英文信息

Principal investigator

Name:

Meiyu GengDistinguished Adjunct Professor from CAS , PhD, Distinguished Adjunct Professor from CAS

Position:

Affiliation:

School of Life Science and Technology, Shanghai Institute of Materia Medica, CAS

Honor:

Education Background:

Working Experience:

Group Introduction

Research Area:

Tumor Pharmacology

Research Interests:

1. Anti-Alzheimer's disease drug development by targeting β-amyloid protein
2. Tyrosine kinases inhibitors of c-Met, ALK and FGFR and the companion biomarkers for cancer therapy
3. Hsp90 inhibitors and the companion biomarkers for cancer therapy
4. Therapeutic opportunities by targeting cancer metabolism
5. Therapeutic opportunities by targeting cancer microenvironment

Group Website:

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

1. Ai, Jing*; Tang, Qingjuan; Wu, Yanlin; Xu, Yang; Feng, Teng; Zhou, Ruiyu; Chen, Yi; Gao, Xin; Zhu, Qingfeng; Yue, Xihua; Pan, Qiuming; Xu, Siyun; Li, Jing; Huang, Min; Daugherty-Holtrop, Jennifer; He, Yuanzheng; Xu, H. Eric; Fan, Jia^#; Ding, Jian; Geng, Meiyu^#.The Role of Polymeric Immunoglobulin Receptor in Inflammation-Induced Tumor Metastasis of Human Hepatocellular Carcinoma.JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2011. 103(22):1696-1712.
2. Zhang, Jing*; Xin, Xianliang; Chen, Qin; Xie, Zuoquan; Gui, Min; Chen, Yi; Lin, Liping; Feng, Jianming; Li, Qiuning; Ding, Jian; Geng, Meiyu^#.Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF-?B via targeting of Mre11.INTERNATIONAL JOURNAL OF CANCER. 2012. 130(2):467-477.
3. Zhu, Caihua*; Chen, Qin; Xie, Zuoquan; Ai, Jing; Tong, Linjiang; Ding, Jian^#; Geng, Meiyu^#.The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc.JOURNAL OF MOLECULAR MEDICINE-JMM. 2011. 89(3):279-289.
4. Du, Lin*; Ai, Jing; Li, Dehai; Zhu, Tianjiao; Wang, Ying; Knauer, Michael; Bruhn, Torsten; Liu, Hongbing; Geng, Meiyu^#; Gu, Qianqun^#; Bringmann, Gerhard^#.Aspergiolides C and D: Spirocyclic Aromatic Polyketides with Potent Protein Kinase c-Met Inhibitory Effects.CHEMISTRY-A EUROPEAN JOURNAL. 2011. 17(4):1319-1326.
5. Wang, Yuanxiang*; Ai, Jing; Wang, Ying; Chen, Yi; Wang, Lu; Liu, Gang; Geng, Meiyu^#; Zhang, Ao^#.Synthesis and c-Met Kinase Inhibition of 3,5-Disubstituted and 3,5,7-Trisubstituted Quinolines: Identification of 3-(4-Acetylpiperazin-1-y1)-5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinoline as a Novel Anticancer Agent.JOURNAL OF MEDICINAL CHEMISTRY. 2011. 54(7):2127-2142.

Meiyu Geng, PhDDistinguished Adjunct Professor from CAS

Principal investigator

Group Introduction

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo