Principal investigator
Name:
Ji HuProfessor , PhD, Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 1999/09-2003/06, Huazhong University of Science and Technology, B.S.
- 2003/09-2005/12, Institute of Neuroscience, Chinese Academy of Sciences, M.S.
- 2005/12-2008/06, National Institute of Biological Sciences (NIBS)/Institute of Biophysics, CAS, Ph.D.
Working Experience:
- 2008/06-2009/05, National Institute of Biological Sciences (NIBS)/Institute of Biophysics, CAS, Postdoctoral Fellow
- 2009/05-2013/02, Picower Institute, MIT., Postdoctoral Fellow
- 2013/02-2014/04, Xi’an Jiaotong University, Professor
- 2014/04-2020/01, ShanghaiTech University, School of Life Science and Technology, Assistant Professor (TENURE-TRACK)
- 2020/01-Present, ShanghaiTech University, School of Life Science and Technology, Associate Professor (TENURED)
Group Introduction
Research Area:
Circuit Mechanism of Emotion
Research Interests:
We develop and apply cutting-edge methods, by combining optical imaging, neuromodulation, genetic labeling and circuit tracings to functional dissect the neural mechanisms of emotion and associated psychiatric diseases. The laboratory has state-of-the-art optical imaging instruments (two-photon microscope, gradient refraction lens, fiber photometric measurement). We are using these new methods to attack several related neurobiological questions: 1. Stress neurobiology; 2. Circuit mechanisms of neuropsychopharmacology; 3. New strategies for the treatment of psychiatric disorders. Our research will contribute to the treatment of important mental illnesses such as depression and anxiety.
Representative Publications (*First Author, # Corresponding Author)
- 1. Feng, Yi-Fan*; Zeng, Zi-Ke; Ni, You; Hu, Yue; Yang, Ke-Xin; Cai, Fang; Zhou, Qin-Ming; Chen, Ming; Zhu, Xiao-Na; Chen, Sheng; Hu, Ji.Parvalbumin neurons mediate neurological phenotypes of anti-NMDAR encephalitis.BRAIN. May 2025. 148(5):1652-1664.
- 2. Peng, Yanmin*; Feng, Chenzhang; Peng, Shiyu; Wang, Ying; Zhang, Qian; Jiao, Zhuolei; Cao, Huateng; Huang, Shajin; Tian, Peihuang; Sun, Xiujia; Xu, Xiaohong; Fu, Yu; Hu, Ji; Zhang, Zhe.GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice.NATURE METABOLISM. Apr 2025. 7(4):730-741.
- 3. Zhou, Haibin*; Dai, Jiajing; Li, Dong; Wang, Luyao; Ye, Meng; Hu, Xiaoling; Loturco, Joseph; Hu, Ji; Sun, Wenzhi.Efficient gene delivery admitted by small metabolites specifically targeting astrocytes in the mouse brain.MOLECULAR THERAPY. 05 Mar 2025. 33(3):1166-1179.
- 4. Hu, Yue*; Feng, Yifan; Luo, Huoqing; Zhu, Xiao-Na; Chen, Siyu; Yang, Kexin; Deng, Ziqing; Luo, Mengqiang; Du, Wenjie; Wang, Qi; Wang, Shubai; Wei, Kai; Hu, Ji; Wang, Yingwei.Dissociation-related behaviors in mice emerge from the inhibition of retrosplenial cortex parvalbumin interneurons.CELL REPORTS. 28 Jan 2025. 44(1).
- 5. Wan, Hanxi*; He, Mengfan*; Cheng, Chun*; Yang, Kexin*; Wu, Huanghui; Cong, Peilin; Huang, Xinwei; Zhang, Qian; Shi, Yufei; Hu, Ji; Tian, Li; Xiong, Lize.Clec7a Worsens Long-Term Outcomes after Ischemic Stroke by Aggravating Microglia-Mediated Synapse Elimination.ADVANCED SCIENCE. Sep 2024. 11(36).
- 6. Sun, Meiyan*; Mao, Sui; Wu, Chao; Zhao, Xiaoyong; Guo, Chengxiao; Hu, Jun; Xu, Shijin; Zheng, Fen; Zhu, Guoqing; Tao, Hui; He, Shufang; Hu, Ji; Zhang, Ye.Piezo1-Mediated Neurogenic Inflammatory Cascade Exacerbates Ventricular Remodeling After Myocardial Infarction.CIRCULATION. 07 May 2024. 149(19):1516-1533.
- 7. Yu, Le*; Zhu, Xiaona; Peng, Kang; Qin, Huimin; Yang, Kexin; Cai, Fang; Hu, Ji; Zhang, Ye.Propofol Alleviates Anxiety-Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVNCRH Neurons via GABAA Receptor β3 Subunits.ADVANCED SCIENCE. Jul 2024. 11(28).
- 8. Zhan, Shulu*; Qi, Zhenhua; Cai, Fang; Gao, Zilong; Xie, Jingdun; Hu, Ji.Oxytocin neurons mediate stress-induced social memory impairment.CURRENT BIOLOGY. 08 Jan 2024. 34(1):36-45.e4.
- 9. Pan, Qian*; Guo, Su -Shan; Chen, Ming; Su, Xin-Yu; Gao, Zi-Long; Xu, Tian -Le; Liu, Ming -Gang; Hu, Ji.Representation and control of pain and itch by distinct prefrontal neural ensembles.NEURON. 2023. 111(15):2414-2431.e7.
- 10. Zhu, Xiao-Na*; Li, Jie; Qiu, Gao-Lin; Wang, Lin; Lu, Chen; Guo, Yi-Ge; Yang, Ke-Xin; Cai, Fang; Xu, Tao; Yuan, Ti-Fei; Hu, Ji.Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter.NEURON. 17 Mar 2023. 111(10):1626-1636.e6.
- 11. Cao, Silu*; Wu, Yiling; Gao, Zilong; Tang, Jinxuan; Xiong, Lize; Hu, Ji; Li, Cheng.Automated phenotyping of postoperative delirium-like behaviour in mice reveals the therapeutic efficacy of dexmedetomidine.COMMUNICATIONS BIOLOGY. 02 Aug 2023. 6(1).
- 12. Zhang, Yi-Zong*; Ni, You; Gao, Yi-Ning; Shen, Ding-Ding; He, Lu; Yin, Dou; Meng, Huan-Yu; Zhou, Qin-Ming; Hu, Ji; Chen, Sheng.Anti-IgLON5 disease: a novel topic beyond neuroimmunology.NEURAL REGENERATION RESEARCH. 01 May 2023. 18(5):1017-1022.
- 13. Lu, Chen*; Zhu, Xiaona; Feng, Yifan; Ao, Weizhen; Li, Jie; Gao, Zilong; Luo, Huoqing; Chen, Ming; Cai, Fang; Zhan, Shulu; Li, Hongxia; Sun, Wenzhi; Hu, Ji.Atypical antipsychotics antagonize GABA(A) receptors in the ventral tegmental area GABA neurons to relieve psychotic behaviors.MOLECULAR PSYCHIATRY. 01 Feb 2023. 28(5):2107-2121.
- 14. Sun, Jing*; Zheng, Yufei; Hu, Ji.Targeting Microglia with Adeno-associated Viruses.NEUROSCIENCE BULLETIN. Nov 2022. 39(5):863-865.
- 15. Ni, You*; Feng, Yifan; Shen, Dingding; Chen, Ming; Zhu, Xiaona; Zhou, Qinming; Gao, Yining; Liu, Jun; Zhang, Qi; Shen, Yuntian; Peng, Lisheng; Zeng, Zike; Yin, Dou; Hu, Ji; Chen, Sheng.Anti-IgLON5 antibodies cause progressive behavioral and neuropathological changes in mice.JOURNAL OF NEUROINFLAMMATION. 11 Jun 2022. 19(1).
- 16. Gao, Zilong*; Wang, Hanqing; Lu, Chen; Lu, Tiezhan; Froudist-Walsh, Sean; Chen, Ming; Wang, Xiao-Jing; Hu, Ji; Sun, Wenzhi.The neural basis of delayed gratification.SCIENCE ADVANCES. Dec 2021. 7(49):1-14.
- 17. Li, Shanshan*; Luo, Huoqing; Lou, Ronghui; Tian, Cuiping; Miao, Chen; Xia, Lisha; Pan, Chen; Duan, Xiaoxiao; Dang, Ting; Li, Hui; Fan, Chengyu; Tang, Pan; Zhang, Zhuangzhuang; Liu, Yan; Li, Yunxia; Xu, Fei; Zhang, Yaoyang; Zhong, Guisheng#; Hu, Ji#; Shui, Wenqing#.Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression.SCIENCE ADVANCES. 2021. 7(30):eabf0634.
- 18. Zeng, Yeting*; Luo, Huoqing*; Gao, Zilong; Zhu, Xiaona; Shen, Yinbo; Li, Yulong; Hu, Ji; Yang, Jiajun.Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine.ISCIENCE. 19 Mar 2021. 24(3).
- 19. Guo, Juan*; Ran, Mingzi*; Gao, Zilong; Zhang, Xinxin; Wang, Dan; Li, Huiming; Zhao, Shiyi; Sun, Wenzhi; Dong, Hailong; Hu, Ji.Cell-type-specific imaging of neurotransmission reveals a disrupted excitatory-inhibitory cortical network in isoflurane anaesthesia.EBIOMEDICINE. Mar 2021. 65.
- 20. Li, Jie*; Lu, Chen; Gao, Zilong; Feng, Yifan; Luo, Huoqing; Lu, Tangsheng; Sun, Xia; Hu, Ji; Luo, Yanli.SNRIs achieve faster antidepressant effects than SSRIs by elevating the concentrations of dopamine in the forebrain.NEUROPHARMACOLOGY. 15 Oct 2020. 177.
- 21. Zhang, Xu*; Lei, Bo*; Yuan, Yuan*; Zhang, Li*; Hu, Lu; Jin, Sen; Kang, Bilin; Liao, Xuebin; Sun, Wenzhi; Xu, Fuqiang; Zhong, Yi; Hu, Ji; Qi, Hai.Brain control of humoral immune responses amenable to behavioural modulation.NATURE. 14 May 2020. 581(7807):204-208.
- 22. Qiu, Gaolin*; Wu, Ying*; Yang, Zeyong; Li, Long; Zhu, Xiaona; Wang, Yiqiao; Sun, Wenzhi; Dong, Hailong; Li, Yuanhai; Hu, Ji.Dexmedetomidine activation of dopamine neurons in the ventral tegmental area attenuates the depth of sedation in mice.ANESTHESIOLOGY. 12 May 2020. 133(2):377-392.
- 23. Wang, Fang*; Zhang, Juen; Yuan, Yuan; Chen, Ming; Gao, Zilong; Zhan, Shulu; Fan, Chengyu; Sun, Wenzhi; Hu, Ji.Salience processing by glutamatergic neurons in the ventral pallidum.SCIENCE BULLETIN. 15 Mar 2020. 65(5):389-401.
- 24. Su, Xin-Yu*; Chen, Ming*; Yuan, Yuan; Li, Ying; Guo, Su-Shan; Luo, Huo-Qing; Huang, Chen; Sun, Wenzhi; Li, Yong; Zhu, Michael X.; Liu, Ming-Gang; Hu, Ji; Xu, Tian-Le.Central Processing of Itch in the Midbrain Reward Center.NEURON. 22 May 2019. 102(4):858-872.
- 25. Yuan, Yuan*; Wu, Wei*; Chen, Ming; Cai, Fang; Fan, Chengyu; Shen, Wei; Sun, Wenzhi; Hu, Ji.Reward Inhibits Paraventricular CRH Neurons to Relieve Stress.CURRENT BIOLOGY. Apr 2019. 29(7):1243-1251.
- 26. Yang, Yan*; Wang, Hao; Hu, Ji; Hu, Hailan.Lateral habenula in the pathophysiology of depression.CURRENT OPINION IN NEUROBIOLOGY. Feb 2018. 48:90-96.
- 27. Hu, Rongfeng*; Zhang, Juen; Luo, Minmin; Hu, Ji.Response Patterns of GABAergic Neurons in the Anterior Piriform Cortex of Awake Mice.CEREBRAL CORTEX. Jun 2017. 27(6):3110-3124.
- 28. Gong, Rong*; Ding, Cheng*; Hu, Ji*; Lu, Yao; Liu, Fei; Mann, Elizabeth; Xu, Fuqiang; Cohen, Mitchell B.; Luo, Minmin.Role for the Membrane Receptor Guanylyl Cyclase-C in Attention Deficiency and Hyperactive Behavior.SCIENCE. 2011. 333(6049):1642-1646.
- 29. Gao, L.*; Hu, J.; Zhong, C.; Luo, M..INTEGRATION OF CO2 AND ODORANT SIGNALS IN THE MOUSE OLFACTORY BULB.NEUROSCIENCE. 2010. 170(3):881-892.
- 30. Sun, Liming*; Wang, Huayi; Hu, Ji; Han, Jinlong; Matsunamic, Hiroaki; Luo, Minmin.Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009. 106(6):2041-2046.
- 31. Luo, Minmin*; Sun, Liming; Hu, Ji.Neural detection of gases - carbon dioxide, oxygen - in vertebrates and invertebrates.CURRENT OPINION IN NEUROBIOLOGY. 2009. 19(4):354-361.
- 32. Duan, Wen-Ying*; Peng, Kang; Qin, Hui-Min; Li, Bai-Ming; Xu, Yun-Xin; Wang, Dan-Jun; Yu, Le; Wang, Hui; Hu, Ji; Wang, Qing-Xiu.Esketamine accelerates emergence from isoflurane general anaesthesia by activating the paraventricular thalamus glutamatergic neurones in mice.BRITISH JOURNAL OF ANAESTHESIA. Feb 2024. 132(2):334-342.
- 33. Hu, Ji*; Zhong, Chun*; Ding, Cheng; Chi, Qiuyi; Walz, Andreas; Mombaerts, Peter; Matsunami, Hiroaki; Luo, Minmin.Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.SCIENCE. 2007. 317(5840):953-957.
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