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Jianjun Cheng, PhDAssistant Professor

Tel: 021-20685237

Email: chengjj@shanghaitech.edu.cn

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中文信息English
Medicinal Chemistry and Drug Discovery

Principal investigator

Name:

Jianjun ChengAssistant Professor , PhD, Assistant Professor

Position:

Affiliation:

Honor:

Education Background:
  • 2001/09-2005/06, Shandong University, BS
  • 2005/09-2010/07, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Ph.D.
Working Experience:
  • 2010/07-2013/10, Shanghai Huilun Life Sciences & Technology, Senior Scientist
  • 2013/11-2016/03, University of Illinois at Chicago, Postdoctoral Research Associate
  • 2016/03-2022/06, ShanghaiTech University, iHuman Institute, Principal Investigator
  • 2022/07-present, ShanghaiTech University, School of Life Science and Technology/iHuman Institute, Assistant Professor (TENURE-TRACK)

Group Introduction

Research Area:
GPCR-targeted drug discovery
Research Interests:

Our lab focuses on GPCR-targeted medicinal chemistry and drug design. Accumulated biological knowledge on the structures and functions of GPCRs is leveraged for the design of novel drug-like molecules and the study of their biological activities. We are interested in novel antipsychotic drug discovery targeting the aminergic GPCRs, and the discovery of novel cancer immunotherapeutics targeting the adenosine receptors.

Group Website:

Research Achievement

1. Structure-based discovery of non-hallucinogenic psychedelic analog IHCH-7086 as a novel antidepressant drug candidate (Science 2022).

2. Structure-based discovery of highly selective dopamine D2 receptor partial agonist IHCH-7041 as a novel preclinical anti-schizophrenia drug candidate (Nature Neuroscience 2022, cover story).

3. PCPMA-based highly selective serotonin 2C agonists with anti-schizophrenia effects (J Med Chem 2015; 2016a; 2016b); highly selective dopamine D3 ligands (J Med Chem 2020); and dopamine D2 partial agonists with anti-schizophrenia effects (J Med Chem 2021).

4. Discovery of dual-acting tumor immunotherapeutics targeting the adenosine A2a receptor and histone deacetylases (J Med Chem 2021; Eur J Med Chem 2022).

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo

  • Name：Huan Wang
    Position：Research Associate Professor
    Duration：2018-
    Email：wanghuan1@shanghaitech.edu.cn
  • Name：Wenzhong Yan
    Position：Research Assistant Professor
    Duration：2017-
    Email：yanwzh@shanghaitech.edu.cn
  • Name：Jinfeng Zhang
    Position：Postdoc
    Duration：2022-
    Email：zhangjf4@shanghaitech.edu.cn
  • Name：Huiqiong Li
    Position：Doctoral Student
    Duration：2022-
    Email：lihq@shanghaitech.edu.cn
  • Name：Rongyan Li
    Position：Postgraduate Student
    Duration：2021-
    Email：liry@shanghaitech.edu.cn
  • Name：Yangyang Liu
    Position：Postgraduate Student
    Duration：2021-
    Email：liuyy3@shanghaitech.edu.cn
  • Name：Yujin Chen
    Position：Postgraduate Student
    Duration：2022-
    Email：chenyj2022@shanghaitech.edu.cn
  • Name：Rui Huang
    Position：Undergraduate Student
    Duration：2022-
    Email：huangrui2022@shanghaitech.edu.cn
  • Name：Xin Ji
    Position：Undergraduate Student
    Duration：2022-
    Email：jixin2022@shanghaitech.edu.cn
  • Name：Huilin Li
    Position：Undergraduate Student
    Duration：2022-
    Email：lihl2022@shanghaitech.edu.cn
  • Name：Jianhang Mao
    Position：Postgraduate Student
    Duration：2020-2023
    Email：maojh@shanghaitech.edu.cn


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