2025年科研成果

June

84.     Long-range gating regulation by leaflet and autoinhibitory domains in mouse type 1 IP3 receptors.

Kozo Hamada, Akiko Terauchi, Kyoko Nakamura, Yiying Li, Jinyi Zhang, Jialong Li, Mingjun Jiang, Youjun Chu, Zhenyun Du, Hideyuki Miyatake, Katsuhiko Mikoshiba.

Biochem Biophys Res Commun. 2025 Jun 20:766:151875. doi: 10.1016/j.bbrc.2025.151875. Epub 2025 Apr 22.

83.    Magnesium promoting OVX rats' rotator cuff tear repair with relieving stem cell senescence effect.

Minghui Sun, Weijiao Zhang, Xin Sun, Kaixu Yu, Xiangming He, Liming Zheng, Ziao Ling, Kaikai Duan, Xiling Qi, Yan Liu, Xin Zhao, Hui Wang, Jiankun Xu, Yifeng Zhang.

Exp Cell Res. 2025 Jun 15;449(2):114593. doi: 10.1016/j.yexcr.2025.114593. Epub 2025 May 8.

82.     ATP13A1 engages SEC61 to facilitate substrate-specific translocation.

Xiaoyan Yang, Yi Li, Chengxi Yang, Tingting Li, Zhiyu Fang, Zhigang Feng, Jun Liao, Yan Zou.

Sci Adv. 2025 Jun 13;11(24):eadt1346. doi: 10.1126/sciadv.adt1346. Epub 2025 Jun 11.

81.    Design and Structural Elucidation of Glycopeptide Fibrils: Emulating Glycosaminoglycan Functions for Biomedical Applications.

Wencheng Xia, Zhongxin Xu, Hui Dong, Shengnan Zhang, Changdong He, Dan Li, Bo Sun, Bin Dai, Suwei Dong, Cong Liu.

J Am Chem Soc. 2025 Jun 11;147(23):20132-20143. doi: 10.1021/jacs.5c07039. Epub 2025 May 31.

80.    ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13.

Hongqin Liu # , Xi Chen #, Hanlin Wang, Guanglei Zhuang, Zheng-Jiang Zhu, Min Zhuang.

J Cell Biol. 2025 Jun 2;224(6):e202407198. doi: 10.1083/jcb.202407198. Epub 2025 Apr 17.

May

79.    Development of a chemically induced dissociation system via phage surface-displayed nanobody screening.

Zhizhuo Dai, Tianbin Yang, Wenqing Xu, Zhizhi Wang.

FEBS Lett. 2025 May 31. doi: 10.1002/1873-3468.70084. Online ahead of print.

78.    An Engineered Intravitreal Injection Retinal-Pigment-Epithelium-Tropic Adeno-Associated Virus Vector Expressing a Bispecific Antibody Binding VEGF-A and ANG-2 Rescues Neovascular Age-Related Macular Degeneration in Animal Models and Patients.

Yuan Cai, Yonghao Gu, Jie Zhang, Ying Zhu, Zhen Ma, Qin He, Yongjia Sun, Mengmeng Yuan, Xiaojun Li, Kai Zhu, Bolong Miao, Jin Zhao, Juan Liu, Min Tang, Dali Tong, Lixia Feng, Ming Ma, Guisheng Zhong, Zilong Qiu, Tian Xue.

Research (Wash D C). 2025 May 29:8:0717. doi: 10.34133/research.0717. eCollection 2025.

77.    Bi-allelic KCTD19 variants associated with meiotic arrest and non-obstructive azoospermia in humans.

Shuai Xu #, Chenwang Zhang #, Chencheng Yao #, Wanze Ni, Dewei Qian, Zizhou Meng, Yifan Sun, Cunzhong Deng, Furong Bai, Jianxiong Zhang, Peng Li, Yuhua Huang, Zhi Zhou, Zheng Li, Na Li, Yuxiang Zhang.

J Hum Genet. 2025 May 23. doi: 10.1038/s10038-025-01350-0. Online ahead of print.

76.    Deciphering enhancers of hearing loss genes for efficient and targeted gene therapy of hereditary deafness.

Simeng Zhao, Qiuxiang Yang, Zehua Yu, Cenfeng Chu, Shengqi Dai, Hongli Li, Min Diao, Lingyue Feng, Junzi Ke, Yilin Xue, Qifang Zhou, Yan Liu, Hanhui Ma, Chao-Po Lin, Yong-Gang Yao, Guisheng Zhong.

Neuron. 2025 May 21;113(10):1579-1596.e5. doi: 10.1016/j.neuron.2025.03.023. Epub 2025 Apr 21.

75.    Malaria Vaccines: Current Achievements and Path Forward.

Jiayan Chen, Qi Wang, Xiaomeng He, Bei Yang.

Vaccines (Basel). 2025 May 19;13(5):542. doi: 10.3390/vaccines13050542.

74.    NRF1 coordinates mitochondrial adaptations to dampen intracellular ROS and inflammatory responses during ischemia reperfusion.

Jiakun Li, Jiawei Yan, Guowei Tu, Wenjiao Jiang, Yue Qiu, Ying Su, Changhong Miao #, Zhe Luo #, Tiffany Horng #.

Cell Death Discov. 2025 May 15;11(1):236. doi: 10.1038/s41420-025-02461-5.

73.    Discovery of novel GluN1/GluN3A NMDA receptor inhibitors using a deep learning-based method.

Shi-Hang Wang #, Yue Zeng #, Hao Yang #, Si-Yuan Tian #, Yong-Qi Zhou #, Lin Wang #, Xue-Qin Chen, Hai-Ying Wang, Zhao-Bing Gao, Fang Bai.

Acta Pharmacol Sin. 2025 May 12. doi: 10.1038/s41401-025-01571-1. Online ahead of print. 

72.    Testis-specific serine/threonine kinase dTSSK2 regulates sperm motility and male fertility in Drosophila.

Ju Peng, Angyang Sun, Jie Zheng, Na Zhang, Xuedi Zhang, Guanjun Gao.

Commun Biol. 2025 May 8;8(1):710. doi: 10.1038/s42003-025-08163-z.

71.    Transport and inhibition mechanisms of human creatine transporter.

Jiahui Chen #, Yimin Zhang #, Nanhao Chen #, Jingpeng Ge, Jie Yu.

Cell Discov. 2025 May 5;11(1):43. doi: 10.1038/s41421-025-00801-4.

70.    Expanding the utilization of binding pockets proves to be effective for noncovalent small molecule inhibitors against SARS-CoV-2 Mpro.

Qi Yang, Xupeng Huang, Hongbo Zhang, Jing Sun, Jielin Tang, Zhao Chen, Lijie Liu, Man Liu, Zeyun Sun, Zhenhao Tang, Dandan Wei, Dong Wang, Yiliang Wang, Mengrong Yan, Li Zhao 5, Airu Zhu, Yihang Zhong, Haitao Yang, Yao Zhao, Jun Dai , Yongxia Shi, Bo Huang, Wei Zhang, Jincun Zhao, Xinwen Chen, Zihe Rao, Wei Peng.

Eur J Med Chem. 2025 May 5:289:117497. doi: 10.1016/j.ejmech.2025.117497. Epub 2025 Mar 10.

69.    FLT4 activation promotes acute lymphoid leukemia survival through stabilization of MDM2/MDMX and inactivation of p53.

Djazia Haferssas #, Marion Dubuissez #, Jonatan Barrera-Chimal, Clémence Messmer, El Bachir Affar, Bruno Larrivée, Xue-Song Liu, Casimiro Gerarduzzi.

Oncogenesis. 2025 May 2;14(1):14. doi: 10.1038/s41389-025-00552-7. 

68.     Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs.

Yong Jiang, Anran Dai, Yuwei Huang, Hua Li, Jian Cui, Haochen Yang, Lu Si, Tao Jiao, Zhengxu Ren, Ziwei Zhang, Si Mou, Hengrui Zhu, Wenhui Guo, Qiang Huang, Yilin Li, Manman Xue, Jingwei Jiang, Fei Wang, Li Li, Qinying Zhong, Kun Wang, Baichuan Liu, Jinjiao Wang 2, Gaofeng Fan, Jun Guo, Liang Chen, Creg J Workman, Zhirong Shen, Yan Kong, Dario A A Vignali, Chenqi Xu, Haopeng Wang.

Cell. 2025 May 1;188(9):2354-2371.e18. doi: 10.1016/j.cell.2025.02.014. Epub 2025 Mar 17.

67.   GW806742X can induce mouse MLKL activation by directly promoting MLKL kinase like domain dimerization.

Feiyang Yuan, Yu Zhang, Xinxin Zhu, Hong Hu, Ning Nan, Huayi Wang.

Exp Cell Res. 2025 May 1;448(1):114539. doi: 10.1016/j.yexcr.2025.114539. Epub 2025 Apr 4. 

66.    Nuclear SREBP2 condensates regulate the transcriptional activation of lipogenic genes and cholesterol homeostasis.

Mengqiang Xu #, Shi-You Jiang #, Shuocheng Tang, Meimei Zhu, Yueer Hu, Juewan Li, Jizhi Yan, Chenyang Qin, Dongxia Tan, Yang An, Yuxiu Qu, Bao-Liang Song, Hanhui Ma, Wei Qi.

Nat Metab. 2025 May;7(5):1034-1051. doi: 10.1038/s42255-025-01291-0. Epub 2025 May 20.

65.   Precise PBAEs: A Highly Efficient Single-Molecularly Defined Gene-Delivery System.

Rong Ma # 1, Yan Chang # 2, Qimingxing Chen 2, Jianfeng Li 2, Bo Qiao 1

Angew Chem Int Ed Engl. 2025 May;64(19):e202422134. doi: 10.1002/anie.202422134. Epub 2025 Mar 26.

April 

64.    Structure and mechanism of a mycobacterial isoniazid efflux pump MsRv1273c/72c with a degenerate nucleotide-binding site.

Jing Yu #, Yuhui Lan #, Chen Zhu, Zhendong Chen, Junyi Pan, Yanfeng Shi, Lan Yang, Tianyu Hu, Yan Gao, Yao Zhao, Xiaobo Chen, Xiuna Yang, Shuihua Lu, Luke W Guddat, Haitao Yang, Zihe Rao, Jun Li.

Nat Commun. 2025 Apr 28;16(1):3969. doi: 10.1038/s41467-025-59300-5.

63.   Integrative role of CTPS cytoophidia in polyploid tissue growth and nutrient adaptation.

Jiayi Hong #, Jiamin Li #, Yuanbing Zhang, Jing Wang, Chengui Li, Ji-Long Liu, Jingnan Liu.

Insect Sci. 2025 Apr 27. doi: 10.1111/1744-7917.70060. Online ahead of print.

62.   A powerful and highly efficient PAI-mediated transgenesis approach in Drosophila.

Wangfei Shi, Xuedi Zhang, Angyang Sun, Jie Zheng, Kailong Zhuang, Ziheng Chen, Ju Peng, Pengchong Fu, Guanjun Gao.

Nucleic Acids Res. 2025 Apr 22;53(8):gkaf317. doi: 10.1093/nar/gkaf317.

61.  Structural basis of β-glucopyranoside salicin recognition by a human bitter taste GPCR.

Xin Wang, Cui Zhou, Weizhen Ao, Lijie Wu, Yiran Wu, Weixiu Xu, Shenhui Liu, Qiwen Tan, Ling Wang, Fei Zhao, Junlin Liu, Yuan Pei, Suwen Zhao, Tian Hua.

Cell Rep. 2025 Apr 21;44(5):115604. doi: 10.1016/j.celrep.2025.115604. Online ahead of print.

60.   Hippocampus alters visual representation to encode new memory.

Chenhui Liu, Zhen Liu, Kaiyuan Liu, Tianfu Zhang, Guangyu Wang, Hong Xie, Ji-Song Guan .

Cell Rep. 2025 Apr 16;44(5):115594. doi: 10.1016/j.celrep.2025.115594. Online ahead of print.

59.   CTPS cytoophidia in Drosophila: distribution, regulation, and physiological roles.

Qingyi Wang, Ji-Long Liu, Jingnan Liu.

Exp Cell Res. 2025 Apr 15;447(2):114536. doi: 10.1016/j.yexcr.2025.114536. Epub 2025 Mar 22.

58.  Structural basis of stepwise proton sensing-mediated GPCR activation.

Xiaolei Yue#, Li Peng#, Shenhui Liu#, Bingjie Zhang, Xiaodan Zhang, Hao Chang, Yuan Pei, Xiaoting Li, Junlin Liu, Wenqing Shui, Lijie Wu, Huji Xu, Zhi-Jie Liu, Tian Hua.

Cell Res. 2025 Apr 11. doi: 10.1038/s41422-025-01092-w. Online ahead of print.

57.   Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches.

Bilal Cakir, Yoshiaki Tanaka, Mu Seog Choe, Pei-Yu Chu, Yangfei Xiang, Kun-Yong Kim, Mei Zhong, Joel Gelernter, Huiping Zhang, John Krystal, In-Hyun Park.

Int J Stem Cells. 2025 Apr 10. doi: 10.15283/ijsc24123. Online ahead of print.

56.   Living Detergents: an in Situ Detergent Tailoring Strategy for Efficient Membrane Protein Stabilization and Analysis.

Yili Dai, Meifang Yang, Weiling Luo, Yanli Qiu, Fang Zhou, Xing Zheng, Fei Zhao, Xu Yao, Suwen Zhao, Houchao Tao.

Chemistry. 2025 Apr 7:e202501128. doi: 10.1002/chem.202501128. Online ahead of print.

55.  Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism.

Chia-Chun Chang, Min Peng, Gerson Dierley Keppeke, Li-Kuang Tsai, Ziheng Zhang, Li-Mei Pai, Li-Ying Sung, Ji-Long Liu.

FEBS J. 2025 Apr 5. doi: 10.1111/febs.70086. Online ahead of print. 

54.   D-STAR: The Gemini Guardians redefining dual-targeting of immune cell therapy.

Yuwei Huang, Haopeng Wang.

Mol Ther. 2025 Apr 2;33(4):1312-1314. doi: 10.1016/j.ymthe.2025.03.011. Epub 2025 Mar 19.

53.   Pbx3-mediated suppression of type I interferon response contributes to leukemia progression driven by MLL-AF9.

Li Tang , Meng Lu, Yulong Du, Jianlong Sun.

Cancer Gene Ther. 2025 Apr;32(4):475-485. doi: 10.1038/s41417-025-00888-7. Epub 2025 Mar 19.

52.   Perillaldehyde Improves Parkinson-Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models.

Minglv Fang, Lingling Luo, Youjia Chen, Ying Liu, Yingxuan Yan, Fei Wang, Yan Zou, Huanhu Zhu, Xiaojun Wu, Zhigang Jin, Cheng Huang, Yu Zhang, Shengjie Fan.

Adv Sci (Weinh). 2025 Apr;12(14):e2412152. doi: 10.1002/advs.202412152. Epub 2025 Feb 14.

51.   Lung-Specific mRNA Delivery by Ionizable Lipids with Defined Structure-Function Relationship and Unique Protein Corona Feature.

Xiaoyan He, Runyuan Wang, Yan Cao, Yan Ding, Yan Chang, Haoru Dong, Rong Xie, Guisheng Zhong, Huiying Yang, Jianfeng Li.

Adv Sci (Weinh). 2025 Apr;12(14):e2416525. doi: 10.1002/advs.202416525. Epub 2025 Feb 18.

50.   Single-Molecule Insight Into α-Synuclein Fibril Structure and Mechanics Modulated by Chemical Compounds.

Xiang Li, Lulu Bi, Shenqing Zhang, Qianhui Xu, Wencheng Xia, Youqi Tao, Shaojuan Wu, Yanan Li, Weidong Le, Wenyan Kang, Dan Li, Bo Sun, Cong Liu.

Adv Sci (Weinh). 2025 Apr;12(14):e2416721. doi: 10.1002/advs.202416721. Epub 2025 Feb 14.

March

49.    The nuclear poly(A)-binding protein Pab2/PABPN1 promotes heterochromatin assembly through the formation of Pab2 nuclear condensates.

Ziyue Liu, Xiuyi Song, Gobi Thillainadesan, Tomoyasu Sugiyama.

PLoS Genet. 2025 Mar 31;21(3):e1011647. doi: 10.1371/journal.pgen.1011647. eCollection 2025 Mar.

48.    Structural basis of oligomerization-modulated activation and autoinhibition of orphan receptor GPR3.

Hao Chang, Xiaoting Li, Hongqing Tu, Lijie Wu, Yanan Yu, Junlin Liu, Na Chen, Wei L Shen, Tian Hua.

Cell Rep. 2025 Mar 28;44(4):115478. doi: 10.1016/j.celrep.2025.115478. Online ahead of print.

47.    Specific and efficient RNA A-to-I editing through cleavage of an ADAR inhibitor.

Guangye Li #, Guo Chen #, Guo-Hua Yuan #, Jia Wei #, Qingyang Ni, Jing Wu, Bei Yang, Li Yang, Jia Chen.

Nat Biotechnol. 2025 Mar 26. doi: 10.1038/s41587-025-02591-2. Online ahead of print.

46.    Leveraging base excision repair for efficient adenine base editing of mitochondrial DNA.

Yuhang Fan #, Wenchao Xu #, Bao-Qing Gao #, Huichao Qin, Xiaoyi Wu, Jia Wei, Qingyang Ni, Lina Zhou, Jiangchao Xiang, Jing Wu, Bei Yang, Li Yang, Jia Chen.

Nat Biotechnol. 2025 Mar 25. doi: 10.1038/s41587-025-02608-w. Online ahead of print. 

45.   Association of iodized salt intake with the risk of physical frailty in patients with type 2 diabetes.

Jiang Li, Jie Li, Ying Sun, Yanqi Fu, Wenqi Shen, Lingli Cai, Fei Xu, Ling Gao, Ningjian Wang, Bin Wang, Yingli Lu.

J Nutr Health Aging. 2025 Mar 25;29(6):100543. doi: 10.1016/j.jnha.2025.100543. Online ahead of print. 

44.    Tonic signaling in CAR-T therapy: the lever long enough to move the planet.

Yuwei Huang, Haopeng Wang.

Front Med. 2025 Mar 21. doi: 10.1007/s11684-025-1130-x. Online ahead of print. 

43.    GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice.

Yanmin Peng #, Chenzhang Feng #, Shiyu Peng, Ying Wang, Qian Zhang, Zhuolei Jiao, Huateng Cao, Shajin Huang, Peihuang Tian, Xiujia Sun, Xiaohong Xu, Yu Fu, Ji Hu, Zhe Zhang.

Nat Metab. 2025 Mar 20. doi: 10.1038/s42255-025-01252-7. Online ahead of print.

42.   Diverse Bone Matrix and Mineral Alterations in Osteoporosis with Different Causes: A Solid-State NMR Study.

Jing-Yu Lin, Xu Guo, Ming-Hui Sun, Yifeng Zhang, Jun-Xia Lu.

ACS Biomater Sci Eng. 2025 Mar 17. doi: 10.1021/acsbiomaterials.4c01581. Online ahead of print.

41.   Peptide-Scaffolded Detergents for Membrane Protein Studies.

Meifang Yang, Yili Dai, Fang Zhou, Xin Zhou, Yanli Qiu, Yan Tan, Suwen Zhao, Dongxiang Xue, Fei Zhao, Houchao Tao.

Chemistry. 2025 Mar 17;31(16):e202404520. doi: 10.1002/chem.202404520. Epub 2025 Feb 28.

40.   Epic, classic, and remarkable: 75 years of Experimental Cell Research.

Ji-Long Liu.

Exp Cell Res. 2025 Mar 15;446(2):114447. doi: 10.1016/j.yexcr.2025.114447. Epub 2025 Feb 21.

39.    Post-translational modifications orchestrate the intrinsic signaling bias of GPR52.

Bingjie Zhang, Wei Ge, Mengna Ma, Shanshan Li, Jie Yu, Guang Yang, Huilan Wang, Jingwen Li, Qingrun Li, Rong Zeng, Boxun Lu, Wenqing Shui.

Nat Chem Biol. 2025 Mar 14. doi: 10.1038/s41589-025-01864-w. Online ahead of print.

38.    Parvalbumin neurons mediate neurological phenotypes of anti-NMDAR encephalitis.

Yi-Fan Feng, Zi-Ke Zeng, You Ni, Yue Hu, Ke-Xin Yang, Fang Cai, Qin-Ming Zhou, Ming Chen, Xiao-Na Zhu, Sheng Chen, Ji Hu.

Brain. 2025 Mar 12:awae374. doi: 10.1093/brain/awae374. Online ahead of print.

37.    Conformational ensembles for protein structure prediction.

Jiaan Yang, Wen Xiang Cheng, Peng Zhang, Gang Wu, Si Tong Sheng, Junjie Yang, Suwen Zhao, Qiyue Hu, Wenxin Ji, Qiong Shi.

Sci Rep. 2025 Mar 12;15(1):8513. doi: 10.1038/s41598-024-84066-z.

36.    Recruitment and rejoining of remote double-strand DNA breaks for enhanced and precise chromosome editing.

Mingyao Wang #, Pengchong Fu #, Ziheng Chen #, Xiangnan Wang #, Hanhui Ma, Xuedi Zhang, Guanjun Gao.

Genome Biol. 2025 Mar 11;26(1):53. doi: 10.1186/s13059-025-03523-8.

35.    Structural basis for catalytic mechanism of human phosphatidylserine synthase 1.

Yingjie Ning #, Ruisheng Xu #, Jie Yu, Jingpeng Ge.

Cell Discov. 2025 Mar 6;11(1):20. doi: 10.1038/s41421-025-00775-3.

34.    Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs.

Yong Jiang1, Anran Dai, Yuwei Huang, Hua Li, Jian Cui, Haochen Yang, Lu Si, Tao Jiao, Zhengxu Ren, Ziwei Zhang, Si Mou, Hengrui Zhu, Wenhui Guo, Qiang Huang, Yilin Li, Manman Xue, Jingwei Jiang, Fei Wang, Li Li, Qinying Zhong, Kun Wang, Baichuan Liu, Jinjiao Wang, Gaofeng Fan, Jun Guo, Liang Chen, Creg J Workman, Zhirong Shen, Yan Kong, Dario A A Vignali, Chenqi Xu, Haopeng Wang.

Cell. 2025 Mar 6:S0092-8674(25)00199-0. doi: 10.1016/j.cell.2025.02.014. Online ahead of print.

33.    Precise PBAEs: A Highly Efficient Single-Molecularly Defined Gene-Delivery System

Rong Ma # 1, Yan Chang # 2, Qimingxing Chen 2, Jianfeng Li 2, Bo Qiao.

Angew Chem Int Ed Engl. 2025 Mar 5:e202422134. doi: 10.1002/anie.202422134. Online ahead of print.

32.    Efficient gene delivery admitted by small metabolites specifically targeting astrocytes in the mouse brain.

Haibin Zhou, Jiajing Dai, Dong Li, Luyao Wang, Meng Ye, Xiaoling Hu, Joseph LoTurco, Ji Hu, Wenzhi Sun.

Mol Ther. 2025 Mar 5;33(3):1166-1179. doi: 10.1016/j.ymthe.2025.01.006. Epub 2025 Jan 10.

31.    β-Lactoglobulin Forms a Conserved Fibril Core That Assembles into Diverse Fibril Polymorphs.

Yongyi Xu, Danni Li, Yiling Zhang, Qinyue Zhao, Bo Sun, Cong Liu, Dan Li, Bin Dai.

Nano Lett. 2025 Mar 5;25(9):3653-3661. doi: 10.1021/acs.nanolett.5c00137. Epub 2025 Feb 24. 

30.    Activation of Imprinted Gene PW1 Promotes Cardiac Fibrosis After Ischemic Injury.

Shan Kou #, Zhengkai Lu #, Defang Deng #, Min Ye, Yu Sui, Lieyang Qin, Teng Feng, Zhen Jiang, Jufeng Meng, Chao-Po Lin, Xiajun Li, Chen Liu #, Juan Tang #, Hui Zhang #.

Circulation. 2025 Mar 4;151(9):623-639. doi: 10.1161/CIRCULATIONAHA.124.070738. Epub 2024 Dec 20.

29.    Targeted Delivery of mRNA with Polymer-Lipid Nanoparticles for In Vivo Base Editing.

Qimingxing Chen, Yan Chang, Xiaoyan He, Yan Ding, Runyuan Wang, Ran Luo, Jialu Yuan, Jiabei Chen, Guisheng Zhong, Huiying Yang, Jia Chen, Jianfeng Li.

ACS Nano. 2025 Mar 4;19(8):7835-7850. doi: 10.1021/acsnano.4c14041. Epub 2025 Feb 17.

28.    Benchmarking copy number aberrations inference tools using single-cell multi-omics datasets.

Minfang Song, Shuai Ma, Gong Wang, Yukun Wang, Zhenzhen Yang, Bin Xie, Tongkun Guo, Xingxu Huang, Liye Zhang.

Brief Bioinform. 2025 Mar 4;26(2):bbaf076. doi: 10.1093/bib/bbaf076.

27.    tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells.

Shan Miao #, Hao Li #, Xiaohan Song #, Yongbo Liu, Gaoyang Wang, Chen Kan, Youqiong Ye, Ru-Juan Liu, Hua-Bing Li.

J Exp Med. 2025 Mar 3;222(3):e20240559. doi: 10.1084/jem.20240559. Epub 2025 Jan 28.

February

26.    OLFML3 Promotes IRG1 Mitochondrial Localization and Modulates Mitochondrial Function in Macrophages.

Qijun Yu, Hong Mei, Qian Gu, Ran Zeng, Yanan Li, Junjie Zhang, Chenxu Gao, Hai Fang, Jieming Qu, Jia Liu.

Int J Biol Sci. 2025 Feb 26;21(5):2275-2295. doi: 10.7150/ijbs.103859. eCollection 2025.

25.    TWEAK-Fn14 signaling protects mice from pulmonary fibrosis by inhibiting fibroblast activation and recruiting pro-regenerative macrophages.

Li Liu, Pei Wu, Yuqi Wei, Meng Lu, Haiyan Ge, Ping Wang, Jianlong Sun, Tiffany Horng, Xiucheng Liu, Xiaoyong Shen, Lingyun Sun, Ying Xi.

Cell Rep. 2025 Feb 25;44(2):115220. doi: 10.1016/j.celrep.2024.115220. Epub 2025 Jan 18.

24.    Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux.

Ning Ding, Yijie Song, Yuhang Zhang, Wei Yu, Xinnan Li, Wei Li, Lei Li.

Autophagy. 2025 Feb 25:1-18. doi: 10.1080/15548627.2025.2466144. Online ahead of print. 

23.    Excision of HIV-1 Provirus in Human Primary Cells with Nanocapsuled TALEN Proteins.

Ming Zhao, Jing Wen, Irvin S Y Chen, Jia Liu, Yunfeng Lu.

ACS Appl Bio Mater. 2025 Feb 17;8(2):1227-1239. doi: 10.1021/acsabm.4c01544. Epub 2025 Jan 31.

22.    IHCH9033, a novel class I HDAC inhibitor, synergizes with FLT3 inhibitor and rescues quizartinib resistance in FLT3-ITD AML via enhancing DNA damage response.

Mingyue Yao #, Wenzhong Yan #, Yafang Wang, Yu Zhao, Xiaowei Xu, Yujun Chen, Chengcheng Yu, Yingnian Li, Hualiang Jiang, Jie Shen, Jianjun Cheng, Chengying Xie.

Exp Hematol Oncol. 2025 Feb 15;14(1):15. doi: 10.1186/s40164-025-00605-y. 

21.    NesT-NABind: a Nested Transformer for Nucleic Acid-Binding Site Prediction on Protein Surface.

Xinyue Ma, Fenglei Li, Qianyu Chen, Shenghua Gao, Fang Bai.

J Chem Inf Model. 2025 Feb 10;65(3):1166-1177. doi: 10.1021/acs.jcim.4c01765. Epub 2025 Jan 17.

20.   Small-Molecule Benzo-Phenoselenazine Derivatives for Multi-Subcellular Biomolecule Profiling.

Han Jia, Jinghua Han, Yajing Qi,Jie Liu,Yuen Ting Leung,Yau Hei Tung,Yuanyuan Chu,Tong Wang,Yi-Man Eva Fung, Yi Wang, Ying Li.

Angew Chem Int Ed Engl. 2025 Feb 10;64(7):e202419904. doi: 10.1002/anie.202419904. Epub 2024 Dec 20.

19.    Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury.

Haoru Dong #, Zongxing He #, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie.

J Nanobiotechnology. 2025 Feb 8;23(1):98. doi: 10.1186/s12951-025-03153-z.

18.    The Anti-TB Structural Center at ShanghaiTech University.

Haitao Yang, Lu Zhang, Quan Wang, Jun Li, Xiuna Yang, Yan Gao, Bing Zhang.

Structure. 2025 Feb 6;33(2):207-212. doi: 10.1016/j.str.2025.01.006.

17.    Visible light-responsive hydrogels for cellular dynamics and spatiotemporal viscoelastic regulation.

Yan Lu, Cheng Chen, Hangyu Li, Peng Zhao, Yuanfeng Zhao, Bohan Li, Wei Zhou, Gaofeng Fan, Dongshi Guan, Yijun Zheng.

Nat Commun. 2025 Feb 4;16(1):1365. doi: 10.1038/s41467-024-54880-0.

16.    Routes to molecular glue degrader discovery.

Yanfen Liu, Jieyun Bai, Dong Li, Yong Cang.

Trends Biochem Sci. 2025 Feb;50(2):134-142. doi: 10.1016/j.tibs.2024.12.006. Epub 2025 Jan 2.

15.    Endogenous cell membrane interactome mapping for the GLP-1 receptor in different cell types.

Ting Dang #, Jie Yu #, Zhihe Cao #, Bingjie Zhang, Shanshan Li, Ye Xin, Lingyun Yang, Ronghui Lou, Min Zhuang, Wenqing Shui.

Nat Chem Biol. 2025 Feb;21(2):256-267. doi: 10.1038/s41589-024-01714-1. Epub 2024 Sep 3.

January

14.    Loss of SGK1 supports metastatic colonization in hepatocellular carcinoma by promoting resistance to T cell-mediated immunity.

Zefan Zhang, Chenlu Geng, Minfang Song, Hengbin Liang, Kaiqian Zhou, Yang Liu, Jing Wu, Xingxu Huang, Jian Zhou, Jia Fan, David H Peng, Liye Zhang, Yong Cang, Yunfan Sun.

J Hepatol. 2025 Jan 30:S0168-8278(25)00064-9. doi: 10.1016/j.jhep.2025.01.027. Online ahead of print.

13.    The measurement, regulation and biological activity of FAHFAs.

Dan Tan, Alan Saghatelian.

Nat Chem Biol. 2025 Jan 28. doi: 10.1038/s41589-024-01827-7. Online ahead of print.

12.    Dissociation-related behaviors in mice emerge from the inhibition of retrosplenial cortex parvalbumin interneurons.

Yue Hu, Yifan Feng, Huoqing Luo, Xiao-Na Zhu, Siyu Chen, Kexin Yang, Ziqing Deng, Mengqiang Luo, Wenjie Du, Qi Wang, Shubai Wang, Kai Wei, Ji Hu, Yingwei Wang .

Cell Rep. 2025 Jan 28;44(1):115086. doi: 10.1016/j.celrep.2024.115086. Epub 2024 Dec 19.

11.    MAI-TargetFisher: A proteome-wide drug target prediction method synergetically enhanced by artificial intelligence and physical modeling.

Shi-Wei Li, Peng-Xuan Ren, Lin Wang, Qi-Lei Han, Feng-Lei Li, Hong-Lin Li, Fang Bai.

Acta Pharmacol Sin. 2025 Jan 27. doi: 10.1038/s41401-024-01444-z. Online ahead of print.

10.    ParSite is a multicolor DNA labeling system that allows for simultaneous imaging of triple genomic loci in living cells.

Xiaohui He, Yadong Sun, Hanhui Ma.

PLoS Biol. 2025 Jan 24;23(1):e3003009. doi: 10.1371/journal.pbio.3003009. eCollection 2025 Jan.

9.      Optical Control of Microtubule Accumulation and Dispersion by Tau-Derived Peptide-Fused Photoresponsive Protein.

Soei Watari, Hiroshi Inaba, Qianru H Lv, Muneyoshi Ichikawa, Takashi Iwasaki, Bingxun Wang, Hisashi Tadakuma, Akira Kakugo, Kazunori Matsuura.

JACS Au. 2025 Jan 23;5(2):791-801. doi: 10.1021/jacsau.4c01017. eCollection 2025 Feb 24.

8.      Cytoophidium complexes resonate with cell fates.

Yi-Lan Li, Ji-Long Liu.

Cell Mol Life Sci. 2025 Jan 21;82(1):54. doi: 10.1007/s00018-025-05578-z.

7.      Response by Sun et al to Letter Regarding Article, Piezo1-Mediated Neurogenic Inflammatory Cascade Exacerbates Ventricular Remodeling After Myocardial Infarction.

Meiyan Sun, Shufang He, Ji Hu, Ye Zhang.

Circulation. 2025 Jan 14;151(2):e23. doi: 10.1161/CIRCULATIONAHA.124.071536. Epub 2025 Jan 13.

6.      Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior.

Mengyu Xia, Junmei Lu, Jiabin Lan, Teng Teng, Rani Shiao, Hongbin Sun, Zheyu Jin, Xueer Liu, Jie Wang, Hongyan Wu, Changchun Wang, Han Yi, Qingqing Qi, Jixi Li, Marc Schneeberger, Wei Shen, Boxun Lu, Lei Chen, Anoj Ilanges, Xinyu Zhou, Xiaofei Yu.

Immunity. 2025 Jan 14;58(1):218-231.e12. doi: 10.1016/j.immuni.2024.11.008. Epub 2024 Dec 6. 

5.      Cryo-EM structure of an activated GPR4-Gs signaling complex.

Yitong Ma #, Yijie Wang #, Mengyuan Tang #, Yuan Weng, Ying Chen, Yueming Xu, Shuxiao An, Yiran Wu, Suwen Zhao, Huanhuan Xu, Dali Li, Mingyao Liu, Weiqiang Lu, Heng Ru, Gaojie Song.

Nat Commun. 2025 Jan 11;16(1):605. doi: 10.1038/s41467-025-55901-2.

4.      Ubiquitin ligase MARCH5 controls the formation of mitochondria-derived pre-peroxisomes.

Jun Zheng, Jing Chen, Zhihe Cao, Kaichen Wu, Jinhui Wang, Yusong Guo, Min Zhuang.

Dev Cell. 2025 Jan 6;60(1):30-39.e3. doi: 10.1016/j.devcel.2024.09.029. Epub 2024 Oct 17.

3.      Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells.

Yao Yin, Wei Zhou, Jinkui Zhu, Ziling Chen, Linlin Jiang, Xuran Zhuang, Jia Chen, Jianfeng Wei, Xiaoxiang Lu, Yantong Liu, Wei Pang, Qinzhi Zhang, Yajing Cao, Zhuoya Li, Yuyan Zhu, Yangfei Xiang.

Cell Stem Cell. 2025 Jan 2;32(1):157-171.e8. doi: 10.1016/j.stem.2024.11.005. Epub 2024 Dec 9.

2.      Structural insights into the regulation of monomeric and dimeric apelin receptor.

Yang Yue #, Lier Liu #, Lijie Wu #, Chanjuan Xu #, Man Na, Shenhui Liu, Yuxuan Liu, Fei Li, Junlin Liu, Songting Shi, Hui Lei, Minxuan Zhao, Tianjie Yang, Wei Ji, Arthur Wang, Michael A Hanson, Raymond C Stevens, Jianfeng Liu, Fei Xu.

Nat Commun. 2025 Jan 2;16(1):310. doi: 10.1038/s41467-024-55555-6.

1.      High-Fat Diet during Mouse Pregnancy Impairs Fetal Heart Development.

Kaixin Ge, Diyaerjiang Aierken, Defang Deng, Zhen Jiang, Teng Feng , Jufeng Meng, Hui Zhang, Jinjun Cao, Chen Liu.

Int Heart J. 2025;66(1):144-156. doi: 10.1536/ihj.24-245.