课题组长
姓名：
丁健中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院上海药物研究所
荣誉称号：
中国工程院院士
课题组简介
研究内容：
分子靶向抗肿瘤药物的研发、机理研究及相关生物标志物探索，主要为激酶及相关信号转导通路；抗肿瘤转移研究；表观遗传修饰研究。
代表性论文（*第一作者，#通讯作者）
- 1. Ai, Jing*; Tang, Qingjuan; Wu, Yanlin; Xu, Yang; Feng, Teng; Zhou, Ruiyu; Chen, Yi; Gao, Xin; Zhu, Qingfeng; Yue, Xihua; Pan, Qiuming; Xu, Siyun; Li, Jing; Huang, Min; Daugherty-Holtrop, Jennifer; He, Yuanzheng; Xu, H. Eric; Fan, Jia#; Ding, Jian; Geng, Meiyu#.The Role of Polymeric Immunoglobulin Receptor in Inflammation-Induced Tumor Metastasis of Human Hepatocellular Carcinoma.JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2011. 103(22):1696-1712.
- 2. Jiang, Yi*; Miao, Ze-Hong#; Xu, Lei; Yu, Bing; Gong, Jing-Xu; Tong, Lin-Jiang; Chen, Yi; Zhou, Zhao-Li; Liu, Hong-Chun; Wang, Yi; Guo, Yue-Wei; Ding, Jian#.Drug Transporter-independent Liver Cancer Cell Killing by a Marine Steroid Methyl Spongoate via Apoptosis Induction.JOURNAL OF BIOLOGICAL CHEMISTRY. 2011. 286(30):26461-26469.
- 3. Xie, Hua#*; Lin, Liping; Tong, Linjiang; Jiang, Yong; Zheng, Mingyue; Chen, Zhuo; Jiang, Xiaoyan; Zhang, Xiaowei; Ren, Xiaowei; Qu, Wenchao; Yang, Yang; Wan, Hua; Chen, Yi; Zuo, Jianping; Jiang, Hualiang; Geng, Meiyu; Ding, Jian.AST1306, A Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both In Vitro and In Vivo.PLOS ONE. 2011. 6(7).
- 4. Zhang, Jing*; Xin, Xianliang; Chen, Qin; Xie, Zuoquan; Gui, Min; Chen, Yi; Lin, Liping; Feng, Jianming; Li, Qiuning; Ding, Jian; Geng, Meiyu#.Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF-?B via targeting of Mre11.INTERNATIONAL JOURNAL OF CANCER. 2012. 130(2):467-477.
- 5. Zhu, Caihua*; Chen, Qin; Xie, Zuoquan; Ai, Jing; Tong, Linjiang; Ding, Jian#; Geng, Meiyu#.The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc.JOURNAL OF MOLECULAR MEDICINE-JMM. 2011. 89(3):279-289.
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