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Hisashi Tadakuma, PhDAssistant Professor

Tel:

Email: tadakumahisashi@@shanghaitech.edu.cn

Fax: 86-21-20685430

Add: 393 Middle Huaxia Road, Pudong, Shanghai

Faculty KMS Profile

中文信息English
Lab of Synthetic Biology

Principal investigator

Name:

Hisashi TadakumaAssistant Professor , PhD, Assistant Professor

Position:

Affiliation:

School of Life Science and Technology

Honor:

Education Background:
  • 1991/04-1995/03, Waseda University(Japan), Bachelor
  • 1995/04-1997/03, Waseda University(Japan), Master
  • 1997/04-2001/03, Waseda University(Japan), Graduate
  • 2004/03-2004/03, Waseda University(Japan), Doctor
Working Experience:
  • 2001-2003, Waseda University, Takashi Funatsu lab, Assistant Professor
  • 2003-2008, University of Tokyo, MichioTomishige lab, Assistant Professor
  • 2008-2010, University of Tokyo, Takuya Ueda / Hideki Taguchi lab, Postdoc
  • 2010-2014/12, University of Tokyo, Takuya Ueda lab, Assistant Professor
  • 2015/01-2016, Kyoto University, Yoshie Harada lab, Postdoct
  • 2016-2019, Osaka University, Yoshie Harada lab, Assistant Professor
  • 2019/11-Present, ShanghaiTech University, School of Life Science and Technology, Assistant Professor (TENURE-TRACK)

Group Introduction

Research Area:
Nanobiology based on Synthetic Biology and Biophysics
Research Interests:

Transcription is the first step of gene expression and thus quite important. Our lab focuses on understanding the basic mechanism of transcription and applies the knowledge to develop novel gene expression control nano-devices. To do that, we will combine a synthetic biology approach (reconstitution of biological systems) and a biophysical approach (single molecule imaging), and will build up unique nano-chips. With the nano-chips, we will mimic the transcription system and will understand the underlying mechanism. Furthermore, we will develop autonomous nano-devices that can sense the environment, compute information and output product, allowing us the precise control of cell fate. In the future, programmable gene expression system will open the way to autonomously cure our body.


Group Website:

Research Achievement

In synthetic biology, the control of gene expression requires a multistep processing of biological signals. The key steps are sensing the environment, computing information and outputting products. To achieve such functions, the laborious, combinational networking of enzymes and substrate-genes is required, and to resolve problems, sophisticated design automation tools have been introduced. However, the complexity of genetic circuits remains low because it is difficult to completely avoid crosstalk between the circuits.

To overcome these problems, we have combined a synthetic biology approach (EMBO J. 2010) and a biophysical approach (Nature 2015, Mol Cell 2015, 2018, 2019), making a unique nano-chip by integrating an actuator (enzyme) and sensors onto a DNA origami-based nanochip (Nature Nanotechnology 2018). This gene nanochip allows us to rationally design the chemical reaction and precise gene expression control in vitro and in vivo. Our approach to component integration on a nanochip may provide a basis for large-scale, integrated genetic circuits.


Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo

  • Name:Xiaoxia CHEN
    Position:Research Assistant Professor
    Duration:2022/08-Now
    Email:chenxx3@@shanghaitech
  • Name:Ruixuan WANG
    Position:Doctoral Student
    Duration:2020/03-Now
    Email:wangrx@@shanghaitech
  • Name:Yuxiang LIU
    Position:Doctoral Student
    Duration:2020/03-Now
    Email:liuyx1@@shanghaitech
  • Name:Qi CHEN
    Position:Postgraduate Student
    Duration:2020/08-Now
    Email:chenqi@@shanghaitech
  • Name:Changfeng LUO
    Position:Doctoral Student
    Duration:2021/01-Now
    Email:luochf@@shanghaitech
  • Name:Bingxun WANG
    Position:Doctoral Student
    Duration:2021/01-Now
    Email:wangbx1@@shanghaitech
  • Name:Jiayuan MA
    Position:Postgraduate Student
    Duration:2021/01-Now
    Email:majy1@@shanghaitech
  • Name:Chenglin SONG
    Position:Doctoral Student
    Duration:2022/08-Now
    Email:songchl@@shanghaitech
  • Name:Zonghao LI
    Position:Doctoral Student
    Duration:2020/07-Now
    Email:lizh1@@shanghaitech
  • Name:Jianchen YU
    Position:Doctoral Student
    Duration:2022/01-Now
    Email:yujch@@shanghaitech
  • Name:Peiqi HUANG
    Position:Doctoral Student
    Duration:2022/01-Now
    Email:huangpq@@shanghaitech
  • Name:Yuanzhe SONG
    Position:Undergraduate Student
    Duration:2021/06-Now
    Email:songyzh1@@shanghaitech
  • Name:Wenyue ZHANG
    Position:Undergraduate Student
    Duration:2021/09-Now
    Email:zhangwy1@@shanghaitech
  • Name:Yunsi ZHENG
    Position:Undergraduate Student
    Duration:2021/09-Now
    Email:zhengys@@shanghaitech
  • Name:Kaijun WANG
    Position:Undergraduate Student
    Duration:2021/11-Now
    Email:wangkj@@shanghaitech
  • Name:Jielin WANG
    Position:Undergraduate Student
    Duration:2022/02-Now
    Email:wangjl3@@shanghaitech

alumni: 2021/07 Dongmin XUN(Undergraduate, CAS)

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