Principal investigator
Name:
Jingpeng GeAssistant Professor , PhD, Assistant Professor
Position:
School of Life Science and Technology
Affiliation:
Honor:
Education Background:
- 2006/09-2010/07, Jilin University, BS
- 2011/09-2016/01, Tsinghua University, Ph. D.
Working Experience:
- 2016/02-2021/10, Vollum Institute, Oregon Health & Science University, Postdoc
- 2021/11-now, School of Life Sciences and Technology, Assistant Professor
Group Introduction
Research Area:
Structural Biology, Neuroscience
Research Interests:
We use a combination of cryo-EM microscopy, electrophysiology and various biochemical/biophysical tools to investigate the structures, functions and molecular mechanisms of key membrane proteins in nervous system. Our long-term research interests are the following three aspects: 1. How animals sense the physical and chemical stimuli; 2. How membrane proteins regulate in lipid/sugar metabolism in nervous system or neurodegenerative diseases; 3. How membrane proteins mediate the interactions between ER and other membrane systems
Representative Publications (*First Author, # Corresponding Author)
- 1. Xu, Ruisheng*; Jiang, Qiqi; Xu, Hongwei; Zhang, Lu; Hu, Xiangzi; Lu, Zizhuo; Deng, Huaqin; Xiong, Haolin; Zhang, Sensen; Chen, Zhongwen; Ge, Yifan; Zhu, Zhengjiang; Zhang, Yaoyang; Chen, Yelin; Ge, Jingpeng#; Yu, Jie#.Conformational diversity and fully opening mechanism of native NMDA receptor.NATURE. 11 Feb 2026.
- 2. Huoqing Luo*; Ming Chen*; Yingjie Ning*; Li Ren*; Yiping Lu; Junyou Sun; Xiaona Zhu; Mingzi Ran; Juan Guo; Chen Lu; Chengyu Fan; Jianjun Cheng; Weimin Zheng; Yue Hu; Tangsheng Lu; Gang Wang#; Wenzhi Sun#; Hailong Dong#; Jingpeng Ge#; Ji Hu#.Inhibition of SERT and NMDAR synergistically confers rapid antidepressant effects of ketamine.National Science Review. 08 Sep 2025. 12(12).
- 3. Zhang, Yimin*; Chen, Jiahui; Chen, Nanhao; Xiong, Haolin; Zhu, Zhengjiang; Yang, Dongxue#; Ge, Jingpeng#; Yu, Jie#.Dimerization and substrate recognition of human taurine transporter.NATURE COMMUNICATIONS. 04 Jul 2025. 16(1).
- 4. Chen, Jiahui*; Zhang, Yimin; Chen, Nanhao; Ge, Jingpeng#; Yu, Jie#.Transport and inhibition mechanisms of human creatine transporter.CELL DISCOVERY. 05 May 2025. 11(1).
- 5. Ning, Yingjie*; Xu, Ruisheng; Yu, Jie*#; Ge, Jingpeng#.Structural basis for catalytic mechanism of human phosphatidylserine synthase 1.CELL DISCOVERY. 06 Mar 2025. 11(1).
- 6. Ruisheng Xu*; Yingjie Ning*; Fandong Ren; Chenxia Gu; Zhengjiang Zhu; Xuefang Pan; Alexey V. Pshezhetsky#; Jingpeng Ge#; Jie Yu#.Structure and mechanism of lysosome transmembrane acetylation by HGSNAT.NATURE STRUCTURAL & MOLECULAR BIOLOGY. Oct 2024. 31(10):1502-1508.
- 7. Jingpeng Ge*; Johannes Elferich*; Sepehr Dehghani-Ghahnaviyeh; Zhiyu Zhao; Marc Meadows; Henrique von Gersdorff; Emad Tajkhorshid; Eric Gouaux#.Molecular mechanism of prestin electromotive signal amplification.CELL. Sep 2021.
- 8. Jingpeng Ge*; Johannes Elferich*; April Goehring; Huaying Zhao; Peter Schuck; Eric Gouaux#.Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.ELIFE. Aug 2018.
- 9. Jingpeng Ge*; Wanqiu Li*; Qiancheng Zhao*; Ningning Li*; Maofei Chen; Peng Zhi; Ruochong Li; Ning Gao#; Bailong Xiao#; Maojun Yang#.Architecture of the mammalian mechanosensitive Piezo1 channel.NATURE. Sep 2015.
- 10. Jie Yu*; Jingpeng Ge*; Johanna Heuveling; Erwin Schneider#; Maojun Yang#.Structural basis for substrate specificity of an amino acid ABC transporter.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Apr 2015.
Group Member and Photo
-
Name：Didi Xu
Position：Undergraduate Student
Duration：2022.12-now
Email：xudd1@shanghaitech.edu.cn
-
Name：CX Gu
Position：Undergraduate Student
Duration：2022.12-now
Email：guchx@shanghaitech.edu.cn
-
Name：KX Qian
Position：Undergraduate Student
Duration：2022.12-now
Email：qiankx@shanghaitech.edu.cn
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