课题组长
姓名：
陈勇中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院分子细胞科学卓越创新中心
荣誉称号：
博士后及工作经历：
- 2020年—，中国生物化学与分子生物学会第十二届基因专业委员会，秘书长
课题组简介
研究内容：
实验室主要关注染色质调控蛋白的结构基础和发挥功能的分子机制。研究对象包括端粒结合蛋白复合物、组蛋白修饰酶、染色质重塑蛋白复合物等。
研究成果展示
实验室在“端粒结合蛋白复合物”、“表观遗传调控相关蛋白复合物”等领域内深入探究了一系列重要分子的结构基础、底物识别机制、活性调节机制等。主要成果包括： （1）揭示了端粒核心蛋白TIN2及其同源蛋白介导端粒复合物组装的分子机制（Cell Res 2017a, b）;
（2）揭示了Bqt4介导端粒和核膜动态作用的分子机制 (Structure 2019; Nucleic Acids Res, 2019);
（3）揭示了MLL家族组蛋白甲基转移酶的活性调控机理（Nature 2016; Nucleic Acids Res 2019）和新型非组蛋白底物（Structure 2020）。
代表性论文（*第一作者，#通讯作者）
- 1. Chen, Guochao*; Li, Wei; Yan, Fuxiang; Wang, Duo; Chen, Yong#.The Structural Basis for Specific Recognition of H3K14 Acetylation by Sth1 in the RSC Chromatin Remodeling Complex.STRUCTURE. 07 Jan 2020. 28(1):111-+.
- 2. Han, Jianming*; Li, Tingting; Li, Yanjing; Li, Muchun; Wang, Xiaoman; Peng, Chao; Su, Chen; Li, Na; Li, Yiwen; Xu, Ying; Chen, Yong#.The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex.NUCLEIC ACIDS RESEARCH. 04 Nov 2019. 47(19):10426-10438.
- 3. Hu, Chunyi*; Inoue, Haruna; Sun, Wenqi; Takeshita, Yumiko; Huang, Yaoguang; Xu, Ying; Kanoh, Junko#; Chen, Yong#.Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast.NUCLEIC ACIDS RESEARCH. 20 Feb 2019. 47(3):1573-1584.
- 4. Hu, Chunyi*; Inoue, Haruna; Sun, Wenqi; Takeshita, Yumiko; Huang, Yaoguang; Xu, Ying; Kanoh, Junko#; Chen, Yong#.The Inner Nuclear Membrane Protein Bqt4 in Fission Yeast Contains a DNA-Binding Domain Essential for Telomere Association with the Nuclear Envelope.STRUCTURE. 05 Feb 2019. 27(2):335-+.
- 5. Chen, Yong#*.The structural biology of the shelterin complex.BIOLOGICAL CHEMISTRY. Apr 2019. 400(4):457-466.
- 6. Li, Qing*; Li, Yanjing; Yang, Suming; Huang, Shuo; Yan, Meng; Ding, Yifu; Tang, Wei; Lou, Xiwen; Yin, Qi; Sun, Zhanfei; Lu, Lei; Shi, Huijuan; Wang, Hongyan; Chen, Yong#; Li, Jinsong#.CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development.NATURE CELL BIOLOGY. Nov 2018. 20(11):1315-+.
- 7. Hu, Chunyi*; Rai, Rekha; Huang, Chenhui; Broton, Cayla; Long, Juanjuan; Xu, Ying; Xue, Jing; Lei, Ming#; Chang, Sandy#; Chen, Yong#.Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex.CELL RESEARCH. Dec 2017. 27(12):1485-1502.
- 8. Xue, Jing*; Chen, Hongwen; Wu, Jian; Takeuchi, Miho; Inoue, Haruna; Liu, Yanmei; Sun, Hong; Chen, Yong#; Kanoh, Junko#; Lei, Ming#.Structure of the fission yeast S-pombe telomeric Tpz1-Poz1-Rap1 complex.CELL RESEARCH. Dec 2017. 27(12):1503-1520.
- 9. Wang, Xiaoman*; Zhao, Yiyue; Zhang, Jian; Chen, Yong#.Structural basis for DAXX interaction with ATRX.PROTEIN & CELL. Oct 2017. 8(10):767-771.
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