Principal investigator
Name:
Guanjun GaoAssociate Professor , PhD, Associate Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Group Introduction
Research Area:
Chromatin and Epigenetics, Gene Editing
Research Interests:
The major mission of Gao-lab is to use Drosophila and mammalian cell systems to achieve a comprehensive understanding of the mechanisms of chromatin and (epi-)genetic factors, particularly with a focus on long non-coding RNAs and histone epigenetic codes in development, reproduction, innate immunology, aging and cancer disease. Towards achieving this mission, Gao-lab bridges the new genetic methods and biochemistry approaches into investigation of the mechanisms of those (epi-)genetics factors involved in fundamental biological processes. Their research will define not only epigenetic molecules and pathways but also many fundamental biological processes that impact human health.
Representative Publications (*First Author, # Corresponding Author)
- 1. Xuedi Zhang, Ju Peng, Menghua Wu*, Angyang Sun, Xiangyu Wu, Jie Zheng, Wangfei Shi & Guanjun Gao#.Broad phosphorylation mediated by testis-specific serine/threonine kinases contributes to spermiogenesis and male fertility.Nature Communications. 06 May 2023.
- 2. Gao, Kaixuan*; Zhang, Xuedi*; Zhang, Zhenwu; Wu, Xiangyu; Guo, Yan; Fu, Pengchong; Sun, Angyang; Peng, Ju; Zheng, Jie; Yu, Pengfei; Wang, Tengfei; Ye, Qinying; Jiang, Jingwei; Wang, Haopeng; Lin, Chao-Po; Gao, Guanjun#.Transcription-coupled donor DNA expression increases homologous recombination for efficient genome editing.Nucleic Acids Research. 01 Aug 2022.
- 3. Xuedi Zhang*, Xiangyu Wu, Ju Peng, Angyang Sun, Yan Guo, Pengchong Fu and Guanjun Gao#.Cis- and trans-regulation by histone H4 basic patch R17/R19 in metazoan development.Open Biology. 12 Nov 2022 .
- 4. Ke Shui, Chenwei Wang, Xuedi Zhang, Shanshan Ma, Qinyu Li, Wanshan Ning, Weizhi Zhang, Miaomiao Chen, Di Peng, Hui Hu, Zheng Fang, Anyuan Guo, Guanjun Gao, Mingliang Ye, Luoying Zhang #& Yu Xue#.Small-sample learning reveals propionylation in determining global protein homeostasis.Nature Communications. 17 May 2023.
- 5. Yan, Cheng*; Liu, Jingqi; Gao, Jiamei; Sun, Ying; Zhang, Lei; Song, Haiyun; Xue, Lei; Zhan, Lixing; Gao, Guanjun; Ke, Zunji; Liu, Yong#; Liu, Jingnan#.IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.CELL DEATH & DISEASE. 22 Oct 2019. 10.
- 6. Zhang, Weimin*; Zhang, Xuedi*; Xue, Zhaoyu*; Li, Yijie*; Ma, Qing; Ren, Xiangle; Zhang, Jiaying; Yang, Songhua; Yang, Lijuan; Wu, Menghua; Ren, Mengda; Xi, Rongwen; Wu, Zheng; Liu, Ji-Long; Matunis, Erika; Dai, Junbiao#; Gao, Guanjun#.Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants.DEVELOPMENTAL CELL. 11 Feb 2019. 48(3):406-419.
- 7. Wu, Menghua*; Zhang, Xuedi; Wei, Wei; Long, Li; An, Sainan; Gao, Guanjun#.CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila.SCIENTIFIC REPORTS. 30 Apr 2020. 10(1).
- 8. Bhaskar Roy*, Jing Zhao, Chao Yang , Wen Luo , Teng Xiong , Yong Li , Xiaodong Fang , Guanjun Gao, Chabungbam O. Singh , Lise Madsen , Yong Zhou and Karsten Kristiansen.CRISPR/Cascade 9-Mediated Genome Editing-Challenges and Opportunities.Frontiers in Genetics. 05 July 2018.
- 9. Xiao, Xiaoping*; Yang, Lijuan*; Pang, Xiaojing*; Zhang, Rudian; Zhu, Yibin; Wang, Penghua; Gao, Guanjun#; Cheng, Gong#.A Mesh-Duox pathway regulates homeostasis in the insect gut.NATURE MICROBIOLOGY. 2017. 2(5).
- 10. Lianxin Hu, Jiajun Xu*, Meng-Xin Yin, Liguo Zhang, Yi Lu, Wenqing Wu, Zhaoyu Xue, Margaret S Ho, Guanjun Gao, Yun Zhao & Lei Zhang#.Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded.Cell Discovery. 23 February 2016.
- 11. Wen, Kejia*; Yang, Lijuan*; Xiong, Tuanlin*; Di, Chao; Ma, Danhui; Wu, Menghua; Xue, Zhaoyu; Zhang, Xuedi; Long, Li; Zhang, Weimin; Zhang, Jiaying; Bi, Xiaolin; Dai, Junbiao; Zhang, Qiangfeng; Lu, Zhi John; Gao, Guanjun#.Critical roles of long noncoding RNAs in Drosophila spermatogenesis.GENOME RESEARCH. 2016. 26(9):1233-1244.
- 12. Xue, Zhaoyu*; Wu, Menghua; Wen, Kejia; Ren, Menda; Long, Li; Zhang, Xuedi; Gao, Guanjun#.CRISPR/Cas9 Mediates Efficient Conditional Mutagenesis in Drosophila.G3-GENES GENOMES GENETICS. 2014. 4(11):2167-2173.
- 13. Gerstein, Mark B.#*; Rozowsky, Joel; Yan, Koon-Kiu; Wang, Daifeng; Cheng, Chao; Brown, James B.; Davis, Carrie A.; Hillier, LaDeana; Sisu, Cristina; Li, Jingyi Jessica; Pei, Baikang; Harmanci, Arif O.; Duff, Michael O.; Djebali, Sarah; Alexander, Roger P.; Alver, Burak H.; Auerbach, Raymond; Bell, Kimberly; Bickel, Peter J.; Boeck, Max E.; Boley, Nathan P.; Booth, Benjamin W.; Cherbas, Lucy; Cherbas, Peter; Di, Chao; Dobins, Alex; Drenkows, Jorg; Ewing, Brent; Fang, Gang; Fastucas, Megan; Feingold, Elise A.; Frankish, Adam; Gao, Guanjun; Good, Peter J.; Guigo, Roderic; Hammonds, Ann; Harrow, Jen; Hoskins, Roger A.; Howald, Cedric; Hu, Long; Huang, Haiyan; Hubbard, Tim J. P.; Huynh, Chau; Jhas, Sonali; Kasper, Dionna; Kato, Masaomi; Kaufman, Thomas C.; Kitchen, Robert R.; Ladewig, Erik; Lagarde, Julien; Lai, Eric; Leng, Ling; Lu, Zhi; MacCoss, Michael; May, Gemma; McWhirter, Rebecca#; Merrihew, Gennifer; Miller, David M.; Mortazavi, Ali; Murad, Rabi; Oliver, Brian; Olson, Sara; Park, Peter J.; Pazin, Michael J.; Perrimon, Norbert; Pervouchine, Dmitri; Reinke, Valerie; Reymond, Alexandre; Robinson, Garrett; Samsonova, Anastasia; Saunders, Gary I.; Schlesingers, Felix; Sethi, Anurag; Slack, Frank J.; Spencer, William C.; Stoiber, Marcus H.; Strasbourger, Pnina; Tanzer, Andrea; Thompson, Owen A.; Wan, Kenneth H.; Wang, Guilin; Wang, Huaien; Watkins, Kathie L.; Wen, Jiayu; Wen, Kejia; Xue, Chenghai; Yang, Li; Yip, Kevin; Zaleskis, Chris; Zhang, Yan; Zheng, Henry; Brenner, Steven E.#; Graveley, Brenton R.#; Ceniker, Susan E.#; Gingeras, Thomas R.#; Waterston, Robert.Comparative analysis of the transcriptome across distant species.NATURE. 2014. 512(7515):445-448.
- 14. Xue, Zhaoyu*; Ren, Mengda; Wu, Menghua; Dai, Junbiao; Rong, Yikang S.; Gao, Guanjun#.Efficient Gene Knock-out and Knock-in with Transgenic Cas9 in Drosophila.G3-GENES GENOMES GENETICS. 2014. 4(5):925-929.
- 15. Wei, Wei*; Xin, Huhu; Roy, Bhaskar; Dai, Junbiao; Miao, Yungen#; Gao, Guanjun#.Heritable Genome Editing with CRISPR/Cas9 in the Silkworm, Bombyx mori.PLOS ONE. 2014. 9(7).
- 16. Yu, Zhongsheng*; Ren, Mengda*; Wang, Zhanxiang; Zhang, Bo; Rong, Yikang S.; Jiao, Renjie#; Gao, Guanjun#.Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila.GENETICS. 2013. 195(1):2890.
- 17. Wei, Chuanxian*; Liu, Jiyong; Yu, Zhongsheng; Zhang, Bo#; Gao, Guanjun#; Jiao, Renjie#.TALEN or Cas9-Rapid, Efficient and Specific Choices for Genome Modifications.JOURNAL OF GENETICS AND GENOMICS. 2013. 40(6):281-289.
- 18. Gao, Guanjun*; Cheng, Yan; Wesolowska, Natalia; Rong, Yikang S.#.Paternal imprint essential for the inheritance of telomere identity in Drosophila.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011. 108(12):4932-4937.
- 19. Gao, Guanjun*; Walser, Jean-Claude; Beaucher, Michelle L.; Morciano, Patrizia; Wesolowska, Natalia; Chen, Jie; Rong, Yikang S.#.HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner.EMBO JOURNAL. 2010. 29(4):819-829.
- 20. Gao, Guanjun*; Bi, Xiaolin; Chen, Jie; Srikanta, Deepa; Rong, Yikang S.#.Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009. 106(26):10728-10733.
- 21. Gao, Guanjun*; McMahon, Conor; Chen, Jie; Rong, Yikang S.#.A powerful method combining homologous recombination and site-specific recombination for targeted mutagenesis in Drosophila.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008. 105(37):13999-14004.
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