英文信息

Principal investigator

Name:

Yong ChenDistinguished Adjunct Professor from CAS , PhD, Distinguished Adjunct Professor from CAS

Position:

Affiliation:

School of Life Science and Technology, Shanghai Institute of Biochemistry and Cell Biology, CAS

Honor:

Education Background:

Working Experience:

2020, The Chinese Society of Biochemistry and Molecular Biology, Gene Division , Secretary

Group Introduction

Research Area:

Research Interests:

The long-term research interest of the lab is on the mechanistic understanding of chromatin regulation by protein complexes, including telomeric protein complexes, histone modifying complexes, and chromatin remodeling complexes. We aim to reveal the molecular mechanisms for enzyme catalysis, activity regulation, chromatin recruitment, and crosstalk mechanism of these epigenetic factors, by structural, biochemical and cellular analyses.

Group Website:

Research Achievement

The lab has focused on structural and functional studies of some important chromatin regulating complexes, including telomeric protein complexes and epigenetic regulators. The representative achievements include: revealed the structural basis of human TIN2 and S.pombe Poz1 in shelterin assembly and functional roles in telomere protection; revealed the molecular mechanism of telomere association with the nuclear membrane in fission yeast by Bqt4; discovered the mechanism on the assembly and activity regulation of MLL-family methyltransferase ; revealed the Taf14’s structural role in scaffolding different transcription-related complexes; revealed the structural basis of H3K14 recognition by RSC chromatin-remodelling complex.

Representative Publications (*First Author, # Corresponding Author)

1. Chen, Guochao*; Li, Wei; Yan, Fuxiang; Wang, Duo; Chen, Yong^#.The Structural Basis for Specific Recognition of H3K14 Acetylation by Sth1 in the RSC Chromatin Remodeling Complex.STRUCTURE. 07 Jan 2020. 28(1):111-+.
2. Han, Jianming*; Li, Tingting; Li, Yanjing; Li, Muchun; Wang, Xiaoman; Peng, Chao; Su, Chen; Li, Na; Li, Yiwen; Xu, Ying; Chen, Yong^#.The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex.NUCLEIC ACIDS RESEARCH. 04 Nov 2019. 47(19):10426-10438.
3. Hu, Chunyi*; Inoue, Haruna; Sun, Wenqi; Takeshita, Yumiko; Huang, Yaoguang; Xu, Ying; Kanoh, Junko^#; Chen, Yong^#.Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast.NUCLEIC ACIDS RESEARCH. 20 Feb 2019. 47(3):1573-1584.
4. Hu, Chunyi*; Inoue, Haruna; Sun, Wenqi; Takeshita, Yumiko; Huang, Yaoguang; Xu, Ying; Kanoh, Junko^#; Chen, Yong^#.The Inner Nuclear Membrane Protein Bqt4 in Fission Yeast Contains a DNA-Binding Domain Essential for Telomere Association with the Nuclear Envelope.STRUCTURE. 05 Feb 2019. 27(2):335-+.
5. Chen, Yong^#*.The structural biology of the shelterin complex.BIOLOGICAL CHEMISTRY. Apr 2019. 400(4):457-466.
6. Li, Qing*; Li, Yanjing; Yang, Suming; Huang, Shuo; Yan, Meng; Ding, Yifu; Tang, Wei; Lou, Xiwen; Yin, Qi; Sun, Zhanfei; Lu, Lei; Shi, Huijuan; Wang, Hongyan; Chen, Yong^#; Li, Jinsong^#.CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development.NATURE CELL BIOLOGY. Nov 2018. 20(11):1315-+.
7. Hu, Chunyi*; Rai, Rekha; Huang, Chenhui; Broton, Cayla; Long, Juanjuan; Xu, Ying; Xue, Jing; Lei, Ming^#; Chang, Sandy^#; Chen, Yong^#.Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex.CELL RESEARCH. Dec 2017. 27(12):1485-1502.
8. Xue, Jing*; Chen, Hongwen; Wu, Jian; Takeuchi, Miho; Inoue, Haruna; Liu, Yanmei; Sun, Hong; Chen, Yong^#; Kanoh, Junko^#; Lei, Ming^#.Structure of the fission yeast S-pombe telomeric Tpz1-Poz1-Rap1 complex.CELL RESEARCH. Dec 2017. 27(12):1503-1520.
9. Wang, Xiaoman*; Zhao, Yiyue; Zhang, Jian; Chen, Yong^#.Structural basis for DAXX interaction with ATRX.PROTEIN & CELL. Oct 2017. 8(10):767-771.

Yong Chen, PhDDistinguished Adjunct Professor from CAS

Principal investigator

Group Introduction

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo