Principle Investigator
Name:
Ji HuAssociate Professor , PhD, Associate Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 1999/09-2003/06, Huazhong University of Science and Technology, B.S.
- 2003/09-2005/12, Institute of Neuroscience, Chinese Academy of Sciences, M.S.
- 2005/12-2008/06, National Institute of Biological Sciences (NIBS)/Institute of Biophysics, CAS, Ph.D.
Working Experience:
- 2008/06-2009/05, National Institute of Biological Sciences (NIBS)/Institute of Biophysics, CAS, Postdoctoral Fellow
- 2009/05-2013/02, Picower Institute, MIT., Postdoctoral Fellow
- 2013/02-2014/04, Xi’an Jiaotong University, Professor
- 2014/04-2020/01, ShanghaiTech University, School of Life Science and Technology, Assistant Professor (TENURE-TRACK)
- 2020/01-Present, ShanghaiTech University, School of Life Science and Technology, Associate Professor (TENURED)
Group Introduction
Research Area:
Circuit Mechanism of Emotion
Research Interests:
We develop and apply cutting-edge methods, by combining optical imaging, neuromodulation, genetic labeling and circuit tracings to functional dissect the neural mechanisms of emotion and associated psychiatric diseases. The laboratory has internationally leading and comprehensive optical imaging instruments (two-photon microscope, gradient refraction lens, fiber photometric measurement) and technical means. We are using these new methods to attack several related neurobiological questions: 1. Stress neurobiology; 2. Circuit mechanisms of neuropsychopharmacology; 3. New strategies for the treatment of psychiatric disorders. Our research will contribute to the treatment of important mental illnesses such as depression and anxiety.
Representative Publications (*First Author, # Corresponding Author)
- 1. Zhang, Xu*; Lei, Bo; Yuan, Yuan; Zhang, Li; Hu, Lu; Jin, Sen; Kang, Bilin; Liao, Xuebin; Sun, Wenzhi; Xu, Fuqiang; Zhong, Yi#; Hu, Ji#; Qi, Hai#.Brain control of humoral immune responses amenable to behavioural modulation.NATURE. 29 Apr 2020.
- 2. Qiu Gaolin*; Wu Ying; Yang Zeyong; Li Long; Zhu Xiaona; Wang Yiqiao; Sun Wenzhi; Dong Hailong; Li Yuanhai; Hu Ji#.Dexmedetomidine activation of dopamine neurons in the ventral tegmental area attenuates the depth of sedation in mice.ANESTHESIOLOGY. 12 May 2020.
- 3. Wang, Fang*; Zhang, Juen; Yuan, Yuan; Chen, Ming; Gao, Zilong; Zhan, Shulu; Fan, Chengyu; Sun, Wenzhi#; Hu, Ji#.Salience processing by glutamatergic neurons in the ventral pallidum.SCIENCE BULLETIN. 15 Mar 2020. 65(5):389-401.
- 4. Su, Xin-Yu*; Chen, Ming; Yuan, Yuan; Li, Ying; Guo, Su-Shan; Luo, Huo-Qing; Huang, Chen; Sun, Wenzhi; Li, Yong; Zhu, Michael X.; Liu, Ming-Gang#; Hu, Ji#; Xu, Tian-Le#.Central Processing of Itch in the Midbrain Reward Center.NEURON. 22 May 2019. 102(4):858-+.
- 5. Yuan, Yuan*; Wu, Wei; Chen, Ming; Cai, Fang; Fan, Chengyu; Shen, Wei; Sun, Wenzhi#; Hu, Ji#.Reward Inhibits Paraventricular CRH Neurons to Relieve Stress.CURRENT BIOLOGY. Apr 2019. 29(7):1243-+.
- 6. Yang, Yan*; Wang, Hao; Hu, Ji#; Hu, Hailan#.Lateral habenula in the pathophysiology of depression.CURRENT OPINION IN NEUROBIOLOGY. Feb 2018. 48:90-96.
- 7. Xiao, Yan*; Luo, Huoqing; Yang, Wen Z.; Zeng, Yeting; Shen, Yinbo; Ni, Xinyan; Shi, Zhaomei; Zhong, Jun; Liang, Ziqi; Fu, Xiaoyu; Tu, Hongqing; Sun, Wenzhi; Shen, Wei L.#; Hu, Ji#; Yang, Jiajun#.A Brain Signaling Framework for Stress-Induced Depression and Ketamine Treatment Elucidated by Phosphoproteomics.FRONTIERS IN CELLULAR NEUROSCIENCE. 07 Apr 2020. 14.
- 8. Zhou, Haibin*; Zhang, Shouhua; Lv, Fei; Sun, Wenzhi; Wang, Lihua; Fan, Chunhai; Li, Jiang#; Hu, Ji#.Citrate-assisted efficient local delivery of naked oligonucleotide into live mouse brain cells.CELL PROLIFERATION. Jul 2019. 52(4).
- 9. Hu, Rongfeng*; Zhang, Juen; Luo, Minmin; Hu, Ji#.Response Patterns of GABAergic Neurons in the Anterior Piriform Cortex of Awake Mice.CEREBRAL CORTEX. Jun 2017. 27(6):3110-3124.
- 10. Hu, Rongfeng*; Jin, Sen; He, Xiaobin; Xu, Fuqiang; Hu, Ji#.Whole-Brain Monosynaptic Afferent Inputs to Basal Forebrain Cholinergic System.FRONTIERS IN NEUROANATOMY. 10 Oct 2016. 10.
- 11. Chen, Tao*; Koga, Kohei; Descalzi, Giannina; Qiu, Shuang; Wang, Jian; Zhang, Le-Shi; Zhang, Zhi-Jian; He, Xiao-Bin; Qin, Xin; Xu, Fu-Qiang; Hu, Ji; Wei, Feng; Huganir, Richard L.; Li, Yun-Qing#; Zhuo, Min#.Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury.MOLECULAR PAIN. 2014. 10.
- 12. Gong, Rong*; Ding, Cheng; Hu, Ji; Lu, Yao; Liu, Fei; Mann, Elizabeth; Xu, Fuqiang; Cohen, Mitchell B.; Luo, Minmin#.Role for the Membrane Receptor Guanylyl Cyclase-C in Attention Deficiency and Hyperactive Behavior.SCIENCE. 2011. 333(6049):1642-1646.
- 13. Zhao, Zheng-dong*; Chen, Zongming; Xiang, Xinkuan; Hu, Mengna; Xie, Hengchang; Jia, Xiaoning; Cai, Fang; Cui, Yuting; Chen, Zijun; Qian, Lechen; Liu, Jiashu; Shang, Congping; Yang, Yiqing; Ni, Xinyan; Sun, Wenzhi; Hu, Ji; Cao, Peng; Li, Haohong#; Shen, Wei L.#.Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting.NATURE NEUROSCIENCE. Jun 2019. 22(6):921-+.
- 14. Zhang, Shouhua*; Lv, Fei; Yuan, Yuan; Fan, Chengyu; Li, Jiang; Sun, Wenzhi; Hu, Ji#.Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons.FRONTIERS IN NEUROSCIENCE. 04 Jun 2019. 13.
- 15. Gao, L.*; Hu, J.; Zhong, C.; Luo, M.#.INTEGRATION OF CO2 AND ODORANT SIGNALS IN THE MOUSE OLFACTORY BULB.NEUROSCIENCE. 2010. 170(3):881-892.
- 16. Hu, Ji*; Zhong, Chun; Ding, Cheng; Chi, Qiuyi; Walz, Andreas; Mombaerts, Peter; Matsunami, Hiroaki; Luo, Minmin#.Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.SCIENCE. 2007. 317(5840):953-957.
- 17. Sun, Liming*; Wang, Huayi; Hu, Ji; Han, Jinlong; Matsunamic, Hiroaki; Luo, Minmin#.Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009. 106(6):2041-2046.
- 18. Luo, Minmin#*; Sun, Liming#; Hu, Ji#.Neural detection of gases - carbon dioxide, oxygen - in vertebrates and invertebrates.CURRENT OPINION IN NEUROBIOLOGY. 2009. 19(4):354-361.
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