英文信息

Principal investigator

Name:

Ji-Song GuanAssociate Professor , PhD, Associate Professor

Position:

Affiliation:

School of Life Science and Technology

Honor:

The National Science Fund for Distinguished Young Scholars

Education Background:

Working Experience:

Group Introduction

Research Area:

Neuroscience, Learning and Memory

Research Interests:

The lab has been focusing on exploring the circuitry and molecular mechanisms underlying memory formation and retrieval. We developed an in vivo imaging tool and data analysis system to directly measure the memory-related cortical responses in large scale. Combined with optogenetic and chemogenetic tools, we identified the memory trace neurons in layer 2 cortex and hippocampal dentate gyrus area and studied their dynamic activity of memory traces, underlying the long-term memory. Furthermore, a mechanism of epigenetic regulation was discovered within memory trace neurons to modulate the memory stability.

Group Website:

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

1. Guan, Ji-Song*; Haggarty, Stephen J.; Giacometti, Emanuela; Dannenberg, Jan-Hermen; Joseph, Nadine; Gao, Jun; Nieland, Thomas J. F.; Zhou, Ying; Wang, Xinyu; Mazitschek, Ralph; Bradner, James E.; DePinho, Ronald A.; Jaenisch, Rudolf; Tsai, Li-Huei^#.HDAC2 negatively regulates memory formation and synaptic plasticity.NATURE. 2009. 459(7243):55-U58.
2. Xie, Hong*; Liu, Yu; Zhu, Youzhi; Ding, Xinlu; Yang, Yuhao; Guan, Ji-Song^#.In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. 111(7):2788-2793.
3. Guan, Ji-Song^#*; Xie, Hong; Ding, XinLu.The role of epigenetic regulation in learning and memory.EXPERIMENTAL NEUROLOGY. 2015. 268:30-36.
4. Guan, Ji-Song^#*; Jiang, Jun; Xie, Hong; Liu, Kai-Yuan.How Does the Sparse Memory "Engram" Neurons Encode the Memory of a Spatial-Temporal Event?.FRONTIERS IN NEURAL CIRCUITS. 2016. 10.
5. Ding, Xinlu*; Liu, Sanxiong; Tian, Miaomiao; Zhang, Wenhao; Zhu, Tao; Li, Dongdong; Wu, Jiawei; Deng, HaiTeng; Jia, Yichang; Xie, Wei; Xie, Hong; Guan, Ji-Song^#.Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation.NATURE NEUROSCIENCE. 2017. 20(5):6900.
6. Jiang, Jun*; Wang, Guang-Yu; Luo, Wenhan; Xie, Hong; Guan, Ji-Song^#.Mammillary body regulates state-dependent fear by alternating cortical oscillations.SCIENTIFIC REPORTS. 07 Sep 2018. 8.
7. Zhang, Jing*; Liu, Xiaojun; Xu, Wenjing; Luo, Wenhan; Li, Ming; Chu, Fangbing; Xu, Lu; Cao, Anyuan; Guan, Jisong; Tang, Shiming; Duan, Xiaojie^#.Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in Vivo.NANO LETTERS. May 2018. 18(5):2903-2911.
8. Wang, Guangyu*; Xie, Hong; Wang, Lun; Luo, Wenhan; Wang, Yixiang; Jiang, Jun; Xiao, Chun; Xing, Feng; Guan, Ji-Song^#.Switching From Fear to No Fear by Different Neural Ensembles in Mouse Retrosplenial Cortex.CEREBRAL CORTEX. Dec 2019. 29(12):5085-5097.
9. Liu, Shiguo*; Tian, Miaomiao; He, Fan; Li, Jiani; Xie, Hong; Liu, Wenmiao; Zhang, Yeting; Zhang, Ru; Yi, Mingji; Che, Fengyuan; Ma, Xu; Zheng, Yi; Deng, Hao; Wang, Guiju; Chen, Lang; Sun, Xue; Xu, Yinglei; Wang, Jingli; Zang, Yucui; Han, Mengmeng; Wang, Xiuhai; Guan, Hongzai; Ge, Yinlin; Wu, Chunmei; Wang, Haiyan; Liang, Hui; Li, Hui; Ran, Ni; Yang, Zhaochuan; Huang, Huanhuan; Wei, Yanzhao; Zheng, Xueping; Sun, Xiangrong; Feng, Xueying; Zheng, Lanlan; Zhu, Tao; Luo, Wenhan; Chen, Qinan; Yan, Yuze; Huang, Zuzhou; Jing, Zhongcui; Guo, Yixia; Zhang, Xuzhan; Schaaf, Christian P.; Xing, Jinchuan; Wang, Chuanyue^#; Yu, Fuli^#; Guan, Ji-Song^#.Mutations in ASH1L confer susceptibility to Tourette syndrome.MOLECULAR PSYCHIATRY. Feb 2020. 25(2):476-490.
10. Luo, Wenhan*; Yun, Di; Hu, Yi; Tian, Miaomiao; Yang, Jiajun; Xu, Yifan; Tang, Yong; Zhan, Yang; Xie, Hong; Guan, Ji-Song^#.Acquiring new memories in neocortex of hippocampal-lesioned mice.NATURE COMMUNICATIONS. 24 Mar 2022. 13(1).
11. Yan, Yuze*; Tian, Miaomiao; Li, Meng; Zhou, Gang; Chen, Qinan; Xu, Mingrui; Hu, Yi; Luo, Wenhan; Guo, Xiuxian; Zhang, Cheng; Xie, Hong; Wu, Qing-Feng; Xiong, Wei^#; Liu, Shiguo^#; Guan, Ji-Song^#.ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder.NEURON. 06 Apr 2022. 110(7).

Ji-Song Guan, PhDAssociate Professor

Principal investigator

Group Introduction

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo