong, Xian Zhou, Chen-Jun Guo, Tianyi Zhang,Yi-Lan Li, Boqi Yin,Ji-Long Liu.

Cell Biosci.2023 May 30;13(1):100. doi: 10.1186/s13578-023-01037-z.

63.Modeling human ectopic pregnancies with trophoblast and vascular organoids.

Xiaoya Zhao, Zhenwu Zhang, Qian Zhu, Yurui Luo, Qinying Ye, Shuxiang Shi, Xueyang He, Jing Zhu, Duo Zhang, Wei Xia, Yiqin Zhang, Linlin Jiang, Long Cui, Yinghui Ye,Yangfei Xiang, Junhao Hu, Jian Zhang,Chao-Po Lin.

Cell Rep.2023 May 23;42(6):112546. doi: 10.1016/j.celrep.2023.112546. Online ahead of print.

62.Biallelic variants in NSUN6 cause an autosomal recessive neurodevelopmental disorder.

Francesca Mattioli, Lina Worpenberg, Cai-Tao Li, Nazia Ibrahim, Shagufta Naz, Saima Sharif, Saghar G Firouzabadi, Shohreh Vosoogh, Radoslava Saraeva-Lamri, Laure Raymond, Carlos Trujillo, Nicolas Guex, Stylianos E Antonarakis, Muhammad Ansar, Hossein Darvish, Ru-Juan Liu, Jean-Yves Roignant,Alexandre Reymond.

Genet Med.2023 May 21;25(9):100900. doi: 10.1016/j.gim.2023.100900. Online ahead of print.

61.Small-sample learning reveals propionylation in determining global protein homeostasis.

Ke Shui #, Chenwei Wang #, Xuedi Zhang, Shanshan Ma, Qinyu Li, Wanshan Ning, Weizhi Zhang, Miaomiao Chen, Di Peng, Hui Hu, Zheng Fang, Anyuan Guo,Guanjun Gao, Mingliang Ye, Luoying Zhang, Yu Xue.

Nat Commun.2023 May 17;14(1):2813. doi: 10.1038/s41467-023-38414-8.

60.Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter.

Xiao-Na Zhu, Jie Li, Gao-Lin Qiu, Lin Wang, Chen Lu, Yi-Ge Guo, Ke-Xin Yang, Fang Cai, Tao Xu, Ti-Fei Yuan,Ji Hu.

Neuron.2023 May 17;111(10):1626-1636.e6. doi: 10.1016/j.neuron.2023.02.017. Epub 2023 Mar 13.

59.Transformation of a Dopamine D2 Receptor Agonist to Partial Agonists as Novel Antipsychotic Agents.

Ruiquan Liu, Jianzhong Qi, Huan Wang, Luyu Fan, Pei Zhang, Jing Yu, Liang Tan, Sheng Wang,Jianjun Cheng.

J Med Chem.2023 May 11;66(9):6274-6287. doi: 10.1021/acs.jmedchem.3c00098. Epub 2023 May 2.

58.Computational markers of risky decision-making predict for relapse to alcohol.

Wei Yuan #, Meng Chen #, Duan-Wei Wang, Qian-Hui Li #, Yuan-Yuan Yin, Bin Li, Hai-Rong Wang,Ji Hu, Yuan-Dong Gong, Ti-Fei Yuan, Tian-Gui Yu.

Eur Arch Psychiatry Clin Neurosci. 2023 May 6. doi: 10.1007/s00406-023-01602-0. Online ahead of print. 

57.Broad phosphorylation mediated by testis-specific serine/threonine kinases contributes to spermiogenesis and male fertility.

Xuedi Zhang #, Ju Peng #, Menghua Wu #, Angyang Sun, Xiangyu Wu, Jie Zheng, Wangfei Shi ,Guanjun Gao.

Nat Commun.2023 May 6;14(1):2629. doi: 10.1038/s41467-023-38357-0.

56.Sustained remission of type 2 diabetes in rodents by centrally administered fibroblast growth factor 4.

Hongbin Sun, Wei Lin, Yu Tang, Hongqing Tu, Ting Chen, Jie Zhou, Dezhong Wang, Qingqing Xu, Jianlou Niu, Wenliya Dong, Sidan Liu, Xinyan Ni, Wen Yang, Yingzheng Zhao, Lei Ying, Jie Zhang, Xiaokun Li, Moosa Mohammadi,Wei L Shen,Zhifeng Huang.

Cell Metab.2023 May 5;S1550-4131(23)00172-9. doi: 10.1016/j.cmet.2023.04.018. Online ahead of print.

55.Cryo-EM structures of a prokaryotic heme transporter CydDC.

Chen Zhu, Yanfeng Shi, Jing Yu, Wenhao Zhao, Lingqiao Li, Liang Jingxi, Xiaolin Yang, Bing Zhang, Yao Zhao, Yan Gao, Xiaobo Chen, Xiuna Yang, Lu Zhang, Luke W Guddat, Lei Liu,Haitao Yang, Zihe Rao,Jun Li.

Protein Cell. 2023 May 5;pwad022. doi: 10.1093/procel/pwad022. Online ahead of print.

54.Generation of ventralized human thalamic organoids with thalamic reticular nucleus.

Ferdi Ridvan Kiral, Bilal Cakir, Yoshiaki Tanaka, Jonghun Kim, Woo Sub Yang, Fabien Wehbe, Young-Jin Kang, Mei Zhong, Gizem Sancer, Sang-Hun Lee,Yangfei Xiang,In-Hyun Park.

Cell Stem Cell.2023 May 4;30(5):677-688.e5. doi: 10.1016/j.stem.2023.03.007. Epub 2023 Apr 4.

53.In Vivo Fate of CXCR2-Overexpressing Mesenchymal Stromal/Stem Cells in Pulmonary Diseases Monitored by Near-Infrared Region 2 Imaging.

Huiying Yang, Qingxia Wu, Jinwei Li, Qimingxing Chen, Lili Su, Xiaoyan He,Jianfeng Li, Xiaoyan Qiu .

ACS Appl Mater Interfaces.2023 May 3;15(17):20742-20752. doi: 10.1021/acsami.3c01741. Epub 2023 Apr 18.

52.Anti-IgLON5 disease: a novel topic beyond neuroimmunology.

Yi-Zong Heng Zhang, You Ni, Yi-Ning Gao, Ding-Ding Shen, Lu He, Dou Yin, Huan-Yu Meng, Qin-Ming Zhou,Ji Hu, Sheng Chen.

Neural Regen Res. 2023 May;18(5):1017-1022. doi: 10.4103/1673-5374.355742.

4月

51.The local density of H3K9me3 dictates the stability of HP1α condensates-mediated genomic interactions.

Ying Feng, Li Guo, Chen Yang, Hui Zheng, Xiao Xiao,Hanhui Ma.

J Genet Genomics.2023 Apr 26:S1673-8527(23)00093-0. doi: 10.1016/j.jgg.2023.04.006. Online ahead of print.

50.Sperm-borne microRNA-34c regulates maternal mRNA degradation and preimplantation embryonic development in mice.

Long Cui, Li Fang, Lili Zhuang, Biwei Shi,Chao-Po Lin, Yinghui Ye.

Reprod Biol Endocrinol.2023 Apr 26;21(1):40. doi: 10.1186/s12958-023-01089-3.

49.Evaluating the effect of two-dimensional molecular layout on DNA origami-based transporters.

Kodai Fukumoto, Yuya Miyazono, Takuya Ueda, Yoshie Harada,Hisashi Tadakuma.

Nanoscale Adv.2023 Apr 19;5(9):2590-2601. doi: 10.1039/d3na00088e. eCollection 2023 May 2.

48.Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response.

Nan Sun, Kexin Yang,Wenzhong Yan, Mingyue Yao,Chengcheng Yu,Wenwen Duan,Xiaoke Gu,Dong Guo, Hualiang Jiang,Chengying Xie,Jianjun Cheng.

J Med Chem.2023 Apr 13;66(7):4802-4826.doi: 10.1021/acs.jmedchem.2c01985. Epub 2023 Mar 19.

47.Small-Caliber Tissue-Engineered Vascular Grafts Based on Human-Induced Pluripotent Stem Cells: Progress and Challenges.

Junyi Ji, Hongju Xu, Chen Li,Jiesi Luo.

Tissue Eng Part B Rev.2023 Apr 12. doi: 10.1089/ten.TEB.2023.0005. Online ahead of print.

46.Accurate prediction of pan-cancer types using machine learning with minimal number of DNA methylation sites.

Wei Ning,Tao Wu,Chenxu Wu, Shixiang Wang, Ziyu Tao,Guangshuai Wang,Xiangyu Zhao, Kaixuan Diao, Jinyu Wang, Jing Chen, Fuxiang Chen,Xue-Song Liu.

J Mol Cell Biol.2023 Apr 10;mjad023. doi: 10.1093/jmcb/mjad023. Online ahead of print.

45.APC/C-dependent degradation of Spd2 regulates centrosome asymmetry in Drosophila neural stem cells.

Francesco Meghini#, Torcato Martins#, Qian Zhang#, Nicolas Loyer, Michelle Trickey, Yusanjiang Abula, Hiroyuki Yamano,Jens Januschke,Yuu Kimata.

EMBO Rep. 2023 Apr 5;24(4):e55607. doi: 10.15252/embr.202255607. Epub 2023 Feb 28.

44.Structural Basis of the Interaction between Human Axin2 and SIAH1 in the Wnt/β-Catenin Signaling Pathway.

Lianqi Chen,Yan-Ping Liu,Li-Fei Tian,Mingzhou Li,Shuyu Yang,Song Wang,Wenqing Xu,Xiao-Xue Yan.

Biomolecules.2023 Apr 4;13(4):647. doi: 10.3390/biom13040647.

43.Mechanism of a rabbit monoclonal antibody broadly neutralizing SARS-CoV-2 variants.

Hangtian Guo #, Yixuan Yang #, Tiantian Zhao #, Yuchi Lu #, Yan Gao, Tinghan Li, Hang Xiao, Xiaoyu Chu, Le Zheng, Wanting Li, Hao Cheng, Haibin Huang, Yang Liu, Yang Lou, Henry C Nguyen, Chao Wu, Yuxin Chen,Haitao Yang, Xiaoyun Ji.

Commun Biol. 2023 Apr 3;6(1):364. doi: 10.1038/s42003-023-04759-5.

42.An examination of the metal ion content in the active sites of human endonucleases CPSF73 and INTS11.

Ji Huang, Xiangyang Liu,Yadong Sun, Zhuang Li,Min-Han Lin, Keith Hamilton, Corey R Mandel, Felix Sandmeir,Elena Conti, Paul H Oyala, Liang Tong.

J Biol Chem.2023 Apr;299(4):103047. doi: 10.1016/j.jbc.2023.103047. Epub 2023 Feb 22.

3月

41.Generation of ventralized human thalamic organoids with thalamic reticular nucleus.

Ferdi Ridvan Kiral, Bilal Cakir, Yoshiaki Tanaka, Jonghun Kim, Woo Sub Yang, Fabien Wehbe, Young-Jin Kang, Mei Zhong, Gizem Sancer, Sang-Hun Lee,Yangfei Xiang,In-Hyun Park .

Cell Stem Cell.2023 Mar 28;S1934-5909(23)00078-4. doi: 10.1016/j.stem.2023.03.007. Online ahead of print.

40.Structural insights into the human niacin receptor HCA2-Gi signalling complex.

Yang Yang #, Hye Jin Kang #, Ruogu Gao #, Jingjing Wang, Gye Won Han, Jeffrey F DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C Stevens, Wei Peng, Bryan L Roth, Zihe Rao,Zhi-Jie Liu.

Nat Commun.2023 Mar 27;14(1):1692. doi: 10.1038/s41467-023-37177-6.

39.Advances in CRISPR/Cas gene therapy for inborn errors of immunity.

Xinyi Liu, Guanglei Li, Yin Liu, Fuling Zhou,Xingxu Huang, Kui Li.

Front Immunol.2023 Mar 27;14:1111777. doi: 10.3389/fimmu.2023.1111777. eCollection 2023.

38.CD19/CD22 bispecific CAR-T cells for MRD-positive adult B cell acute lymphoblastic leukemia: a phase I clinical study.

Jiahua Niu#, Huiying Qiu#, Fang Xiang#, Lin Zhu,Jun Yang,Chongmei Huang,Kun Zhou,Yin Tong,Yu Cai,Baoxia Dong,Yuan Lu,Xuedong Sun,Liping Wan,Xueying Ding,Haopeng Wang,Xianmin Song.

Blood Cancer J.2023 Mar 24;13(1):44. doi: 10.1038/s41408-023-00813-x.

37.TLimmuno2: predicting MHC class II antigen immunogenicity through transfer learning.

Guangshuai Wang,Tao Wu,Wei Ning,Kaixuan Diao,Xiaoqin Sun,Jinyu Wang,Chenxu Wu,Jing Chen, Dongliang Xu,Xue-Song Liu.

Brief Bioinform.2023 Mar 23;bbad116. doi: 10.1093/bib/bbad116. Online ahead of print.

36.The repertoire of copy number alteration signatures in human cancer.

Ziyu Tao,Shixiang Wang,Chenxu Wu,Tao Wu, Xiangyu Zhao,Wei Ning,Guangshuai Wang,Jinyu Wang, Jing Chen, Kaixuan Diao, Fuxiang Chen,Xue-Song Liu.

Brief Bioinform.2023 Mar 19;24(2):bbad053. doi: 10.1093/bib/bbad053.

35.UNC-43/CaMKII-triggered anterograde signals recruit GABAARs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs.

Yue Hao#, Haowen Liu#, Xian-Ting Zeng,Ya Wang,Wan-Xin Zeng,Kang-Ying Qian,Lei Li, Ming-Xuan Chi,Shangbang Gao,Zhitao Hu,Xia-Jing Tong.

Nat Commun.2023 Mar 15;14(1):1436. doi: 10.1038/s41467-023-37137-0.

34.Structural basis of selective cannabinoid CB2 receptor activation.

Xiaoting Li#, Hao Chang#, Jara Bouma#, Laura V de Paus,Partha Mukhopadhyay,Janos Paloczi, Mohammed Mustafa, Cas van der Horst,Sanjay Sunil Kumar, Lijie Wu,Yanan Yu, Richard J B H N van den Berg, Antonius P A Janssen, Aron Lichtman,Zhi-Jie Liu, Pal Pacher, Mario van der Stelt, Laura H Heitman,Tian Hua.

Nat Commun. 2023 Mar 15;14(1):1447. doi: 10.1038/s41467-023-37112-9.

33.Quantification of Neoantigen-Mediated Immunoediting in Cancer Evolution-Reply.

Tao Wu,Kaixuan Diao,Xue-Song Liu.

Cancer Res.2023 Mar 15;83(6):973. doi: 10.1158/0008-5472.CAN-22-3218.

32.Affinity selection of double-click triazole libraries for rapid discovery of allosteric modulators for GLP-1 receptor.

Ye Xin,Shuo Liu, Yan Liu,Zhen Qian, Hongyue Liu, Bingjie Zhang, Taijie Guo,Garth J Thompson, Raymond C Stevens, K Barry Sharpless, Jiajia Dong,Wenqing Shui.

Proc Natl Acad Sci U S A.2023 Mar 14;120(11):e2220767120. doi: 10.1073/pnas.2220767120. Epub 2023 Mar 9.

31.Exploring and Learning the Universe of Protein Allostery Using Artificial Intelligence Augmented Biophysical and Computational Approaches.

Steve Agajanian, Mohammed Alshahrani,Fang Bai,Peng Tao,Gennady M Verkhivker.

J Chem Inf Model.2023 Mar 13;63(5):1413-1428. doi: 10.1021/acs.jcim.2c01634. Epub 2023 Feb 24.

30.Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness.

Jian Chen#, Shizhen Qiu#, Wentao Li#, Kun Wang,Yu Zhang, Han Yang,Baichuan Liu,Guangfei Li, Li Li,Min Chen,Junjie Lan,Jiahua Niu,Peijie He, Lei Cheng,Gaofeng Fan, Xin Liu, Xianmin Song,Chenqi Xu,Haitao Wu,Haopeng Wang.

Cell Res. 2023 Mar 8. doi: 10.1038/s41422-023-00789-0. Online ahead of print.

29.Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter.

Xiao-Na Zhu, Jie Li,Gao-Lin Qiu, Lin Wang, Chen Lu, Yi-Ge Guo, Ke-Xin Yang, Fang Cai, Tao Xu, Ti-Fei Yuan,Ji Hu.

Neuron.2023 Mar 6;S0896-6273(23)00121-6. doi: 10.1016/j.neuron.2023.02.017. Online ahead of print.

28.Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2.

Pengxuan Ren, Changyue Yu, Ruxue Zhang, Tianqing Nie, Qiaoyu Hu, Hui Li, Xianglei Zhang, Xueyuan Zhang, Shiwei Li, Lu Liu,Wenhao Dai, Jian Li, Yechun Xu, Haixia Su, Leike Zhang, Hong Liu,Fang Bai.

Eur J Med Chem. 2023 Mar 5;249:115129. doi: 10.1016/j.ejmech.2023.115129. Epub 2023 Jan 18.

27.Point mutations of homologs as an adaptive solution to the gene loss.

Guosheng Ma, Xiaojing Zhao, Xinyi Shentu,Liye Zhang.

J Genet Genomics. 2023 Mar 2;S1673-8527(23)00051-6. doi: 10.1016/j.jgg.2023.02.012. Online ahead of print.

26.Solid-state NMR studies of amyloids.

Jing Liu, Xia-Lian Wu, Yu-Teng Zeng,Zhi-Heng Hu,Jun-Xia Lu.

Structure. 2023 Mar 2;31(3):230-243. doi: 10.1016/j.str.2023.01.005. Epub 2023 Feb 6.

25.Effects of novel variants in BMP15 gene on litter size in Mongolia and Ujimqin sheep breeds.

Yilin Wang,Zhijiao Chi,Shunan Jia,Suwen Zhao,Guifang Cao,Chimgee Purev,Ming Cang, Haiquan Yu, Xihe Li,Siqin Bao,Yongbin Liu,Jianguo Wang, Bin Tong.

Theriogenology.2023 Mar 1;198:1-11. doi: 10.1016/j.theriogenology.2022.12.005. Epub 2022 Dec 10.

2月

24.The activation mechanism and antibody binding mode for orphan GPR20.

Xi Lin #, Shan Jiang #, Yiran Wu, Xiaohu Wei, Gye-Won Han, Lijie Wu, Junlin Liu, Bo Chen, Zhibin Zhang, Suwen Zhao, Vadim Cherezov,Fei Xu.

Cell Discov.2023 Feb 28;9(1):23. doi: 10.1038/s41421-023-00520-8.

23.APC/C-dependent degradation of Spd2 regulates centrosome asymmetry in Drosophila neural stem cells.

Francesco Meghini #, Torcato Martins #, Qian Zhang #, Nicolas Loyer, Michelle Trickey,Yusanjiang Abula, Hiroyuki Yamano, Jens Januschke,Yuu Kimata.

EMBO Rep.2023 Feb 28;e55607. doi: 10.15252/embr.202255607. Online ahead of print.

22.EZH2 W113C is a gain-of-function mutation in B-cell lymphoma enabling both PRC2 methyltransferase activation and tazemetostat resistance.

Liping Chu,Dongxia Tan,Meimei Zhu,Yuxiu Qu, Xin Ma, Bao-Liang Song,Wei Qi.

J Biol Chem.2023 Feb 27;299(4):103073. doi: 10.1016/j.jbc.2023.103073. Online ahead of print.

21.The interconnection of endoplasmic reticulum and microtubule and its implication in Hereditary Spastic Paraplegia.

Xinjian Wang, Chengyu Fan, Yanfen Liu,Yan Zou.

Comput Struct Biotechnol J. 2023 Feb 20;21:1670-1677. doi: 10.1016/j.csbj.2023.02.025. eCollection 2023.

20.Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice.

Shan Yao#, Min-Dong Xu#, Ying Wang#, Shen-Ting Zhao#, Jin Wang, Gui-Fu Chen, Wen-Bing Chen, Jian Liu, Guo-Bin Huang, Wen-Juan Sun, Yan-Yan Zhang, Huan-Li Hou,Lei Li, Xiang-Dong Sun.

Nat Commun. 2023 Feb 9;14(1):729. doi: 10.1038/s41467-023-36209-5.

19.Atypical antipsychotics antagonize GABAA receptors in the ventral tegmental area GABA neurons to relieve psychotic behaviors.

Chen Lu #, Xiaona Zhu #, Yifan Feng #, Weizhen Ao, Jie Li, Zilong Gao, Huoqing Luo, Ming Chen, Fang Cai, Shulu Zhan, Hongxia Li, Wenzhi Sun,Ji Hu.

Mol Psychiatry.2023 Feb 8. doi: 10.1038/s41380-023-01982-8. Online ahead of print.

18.Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice.

Qian Zhou, Xin Fu, Jianhui Xu, Shiming Dong, Changhao Liu, Dali Cheng, Cuicui Gao, Minhua Huang, Zhiduo Liu, Xinyan Ni, Rong Hua, Hongqing Tu, Hongbin Sun, Qiwei Shen, Baoting Chen, Jin Zhang,Liye Zhang, Haitao Yang,Ji Hu, Wei Yang, Weihua Pei, Qiyuan Yao, Xing Sheng, Jie Zhang, Wen Z Yang,Wei L Shen.

Neuron. 2023 Feb 1;111(3):387-404.e8. doi: 10.1016/j.neuron.2022.11.008. Epub 2022 Dec 6.

17.Myh6 promoter-driven Cre recombinase excises floxed DNA fragments in a subset of male germline cells.

Caroline Sheldon, Chase W Kessinger, Yan Sun, Maria I Kontaridis, Qianyi Ma, Saher Sue Hammoud, Zibei Gao,Hui Zhang,Zhiqiang Lin.

J Mol Cell Cardiol. 2023 Feb;175:62-66. doi: 10.1016/j.yjmcc.2022.12.005. Epub 2022 Dec 28.

16.Manganese immunotherapy for treating osteosarcoma: Glycosylating 1V209 anchored MnO2 nanosheets prompt pro-inflammatory macrophage polarization.

Author links open overlay panelChao Liang,Naping Xiong, Mengfan Liu,Yue Chen, Wenxin Li, Jiankun Xu,Yin Sun,Yongjie Wang,Yang Dong, Wenpei Fan,Yifeng Zhang, Zhichang Zhang.

Nano Today.2023 Feb; 48: 101670.

1月

15.STAMP: Spatio-Temporal Association Mapping of Proteins.

Yuanbing Zhang, Bo Zhang,Ji-Long Liu.

Methods Mol Biol. 2023 Jan 31.2626:365-379. doi: 10.1007/978-1-0716-2970-3_20.

14.Neurocircuitry of Predatory Hunting.

Zheng-Dong Zhao#, Li Zhang#, Xinkuan Xiang#,Daesoo Kim, Haohong Li,Peng Cao,Wei L Shen.

Neurosci Bull. 2023 Jan 27. doi: 10.1007/s12264-022-01018-1. Online ahead of print.

13.Optical-Controlled Kinetic Switch: Fine-Tuning of the Residence Time of an Antagonist Binding to the Vasopressin V2 Receptor in In Vitro, Ex Vivo, and In Vivo Models of ADPKD.

Xiaoke Gu, Haoxing Yuan,Wenchao Zhao,Nan Sun, Wenzhong Yan,Chunyu Jiang, Yan He,Hongli Liu,Jianjun Cheng, Dong Guo.

J Med Chem.2023 Jan 26;66(2):1454-1466. doi: 10.1021/acs.jmedchem.2c01625. Epub 2022 Dec 23.

12.BAP1 is a novel regulator of HIF-1α.

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Proc Natl Acad Sci U S A.2023 Jan 24;120(4):e2217840120. doi: 10.1073/pnas.2217840120. Epub 2023 Jan 19.

11.Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.

Cuiwei Yang, Zhangshun Wang, Yingjin Kang, Qianqian Yi,Tong Wang,Yun Bai,Yanfen Liu.

Autophagy.2023 Jan 24;1-18. doi: 10.1080/15548627.2022.2164427. Online ahead of print.

10.Development of Yin-Yang ligand for cannabinoid receptors.

Yanli Qiu, Yitian Zhao, Tao Hu, Meifang Yang, Fei Li, Cuixia Li, Weiliang Gu, Xiaodi Yang, Suwen Zhao, Houchao Tao .

Bioorg Chem.2023 Jan 20;133:106377. doi: 10.1016/j.bioorg.2023.106377. Online ahead of print.

9. Synthesis of maleimide-braced peptide macrocycles and their potential anti-SARS-CoV-2 mechanisms.

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Chem Commun (Camb).2023 Jan 19;59(7):868-871. doi: 10.1039/d2cc06371a.

8. Editorial: Non-lymphoid functions of regulatory T cells in health and disease

Paula D Bos, Akihiko Yoshimura, Dipayan Rudra.

Front Immunol. 2023 Jan 16;14:1109245. doi: 10.3389/fimmu.2023.1109245. eCollection 2023.

7. Structural insight into the constitutive activity of human orphan receptor GPR12.

Hao Li, Jinyi Zhang, Yanan Yu, Feng Luo, Lijie Wu, Junlin Liu, Na Chen, Zhijie Liu, Tian Hua.

Sci Bull (Beijing). 2023 Jan 15;68(1):95-104. doi: 10.1016/j.scib.2022.12.023. Epub 2022 Dec 26.

6. Production and characterization of cell-penetrating recombinant botulinum neurotoxin type A.

Xuan Wei, Jiage Hu, Liling Jiang, Lu Li,Jia Liu.

STAR Protoc.2023 Jan 13;4(1):102026. doi: 10.1016/j.xpro.2022.102026. Online ahead of print.

5. Cryo-EM structures of orphan GPR21 signaling complexes.

Xi Lin #, Bo Chen #, Yiran Wu #, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng,Suwen Zhao, Fei Xu .

Nat Commun. 2023 Jan 13;14(1):216. doi: 10.1038/s41467-023-35882-w.

4. Benchmarking commonly used software suites and analysis workflows for DIA proteomics and phosphoproteomics.

Ronghui Lou #, Ye Cao #, Shanshan Li #, Xiaoyu Lang, Yunxia Li, Yaoyang Zhang,Wenqing Shui.

Nat Commun. 2023 Jan 6;14(1):94. doi: 10.1038/s41467-022-35740-1.

3. Discrete RNA-DNA hybrid cleavage by the EXD2 exonuclease pinpoints two rate-limiting steps.

Xinshuo Jia #, Yanan Li #, Teng Wang, Lulu Bi, Lijuan Guo, Ziting Chen, Xia Zhang, Shasha Ye, Jia Chen, Bei Yang,Bo Sun.

EMBO J. 2023 Jan 4;42(1):e111703. doi: 10.15252/embj.2022111703. Epub 2022 Nov 3.

2. Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli.

Li-Fei Tian, Xiaolin Kuang, Ke Ding, Hongwei Gao, Qun Tang, Xiao-Xue Yan,Wenqing Xu.

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1. Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model.

Xinyan Huang #, Lei Yan #, Jufeng Meng, Nanbo Liu, Shuoji Zhu, Zhen Jiang, Shan Kou, Teng Feng, Chao-Po Lin, Bin Zhou, Juan Tang, Ping Zhu,Hui Zhang.

Sci China Life Sci. 2023 Jan;66(1):51-66. doi: 10.1007/s11427-022-2176-6. Epub 2022 Oct 27.