Principal investigator
Name:
Ji HuAssociate Professor , PhD, Associate Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 1999/09-2003/06, Huazhong University of Science and Technology, B.S.
- 2003/09-2005/12, Institute of Neuroscience, Chinese Academy of Sciences, M.S.
- 2005/12-2008/06, National Institute of Biological Sciences (NIBS)/Institute of Biophysics, CAS, Ph.D.
Working Experience:
- 2008/06-2009/05, National Institute of Biological Sciences (NIBS)/Institute of Biophysics, CAS, Postdoctoral Fellow
- 2009/05-2013/02, Picower Institute, MIT., Postdoctoral Fellow
- 2013/02-2014/04, Xi’an Jiaotong University, Professor
- 2014/04-2020/01, ShanghaiTech University, School of Life Science and Technology, Assistant Professor (TENURE-TRACK)
- 2020/01-Present, ShanghaiTech University, School of Life Science and Technology, Associate Professor (TENURED)
Group Introduction
Research Area:
Circuit Mechanism of Emotion
Research Interests:
We develop and apply cutting-edge methods, by combining optical imaging, neuromodulation, genetic labeling and circuit tracings to functional dissect the neural mechanisms of emotion and associated psychiatric diseases. The laboratory has state-of-the-art optical imaging instruments (two-photon microscope, gradient refraction lens, fiber photometric measurement). We are using these new methods to attack several related neurobiological questions: 1. Stress neurobiology; 2. Circuit mechanisms of neuropsychopharmacology; 3. New strategies for the treatment of psychiatric disorders. Our research will contribute to the treatment of important mental illnesses such as depression and anxiety.
Representative Publications (*First Author, # Corresponding Author)
- 1. Li, Shanshan*; Luo, Huoqing; Lou, Ronghui; Tian, Cuiping; Miao, Chen; Xia, Lisha; Pan, Chen; Duan, Xiaoxiao; Dang, Ting; Li, Hui; Fan, Chengyu; Tang, Pan; Zhang, Zhuangzhuang; Liu, Yan; Li, Yunxia; Xu, Fei; Zhang, Yaoyang; Zhong, Guisheng#; Hu, Ji#; Shui, Wenqing#.Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression.SCIENCE ADVANCES. 2021. 7(30):eabf0634.
- 2. Gao, Zilong*; Wang, Hanqing; Lu, Chen; Lu, Tiezhan; Froudist-Walsh, Sean; Chen, Ming; Wang, Xiao-Jing#; Hu, Ji#; Sun, Wenzhi#.The neural basis of delayed gratification.ADVANCED SCIENCE. 01 Dec 2021. 7(49):1-14.
- 3. Ni, You*; Feng, Yifan*; Shen, Dingding; Chen, Ming; Zhu, Xiaona; Zhou, Qinming; Gao, Yining; Liu, Jun; Zhang, Qi; Shen, Yuntian; Peng, Lisheng; Zeng, Zike; Yin, Dou; Hu, Ji#; Chen, Sheng#.Anti-IgLON5 antibodies cause progressive behavioral and neuropathological changes in mice.JOURNAL OF NEUROINFLAMMATION. 11 Jun 2022. 19(1).
- 4. Zeng, Yeting*; Luo, Huoqing*; Gao, Zilong; Zhu, Xiaona; Shen, Yinbo; Li, Yulong; Hu, Ji#; Yang, Jiajun#.Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine.ISCIENCE. 2021. 24(3).
- 5. Guo, Juan*; Ran, Mingzi*; Gao, Zilong; Zhang, Xinxin; Wang, Dan; Li, Huiming; Zhao, Shiyi; Sun, Wenzhi#; Dong, Hailong#; Hu, Ji#.Cell-type-specific imaging of neurotransmission reveals a disrupted excitatory-inhibitory cortical network in isoflurane anaesthesia.EBIOMEDICINE. 2021. 65.
- 6. Wang, Fang*; Zhang, Juen; Yuan, Yuan; Chen, Ming; Gao, Zilong; Zhan, Shulu; Fan, Chengyu; Sun, Wenzhi#; Hu, Ji#.Salience processing by glutamatergic neurons in the ventral pallidum.SCIENCE BULLETIN. 15 Mar 2020. 65(5):389-401.
- 7. Zhang, Xu*; Lei, Bo*; Yuan, Yuan*; Zhang, Li*; Hu, Lu; Jin, Sen; Kang, Bilin; Liao, Xuebin; Sun, Wenzhi; Xu, Fuqiang; Zhong, Yi#; Hu, Ji#; Qi, Hai#.Brain control of humoral immune responses amenable to behavioural modulation.NATURE. 29 Apr 2020.
- 8. Qiu, Gaolin*; Wu, Ying*; Yang, Zeyong; Li, Long; Zhu, Xiaona; Wang, Yiqiao; Sun, Wenzhi; Dong, Hailong; Li, Yuanhai; Hu, Ji#.Dexmedetomidine activation of dopamine neurons in the ventral tegmental area attenuates the depth of sedation in mice.ANESTHESIOLOGY. 12 May 2020. 133(2):377-392.
- 9. Xiao, Yan*; Luo, Huoqing*; Yang, Wen Z.; Zeng, Yeting; Shen, Yinbo; Ni, Xinyan; Shi, Zhaomei; Zhong, Jun; Liang, Ziqi; Fu, Xiaoyu; Tu, Hongqing; Sun, Wenzhi; Shen, Wei L.#; Hu, Ji#; Yang, Jiajun#.A Brain Signaling Framework for Stress-Induced Depression and Ketamine Treatment Elucidated by Phosphoproteomics.FRONTIERS IN CELLULAR NEUROSCIENCE. 07 Apr 2020. 14.
- 10. Li, Jie*; Lu, Chen; Gao, Zilong; Feng, Yifan; Luo, Huoqing; Lu, Tangsheng; Sun, Xia; Hu, Ji#; Luo, Yanli#.SNRIs achieve faster antidepressant effects than SSRIs by elevating the concentrations of dopamine in the forebrain.NEUROPHARMACOLOGY. 15 Oct 2020. 177.
- 11. Wang, Chi*; Liu, Hui; Li, Kun; Wu, Zhen-Zhen; Wu, Chen; Yu, Jing-Ying; Gong, Qian; Fang, Ping; Wang, Xing-Xing; Duan, Shu-Min; Wang, Hao; Gu, Yan; Hu, Ji; Pan, Bing-Xing; Schmidt, Mathias V.; Liu, Yi-Jun; Wang, Xiao-Dong#.Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis.NATURE COMMUNICATIONS. 27 Dec 2020. 11(1).
- 12. Su, Xin-Yu*; Chen, Ming*; Yuan, Yuan; Li, Ying; Guo, Su-Shan; Luo, Huo-Qing; Huang, Chen; Sun, Wenzhi; Li, Yong; Zhu, Michael X.; Liu, Ming-Gang#; Hu, Ji#; Xu, Tian-Le#.Central Processing of Itch in the Midbrain Reward Center.NEURON. 22 May 2019. 102(4):858-872.
- 13. Yuan, Yuan*; Wu, Wei*; Chen, Ming; Cai, Fang; Fan, Chengyu; Shen, Wei; Sun, Wenzhi#; Hu, Ji#.Reward Inhibits Paraventricular CRH Neurons to Relieve Stress.CURRENT BIOLOGY. Apr 2019. 29(7):1243-1251.
- 14. 周海斌*; 李江; 胡霁; 王丽华.针对中枢神经系统的核酸递送策略及其诊疗应用.HE JISHU/NUCLEAR TECHNIQUES. 2019. 42(5).
- 15. Zhao, Zheng-dong*; Chen, Zongming*; Xiang, Xinkuan; Hu, Mengna; Xie, Hengchang; Jia, Xiaoning; Cai, Fang; Cui, Yuting; Chen, Zijun; Qian, Lechen; Liu, Jiashu; Shang, Congping; Yang, Yiqing; Ni, Xinyan; Sun, Wenzhi; Hu, Ji; Cao, Peng; Li, Haohong#; Shen, Wei L.#.Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting.NATURE NEUROSCIENCE. Jun 2019. 22(6):921-932.
- 16. Zhang, Shouhua*; Lv, Fei; Yuan, Yuan; Fan, Chengyu; Li, Jiang; Sun, Wenzhi; Hu, Ji#.Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons.FRONTIERS IN NEUROSCIENCE. 04 Jun 2019. 13.
- 17. Zhou, Haibin*; Zhang, Shouhua; Lv, Fei; Sun, Wenzhi; Wang, Lihua; Fan, Chunhai; Li, Jiang#; Hu, Ji#.Citrate-assisted efficient local delivery of naked oligonucleotide into live mouse brain cells.CELL PROLIFERATION. Jul 2019. 52(4).
- 18. Yang, Yan*; Wang, Hao; Hu, Ji#; Hu, Hailan#.Lateral habenula in the pathophysiology of depression.CURRENT OPINION IN NEUROBIOLOGY. Feb 2018. 48:90-96.
- 19. Hu, Rongfeng*; Zhang, Juen; Luo, Minmin; Hu, Ji#.Response Patterns of GABAergic Neurons in the Anterior Piriform Cortex of Awake Mice.CEREBRAL CORTEX. Jun 2017. 27(6):3110-3124.
- 20. Hu, Rongfeng*; Jin, Sen; He, Xiaobin; Xu, Fuqiang; Hu, Ji#.Whole-Brain Monosynaptic Afferent Inputs to Basal Forebrain Cholinergic System.FRONTIERS IN NEUROANATOMY. 10 Oct 2016. 10.
- 21. Chen, Tao*; Koga, Kohei; Descalzi, Giannina; Qiu, Shuang; Wang, Jian; Zhang, Le-Shi; Zhang, Zhi-Jian; He, Xiao-Bin; Qin, Xin; Xu, Fu-Qiang; Hu, Ji; Wei, Feng; Huganir, Richard L.; Li, Yun-Qing#; Zhuo, Min#.Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury.MOLECULAR PAIN. 2014. 10.
- 22. Gong, Rong*; Ding, Cheng*; Hu, Ji*; Lu, Yao; Liu, Fei; Mann, Elizabeth; Xu, Fuqiang; Cohen, Mitchell B.; Luo, Minmin#.Role for the Membrane Receptor Guanylyl Cyclase-C in Attention Deficiency and Hyperactive Behavior.SCIENCE. 2011. 333(6049):1642-1646.
- 23. Wang, Hui*; Yu, Le; Qin, Yuan-Jun; Chen, Ming; Wang, Xin; Luo, Huo-Qing; Cong, Pei-Lin; Wang, Xiao-Li; Cai, Hong-Miao; Zhang, Ai-Lian; Juan-Guo; Sun, Xiao-Hui; Li, Zhao; Xue, Ming; Sun, Na; Wang, Qing-Xiu#; Hu, Ji#.Restoring VTA DA neurons excitability accelerates emergence from sevoflurane general anesthesia of anxiety state.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021. 565:21-28.
- 24. Li, Shanshan*; Luo, Huoqing; Lou, Ronghui; Tian, Cuiping; Miao, Chen; Xia, Lisha; Pan, Chen; Duan, Xiaoxiao; Dang, Ting; Li, Hui; Fan, Chengyu; Tang, Pan; Zhang, Zhuangzhuang; Liu, Yan; Li, Yunxia; Xu, Fei; Zhang, Yaoyang; Zhong, Guisheng; Hu, Ji; Shui, Wenqing.Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression.SCIENCE ADVANCES. 2021. 7(30).
- 25. Yu, Jinsong*; Xiao, Ke; Chen, Xiaohua; Deng, Lulu; Zang, Lu; Li, Yue; Gao, Anran; Gao, Junjun; Wu, Chengchao; Yang, Xinmei; Zhou, Qiudi; Yang, Jian; Bao, Chenyu; Jiao, Jiaji; Cheng, Sheng; Guo, Zhiqing; Xu, Weize; Cao, Xiaojian; Guo, Zheng; Dai, Jinxia; Hu, Ji; Fu, Zhenfan; Cao, Gang#.Neuron-derived neuropeptide Y fine-tunes the splenic immune responses.NEURON. 20 Apr 2022. 110(8).
- 26. Zeng, Wenwen#*; Yang, Fan#; Shen, Wei L.#; Zhan, Cheng#; Zheng, Peng#; Hu, Ji.Interactions between central nervous system and peripheral metabolic organs.SCIENCE CHINA-LIFE SCIENCES. 01 Jun 2022.
- 27. Lu, Chen*; Feng, Yifan*; Li, Hongxia; Gao, Zilong; Zhu, Xiaona#; Hu, Ji#.A preclinical study of deep brain stimulation in the ventral tegmental area for alleviating positive psychotic-like behaviors in mice.FRONTIERS IN HUMAN NEUROSCIENCE. 10 Aug 2022. 16.
- 28. Qi, Meiru*; Li, Chenglin; Li, Jie; Zhu, Xiao na; Lu, Chen; Luo, Huoqing; Feng, Yifan; Cai, Fang; Sun, Xia; Li, Shi Ting; Hu, Ji; Luo, Yanli.Fluoxetine reverses hyperactivity of anterior cingulate cortex and attenuates chronic stress-induced hyperalgesia.NEUROPHARMACOLOGY. 01 Dec 2022. 220.
- 29. Gao, L.*; Hu, J.; Zhong, C.; Luo, M.#.INTEGRATION OF CO2 AND ODORANT SIGNALS IN THE MOUSE OLFACTORY BULB.NEUROSCIENCE. 2010. 170(3):881-892.
- 30. Luo, Minmin#*; Sun, Liming#; Hu, Ji#.Neural detection of gases - carbon dioxide, oxygen - in vertebrates and invertebrates.CURRENT OPINION IN NEUROBIOLOGY. 2009. 19(4):354-361.
- 31. Sun, Liming*; Wang, Huayi; Hu, Ji; Han, Jinlong; Matsunamic, Hiroaki; Luo, Minmin#.Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009. 106(6):2041-2046.
- 32. Hu, Ji*; Zhong, Chun*; Ding, Cheng; Chi, Qiuyi; Walz, Andreas; Mombaerts, Peter; Matsunami, Hiroaki; Luo, Minmin#.Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.SCIENCE. 2007. 317(5840):953-957.
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