2026年科研成果

Achievement in the year of 2026

January

8.       Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells.

Lu Hu, Jinyu Lin, Liping Sun, Alison M Berezuk, Katharine S Tuttle, Xing Zhu, Hyuk-Soo Seo, Sirano Dhe-Paganon, Pan Li, Yang Sun, Lisheng Ni, Jianan Zhang, Dazhi Tan, Hiroaki Wakimoto, Daniel P Cahill, Xiaochen Bai, Xuelian Luo, John M Asara, Sriram Subramaniam,Yibing Shan, Xu Wu.

Nat Chem Biol. 2026 Jan 13. doi: 10.1038/s41589-025-02131-8. Online ahead of print.

7.       Human PSC-derived organoids model sympathetic ganglion development and its functional crosstalk with the heart.

Yantong Liu, Jinkui Zhu, Xiaoxiang Lu, Xuran Zhuang, Jianfeng Wei, Linlin Jiang, Wei Zhou, Wei Pang, Yao Yin, Ziling Chen, Yajing Cao, Qinzhi Zhang, Sisi Chen, Siyuan Chu, Xinrui Zhang, Yangfei Xiang.

Cell Stem Cell. 2026 Jan 8;33(1):29-43.e7. doi: 10.1016/j.stem.2025.11.003. Epub 2025 Dec 11.

6.       Dysplastic epithelial repair promotes the tissue residence of lymphocytes to inhibit alveolar regeneration post viral infection.

Tiantian Lu, Li Liu, Ping Wang, Zhe Chen, Pei Wu,Jiawei Chen,Guilin Peng, Ruijuan Guan, Chaoqun Wang, Pengfei Sui, Haopeng Wang, Xiao Su, Jincun Zhao,Tao Ren, Ying Xi.

Cell Stem Cell. 2026 Jan 8;33(1):108-124.e6. doi: 10.1016/j.stem.2025.12.005. Epub 2025 Dec 23.

5.        Cryo-EM structure of the RfxCas13d-crRNA-off-target-RNA complex.

Qianxi Yang,Yifang Sun,Lei Sun,Tian Chi,Zhenguo Chen.

Structure. 2026 Jan 8;34(1):11-19.e2. doi: 10.1016/j.str.2025.09.010. Epub 2025 Oct 23.

4.      Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3.

Lei Ji#, Chue Vin Chin#, Gangyu Sun#, Olga Charlats, Chad Vickers, Bo Lu, Frederic Sigoillot,Zhizhi Wang, Wenqing Xu, Feng Cong.

Genes Dev. 2026 Jan 5;40(1-2):56-69. doi: 10.1101/gad.352622.125.

3.        Effect of Painful Stimuli on PVN CRH Neurons: Implications for States of Consciousness Under Isoflurane Anesthesia.

Le Yu,Xiaona Zhu,Wenying Duan,Kexin Yang,Ji Hu,Ye Zhang.

Anesth Analg. 2026 Jan 1;142(1):149-159. doi: 10.1213/ANE.0000000000007411. Epub 2025 Feb 18.

2.       AiCE: a concise and effective next generation method for protein engineering.

Ruiyi Zhang, Suwen Zhao.

Sci China Life Sci. 2026 Jan;69(1):316-318. doi: 10.1007/s11427-025-3055-3. Epub 2025 Aug 22.

1.        Discovery of selective GluN1/GluN3A NMDA receptor inhibitors using integrated AI and physics-based approaches.

Shi-Wei Li#,Yue Zeng#,Sa-Nan Wu#,Xin-Yue Ma#,Chao Xu#,Zong-Quan Li#,Sui Fang,Xue-Qin Chen,Zhao-Bing Gao, Fang Bai.

Acta Pharmacol Sin. 2026 Jan;47(1):22-31. doi: 10.1038/s41401-025-01607-6. Epub 2025 Jul 14.