2026年科研成果

Achievement in the year of 2026

June

28.     Control of regulatory T cell differentiation and function by glycan remodeling.

Yanwen Wang, Yunyue Shen, Kaini Liu, Rui Liang, Fangkang Meng, Rongliang Zhang, Ziqi Jiang, Aiting Wang, Jieqiong Chen, Yangyang Li.

Immunol Lett. 2026 Jun:279:107138. doi: 10.1016/j.imlet.2026.107138. Epub 2026 Jan 11.

April

27.    Fasting-mimicking diet induces IFNβ secretion in tumor-associated macrophages via NRF1-mediated ubiquitin-dependent proteolysis of Trex1.

Jiakun Li,Wenjiao Jiang,Guowei Tu,Ziwen Zhong,Zhe Luo#,Tiffany Horng#,Changhong Miao#.

Br J Cancer. 2026 Apr;134(7):1042-1056. doi: 10.1038/s41416-025-03319-4. Epub 2026 Jan 29.

March

26.    Tuning the sensitivity of mechanosensory receptors through histidine scanning.

Yuanhao Wang, Yuhan Wang, Wenjie Yuan, Mingyu Fan, Xiaojing Wang, Anhui Wang, Yanling Bao, Yajing Zhang, Jia Chi Tan, Jianglai Wang, Junshuang Liu, Tianqi Huang, Zixuan Han, Biling Pei, Lijuan Chen, Zhengxu Re, Xueqing Wang, Lanxin H, Siqi W, Mengke Pang, Sifan Wan, Zihuan Yang, Jiaze L, Delian Huang, Shuai Shao, Huairui Yuan, Ling W, Yinnian Feng, Penghui Zhou 8, Guohui Li, Bo Sun, Chenqi Xu, Nicholas R J Gascoigne , Xiang Zhao.

Cell. 2026 Mar 19;189(6):1680-1700.e48. doi: 10.1016/j.cell.2025.12.050. Epub 2026 Feb 18.

25.   DeepDegradome: A structure-aware deep learning framework for PROTAC and ligand generation against protein targets.

Qiaoyu Hu#, Yu Cao#, PengXuan Ren#, Xianglei Zhang, Fenglei Li, Xueyuan Zhang, Fengyu Cai, Ran Zhang, Yongqi Zhou, Lianghe Mei, Fang Bai.

Proc Natl Acad Sci U S A. 2026 Mar 17;123(11):e2518248123. doi: 10.1073/pnas.2518248123. Epub 2026 Mar 12.

24.    Pharmacokinetics-Driven Optimization of Immunotherapeutic Agents Targeting the Adenosine A2A Receptor (A2AR) and Histone Deacetylases (HDACs).

Wenzhong Yan, Mingshun Feng, Kexin Yang, Chengcheng Yu, Wenxin Zhang, Junjun Liu, Chengying Xie,Jianjun Cheng.

J Med Chem. 2026 Mar 12;69(5):6038-6062. doi: 10.1021/acs.jmedchem.5c03481. Epub 2026 Feb 19.

23.    Structural decoding of reversible covalent linkage of odorants in human olfactory receptor OR6A2.

Tian Wang, Yiran Wu, Ling Wang, Shanshan Li, Fei Zhao, Lijie Wu, Yue Liu, Jingzi Qin, Qiwen Tan, Junlin Liu, Liting Zeng, Yilin Chen, Shenyuan Gao,Wenqing Shui, Suwen Zhao, Tian Hua, Zhi-Jie Liu.

Cell. 2026 Mar 5;189(5):1451-1464.e27. doi: 10.1016/j.cell.2025.12.017. Epub 2026 Jan 21.

22.     Discovery of novel and potent harringtonine derivative P2 via systematic structure-activity Optimization: Semi-Synthesis, anti-leukemia activity, and mechanism study.

Zhongli Xu, Shuting Shen, Xinyu Ding, Xiaoyu Wang, Dejin Zhang, Yuanchao Li, Ping Xing, Hongli Chen, Fang Bai, Qianqian Yin, Biao Jiang.

Eur J Med Chem. 2026 Mar 5:305:118546. doi: 10.1016/j.ejmech.2025.118546. Epub 2025 Dec 31.

21.    HOP2-MND1 chaperones a diffusing DMC1-ssDNA complex to survey dsDNA for homology recognition during meiotic recombination.

Bingkai Cheng, Yanan Li, Yi Zhao, Yuting Zhang, Xia Zhang, Lishuang Chen, Hao Yang, Xiaoxuan Song, Zhiyun Ren, Cong Liu, Jingdong Xue, Bing Li, Chao Liu, Wei Li, Bo Sun.

Proc Natl Acad Sci U S A. 2026 Mar 3;123(9):e2529249123. doi: 10.1073/pnas.2529249123. Epub 2026 Feb 26.

20.    Hematopoietic stem cells activate a latent differentiation pathway to facilitate recovery after 5-fluorouracil-induced myeloablation.

Zhen Zhang, Ben Jin, Chenyu You, Ya Li, Li Lin,Jianlong Sun.

Dev Cell. 2026 Mar 2:S1534-5807(26)00043-2. doi: 10.1016/j.devcel.2026.02.003. Online ahead of print.

February

19.    Cell-Penetrating Botulinum Neurotoxin Type A Proteins Alleviate Skeletal Muscle Hypertrophy with Associated Alterations of Mitochondrial Homeostasis.

Lu Li, Xuan Wei, Liling Jiang, Zhen Gao,Jia Liu.

Toxins (Basel). 2026 Feb 19;18(2):103. doi: 10.3390/toxins18020103.

18.    RYK is a GPNMB receptor that drives MASH.

Yue Xi, Waner Zeng, Jie Luo, Jian Zhou, Lin Wang, Jingyi Sun, Zengyiting He, Weihui Li, Sitao Zhu,Wei Qi, Bao-Liang Song.

Nature. 2026 Feb 18. doi: 10.1038/s41586-026-10160-z. Online ahead of print.

17.    Humanized and Charge-Optimized CSPG4-Specific CAR-T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma.

Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu,Haopeng Wang, Jian Chen.

Adv Sci (Weinh). 2026 Feb 16:e19746. doi: 10.1002/advs.202519746. Online ahead of print.

16.    Targeting class I HDACs suppresses oncogenic vulnerabilities and potentiates KRAS/MAPK pathway inhibitors in KRAS-mutant cancers.

Kexin Yang, Xiaolong Qin, Yafang Wang, Wenzhong Yan, Mingyue Ya, Chengcheng Yu, Chuwei Yu, Shangxuan Shi, Yu Zhao, Lina Zhou, Cheng Li, Xiangjun Meng, Jianjun Cheng, Chengying Xie.

J Adv Res. 2026 Feb 13:S2090-1232(26)00144-X. doi: 10.1016/j.jare.2026.02.013. Online ahead of print.

15.     Conformational diversity and fully opening mechanism of native NMDA receptor.

Ruisheng Xu, Qiqi Jiang, Hongwei Xu, Lu Zhang, Xiangzi Hu, Zizhuo Lu, Huaqin Deng, Haolin Xiong, Sensen Zhang, Zhongwen Chen, Yifan Ge, Zhengjiang Zhu, Yaoyang Zhang, Yelin Chen, Jingpeng Ge, Jie Yu.

Nature. 2026 Feb 11. doi: 10.1038/s41586-026-10139-w. Online ahead of print.

14.    Linear ubiquitination of the NMDA receptor GluN2A subunit facilitates the GluN2B-to-GluN2A switch and synaptic maturation.

Yuanyuan Chu #, Yiwen Xu #, Maoqing Huang #, Xueying Fang, Xinying Huang, Zhengwei Yao, Jian Wu, Ning Zhou, Kaiwen He, Yanfen Liu, Tong Wang.

Proc Natl Acad Sci U S A. 2026 Feb 10;123(6):e2515389123. doi: 10.1073/pnas.2515389123. Epub 2026 Feb 4.

13.    Tuning the state: Matching condensate material properties with physiological demands and pathological dysfunction.

Jingxuan Luo, Zhehao Li, Ziyin Shen, Xiaoyu Zhai, Jiayue Chen, Hanchun Wang, Xueping Zhao, Jing He, Mingrui Ding.

Cell Insight. 2026 Feb 4;5(2):100309. doi: 10.1016/j.cellin.2026.100309. eCollection 2026 Apr.

12.    Dynamic response by commensal E. coli two-component system Cpx contributes to C. elegans development.

Huiyang Xiong#, Beilei Hua#, Huanhu Zhu.

BMC Biol. 2026 Feb 3;24(1):63. doi: 10.1186/s12915-026-02513-x.

January

11.   Botulinum neurotoxin type A1 alleviates bleomycin-induced skin fibrosis by inhibiting phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) pathway and associated cell cycle and proliferation.

Fangzhou Xie, Yun Xie, Jia Liu.

J Invest Dermatol. 2026 Jan 23:S0022-202X(26)00030-8. doi: 10.1016/j.jid.2026.01.009. Online ahead of print. 

10.    Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protein Degradation Approaches.

Yang Liu, Yifeng Sun, Tian-Yu Song, Si-Yuan Ni, Yi-Sheng Pu, Yuan-Chen Chang, Wenrong Zhou, Zhen-Gang Peng, Jiajia Liu, Jun Shi, Wei Lu,Yong Cang.

Cancer Res. 2026 Jan 13. doi: 10.1158/0008-5472.CAN-25-3941. Online ahead of print.

9.      Biopsy-resolved cryo-EM structures of amyloid fibrils provide molecular insights into AL amyloidosis.

Yuxuan Yao #, Qinyue Zhao #, Shun Yao #, Yamei Xu, Kaien Liu, Tianyi Cao, Bo Sun, Jingmin Zhou, Cong Liu, Dan Li.

Proc Natl Acad Sci U S A. 2026 Jan 13;123(2):e2515454123. doi: 10.1073/pnas.2515454123. Epub 2026 Jan 6.

8.       Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells.

Lu Hu, Jinyu Lin, Liping Sun, Alison M Berezuk, Katharine S Tuttle, Xing Zhu, Hyuk-Soo Seo, Sirano Dhe-Paganon, Pan Li, Yang Sun, Lisheng Ni, Jianan Zhang, Dazhi Tan, Hiroaki Wakimoto, Daniel P Cahill, Xiaochen Bai, Xuelian Luo, John M Asara, Sriram Subramaniam,Yibing Shan, Xu Wu.

Nat Chem Biol. 2026 Jan 13. doi: 10.1038/s41589-025-02131-8. Online ahead of print.

7.       Human PSC-derived organoids model sympathetic ganglion development and its functional crosstalk with the heart.

Yantong Liu, Jinkui Zhu, Xiaoxiang Lu, Xuran Zhuang, Jianfeng Wei, Linlin Jiang, Wei Zhou, Wei Pang, Yao Yin, Ziling Chen, Yajing Cao, Qinzhi Zhang, Sisi Chen, Siyuan Chu, Xinrui Zhang,Yangfei Xiang.

Cell Stem Cell. 2026 Jan 8;33(1):29-43.e7. doi: 10.1016/j.stem.2025.11.003. Epub 2025 Dec 11.

6.       Dysplastic epithelial repair promotes the tissue residence of lymphocytes to inhibit alveolar regeneration post viral infection.

Tiantian Lu, Li Liu, Ping Wang, Zhe Chen, Pei Wu,Jiawei Chen,Guilin Peng, Ruijuan Guan, Chaoqun Wang, Pengfei Sui, Haopeng Wang, Xiao Su, Jincun Zhao,Tao Ren, Ying Xi.

Cell Stem Cell. 2026 Jan 8;33(1):108-124.e6. doi: 10.1016/j.stem.2025.12.005. Epub 2025 Dec 23.

5.        Cryo-EM structure of the RfxCas13d-crRNA-off-target-RNA complex.

Qianxi Yang,Yifang Sun,Lei Sun,Tian Chi,Zhenguo Chen.

Structure. 2026 Jan 8;34(1):11-19.e2. doi: 10.1016/j.str.2025.09.010. Epub 2025 Oct 23.

4.      Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3.

Lei Ji#, Chue Vin Chin#, Gangyu Sun#, Olga Charlats, Chad Vickers, Bo Lu, Frederic Sigoillot,Zhizhi Wang, Wenqing Xu, Feng Cong.

Genes Dev. 2026 Jan 5;40(1-2):56-69. doi: 10.1101/gad.352622.125.

3.        Effect of Painful Stimuli on PVN CRH Neurons: Implications for States of Consciousness Under Isoflurane Anesthesia.

Le Yu,Xiaona Zhu,Wenying Duan,Kexin Yang,Ji Hu,Ye Zhang.

Anesth Analg. 2026 Jan 1;142(1):149-159. doi: 10.1213/ANE.0000000000007411. Epub 2025 Feb 18.

2.       AiCE: a concise and effective next generation method for protein engineering.

Ruiyi Zhang, Suwen Zhao.

Sci China Life Sci. 2026 Jan;69(1):316-318. doi: 10.1007/s11427-025-3055-3. Epub 2025 Aug 22.

1.        Discovery of selective GluN1/GluN3A NMDA receptor inhibitors using integrated AI and physics-based approaches.

Shi-Wei Li#,Yue Zeng#,Sa-Nan Wu#,Xin-Yue Ma#,Chao Xu#,Zong-Quan Li#,Sui Fang,Xue-Qin Chen,Zhao-Bing Gao, Fang Bai.

Acta Pharmacol Sin. 2026 Jan;47(1):22-31. doi: 10.1038/s41401-025-01607-6. Epub 2025 Jul 14.