课题组长
姓名：
耿美玉中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院上海药物研究所
荣誉称号：
课题组简介
研究内容：
1.受体酪氨酸激酶c-Met、ALK、FGFR抑制剂及其生物标志物； 2.肿瘤代谢及其抑制剂； 3.肿瘤微环境与肿瘤转移； 4.蛋白激酶后修饰与肿瘤。
代表性论文（*第一作者，#通讯作者）
- 1. Ai, Jing*; Tang, Qingjuan; Wu, Yanlin; Xu, Yang; Feng, Teng; Zhou, Ruiyu; Chen, Yi; Gao, Xin; Zhu, Qingfeng; Yue, Xihua; Pan, Qiuming; Xu, Siyun; Li, Jing; Huang, Min; Daugherty-Holtrop, Jennifer; He, Yuanzheng; Xu, H. Eric; Fan, Jia#; Ding, Jian; Geng, Meiyu#.The Role of Polymeric Immunoglobulin Receptor in Inflammation-Induced Tumor Metastasis of Human Hepatocellular Carcinoma.JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2011. 103(22):1696-1712.
- 2. Zhang, Jing*; Xin, Xianliang; Chen, Qin; Xie, Zuoquan; Gui, Min; Chen, Yi; Lin, Liping; Feng, Jianming; Li, Qiuning; Ding, Jian; Geng, Meiyu#.Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF-?B via targeting of Mre11.INTERNATIONAL JOURNAL OF CANCER. 2012. 130(2):467-477.
- 3. Zhu, Caihua*; Chen, Qin; Xie, Zuoquan; Ai, Jing; Tong, Linjiang; Ding, Jian#; Geng, Meiyu#.The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc.JOURNAL OF MOLECULAR MEDICINE-JMM. 2011. 89(3):279-289.
- 4. Du, Lin*; Ai, Jing; Li, Dehai; Zhu, Tianjiao; Wang, Ying; Knauer, Michael; Bruhn, Torsten; Liu, Hongbing; Geng, Meiyu#; Gu, Qianqun#; Bringmann, Gerhard#.Aspergiolides C and D: Spirocyclic Aromatic Polyketides with Potent Protein Kinase c-Met Inhibitory Effects.CHEMISTRY-A EUROPEAN JOURNAL. 2011. 17(4):1319-1326.
- 5. Wang, Yuanxiang*; Ai, Jing; Wang, Ying; Chen, Yi; Wang, Lu; Liu, Gang; Geng, Meiyu#; Zhang, Ao#.Synthesis and c-Met Kinase Inhibition of 3,5-Disubstituted and 3,5,7-Trisubstituted Quinolines: Identification of 3-(4-Acetylpiperazin-1-y1)-5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinoline as a Novel Anticancer Agent.JOURNAL OF MEDICINAL CHEMISTRY. 2011. 54(7):2127-2142.
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