英文信息

Principal investigator

Name:

Jianping DingDistinguished Adjunct Professor from CAS , PhD, Distinguished Adjunct Professor from CAS

Position:

Affiliation:

School of Life Science and Technology, Shanghai Institute of Biochemistry and Cell Biology, CAS

Honor:

Education Background:

Working Experience:

2003-Now, Chinese Society of Proteomics, CSBMB, Executive Council Member , Chair , Deputy Chair
2003-Now, Chinese Crystallographic Society (CCrS), Council Member , Executive Council Member , Deputy Secretary General
2006-Now, Asian Crystallographic Association (AsCA), Council Member
2006-Now, Biophysical Society of China (BSC), Chairman Council Member Vice President and Executive Council Member
2006-Now, Shanghai Society of Biophysics (SSB), President
2008-2020, Shanghai Society of Biochemistry and Molecular Biology (SSBMB), Council Member, Executive Council Member , Vice President
2019-Now, International Union of Biochemistry and Molecular Biology (IUBMB), Member

Group Introduction

Research Area:

Structural Biology and Molecular Biology

Research Interests:

Our group is interested in the studies of structures, functions, and molecular mechanisms of proteins and protein complexes involved in the regulation of gene expression in eukaryotes, in particular these of significant biological importance and/or related to human diseases. The primary goal of our research works is to understand the basic sciences of biology and in particular the structure-function relationships of proteins and protein complexes. The ultimate goal of our research works is to utilize the gained structural and functional knowledge to understand molecular basis of pathogenesis of human diseases and to develop effective drugs for the treatments of human diseases.

Group Website:

Research Achievement

In the past five years, our research works have been largely focused on the structural and functional studies of proteins and protein complexes involved in the epigenetic regulation, the mTORC1 signaling pathway, and the metabolic pathways. We have made substantial progresses and achievements in all these topics and published 35 research papers on high-profile scientific journals, of which 24 are as corresponding or co-corresponding author and 11 as co-author.

Representative Publications (*First Author, # Corresponding Author)

1. Zhang, Tianlong*; Peli-Gulli, Marie-Pierre; Zhang, Zhen; Tang, Xin; Ye, Jie; De Virgilio, Claudio^#; Ding, Jianping^#.Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases.SCIENCE ADVANCES. Sep 2019. 5(9).
2. Li, Wenjing*; Shi, Yu; Zhang, Tianlong; Ye, Jie; Ding, Jianping^#.Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase.CELL DISCOVERY. 10 Sep 2019. 5.
3. Zhang, Shicheng*; Wang, Linlin; Tao, Ye; Bai, Tuya; Lu, Rong; Zhang, Tianlong; Chen, Jiangye; Ding, Jianping^#.Structural basis for the functional role of the Shu complex in homologous recombination.NUCLEIC ACIDS RESEARCH. 15 Dec 2017. 45(22).
4. Zhang, Tianlong*; Wang, Rong; Wang, Zhijing; Wang, Xiangxiang; Wang, Fang; Ding, Jianping^#.Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.NATURE COMMUNICATIONS. 09 Nov 2017. 8.
5. Zhong, Chen^#*; Shen, Jinlong; Zhang, Huibing; Li, Guangyi; Shen, Senlin; Wang, Fang; Hu, Kuan; Cao, Longxing; He, Yongning; Ding, Jianping^#.Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions.CELL REPORTS. 05 Sep 2017. 20(10):2328-2340.
6. Zhong, Chen*; Huo, Rongfen; Hu, Kuan; Shen, Jinlong; Li, Dangsheng; Li, Ningli^#; Ding, Jianping^#.Molecular basis for the recognition of CCN1 by monoclonal antibody 093G9.JOURNAL OF MOLECULAR RECOGNITION. Nov 2017. 30(11).
7. Tao, Ye*; Zhong, Chen; Zhu, Junjun; Xu, Shutong; Ding, Jianping^#.Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2.NUCLEIC ACIDS RESEARCH. 02 Jun 2017. 45(10):5707-5719.
8. Ma, Tengfei*; Peng, Yingjie; Huang, Wei; Ding, Jianping^#.Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.SCIENTIFIC REPORTS. 18 Jan 2017. 7.
9. Ma, Tengfei*; Peng, Yingjie; Huang, Wei; Liu, Yabing; Ding, Jianping^#.The beta and gamma subunits play distinct functional roles in the alpha(2)beta gamma heterotetramer of human NAD-dependent isocitrate dehydrogenase.SCIENTIFIC REPORTS. 31 Jan 2017. 7.
10. Wang, Rong*; Wang, Zhijing; Wang, Kaikai; Zhang, Tianlong^#; Ding, Jianping^#.Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1.JOURNAL OF MOLECULAR CELL BIOLOGY. Oct 2016. 8(5):459-461.
11. Tang, Qingyu*; Liu, Caifeng; Zhong, Chen; Ding, Jianping^#.Crystal Structures of Arabidopsis thaliana Nudix Hydrolase NUDT7 Reveal a Previously Unobserved Conformation.MOLECULAR PLANT. 05 Oct 2015. 8(10):1557-1559.

Jianping Ding, PhDDistinguished Adjunct Professor from CAS

Principal investigator

Group Introduction

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo