2024年科研成果

10月

137. Ubiquitin ligase MARCH5 controls the formation of mitochondria-derived pre-peroxisomes.

Jun Zheng, Jing Chen, Zhihe Cao, Kaichen Wu, Jinhui Wang, Yusong Guo, Min Zhuang.

Dev Cell. 2024 Oct 17:S1534-5807(24)00600-2. doi: 10.1016/j.devcel.2024.09.029. Online ahead of print.

136．Structural Basis of Bifunctional CTP/dCTP Synthase.

Chen-Jun Guo , Zherong Zhang , Jia-Li Lu , Jiale Zhong , Yu-Fen Wu , Shu-Ying Guo , Ji-Long Liu.

J Mol Biol. 2024 Oct 15;436(20):168750. doi: 10.1016/j.jmb.2024.168750. Epub 2024 Aug 20.

135. Structural basis of psychedelic LSD recognition at dopamine D1 receptor.

Luyu Fan, Youwen Zhuang, Hongyu Wu, Huiqiong Li, Youwei Xu, Yue Wang, Licong He, Shishan Wang, Zhangcheng Chen, Jianjun Cheng, H Eric Xu, Sheng Wang.

Neuron. 2024 Oct 9;112(19):3295-3310.e8. doi: 10.1016/j.neuron.2024.07.003. Epub 2024 Aug 1.

134.  Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei.

Wei Pang, Jinkui Zhu, Kexin Yang, Xiaona Zhu, Wei Zhou, Linlin Jiang, Xuran Zhuang, Yantong Liu, Jianfeng Wei, Xiaoxiang Lu, Yao Yin, Ziling Chen, Yangfei Xiang.

Cell Stem Cell. 2024 Oct 3;31(10):1501-1512.e8. doi: 10.1016/j.stem.2024.08.004. Epub 2024 Aug 28.

9月

133. 1H-MRS reveals abnormal energy metabolism and excitatory-inhibitory imbalance in a chronic migraine-like state induced by nitroglycerin in mice.

Jinggui Gao #, Da Wang #, Chenlu Zhu #, Jian Wang, Tianxiao Wang, Yunhao Xu, Xiao Ren, Kaibo Zhang, Cheng Peng, Jisong Guan, Yonggang Wang.

J Headache Pain. 2024 Sep 30;25(1):163. doi: 10.1186/s10194-024-01872-6.

132.Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation.

Shuangshuang Sun #, Zhe Xu #, Liying He, Yihui Shen, Yuqing Yan, Xubing Lv, Xujing Zhu, Wei Li, Wei-Ya Tian, Yongjun Zheng, Sen Lin, Yadong Sun, Lei Li.

Nat Commun. 2024 Sep 27;15(1):8377. doi: 10.1038/s41467-024-52729-0.

131.  Giant infrared bulk photovoltaic effect in tellurene for broad-spectrum neuromodulation.

Zhen Wang #, Chunhua Tan #, Meng Peng #, Yiye Yu, Fang Zhong, Peng Wang, Ting He, Yang Wang, Zhenhan Zhang, Runzhang Xie, Fang Wang, Shuijin He, Peng Zhou, Weida Hu.

Light Sci Appl. 2024 Sep 27;13(1):277. doi: 10.1038/s41377-024-01640-w.

130.Inhibitor Development for α-Synuclein Fibril's Disordered Region to Alleviate Parkinson's Disease Pathology.

Shenqing Zhang, Huaijiang Xiang, Youqi Tao, Juan Li, Shuyi Zeng, Qianhui Xu, Haonan Xiao, Shiran Lv, Caiwei Song, Yan Cheng, Martin Li, Zeyun Zhu, Shengnan Zhang, Bo Sun, Dan Li, ShengQi Xiang, Li Tan, Cong Liu.

J Am Chem Soc. 2024 Sep 27. doi: 10.1021/jacs.4c08869. Online ahead of print.

129. Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation.

Jiawei Yan, Xin Zhang, Huiying Wang, Xinglong Jia, Ruohong Wang, Shuangyang Wu, Zheng-Jiang Zhu, Minjia Tan, Tiffany Horng.

Cell Rep. 2024 Sep 25;43(10):114780. doi: 10.1016/j.celrep.2024.114780. Online ahead of print.

128. Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation.

Ting Zhang, Shuaiyu Liu, Olanrewaju Durojaye, Fangyuan Xiong, Zhiyou Fang, Tahir Ullah, Chuanhai Fu, Bo Sun, Hao Jiang, Peng Xia, Zhikai Wang, Xuebiao Yao, Xing Liu.

Cell Rep. 2024 Sep 24;43(9):114739. doi: 10.1016/j.celrep.2024.114739. Epub 2024 Sep 13.

127. Zona Incerta GABAergic Neurons Facilitate Emergence from Isoflurane Anesthesia in Mice.

Hong Chen, Chengxi Liu, Junxiao Liu, Chengdong Yuan, Haifeng He, Yu Zhang, Shouyang Yu, Tianyuan Luo, Wei Shen, Tian Yu.

Neurochem Res. 2024 Sep 23. doi: 10.1007/s11064-024-04230-9. Online ahead of print.

126.Targeting IGF1/IGF1r signaling relieve pain and autophagic dysfunction in NTG-induced chronic migraine model of mice.

Tianxiao Wang, Chenlu Zhu, Kaibo Zhang, Jinggui Gao, Yunhao Xu, Chenyang Duan, Shouyi Wu, Cheng Peng, Jisong Guan #, Yonggang Wang #.

J Headache Pain. 2024 Sep 20;25(1):156. doi: 10.1186/s10194-024-01864-6. 

125. CORD: The chordata olfactory receptor database.

Wei Han, Siyu Bao, Jintao Liu, Yiran Wu, Liting Zeng, Tao Zhang, Ningmeng Chen, Kai Yao, Shunguo Fan, Aiping Huang, Yuanyuan Feng, Guiquan Zhang, Ruiyi Zhang, Hongjin Zhu, Tian Hua, Zhijie Liu, Lina Cao, Xingxu Huang, Suwen Zhao.

Protein Cell. 2024 Sep 20:pwae050. doi: 10.1093/procel/pwae050. Online ahead of print.

124. α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy.

Qianhui Xu#, Huilan Wang#, Ruonan Yang,Youqi Tao,Ziying Wang, Shengnan Zhang,Bo Sun, Dan Li, Boxun Lu, Cong Liu.

Cell Res. 2024 Sep 19. doi: 10.1038/s41422-024-01022-2. Online ahead of print.

123. The Impact of Developmental and Metabolic Cues on Cytoophidium Formation.

Yuanbing Zhang, Ji-Long Liu.

Int J Mol Sci. 2024 Sep 19;25(18):10058. doi: 10.3390/ijms251810058.

122. Architecture of CTPS filament networks revealed by cryo-electron tomography.

You Fu, Chen-Jun Guo, Zhi-Jie Liu, Ji-Long Liu.

Exp Cell Res. 2024 Sep 19;442(2):114262. doi: 10.1016/j.yexcr.2024.114262. Online ahead of print.

121. Differential Cytoophidium Assembly between Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Ruolan Deng, Yi-Lan Li, Ji-Long Liu.

Int J Mol Sci. 2024 Sep 19;25(18):10092. doi: 10.3390/ijms251810092.

120. Nicotinamide mononucleotide enhances fracture healing by promoting skeletal stem cell proliferation.

Yitian Shi, Jiayin Peng, Mengfan Liu, Xiling Qi, Siyu Li, Qiangqiang Li, Qing Jiang, Liming Zheng, Jiankun Xu, Yun Zhao, Yifeng Zhang.

Theranostics. 2024 Sep 16;14(15):5999-6015. doi: 10.7150/thno.98149. eCollection 2024.

119.Inherent symmetry and flexibility in hepatitis B virus subviral particles.

Quan Wang #, Tao Wang #, Lin Cao #, An Mu #, Sheng Fu #, Peipei Wang #, Yan Gao, Wenxin Ji, Zhenyu Liu, Zhanqiang Du, Luke W Guddat, Wenchi Zhang, Shuang Li, Xuemei Li, Zhiyong Lou, Xiangxi Wang, Zhongyu Hu, Zihe Rao.

Science. 2024 Sep 13;385(6714):1217-1224. doi: 10.1126/science.adp1453. Epub 2024 Sep 12.

118.Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation.

Ting Zhang, Shuaiyu Liu, Olanrewaju Durojaye, Fangyuan Xiong, Zhiyou Fang, Tahir Ullah, Chuanhai Fu, Bo Sun, Hao Jiang, Peng Xia, Zhikai Wang, Xuebiao Yao, Xing Liu.

Cell Rep. 2024 Sep 13;43(9):114739. doi: 10.1016/j.celrep.2024.114739. Online ahead of print.

117.CasRx-based Wnt activation promotes alveolar regeneration while ameliorating pulmonary fibrosis in a mouse model of lung injury.

Shengxi Shen, Ping Wang, Pei Wu, Pengyu Huang, Tian Chi, Wenqing Xu, Ying Xi.

Mol Ther. 2024 Sep 7:S1525-0016(24)00593-8. doi: 10.1016/j.ymthe.2024.09.008. Online ahead of print.

116. Structural review of SARS-CoV-2 antiviral targets.

Wen Cui, Yinkai Duan, Yan Gao, Wei Wang, Haitao Yang.

Structure. 2024 Sep 5;32(9):1301-1321. doi: 10.1016/j.str.2024.08.005.

115. De novo design of SARS-CoV-2 main protease inhibitors with characteristic binding modes.

Yan Zhu, Jiaolong Meng, Bo Feng, Yao Zhao, Yi Zang, Lingling Lu, Mingbo Su, Qi Yang, Qi Zhang, Lu Feng, Jinyi Zhao, Maolin Shao, Yuanyuan Ma, Xiuna Yang, Haitao Yang, Jia Li, Xuefeng Jiang, Zihe Rao.

Structure. 2024 Sep 5;32(9):1327-1334.e3. doi: 10.1016/j.str.2024.05.019. Epub 2024 Jun 25. 

114. EXTL3 and NPC1 are mammalian host factors for Autographa californica multiple nucleopolyhedrovirus infection.

Yuege Huang #, Hong Mei #, Chunchen Deng, Wei Wang, Chao Yuan, Yan Nie, Jia-Da Li, Jia Liu.

Nat Commun. 2024 Sep 4;15(1):7711. doi: 10.1038/s41467-024-52193-w.

113.Endogenous cell membrane interactome mapping for the GLP-1 receptor in different cell types.

Ting Dang #, Jie Yu #, Zhihe Cao #, Bingjie Zhang, Shanshan Li, Ye Xin, Lingyun Yang, Ronghui Lou, Min Zhuang, Wenqing Shui.

Nat Chem Biol. 2024 Sep 3. doi: 10.1038/s41589-024-01714-1. Online ahead of print.

112.Structural transition of GP64 triggered by a pH-sensitive multi-histidine switch.

Jinliang Guo #, Shangrong Li #, Lisha Bai #, Huimin Zhao #, Wenyu Shang, Zhaojun Zhong, Tuerxunjiang Maimaiti, Xueyan Gao, Ning Ji, Yanjie Chao, Zhaofei Li, Dijun Du.

Nat Commun. 2024 Sep 3;15(1):7668. doi: 10.1038/s41467-024-51799-4.

111. Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation.

Yu Qian #, Zhengxiong Ma #, Zhenmei Xu, Yaning Duan, Yangjie Xiong, Ruixue Xia, Xinyan Zhu, Zongwei Zhang, Xinyu Tian, Han Yin, Jian Liu, Jing Song, Yang Lu, Anqi Zhang, Changyou Guo, Lihua Jin, Woo Jae Kim, Jiyuan Ke, Fei Xu, Zhiwei Huang, Yuanzheng He.

Nat Commun. 2024 Sep 2;15(1):7644. doi: 10.1038/s41467-024-52174-z.

8月

110. Design and synthesis of Thieno[3, 2-b]pyridinone derivatives exhibiting potent activities against Mycobacterium tuberculosis in vivo by targeting Enoyl-ACP reductase.

Lihong Liang, Zhiyong Liu, Jie Chen, Qin Zha, Yihuan Zhou, Jun Li, Yangbo Hu, Xinwen Chen, Tianyu Zhang, Niuniu Zhang.

Eur J Med Chem. 2024 Aug 31:279:116806. doi: 10.1016/j.ejmech.2024.116806. Online ahead of print.

109.RPA transforms RNase H1 to a bidirectional exoribonuclease for processive RNA-DNA hybrid cleavage.

Yanan Li #, Chao Liu #, Xinshuo Jia, Lulu Bi, Zhiyun Ren, Yilin Zhao, Xia Zhang, Lijuan Guo, Yanling Bao, Cong Liu, Wei Li, Bo Sun.

Nat Commun. 2024 Aug 29;15(1):7464. doi: 10.1038/s41467-024-51984-5.

108.Conformational Space Profiling Enhances Generic Molecular Representation for AI-Powered Ligand-Based Drug Discovery.

Lin Wang, Shihang Wang, Hao Yang, Shiwei Li, Xinyu Wang, Yongqi Zhou, Siyuan Tian, Lu Liu, Fang Bai.

Adv Sci (Weinh). 2024 Aug 29:e2403998. doi: 10.1002/advs.202403998. Online ahead of print.

107.Binding adaptability of chemical ligands to polymorphic α-synuclein amyloid fibrils.

Kaien Liu #, Youqi Tao #, Qinyue Zhao, Wencheng Xia, Xiang Li, Shenqing Zhang, Yuxuan Yao, Huaijiang Xiang, Chao Han, Li Tan, Bo Sun, Dan Li, Ang Li, Cong Liu.

Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2321633121. doi: 10.1073/pnas.2321633121. Epub 2024 Aug 22.

106.A hominoid-specific signaling axis regulating the tempo of synaptic maturation.

Jian Dong, Xiao-Na Zhu, Peng-Ming Zeng, Dong-Dong Cao, Yang Yang, Ji Hu, Zhen-Ge Luo.

Cell Rep. 2024 Aug 27;43(8):114548. doi: 10.1016/j.celrep.2024.114548. Epub 2024 Jul 24.

105. Discovery of Trametinib as an orchestrator for cytoskeletal vimentin remodeling.

Shuangshuang Zhao, Zhifang Li, Qian Zhang, Yue Zhang, Jiali Zhang, Gaofeng Fan, Xiaobao Cao, Yaming Jiu.

J Mol Cell Biol. 2024 Aug 26;16(3):mjae009. doi: 10.1093/jmcb/mjae009.

104.Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei.

Wei Pang, Jinkui Zhu, Kexin Yang, Xiaona Zhu, Wei Zhou, Linlin Jiang, Xuran Zhuang, Yantong Liu, Jianfeng Wei, Xiaoxiang Lu, Yao Yin, Ziling Chen, Yangfei Xiang.

Cell Stem Cell. 2024 Aug 24:S1934-5909(24)00290-X. doi: 10.1016/j.stem.2024.08.004. Online ahead of print.

103.PINX1 loss confers susceptibility to PARP inhibition in pan-cancer cells.

Mei Huang, Xiaotong Zhu, Chen Wang, Liying He, Lei Li, Haopeng Wang, Gaofeng Fan, Yu Wang .

Cell Death Dis. 2024 Aug 22;15(8):610. doi: 10.1038/s41419-024-07009-6.

102. Low-intensity pulsed ultrasound modulates disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis.

Zihao Liu, Huan Zhang, Kaili Lu, Li Chen, Yueqi Zhang, Zhouwei Xu, Hongsheng Zhou, Junfeng Sun, Mengyang Xu, Qi Ouyang, Garth J Thompson, Yi Yang, Ni Su, Xiaojun Cai, Li Cao, Yuwu Zhao, Lixian Jiang, Yuanyi Zheng, Xiaojie Zhang.

Cell Rep. 2024 Aug 22;43(9):114660. doi: 10.1016/j.celrep.2024.114660. Online ahead of print.

101.  The structure of mouse RIPK1 RHIM-containing domain as a homo-amyloid and in RIPK1/RIPK3 complex.

Jing Liu, Xia-Lian Wu, Jing Zhang, Bing Li, Hua-Yi Wang, Jian Wang, Jun-Xia Lu.

Nat Commun. 2024 Aug 14;15(1):6975. doi: 10.1038/s41467-024-51303-y.

100. Targeting cardiac fibrosis with chimeric antigen receptor macrophages.

Zibei Gao #, Lei Yan #, Jufeng Meng #, Zhengkai Lu, Kaixin Ge, Zhen Jiang, Teng Feng, Haopeng Wang, Chen Liu, Juan Tang, Hui Zhang.

Cell Discov. 2024 Aug 13;10(1):86. doi: 10.1038/s41421-024-00718-4.

99.  Recent progress in gene therapy for familial hypercholesterolemia treatment.

Yaxin Luo, Yaofeng Hou, Wenwen Zhao, Bei Yang.

iScience. 2024 Aug 10;27(9):110641. doi: 10.1016/j.isci.2024.110641. eCollection 2024 Sep 20.

98.  A Small-Molecule NIR-II Probe for the Diagnosis of Hemorrhagic Diseases.

Jinwei Li, Tongtong Xu, Jiabei Chen, Xiaoyan He, Renwei Ma, Xiuhong Lu, Jialu Yuan, Minghua Yao, Yaohui Tang, Jianfeng Li.

Adv Healthc Mater. 2024 Aug 10:e2402333. doi: 10.1002/adhm.202402333. Online ahead of print.

97.  DNAJA2 and Hero11 mediate similar conformational extension and aggregation suppression of TDP-43.

Andy Y W Lam, Kotaro Tsuboyama, Hisashi Tadakuma, Yukihide Tomari.

RNA. 2024 Aug 8:rna.080165.124. doi: 10.1261/rna.080165.124. Online ahead of print.

96.  TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.

Haofeng Wang, Xiaoce Liu, Xiang Zhang, Zhuoqian Zhao, Yuchi Lu, Dingzhe Pu, Zeyang Zhang, Jie Chen, Yajie Wang, Mengfei Li, Xuxue Dong, Yinkai Duan, Yujia He, Qiyu Mao, Hangtian Guo, Haoran Sun, Yihan Zhou, Qi Yang, Yan Gao, Xiuna Yang, Hongzhi Cao, Luke Guddat, Lei Sun, Zihe Rao, Haitao Yang.

Cell. 2024 Aug 8;187(16):4261-4271.e17. doi: 10.1016/j.cell.2024.06.016. Epub 2024 Jul 3.

95.   Actomyosin-II protects axons from degeneration induced by mild mechanical stress.

Xiaorong Pan #, Yiqing Hu #, Gaowei Lei, Yaxuan Wei, Jie Li, Tongshu Luan, Yunfan Zhang, Yuanyuan Chu, YuFeng, Wenrong Zhan, Chunxia Zhao, Frédéric A Meunier, Yifan Liu, Yi Li, Tong Wang.

J Cell Biol. 2024 Aug 5;223(8):e202206046. doi: 10.1083/jcb.202206046. Epub 2024 May 7.

94.  Axonopathy Underlying Amyotrophic Lateral Sclerosis: Unraveling Complex Pathways and Therapeutic Insights.

Tongshu Luan #, Qing Li #, Zhi Huang #, Yu Feng, Duo Xu, Yujie Zhou, Yiqing Hu, Tong Wang.

Neurosci Bull. 2024 Aug 4. doi: 10.1007/s12264-024-01267-2. Online ahead of print.

93.  RNA polymerase stalling-derived genome instability underlies ribosomal antibiotic efficacy and resistance evolution.

Yayun Zheng #, Ruochen Chai #, Tianmin Wang #, Zeqi Xu, Yihui He, Ping Shen, Jintao Liu.

Nat Commun. 2024 Aug 3;15(1):6579. doi: 10.1038/s41467-024-50917-6.

92.  Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases.

Kun Zhang, Ping Wan, Liren Wang, Zhen Wang, Fangzhi Tan, Jie Li, Xiaolong Ma, Jin Cen, Xiang Yuan, Yang Liu, Zhen Sun, Xi Cheng, Yuanhua Liu, Xuhao Liu, Jiazhi Hu, Guisheng Zhong, Dali Li, Qiang Xia, Lijian Hui.

Cell Stem Cell. 2024 Aug 1;31(8):1187-1202.e8. doi: 10.1016/j.stem.2024.04.022. Epub 2024 May 20.

91.  Clec7a Worsens Long-Term Outcomes after Ischemic Stroke by Aggravating Microglia-Mediated Synapse Elimination.

Hanxi Wan, Mengfan He, Chun Cheng, Kexin Yang, Huanghui Wu, Peilin Cong, Xinwei Huang, Qian Zhang, Yufei Shi, Ji Hu, Li Tian, Lize Xiong.

Adv Sci (Weinh). 2024 Aug 1:e2403064. doi: 10.1002/advs.202403064. Online ahead of print.

7月

90.  Structural basis of antagonist selectivity in endothelin receptors.

Junyi Hou #, Shenhui Liu #, Xiaodan Zhang #, Guowei Tu #, Lijie Wu, Yijie Zhang, Hao Yang, Xiangcheng Li, Junlin Liu, Longquan Jiang, Qiwen Tan, Fang Bai, Zhijie Liu, Changhong Miao, Tian Hua, Zhe Luo.

Cell Discov. 2024 Jul 30;10(1):79. doi: 10.1038/s41421-024-00705-9.

89.   DiffPROTACs is a deep learning-based generator for proteolysis targeting chimeras.

Fenglei Li, Qiaoyu Hu, Yongqi Zhou, Hao Yang, Fang Bai.

Brief Bioinform. 2024 Jul 25;25(5):bbae358. doi: 10.1093/bib/bbae358.

88.  Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale.

Ruiwen Zhang, Zhou He, Yajing Shi, Xiangkun Sun, Xinyu Chen, Guoquan Wang, Yizhou Zhang, Pan Gao, Ying Wu, Shuhan Lu, Junyi Duan, Shangwu Sun, Na Yang, Wei Fan, Kaitao Zhao, Bei Yang, Yuchen Xia, Yan Zhang, Ying Zhang, Hao Yin.

Cell. 2024 Jul 25;187(15):3936-3952.e19. doi: 10.1016/j.cell.2024.05.056. Epub 2024 Jun 26.

87.  Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R).

Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Wolfgang Guba, Xiaoting Li, Calvin Höffelmeyer, Axel Hentsch, Thais Gazzi, Yelena Mostinski, Malgorzata Wasinska-Kalwa, Fabio de Molnier, Cas van der Horst, Jens Peter von Kries, Marc Vendrell, Tian Hua, Dmitry B Veprintsev, Laura H Heitman, Uwe Grether, Marc Nazare.

J Med Chem. 2024 Jul 25;67(14):11841-11867. doi: 10.1021/acs.jmedchem.4c00465. Epub 2024 Jul 11.

86.   A hominoid-specific signaling axis regulating the tempo of synaptic maturation.

Jian Dong, Xiao-Na Zhu, Peng-Ming Zeng, Dong-Dong Cao, Yang Yang, Ji Hu, Zhen-Ge Luo.

Cell Rep. 2024 Jul 24;43(8):114548. doi: 10.1016/j.celrep.2024.114548. Online ahead of print.

85.    Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor.

Hongyue Liu, Pengfei Yan, Zhaoyu Zhang, Hongbo Han, Qingtong Zhou, Jie Zheng, Jian Zhang, Fei Xu, Wenqing Shui.

J Am Chem Soc. 2024 Jul 24;146(29):20045-20058. doi: 10.1021/jacs.4c03922. Epub 2024 Jul 13.

84.    Comparative transcriptomic profiling reveals a role for Olig1 in promoting axon regeneration.

Xiu-Qing Fu, Wen-Rong Zhan, Wei-Ya Tian, Peng-Ming Zeng,Zhen-Ge Luo.

Cell Rep. 2024 Jul 23;43(7):114514. doi: 10.1016/j.celrep.2024.114514. Epub 2024 Jul 13.

83.   The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules.

Kexin Jiang, You Zheng, Liting Zeng, Ling Wang, Fei Li, Jun Pu, Yingli Lu, Suwen Zhao, Fei Xu.

Cell Rep. 2024 Jul 23;43(7):114505. doi: 10.1016/j.celrep.2024.114505. Epub 2024 Jul 13.

82.  Developing Device of Death Operation (DODO) to Detect Apoptosis in 2D and 3D Cultures.

Ziheng Zhang, Zhe Sun, Ji-Long Liu.

Cells. 2024 Jul 20;13(14):1224. doi: 10.3390/cells13141224.

81.  Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.

Hang Qiao #, Zilu Wang #, Hao Yang #, Mingyu Xia, Guang Yang, Fang Bai, Jing Wang, Pengfei Fang .

Commun Biol. 2024 Jul 16;7(1):867. doi: 10.1038/s42003-024-06559-x.

80.    Kdm4a is an activity downregulated barrier to generate engrams for memory separation.

Xiuxian Guo, Pengfei Hong, Songhai Xiong, Yuze Yan, Hong Xie, Ji-Song Guan.

Nat Commun. 2024 Jul 13;15(1):5887. doi: 10.1038/s41467-024-50218-y.

79.  Perillaldehyde alleviates polyQ-induced neurodegeneration through the induction of autophagy and mitochondrial UPR in Caenorhabditis elegans.

Minglv Fang, Ying Liu, Xiaoyan Gao, Jing Yu, Xiaohui Tu, Xueying Mo, Huanhu Zhu, Yan Zou, Cheng Huang, Shengjie Fan.

Biofactors. 2024 Jul 11. doi: 10.1002/biof.2089. Online ahead of print.

78.  Organ-Specific Gene Expression Control Using DNA Origami-Based Nanodevices.

Yuxiang Liu, Ruixuan Wang, Qimingxing Chen, Yan Chang, Qi Chen, Kodai Fukumoto, Bingxun Wang, Jianchen Yu, Changfeng Luo, Jiayuan Ma, Xiaoxia Chen, Yuko Murayama, Kenichi Umeda, Noriyuki Kodera, Yoshie Harada, Shun-Ichi Sekine, Jianfeng Li, Hisashi Tadakuma.

Nano Lett. 2024 Jul 10;24(27):8410-8417. doi: 10.1021/acs.nanolett.4c02104. Epub 2024 Jun 26.

77.   Engineering miniature IscB nickase for robust base editing with broad targeting range.

Linxiao Han #, Yueer Hu #, Qiqin Mo #, Hao Yang, Feng Gu,Fang Bai, Yadong Sun, Hanhui Ma.

Nat Chem Biol. 2024 Jul 8. doi: 10.1038/s41589-024-01670-w. Online ahead of print.

76.    Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering.

Peng Cheng #, Cong Mao #, Jin Tang #, Sen Yang #, Yu Cheng, Wuke Wang, Qiuxi Gu, Wei Han, Hao Chen, Sihan Li, Yaofeng Chen, Jianglin Zhou, Wuju Li, Aimin Pan, Suwen Zhao, Xingxu Huang, Shiqiang Zhu, Jun Zhang, Wenjie Shu, Shengqi Wang.

Cell Res. 2024 Jul 5. doi: 10.1038/s41422-024-00989-2. Online ahead of print.

75.    Essential function of transmembrane transcription factor MYRF in promoting transcription of miRNA lin-4 during C. elegans development.

Zhimin Xu, Zhao Wang, Lifang Wang, Yingchuan B Qi.

Elife. 2024 Jul 4:12:RP89903. doi: 10.7554/eLife.89903.

74.     Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.

Xiaolong Hu#, Weizhen Ao#, Mingxin Gao#, Lijie Wu#, Yuan Pei, Shenhui Liu, Yiran Wu, Fei Zhao, Qianqian Sun, Junlin Liu, Longquan Jiang, Xin Wang, Yan Li, Qiwen Tan, Jie Cheng, Fan Yang, Chi Yang, Jinpeng Sun, Tian Hua, Zhi-Jie Liu.

Nature. 2024 Jul;631(8020):459-466. doi: 10.1038/s41586-024-07569-9. Epub 2024 May 22.

73.   Legionella effector LnaB is a phosphoryl-AMPylase that impairs phosphosignalling.

Ting Wang #, Xiaonan Song #, Jiaxing Tan #, Wei Xian, Xingtong Zhou, Mingru Yu, Xiaofei Wang  Yan Xu, Ting Wu, Keke Yuan, Yu Ran, Bing Yang, Gaofeng Fan, Xiaoyun Liu, Yan Zhou, Yongqun Zhu.

Nature. 2024 Jul;631(8020):393-401. doi: 10.1038/s41586-024-07573-z. Epub 2024 May 22.

6月

72.    A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug.

Qianyun Liu#, Yuchi Lu#, Chenguang Cai#, Yanyan Huang#, Li Zhou, Yanbin Guan, Shiying Fu, Youyou Lin, Huan Yan, Zhen Zhang, Xiang Li, Xiuna Yang, Haitao Yang, Hangtian Guo, Ke Lan, Yu Chen, Shin-Chen Hou, Yi Xiong.

Cell Death Dis. 2024 Jun 28;15(6):458. doi: 10.1038/s41419-024-06802-7.

71.   Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15.

Zhongyuan Zhang #, You Zheng #, Lu Xu, Yang Yue, Kexin Xu, Fei Li, Fei Xu.

Cell Discov. 2024 Jun 25;10(1):69. doi: 10.1038/s41421-024-00698-5.

70.    Phase-separated ParB enforces diverse DNA compaction modes and stabilizes the parS-centered partition complex.

Yilin Zhao 1, Lijuan Guo, Jiaojiao Hu, Zhiyun Ren, Yanan Li, Meng Hu, Xia Zhang, Lulu Bi, Dan Li, Hanhui Ma, Cong Liu, Bo Sun.

Nucleic Acids Res. 2024 Jun 22:gkae533. doi: 10.1093/nar/gkae533. Online ahead of print.

69.    NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers.

Xiaotong Zhu, Ye Li, Haixia Liu, Yuetong Wang, Renhong Sun, Zhenzhou Jiang, Chun Hou, Xianyu Hou, Suming Huang, Huijuan Zhang, Haopeng Wang, Biao Jiang, Xiaobao Yang, Bin Xu, Gaofeng Fan.

Cell Chem Biol. 2024 Jun 20;31(6):1203-1218.e17. doi: 10.1016/j.chembiol.2024.05.007. 

68.    The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer.

Pengfei Yan #, Xi Lin #, Lijie Wu, Lu Xu, Fei Li, Junlin Liu, Fei Xu.

Nat Commun. 2024 Jun 19;15(1):5255. doi: 10.1038/s41467-024-49625-y.

67.     Structures of SenB and SenA enzymes from Variovorax paradoxus provide insights into carbon-selenium bond formation in selenoneine biosynthesis.

Sihan Xu, Jinyi Zhao, Xiang Liu, Xiuna Yang, Zili Xu, Yan Gao, Yuanyuan Ma, Haitao Yang.

Heliyon. 2024 Jun 14;10(12):e32888. doi: 10.1016/j.heliyon.2024.e32888. eCollection 2024 Jun 30.

66.   The fission yeast ortholog of Coilin, Mug174, forms Cajal body-like nuclear condensates and is essential for cellular quiescence.

Xiaoling Deng, Qinglian Yao, Attila Horvath, Ziling Jiang, Junjie Zhao, Tamás Fischer, Tomoyasu Sugiyama.

Nucleic Acids Res. 2024 Jun 3:gkae463. doi: 10.1093/nar/gkae463. Online ahead of print.

5月

65.   All-in-one Hangzhou Protocol: killing four birds with one stone.

Haopeng Wang #, Shizhen Qiu #, Mohamad Mohty.

Cell Res. 2024 May 31. doi: 10.1038/s41422-024-00983-8. Online ahead of print.

64.    Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.

Xiaolong Hu #, Weizhen Ao #, Mingxin Gao #, Lijie Wu #, Yuan Pei, Shenhui Liu, Yiran Wu, Fei Zhao, Qianqian Sun, Junlin Liu, Longquan Jiang, Xin Wang, Yan Li, Qiwen Tan, Jie Cheng, Fan Yang, Chi Yang, Jinpeng Sun, Tian Hua, Zhi-Jie Liu.

Nature. 2024 May 22. doi: 10.1038/s41586-024-07569-9. Online ahead of print.

63.    Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.

Dongdong Wang #, Yanxia Li #, Hao Yang #, Xiaoqi Shen, Xiaolin Shi, Chenyu Li, Yongjing Zhang, Xiaoyu Liu, Bin Jiang, Xudong Zhu, Hanwen Zhang, Xiaoyu Li, Hui Bai, Qing Yang, Wei Gao,Fang Bai, Yong Ji, Qi Chen, Jingjing Ben.

Nat Commun. 2024 May 21;15(1):4340. doi: 10.1038/s41467-024-48708-0.

62.   Structure and mechanism of lysosome transmembrane acetylation by HGSNAT.

Ruisheng Xu #, Yingjie Ning #, Fandong Ren, Chenxia Gu, Zhengjiang Zhu, Xuefang Pan, Alexey V Pshezhetsky, Jingpeng Ge, Jie Yu.

Nat Struct Mol Biol. 2024 May 20. doi: 10.1038/s41594-024-01315-5. Online ahead of print.

61.   The neuroscience of pain, addiction, and anesthesia.

Ji Hu, Ping Zheng.

Zool Res. 2024 May 18;45(3):709-710. doi: 10.24272/j.issn.2095-8137.2024.138.

60.     Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity.

Zhengxu Ren, Kun Wang, Yong Zhang, Hui Chen, Yiming Zhu, Hua Li, Jizhong Lou, Haopeng Wang, Chenqi Xu.

Cell Chem Biol. 2024 May 16;31(5):920-931.e6. doi: 10.1016/j.chembiol.2024.04.005.

59.    A Tau PET tracer PBB3 binds to TMEM106B amyloid fibril in brain.

Qinyue Zhao #, Yun Fan #, Wanbing Zhao, You Ni, Youqi Tao, Jiang Bian, Wencheng Xia, Wenbo Yu, Zhen Fan, Cong Liu, Bo Sun, Weidong Le, Wensheng Li, Jian Wang, Dan Li.

Cell Discov. 2024 May 14;10(1):50. doi: 10.1038/s41421-024-00674-z.

58.   Rbm46 inhibits reactive oxygen species in mouse embryonic stem cells through modulating BNIP3-mediated mitophagy.

Jinchen Zhong, Jing Xu, Xiaoyang Chen, Na Li, Sha Li, Zhiwen Deng, Huimin Feng, Xiaohan Ling, Chenchen Wang, Zhi Zhou, Lingsong Li.

Biochem Biophys Res Commun. 2024 May 14:708:149779. doi: 10.1016/j.bbrc.2024.149779. Epub 2024 Mar 13.

57.   Dynamic Arabidopsis P5CS filament facilitates substrate channelling.

Chen-Jun Guo #, Tianyi Zhang #, Qingqing Leng, Xian Zhou, Jiale Zhong, Ji-Long Liu.

Nat Plants. 2024 May 13. doi: 10.1038/s41477-024-01697-w. Online ahead of print.

56.   USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy.

Man Zhang, Zhangshun Wang, Qing Zhao, Qian Yang, Jieyun Bai, Cuiwei Yang, Zai-Rong Zhang, Yanfen Liu.

Autophagy. 2024 May 12:1-18. doi: 10.1080/15548627.2024.2347103. Online ahead of print.

55.    The MuSK agonist antibody protects the neuromuscular junction and extends the lifespan in C9orf72-ALS mice.

Shuangshuang Sun, Yihui Shen, Xu Zhang, Ning Ding, Zhe Xu, Qijie Zhang, Lei Li.

Mol Ther. 2024 May 11:S1525-0016(24)00318-6. doi: 10.1016/j.ymthe.2024.05.016. Online ahead of print.

54.   The IMPDH cytoophidium couples metabolism and fetal development in mice.

Min Peng, Gerson D Keppeke, Li-Kuang Tsai, Chia-Chun Chang, Ji-Long Liu, Li-Ying Sung.

Cell Mol Life Sci. 2024 May 8;81(1):210. doi: 10.1007/s00018-024-05233-z.

53.   Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity

Lingfeng Tong, Zhangbing Chen, Yangyang Li, Xinxia Wang, Changjie Yang, Yakui Li, Yemin Zhu, Ying Lu, Qi Liu, Nannan Xu, Sijia Shao, Lifang Wu, Ping Zhang, Guangyu Wu, Xiaoyu Wu, Xiaosong Chen, Junwei Fang, Renbing Jia, Tianle Xu, Bin Li, Liang Zheng, Junling Liu, Xuemei Tong.

Cell Metab. 2024 May 7;36(5):1013-1029.e5. doi: 10.1016/j.cmet.2024.03.003. Epub 2024 Mar 27.

52.  Piezo1-Mediated Neurogenic Inflammatory Cascade Exacerbates Ventricular Remodeling After Myocardial Infarction.

Meiyan Sun #, Sui Mao #, Chao Wu #, Xiaoyong Zhao, Chengxiao Guo, Jun Hu, Shijin Xu, Fen Zheng, Guoqing Zhu, Hui Tao, Shufang He, Ji Hu.

Circulation. 2024 May 7;149(19):1516-1533. doi: 10.1161/CIRCULATIONAHA.123.065390. Epub 2024 Jan 18.

51.    Filamentation and inhibition of prokaryotic CTP synthase with ligands.

Chenjun Guo, Zixuan Wang, Ji-Long Liu.

mLife.2024 May 2; doi:10.1002/mlf2.12119.

50.    eCRUIS captures RNA-protein interaction in vitro and in vivo.

Ziheng Zhang, Yuanbing Zhang, Ji-Long Liu.

Exp Cell Res. 2024 May 1;438(1):114051. doi: 10.1016/j.yexcr.2024.114051. Epub 2024 Apr 16.

49.   Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism.

Zhiwen Deng #, Liangyu Zhao #, Sha Li #, Xiaoyang Chen, Xiaohan Ling, Jiajun Zheng, Kunkun Yu, Jing Xu, Chencheng Yao, Sha Han, Jiayi Liang, Huimin Feng, Lanlan Wu, Peng Li, Ruhui Tian, Tao Jing, Yuxin Tang, Yingbo Dai, Minbo Yan, Chenchen Wang, Zheng Li, Zhi Zhou.

Nat Aging. 2024 May;4(5):647-663. doi: 10.1038/s43587-024-00614-2. Epub 2024 Apr 22.

48.   Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging.

Hankui Cheng , Du Chen, Xiao Li, Umar Al-Sheikh, Duo Duan, Yuedan Fan, Linhui Zhu, Wanxin Zeng, Zhitao Hu,Xiajing Tong, Guohua Zhao, Yongming Zhang, Wenjuan Zou, Shumin Duan, Lijun Kang.

Neuron. 2024 May 1;112(9):1473-1486.e6. doi: 10.1016/j.neuron.2024.02.006. Epub 2024 Mar 5.

47.     A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron.

Garima Sharma #, Amit Sharma #, Inhae Kim, Dong Gon Cha, Somi Kim, Eun Seo Park, Jae Gyun Noh, Juhee Lee, Ja Hyeon Ku, Yoon Ha Choi, JungHo Kong, Haena Lee, Haeun Ko, Juhun Lee, Anna Notaro, Seol Hee Hong, Joon Haeng Rhee, Sang Geon Kim, Cristina De Castro, Antonio Molinaro, Kunyoo Shin, Sanguk Kim, Jong Kyoung Kim, Dipayan Rudra, Sin-Hyeog Im.

Nat Immunol. 2024 May;25(5):790-801. doi: 10.1038/s41590-024-01816-x. Epub 2024 Apr 25.

46. The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson's disease.

Shuanglong Yi, Linfang Wang,Margaret S Ho, Shiping Zhang.

Neural Regen Res. 2024 May;19(5):1150-1155. doi: 10.4103/1673-5374.382259.

4月

45.    Flexible scaffold-based cheminformatics approach for polypharmacological drug design.

Zhangcheng Chen, Jing Yu, Huan Wang, Peiyu Xu, Luyu Fan, Fengxiu Sun, Sijie Huang, Pei Zhang, He Huang, Shuo Gu, Bowen Zhang, Yue Zhou, Xiaobo Wan, Gang Pei, H Eric Xu, Jianjun Cheng, Sheng Wang.

Cell. 2024 Apr 25;187(9):2194-2208.e22. doi: 10.1016/j.cell.2024.02.034. Epub 2024 Mar 28.

44.   Tonic-ing emissions and compatibility to turbocharge CAR-T.

Haopeng Wang #, Yuwei Huang #, Ruoning Wang.

Nat Metab. 2024 Apr 24. doi: 10.1038/s42255-024-01022-x. Online ahead of print.

43.    Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism.

Zhiwen Deng #, Liangyu Zhao #, Sha Li #, Xiaoyang Chen, Xiaohan Ling, Jiajun Zheng, Kunkun Yu, Jing Xu, Chencheng Yao, Sha Han, Jiayi Liang, Huimin Feng, Lanlan Wu, Peng Li, Ruhui Tian, Tao Jing, Yuxin Tang, Yingbo Dai, Minbo Yan, Chenchen Wang, Zheng Li, Zhi Zhou.

Nat Aging. 2024 Apr 22. doi: 10.1038/s43587-024-00614-2. Online ahead of print.

42.    Propofol Alleviates Anxiety-Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVNCRH Neurons via GABAA Receptor β3 Subunits.

Le Yu, Xiaona Zhu, Kang Peng, Huimin Qin, Kexin Yang, Fang Cai, Ji Hu, Ye Zhang.

Adv Sci (Weinh). 2024 Apr 19:e2309059. doi: 10.1002/advs.202309059. Online ahead of print.

41.    Size-Selective Capturing of Exosomes Using DNA Tripods.

Ryosuke Iinuma, Xiaoxia Chen, Takeya Masubuchi, Takuya Ueda, Hisashi Tadakuma.

J Am Chem Soc. 2024 Apr 17;146(15):10293-10298. doi: 10.1021/jacs.3c11067. Epub 2024 Apr 3.

40.    Expanding RNA editing toolkit using an IDR-based strategy.

Minghui Di, Junjun Lv, Zhengyu Jing, Yijie Yang, Kunlun Yan, Jianguo Wu, Jianyang Ge, Simone Rauch, Bryan C Dickinson, Tian Chi.

Mol Ther Nucleic Acids. 2024 Apr 16;35(2):102190. doi: 10.1016/j.omtn.2024.102190. eCollection 2024 Jun 11.

39.    Conjunctive encoding of exploratory intentions and spatial information in the hippocampus.

Yi-Fan Zeng, Ke-Xin Yang, Yilong Cui, Xiao-Na Zhu, Rui Li, Hanqing Zhang, Dong Chuan Wu, Raymond C Stevens, Ji Hu, Ning Zhou.

Nat Commun. 2024 Apr 15;15(1):3221. doi: 10.1038/s41467-024-47570-4.

38.    THUMPD2 catalyzes the N2-methylation of U6 snRNA of the spliceosome catalytic center and regulates pre-mRNA splicing and retinal degeneration.

Wen-Qing Yang, Jian-Yang Ge, Xiaofeng Zhang, Wen-Yu Zhu, Lin Lin, Yigong Shi, Beisi Xu,Ru-Juan Liu.

Nucleic Acids Res. 2024 Apr 12;52(6):3291-3309. doi: 10.1093/nar/gkad1243.

37.    Prophylactic efficacy of an intranasal spray with 2 synergetic antibodies neutralizing Omicron.

Xinghai Zhang, Feiyang Luo, Huajun Zhang, Hangtian Guo, Junhui Zhou, Tingting Li, Shaohong Chen, Shuyi Song, Meiying Shen, Yan Wu, Yan Gao, Xiaojian Han, Yingming Wang, Chao Hu, Xiaodong Zhao, Huilin Guo, Dazhi Zhang, Yuchi Lu, Wei Wang, Kai Wang, Ni Tang, Tengchuan Jin, Menglu Ding, Shuhui Luo, Cuicui Lin, Tingting Lu, Bingxia Lu, Yang Tian, Chengyong Yang, Guofeng Cheng, Haitao Yang, Aishun Jin, Xiaoyun Ji, Rui Gong, Sandra Chiu, Ailong Huang .

JCI Insight. 2024 Apr 8;9(7):e171034. doi: 10.1172/jci.insight.171034.

36.     Robust miniature Cas-based transcriptional modulation by engineering Un1Cas12f1 and tethering Sso7d.

Xiangnan Wang, Lingyun Li, Li Guo, Ying Feng, Zengming Du, Wei Jiang, Xia Wu, Jing Zheng, Xiao Xiao,Hui Zheng, Yadong Sun, Hanhui Ma.

Mol Ther. 2024 Apr 3;32(4):910-919. doi: 10.1016/j.ymthe.2024.02.013. Epub 2024 Feb 12.

35.     Accurate Characterization of Binding Kinetics and Allosteric Mechanisms for the HSP90 Chaperone Inhibitors Using AI-Augmented Integrative Biophysical Studies.

Chao Xu, Xianglei Zhang, Lianghao Zhao, Gennady M Verkhivker, Fang Bai.

JACS Au. 2024 Apr 1;4(4):1632-1645. doi: 10.1021/jacsau.4c00123. eCollection 2024 Apr 22.

34.   Mechanical activation opens a lipid-lined pore in OSCA ion channels.

Yaoyao Han #, Zijing Zhou #, Ruitao Jin #, Fei Dai, Yifan Ge, Xisan Ju, Xiaonuo Ma, Sitong He, Ling Yuan, Yingying Wang, Wei Yang, Xiaomin Yue, Zhongwen Chen, YadongSun, Ben Corry, Charles D Cox, Yixiao Zhang.

Nature.2024 Apr;628(8009):910-918. doi: 10.1038/s41586-024-07256-9. Epub 2024 Apr 3.

33.   Nonlinear relationship between body mass index and serum uric acid: An observational and Mendelian randomization study among Chinese adults.

Yanqi Fu, Yuefeng Yu, Yuying Wang, Ying Sun, Kun Zhang,Fei Xu, Ningjian Wang, Bin Wang, Yingli Lu.

Nutr Metab Cardiovasc Dis. 2024 Apr;34(4):998-1007. doi: 10.1016/j.numecd.2023.12.005. Epub 2023 Dec 20.

3月

32.   An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality.

Xiaolin Yang #, Tianyu Hu #, Jingxi Liang, Zhiqi Xiong, Zhenli Lin, Yao Zhao, Xiaoting Zhou, Yan Gao, Shan Sun, Xiuna Yang, Luke W Guddat, Haitao Yang, Zihe Rao, Bing Zhang.

Nat Struct Mol Biol. 2024 Mar 28. doi: 10.1038/s41594-024-01256-z. Online ahead of print.

31.     Cell-fate conversion of intestinal cells in adult Drosophila midgut by depleting a single transcription factor.

Xingting Guo, Chenhui Wang, Yongchao Zhang, Ruxue Wei, Rongwen Xi.

Nat Commun. 2024 Mar 26;15(1):2656. doi: 10.1038/s41467-024-46956-8.

30.   Hepatic progenitor cell-originated ductular reaction facilitates liver fibrosis through activation of hedgehog signaling.

Yonghong Hu, Xinyu Bao, Zheng Zhang, Long Chen, Yue Liang, Yan Qu, Qun Zhou, Xiaoxi Zhou, Jing Fang, Zhun Xiao, Yadong Fu, Hailin Yang, Wei Liu, Ying Lv, Hongyan Cao, Gaofeng Chen, Jian Ping, Hua Zhang, Yongping Mu, Chenghai Liu, Chao-Po Lin, Jian Wu, Ping Liu, Jiamei Chen.

Theranostics. 2024 Mar 25;14(6):2379-2395. doi: 10.7150/thno.91572. eCollection 2024.

29.  The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b.

Xiaowen Jiang, Kun Zhao, Yi Sun, Xinyue Song, Chao Yi, Tianlong Xiong, Sen Wang, Yi Yu, Xiduo Chen, Run Liu, Xin Yan, Christopher L Antos.

PLoS Biol. 2024 Mar 25;22(3):e3002565. doi: 10.1371/journal.pbio.3002565. eCollection 2024 Mar.

28. Flexible scaffold-based cheminformatics approach for polypharmacological drug design.

Zhangcheng Chen, Jing Yu, Huan Wang, Peiyu Xu, Luyu Fan, Fengxiu Sun, Sijie Huang, Pei Zhang, He Huang, Shuo Gu, Bowen Zhang, Yue Zhou, Xiaobo Wan, Gang Pei, H Eric Xu, Jianjun Cheng, Sheng Wang.

Cell. 2024 Mar 21:S0092-8674(24)00237-X. doi: 10.1016/j.cell.2024.02.034. Online ahead of print.

27. Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis.

Shan Gao #, Fangyu Wu #, Sudagar S Gurcha, Sarah M Batt, Gurdyal S Besra, Zihe Rao, Lu Zhang.

Nat Microbiol. 2024 Mar 15. doi: 10.1038/s41564-024-01643-8. Online ahead of print.

26.    Engineered MgO nanoparticles for cartilage-bone synergistic therapy.

Liming Zheng, Sheng Zhao, Yixuan Li, Jiankun Xu, Wenjin Yan, Baosheng Guo, Jianbin Xu, Lifeng Jiang, Yifeng Zhang, Hui Wei, Qing Jiang.

Sci Adv. 2024 Mar 8;10(10):eadk6084. doi: 10.1126/sciadv.adk6084. Epub 2024 Mar 8.

25.    Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies.

Wanbing Zhao #, Kaien Liu #, Yun Fan #, Qinyue Zhao, Youqi Tao, Mengwei Zhang, Linhua Gan, Wenbo Yu, Bo Sun, Dan Li, Cong Liu, Jian Wang.

Cell Discov. 2024 Mar 7;10(1):27. doi: 10.1038/s41421-023-00637-w.

24.    From suppressor to enhancer: IL-10's alternative role in CAR-T cell therapies against solid tumors.

Yuwei Huang,Haopeng Wang.

Cell Stem Cell. 2024 Mar 7;31(3):285-287. doi: 10.1016/j.stem.2024.02.003.

23. Interplay Between Intracellular Transport Dynamics and Liquid-Liquid Phase Separation.

Ming-Li Zhang, Ziheng Zhang, Xue-Zhi Niu, Hui-Ying Ti, Yu-Xuan Zhou, Bo Gao, Yiwei Li, Ji-Long Liu, Xiaosong Chen, Hui Li.

Adv Sci (Weinh). 2024 Mar 6:e2308338. doi: 10.1002/advs.202308338. Online ahead of print.

22. Targeting the intracellular neurexin interactome by in vivo proximity ligation.

Ming-Han Wang, Yue Hao, Xia-Jing Tong.

Trends Neurosci. 2024 Mar 6:S0166-2236(24)00023-7. doi: 10.1016/j.tins.2024.02.007. Online ahead of print.

21. Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging.

Hankui Cheng, Du Chen, Xiao Li, Umar Al-Sheikh, Duo Duan, Yuedan Fan, Linhui Zhu, Wanxin Zeng, Zhitao Hu, Xiajing Tong, Guohua Zhao, Yongming Zhang, Wenjuan Zou, Shumin Duan, Lijun Kang.

Neuron. 2024 Mar 1:S0896-6273(24)00090-4. doi: 10.1016/j.neuron.2024.02.006. Online ahead of print.

2月

20.    Tracking pairwise genomic loci by the ParB-ParS and Noc-NBS systems in living cells.

Xiaohui He, Yuxi Tan, Ying Feng, Yadong Sun, Hanhui Ma.

Nucleic Acids Res. 2024 Feb 27:gkae134. doi: 10.1093/nar/gkae134. Online ahead of print.

19.     High-throughput mapping of single-neuron projection and molecular features by retrograde barcoded labeling.

Peibo Xu #, Jian Peng #, Tingli Yuan #, Zhaoqin Chen #, Hui He #, Ziyan Wu, Ting Li, Xiaodong Li, Luyue Wang, Le Gao, Jun Yan, Wu Wei, Chengyu T Li, Zhen-Ge Luo, Yuejun Chen.

Elife. 2024 Feb 23:13:e85419. doi: 10.7554/eLife.85419.

18. CAR-Toner: an AI-driven approach for CAR tonic signaling prediction and optimization.

Shizhen Qiu#,Jian Chen#,Tao Wu#, Li Li Gang Wang,Haitao Wu, Xianmin Song,Xuesong Liu, Haopeng Wang.

Cell Res. 2024 Feb 14. doi: 10.1038/s41422-024-00936-1. Online ahead of print.

17. A case of too much sugar: Lung DCs flummoxed by flu.

Ying Xi, Tiffany Horng.

Immunity. 2024 Feb 13;57(2):203-205. doi: 10.1016/j.immuni.2024.01.014.

16. Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8.

Shan Jiang, Xi Lin, Lijie Wu, Ling Wang, Yiran Wu, Ziyi Xu, Fei Xu.

Sci Adv. 2024 Feb 2;10(5):eadj7500. doi: 10.1126/sciadv.adj7500. Epub 2024 Feb 2.

15. Salvianolic acid B attenuates liver fibrosis by targeting Ecm1 and inhibiting hepatocyte ferroptosis.

Yadong Fu, Xiaoxi Zhou, Lin Wang, Weiguo Fan, Siqi Gao, Danyan Zhang, Zhiyang Ling, Yaguang Zhang, Liyan Ma, Fang Bai, Jiamei Chen, Bing Sun, Ping Liu.

Redox Biol. 2024 Feb:69:103029. doi: 10.1016/j.redox.2024.103029. Epub 2024 Jan 3.

14. Acquisition and Analysis of DIA-Based Proteomic Data: A Comprehensive Survey in 2023.

Ronghui Lou, Wenqing Shui.

Mol Cell Proteomics. 2024 Feb;23(2):100712. doi: 10.1016/j.mcpro.2024.100712. Epub 2024 Jan 3.

1月

13. Epigenetic regulation in adult neural stem cells.

Jiajia Shi, Zilin Wang, Zhijun Wang, Guofeng Shao,Xiajun Li.

Front Cell Dev Biol. 2024 Jan 31:12:1331074. doi: 10.3389/fcell.2024.1331074. eCollection 2024.

12. BacPE: a versatile prime-editing platform in bacteria by inhibiting DNA exonucleases.

Hongyuan Zhang, Jiacheng Ma, Zhaowei Wu, Xiaoyang Chen, Yangyang Qian, Weizhong Chen, Zhipeng Wang, Ya Zhang, Huanhu Zhu, Xingxu Huang, Quanjiang Ji.

Nat Commun. 2024 Jan 27;15(1):825. doi: 10.1038/s41467-024-45114-4.

11. Connecting Hippo Pathway and Cytoophidia in Drosophila Posterior Follicle Cells.

Rui-Yu Weng, Lei Zhang, Ji-Long Liu.

Int J Mol Sci. 2024 Jan 25;25(3):1453. doi: 10.3390/ijms25031453.

10. Association between glycemia risk index and arterial stiffness in type 2 diabetes.

Lingli Cai, Wenqi Shen, Jiang Li, Bin Wang, Ying Sun, Yi Chen, Ling Gao,Fei Xu, Xinhua Xiao, Ningjian Wang, Yingli Lu.

J Diabetes Investig. 2024 Jan 22. doi: 10.1111/jdi.14153. Online ahead of print.

9. An Electroencephalography Profile of Paroxysmal Kinesigenic Dyskinesia.

Huichun Luo, Xiaojun Huang, Ziyi Li, Wotu Tian, Kan Fang, Taotao Liu, Shige Wang, Beisha Tang, Ji Hu, Ti-Fei Yuan, Li Cao.

Adv Sci (Weinh). 2024 Jan 16:e2306321. doi: 10.1002/advs.202306321. Online ahead of print.

8. BMP-ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B-Cell Lymphoma.

Dongdong Liu, Zhen Li, Dongxia Tan, Yang An, Liping Chu, Tiancheng Chen, Weijia Li, Ailin Zhou, Ruijie Xiang,Liye Zhang,Yuxiu Qu,Wei Qi.

Adv Sci (Weinh). 2024 Jan 16:e2306499. doi: 10.1002/advs.202306499. Online ahead of print.

7. Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants.

Wenwen Duan, Dongmei Cao, Sheng Wang,Jianjun Cheng.

Chem Rev. 2024 Jan 10;124(1):124-163. doi: 10.1021/acs.chemrev.3c00375. Epub 2023 Nov 30. 

6. A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.

Zhibin Zhang #, Xi Lin #, Ling Wei #, Yiran Wu, Lu Xu, Lijie Wu, Xiaohu Wei, Suwen Zhao, Xiangjia Zhu, Fei Xu.

Cell Discov. 2024 Jan 5;10(1):3. doi: 10.1038/s41421-023-00627-y. 

5. Roles and regulation of tRNA-derived small RNAs in animals.

Sowndarya Muthukumar #, Cai-Tao Li #, Ru-Juan Liu, Cristian Bellodi.

Nat Rev Mol Cell Biol. 2024 Jan 5. doi: 10.1038/s41580-023-00690-z. Online ahead of print. 

4. THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development.

Jiali Zhang #, Zhenzhou Jiang #, Xueyuan Zhang, Ziqun Yang, Jinjiao Wang, Jialing Chen, Li Chen, Minfang Song, Yanchun Zhang, Mei Huang, Shengmiao Chen, Xuexue Xiong, Yuetong Wang, Piliang Hao,Tiffany Horng,Min Zhuang,Liye Zhang,Erwei Zuo,Fang Bai,Jie Zheng, Haopeng Wang,Gaofeng Fan.

Nat Struct Mol Biol. 2024 Jan 4. doi: 10.1038/s41594-023-01131-3. Online ahead of print.

3. Cytoophidia Influence Cell Cycle and Size in Schizosaccharomyces pombe.

Ruolan Deng, Yi-Lan Li,Ji-Long Liu.

Int J Mol Sci. 2024 Jan 3;25(1):608. doi: 10.3390/ijms25010608.

2. Critical role of TPRN rings in the stereocilia for hearing.

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