课题组长
姓名:
管吉松副教授 研究员 博士生导师, PhD, 副教授
职务:
所在院所:
生命科学与技术学院
荣誉称号:
国家杰青
教育经历:
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1997/09—2001/07,南京大学,学士
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2001/09—2006/07,中国科学院神经科学研究所,博士
博士后及工作经历:
- 2006/11—2010/12,美国麻省理工学院,博士后
- 2011/01—2017/11,清华大学,特聘研究员
- 2017/11—2021/12,上海科技大学,生命科学与技术学院,副教授(TENURE-TRACK)
- 2021/12—至今,上海科技大学,生命科学与技术学院,副教授(TENURED)
课题组简介
研究内容:
探索哺乳动物大脑中的记忆存储和提取背后的编码规律和机制。 (1) 开发大规模单神经元解析度的在体成像技术,寻找和追踪记忆活动和多模态信息存储; (2)解析记忆神经环路以及其表观遗传调控; (3)利用脑机接口等工程与医学手段,探索对脑损伤、脑疾病的修复治疗新方法。
研究成果展示
通过大规模神经活动信号在体记录方法揭示了特异性场景记忆储存在稀疏分布的皮层II 层神经元中。基于皮层环路的神经环路结构,提出了新的记忆介导的认知模型。针对记忆印迹神经元深入研究,发现了SUV39H1、HDAC2 等调控因子在神经元活动后诱发的表观遗传过程中的作用,确立了记忆稳定性的调控机制。融合人工智能技术,发展新型脑机接口,以用于记忆损伤相关疾病的诊断和治疗。部分成果发表在国际顶级杂志上(包括《Nature》、《Cell》、《Nature Neuroscience》、《Neuron》、《Nature Communications》、《Molecular Pychriatry》和《PNAS》等)。
代表性论文(*第一作者,#通讯作者)
- 1. Guan, Ji-Song*; Haggarty, Stephen J.; Giacometti, Emanuela; Dannenberg, Jan-Hermen; Joseph, Nadine; Gao, Jun; Nieland, Thomas J. F.; Zhou, Ying; Wang, Xinyu; Mazitschek, Ralph; Bradner, James E.; DePinho, Ronald A.; Jaenisch, Rudolf; Tsai, Li-Huei#; .HDAC2 negatively regulates memory formation and synaptic plasticity.NATURE. 2009. 459(7243):55-U58.
- 2. Xie, Hong*; Liu, Yu; Zhu, Youzhi; Ding, Xinlu; Yang, Yuhao; Guan, Ji-Song#; .In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. 111(7):2788-2793.
- 3. Guan, Ji-Song*; Xie, Hong; Ding, XinLu; .The role of epigenetic regulation in learning and memory.EXPERIMENTAL NEUROLOGY. 2015. 268:30-36.
- 4. Liu Peng*; Zhu Tao; Bai Bing; Gao Guanjun; Guan Jisong#; .A One-Step Screening System for Multi-Zinc Finger Proteins Targeting a Long-DNA Sequence.中国科学.生命科学. 24 Oct 2014. 44(10):1061-1072.
- 5. Zhu, Tao*; Liang, Chen; Li, Dongdong; Tian, Miaomiao; Liu, Sanxiong; Gao, Guanjun; Guan, Ji-Song#; .Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1 alpha.SCIENTIFIC REPORTS. 2016. 6.
- 6. Guan, Ji-Song*; Jiang, Jun; Xie, Hong; Liu, Kai-Yuan; .How Does the Sparse Memory "Engram" Neurons Encode the Memory of a Spatial-Temporal Event?.FRONTIERS IN NEURAL CIRCUITS. 2016. 10.
- 7. Ding, Xinlu*; Liu, Sanxiong; Tian, Miaomiao; Zhang, Wenhao; Zhu, Tao; Li, Dongdong; Wu, Jiawei; Deng, HaiTeng; Jia, Yichang; Xie, Wei; Xie, Hong; Guan, Ji-Song#; .Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation.NATURE NEUROSCIENCE. 2017. 20(5):6900.
- 8. Jiang, Jun*; Wang, Guang-Yu; Luo, Wenhan; Xie, Hong; Guan, Ji-Song#; .Mammillary body regulates state-dependent fear by alternating cortical oscillations.SCIENTIFIC REPORTS. 07 Sep 2018. 8.
- 9. Fu, Ruxing*; Luo, Wenhan; Nazempour, Roya; Tan, Daxin; Ding, He; Zhang, Kaiyuan; Yin, Lan; Guan, Jisong#; Sheng, Xing#; .Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces.ADVANCED OPTICAL MATERIALS. 05 Feb 2018. 6(3).
- 10. Zhang, Jing*; Liu, Xiaojun; Xu, Wenjing; Luo, Wenhan; Li, Ming; Chu, Fangbing; Xu, Lu; Cao, Anyuan; Guan, Jisong; Tang, Shiming; Duan, Xiaojie#; .Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in Vivo.NANO LETTERS. May 2018. 18(5):2903-2911.
- 11. Li, Dong*; Zavaglia, Melissa; Wang, Guangyu; Xie, Hong; Hu, Yi; Werner, Rene; Guan, Ji-Song; Hilgetag, Claus C.#; .Discrimination of the hierarchical structure of cortical layers in 2-photon microscopy data by combined unsupervised and supervised machine learning.SCIENTIFIC REPORTS. 15 May 2019. 9.
- 12. Li, Dong*; Wang, Guangyu; Xie, Hong; Hu, Yi; Guan, Ji-Song#; Hilgetag, Claus C.#; .Multimodal Memory Components and Their Long-Term Dynamics Identified in Cortical Layers II/III but Not Layer V.FRONTIERS IN INTEGRATIVE NEUROSCIENCE. 01 Oct 2019. 13(54).
- 13. Wang, Guangyu*; Xie, Hong; Wang, Lun; Luo, Wenhan; Wang, Yixiang; Jiang, Jun; Xiao, Chun; Xing, Feng; Guan, Ji-Song#; .Switching From Fear to No Fear by Different Neural Ensembles in Mouse Retrosplenial Cortex.CEREBRAL CORTEX. Dec 2019. 29(12):5085-5097.
- 14. Liu, Shiguo*; Tian, Miaomiao; He, Fan; Li, Jiani; Xie, Hong; Liu, Wenmiao; Zhang, Yeting; Zhang, Ru; Yi, Mingji; Che, Fengyuan; Ma, Xu; Zheng, Yi; Deng, Hao; Wang, Guiju; Chen, Lang; Sun, Xue; Xu, Yinglei; Wang, Jingli; Zang, Yucui; Han, Mengmeng; Wang, Xiuhai; Guan, Hongzai; Ge, Yinlin; Wu, Chunmei; Wang, Haiyan; Liang, Hui; Li, Hui; Ran, Ni; Yang, Zhaochuan; Huang, Huanhuan; Wei, Yanzhao; Zheng, Xueping; Sun, Xiangrong; Feng, Xueying; Zheng, Lanlan; Zhu, Tao; Luo, Wenhan; Chen, Qinan; Yan, Yuze; Huang, Zuzhou; Jing, Zhongcui; Guo, Yixia; Zhang, Xuzhan; Schaaf, Christian P.; Xing, Jinchuan; Wang, Chuanyue#; Yu, Fuli#; Guan, Ji-Song#; .Mutations in ASH1L confer susceptibility to Tourette syndrome.MOLECULAR PSYCHIATRY. Feb 2020. 25(2):476-490.
- 15. Zhang, Xue*; Wang, Fengchao; Hu, Yi; Chen, Runze; Meng, Dawei; Guo, Liang; Lv, Hailong; Guan, Jisong; Jia, Yichang#; .In vivo stress granule misprocessing evidenced in a FUS knock-in ALS mouse.BRAIN. May 2020. 143:1350-1367.
- 16. Wang, Guangyu*; Xie, Hong; Hu, Yi; Chen, Qinan; Liu, Chenhui; Liu, Kaiyuan; Yan, Yuze; Guan, Ji-Song#; .Egr1-EGFP transgenic mouse allows in vivo recording of Egr1 expression and neural activity.JOURNAL OF NEUROSCIENCE METHODS. 01 Nov 2021. 363.
- 17. Wang, Fei*; Jiang, Weiqing; Gao, Li; Liu, Chen; Deng, Mingzhu; Ren, Xiao; Zhu, Chenlu; Guan, Ji-Song; Wang, Yonggang#; .Detecting Abnormal Neuronal Activity in a Chronic Migraine Model by Egr1-EGFP Transgenic Mice.FRONTIERS IN NEUROSCIENCE. 12 Aug 2021. 15.
- 18. 管吉松*; 陆巍; .记忆可以被操纵和移植吗?.前沿科学. 28 Jun 2021. 15(2):10-15.
- 19. Jiang, Yan*; Fu, Xing; Zhang, Yuhan; Wang, Shen-Fei; Zhu, Hong; Wang, Wei-Kang; Zhang, Lin; Wu, Ping; Wong, Catherine C. L.; Li, Jinsong; Ma, Jinbiao; Guan, Ji-Song; Huang, Ying#; Hui, Jingyi#; .Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models.NATURE COMMUNICATIONS. 01 Oct 2021. 12(1).
- 20. Chen, Qi-Nan*; Ding, Xin-Lu; Guo, Xiu-Xian; Zhou, Gang; Guan, Ji-Song#; .Suv39h1 regulates memory stability by inhibiting the expression of Shank1 in hippocampal newborn neurons.EUROPEAN JOURNAL OF NEUROSCIENCE. Mar 2022.
- 21. Liu, Kai-Yuan*; Li, Xing-Yu; Lai, Yu-Rui; Su, Hang; Wang, Jia-Chen; Guo, Chun-Xu; Xie, Hong; Guan, Ji-Song#; Zhou, Yi#; .Denoised Internal Models: A Brain-inspired Autoencoder Against Adversarial Attacks.MACHINE INTELLIGENCE RESEARCH. Oct 2022. 19(5):456-471.
- 22. Luo, Wenhan*; Yun, Di; Hu, Yi; Tian, Miaomiao; Yang, Jiajun; Xu, Yifan; Tang, Yong; Zhan, Yang; Xie, Hong; Guan, Ji Song; .Acquiring new memories in neocortex of hippocampal-lesioned mice.NATURE COMMUNICATIONS. 24 Mar 2022. 13(1).
- 23. Yan, Yuze*; Tian, Miaomiao; Li, Meng; Zhou, Gang; Chen, Qinan; Xu, Mingrui; Hu, Yi; Luo, Wenhan; Guo, Xiuxian; Zhang, Cheng; Xie, Hong; Wu, Qing-Feng; Xiong, Wei#; Liu, Shiguo#; Guan, Ji-Song#; .ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder.NEURON. 06 Apr 2022. 110(7).
- 24. Xie, Hong*; Cheng, Ruixi; Yun, Di; Guan, Ji-Song#; .Neural mechanism of long-term memory storage and modulation.KEXUE TONGBAO/CHINESE SCIENCE BULLETIN. 2023. 68(16):2016-2028.
- 25. Du, Wan-Jie*; Yang, Huan; Tong, Fang; Liu, Shuai; Zhang, Chen; Chen, Yeying; Yan, Yuze; Xiang, Yan-Wei; Hua, Ling-Yang; Gong, Ye; Xu, Zhi-Xiang; Liu, Xiaoyan; Jiang, Xingyu; Lu, Mingfang; Guan, Ji-Song#; Han, Qingjian#; .Ash1L ameliorates psoriasis via limiting neuronal activity-dependent release of miR-let-7b.BRITISH JOURNAL OF PHARMACOLOGY. 01 Nov 2023.
- 26. Guo, Xiuxian*; Hong, Pengfei; Xiong, Songhai; Yan, Yuze; Xie, Hong#; Guan, Ji-Song#; .Kdm4a is an activity downregulated barrier to generate engrams for memory separation.NATURE COMMUNICATIONS. 13 Jul 2024. 15(1).
- 27. Wang, Tianxiao*; Zhu, Chenlu; Zhang, Kaibo; Gao, Jinggui; Xu, Yunhao; Duan, Chenyang; Wu, Shouyi; Peng, Cheng; Guan, Jisong#; Wang, Yonggang#; .Targeting IGF1/IGF1r signaling relieve pain and autophagic dysfunction in NTG-induced chronic migraine model of mice.JOURNAL OF HEADACHE AND PAIN. 20 Sep 2024. 25(1).
- 28. Gao, Jinggui*; Wang, Da; Zhu, Chenlu; Wang, Jian; Wang, Tianxiao; Xu, Yunhao; Ren, Xiao; Zhang, Kaibo; Peng, Cheng; Guan, Jisong#; Wang, Yonggang#; .1H-MRS reveals abnormal energy metabolism and excitatory-inhibitory imbalance in a chronic migraine-like state induced by nitroglycerin in mice.JOURNAL OF HEADACHE AND PAIN. 30 Sep 2024. 25(1).
- 29. Xie, Hong*; Liu, Kaiyuan; Li, Dong; Zhang, Chang-Shui; Hilgetag, Claus C.; Guan, Ji-Song#; .Rectified activity-dependent population plasticity implicates cortical adaptation for memory and cognitive functions.COMMUNICATIONS BIOLOGY. 11 Nov 2024. 7(1).
- 30. Chenhui Liu, Zhen Liu, Kaiyuan Liu, Tianfu Zhang, Guangyu Wang, Hong Xie, and Ji-Song Guan.Hippocampus alters visual representation to encode new memory.CELL REPORTS. 27 May 2025. 44(5):115594.
专著
1. Guan, J. (2022). Development of Memory Circuits under Epigenetic Regulation. In M. Krause, K. Hollis, & M. Papini (Eds.), Evolution of Learning and Memory Mechanisms (pp. 438-453). Cambridge: Cambridge University Press. doi:10.1017/9781108768450.029
项目
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1. 长期记忆存储与提取的神经元编码,科技部,科技创新2030重大项目,课题负责人
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2. ASH1L基因参与的神经发育与功能疾病机制研究,NSFC,项目负责人
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3. 记忆的存储与提取机制,国自然基金委,杰出青年科学基金,项目负责人
奖励
- 1. 2015,北京市科技新星
- 2. 2015,国家“万人计划”青年拔尖人才
- 3. 2015年,中国神经科学学会,理事
- 4. 2016年,中国细胞生物学学会神经细胞生物学分会,秘书长
- 5. 2016年,中国神经科学学会认知神经生物学分会,委员
- 6. 2019年,中国神经科学学会学习记忆基础与临床分会,委员
- 7. 2019,第一届中国细胞生物学学会神经细胞生物学青年前沿论坛奖
- 8. 2018,中科院脑智卓越中心青年骨干
- 9. 2021,“2021年北京地区广受关注学术成果报告会(脑科学领域)优秀论文奖
- 10. 2022年,国家杰出青年科学基金
课题组成员及合影
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姓名:袁敏娟
身份:实验室管理员
在组时间:2022/06-至今
邮箱:mjyuan2015@163.com
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姓名:韵迪
身份:助理研究员
在组时间:2018/06-至今
邮箱:yundi@@shanghaitech.edu.cn
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姓名:刘真
身份:博士后
在组时间:2022/01-至今
邮箱:liuzhen1@shanghaitech.edu.cn
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姓名:闫宇泽
身份:博士后
在组时间:2018/05-至今
邮箱:yanyz@shanghaitech.edu.cn
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姓名:郭修贤
身份:博士后
在组时间:2018/04-至今
邮箱:guoxx@@shanghaitech.edu.cn
-
姓名:刘辰辉
身份:博士研究生
在组时间:2019/03-至今
邮箱:liuchh2@@shanghaitech.edu.cn
-
姓名:张天夫
身份:博士研究生
在组时间:2020/05-至今
邮箱:zhangtf@@shanghaitech.edu.cn
-
姓名:周罡
身份:博士研究生
在组时间:2020/03-至今
邮箱:zhougang@@shanghaitech.edu.cn
-
姓名:熊诵海
身份:博士研究生
在组时间:2020/09-至今
邮箱:xiongsh@shanghaitech.edu.cn
-
姓名:王政
身份:博士研究生
在组时间:2021/09-至今
邮箱:wangzheng1@shanghaitech.edu.cn
-
姓名:杨青宁
身份:博士研究生
在组时间:2021/09-至今
邮箱:yangqn@@shanghaitech.edu.cn
-
姓名:洪鹏飞
身份:博士研究生
在组时间:2022/09-至今
邮箱:hongpf2022@shanghaitech.edu.cn
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姓名:赵圣霖
身份:博士研究生
在组时间:2022/11-至今
邮箱:zhaoshl2022@shanghaitech.edu.cn
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姓名:梁鸿淞
身份:博士研究生
在组时间:2022/09-至今
邮箱:lianghs2022@shanghaitech.edu.cn
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姓名:周左尧
身份:硕士研究生
在组时间:2023/09-至今
邮箱:zhouzy32023@shanghaitech.edu.cn
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姓名:刘怡莹
身份:博士研究生
在组时间:2023/11-至今
邮箱:liuyy2023@shanghaitech.edu.cn
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姓名:欧海亘
身份:硕士研究生
在组时间:2024/12-至今
邮箱:ouhg2024@shanghaitech.edu.cn
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姓名:李若冰
身份:硕士研究生
在组时间:2025/02-至今
邮箱:lirb2024@shanghaitech.edu.cn

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