Principal investigator
Name:
Lan BaoDistinguished Adjunct Professor from CAS , PhD, Distinguished Adjunct Professor from CAS
Position:
Affiliation:
School of Life Science and Technology, ShanghaiTech / Shanghai Institute of Biochemistry and Cell Biology, CAS
Honor:
Group Introduction
Research Area:
Nerve Cell Protein Transport Mechanism and Function
Research Interests:
The proteins are transported to different subcellular areas to exhibit their functions after synthesis in cells. Neurons are highly specialized cells with axon and dendrites. Our group is interested in the molecular and cellular mechanisms of protein transport in neurons. One direction of research is exploring the mechanisms of receptor and ion channel transport and related significance in sensory sensation and pain modulation. Another direction is identifying the post-translational modifications of tubulins and their roles in neuronal development and neurodegenerative diseases. Receptors and ion channels play an important roles in sensory transmission and modulation. The sorting, trafficking and localization of receptors and ion channels are precisely controlled in sensory neurons. We use the techniques of Molecule Biology, Cell Biology and Neurobiology to study the transport route of these membrane proteins in physiological and pathological (peripheral inflammation and nerve injury) conditions. Furthermore, we identify the localizing signals within receptors and ion channels, extracellular factors, interacting proteins and signaling pathways to regulate the localization and trafficking of these proteins. Our studies contribute to the basic theory of sorting and trafficking of receptors and ion channels, and also to the mechanisms of sensory sensation and pain. In neurons, microtubule provides tracks for protein and vesicle transportation in cell body especially in axon and dendrite. Microtubule dynamics can be modulated by intracellular molecules and extracellular factors which leads to microtubule assembly and disassembly. During neuronal development, proper regulation of microtubule dynamics is essential for neurite outgrowth, neuronal polarity and migration. We identify the post-translational modifications to tubulin subunits, detect their effects on microtubule dynamics, explore their regulatory molecules and signaling pathways, and investigate their roles in neuronal development (neurite outgrowth, neuronal polarity and migration) and neurodegenerative diseases.
Representative Publications (*First Author, # Corresponding Author)
- 1. Wang, Bin*; Pan, Lin; Wei, Manyi; Wang, Qiong; Liu, Wen-Wen; Wang, Nuoxin; Jiang, Xing-Yu; Zhang, Xu; Bao, Lan#.FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1.CELL REPORTS. 29 Dec 2015. 13(12):2794-2807.
- 2. Bao, Lan#*.Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons.MOLECULAR PAIN. 2015. 11.
- 3. Zhang, X.#*; Bao, L.; Li, S..Opioid receptor trafficking and interaction in nociceptors.BRITISH JOURNAL OF PHARMACOLOGY. 2015. 172(2):364-374.
- 4. Chen, Xu-Qiao*; Zhu, Jing-Xiang; Wang, Yan; Zhang, Xu; Bao, Lan#.CaMKII alpha and caveolin-1 cooperate to drive ATP-induced membrane delivery of the P2X3 receptor.JOURNAL OF MOLECULAR CELL BIOLOGY. 2014. 6(2):140-153.
- 5. Su, Yuan-Yuan*; Ye, Mingyu; Li, Lei; Liu, Chao; Pan, Jing; Liu, Wen-Wen; Jiang, Yanbo; Jiang, Xing-Yu; Zhang, Xu; Shu, Yousheng; Bao, Lan#.KIF5B Promotes the Forward Transport and Axonal Function of the Voltage-Gated Sodium Channel Na(v)1.8.JOURNAL OF NEUROSCIENCE. 2013. 33(45):17884-17896.
- 6. Han, Qing-Jian*; Gao, Nan-Nan; Ma, Guo-Qiang; Zhang, Zhen-Ning; Yu, Wen-Hui; Pan, Jing; Wang, Qiong; Zhang, Xu; Bao, Lan#.IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF-beta/Smad signaling.JOURNAL OF CELL SCIENCE. 2013. 126(2):542-553.
- 7. Li, Lei*; Wei, Dan; Wang, Qiong; Pan, Jing; Liu, Rong; Zhang, Xu; Bao, Lan#.MEC-17 Deficiency Leads to Reduced alpha-Tubulin Acetylation and Impaired Migration of Cortical Neurons.JOURNAL OF NEUROSCIENCE. 2012. 32(37):12673-12683.
- 8. Chen, Xu-Qiao*; Wang, Bin; Wu, Chengbiao; Pan, Jin; Yuan, Bo; Su, Yuan-Yuan; Jiang, Xing-Yu; Zhang, Xu; Bao, Lan#.Endosome-mediated retrograde axonal transport of P2X(3) receptor signals in primary sensory neurons.CELL RESEARCH. 2012. 22(4):677-696.
- 9. Wu, Qing-Feng*; Yang, Liu; Li, Shuai; Wang, Qiong; Yuan, Xiao-Bin; Gao, Xiang; Bao, Lan; Zhang, Xu#.Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration.CELL. 2012. 149(7):1549-1564.
- 10. Zhang, Xu#*; Bao, Lan.Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons.NEUROSCIENCE BULLETIN. 2012. 28(2):121-130.
- 11. He, Shao-Qiu*; Zhang, Zhen-Ning; Guan, Ji-Song; Liu, Hong-Rui; Zhao, Bo; Wang, Hai-Bo; Li, Qian; Yang, Hong; Luo, Jie; Li, Zi-Yan; Wang, Qiong; Lu, Ying-Jin; Bao, Lan#; Zhang, Xu#.Facilitation of mu-Opioid Receptor Activity by Preventing delta-Opioid Receptor-Mediated Codegradation.NEURON. 2011. 69(1):120-131.
- 12. Li, Qian*; Su, Yuan-Yuan; Wang, Hao; Li, Lei; Wang, Qiong; Bao, Lan#.Transmembrane Segments Prevent Surface Expression of Sodium Channel Na(v)1.8 and Promote Calnexin-dependent Channel Degradation.JOURNAL OF BIOLOGICAL CHEMISTRY. 2010. 285(43):32977-32987.
- 13. Wang, Hai-Bo*; Zhao, Bo; Zhong, Yan-Qing; Li, Kai-Cheng; Li, Zi-Yan; Wang, Qiong; Lu, Yin-Jing; Zhang, Zhen-Ning; He, Shao-Qiu; Zheng, Han-Cheng; Wu, Sheng-Xi; Hokfelt, Tomas G. M.#; Bao, Lan#; Zhang, Xu#.Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010. 107(29):13117-13122.
- 14. Liu, Chao*; Li, Qian; Su, Yuanyuan; Bao, Lan#.Prostaglandin E-2 Promotes Na(v)1.8 Trafficking via Its Intracellular RRR Motif Through the Protein Kinase A Pathway.TRAFFIC. 2010. 11(3):405-417.
- 15. Zhang, Xu#*; Bao, Lan#; Ma, Guo-Qiang.Sorting of neuropeptides and neuropeptide receptors into secretory pathways.PROGRESS IN NEUROBIOLOGY. 2010. 90(2):276-283.
- 16. Ma, Guo-Qiang*; Wang, Bin; Wang, Hai-Bo; Wang, Qiong; Bao, Lan#.Short Elements with Charged Amino Acids Form Clusters to Sort Protachykinin into Large Dense-Core Vesicles.TRAFFIC. 2008. 9(12):2165-2179.
- 17. Zhang, Zhen-Ning*; Li, Qian; Liu, Chao; Wang, Hai-Bo; Wang, Qiong; Bao, Lan#.The voltage-gated Na(+) channel Na(v)1.8 contains an ER-retention/retrieval signal antagonized by the beta 3 subunit.JOURNAL OF CELL SCIENCE. 2008. 121(19):3243-3252.
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