Principal investigator
Name:
Tiffany HorngProfessor , PhD, Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 1995-1999, UC Berkeley, B.A.
- 1999-2003, Yale University, Immunology
Working Experience:
- 2003-2007, Lab of Dr. Ruslan Medzhitov, Yale University, Postdoctoral Fellow
- 2007-2008, Lab of Dr. Anjana Rao, Immune Disease Institute, Harvard Medical School, Postdoctoral Fellow
- 2008-2014, Harvard T.H. Chan School of Public Health, Assistant Professor
- 2015-2018, Harvard T.H. Chan School of Public Health, Associate Professor
- 2018-2021/11, School of Life Science and Technology, ShanghaiTech University, Associate Professor（TENURE TRACK）
- 2021/11-Now, School of Life Science and Technology, ShanghaiTech University, Professor (TENURED）
Group Introduction
Research Area:
Macrophage Metabolism, Function, and Biology
Research Interests:
Macrophages are dynamic cells of the innate immune system. Our lab is focused on how cellular metabolism influences the functions of macrophages, especially their regulation of inflammatory responses. Provide forward-looking ideas and possible diagnosis and treatment methods for infectious diseases and other diseases.
Research Achievement
Our lab has recently shown that macrophage metabolism, and in particular a pathway centered on a mitochondrial metabolism-histone modification axis, regulates inflammatory responses. While most studies have focused on metabolic support for induction of inflammatory responses, we have revealed how this pathway can modulate both inflammatory response induction and suppression, which we believe may be relevant to many settings of dysregulated inflammation including overwhelming infection, antitumor immunity, aging, and autoimmunity. In ongoing studies, we combine metabolic, genetic, and biochemical tools and analyses and cell biological and mouse models to further elucidate the rationale and etiology of metabolic regulation of inflammatory responses, especially inflammatory response suppression.
Representative Publications (*First Author, # Corresponding Author)
- 1. Medzhitov, Ruslan##*; Horng, Tiffany##; .Transcriptional control of the inflammatory response.NATURE REVIEWS IMMUNOLOGY. 2009. 9(10):692-703.
- 2. Hargreaves, Diana C.*; Horng, Tiffany##; Medzhitov, Ruslan##; .Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation.CELL. 2009. 138(1):129-145.
- 3. Murakami, Tomohiko*; Ockinger, Johan; Yu, Jiujiu; Byles, Vanessa; McColl, Aisleen; Hofer, Aldebaran M.; Horng, Tiffany##; .Critical role for calcium mobilization in activation of the NLRP3 inflammasome.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012. 109(28):11282-11287.
- 4. Byles, Vanessa**; Covarrubias, Anthony J.**; Ben-Sahra, Issam; Lamming, Dudley W.; Sabatini, David M.; Manning, Brendan D.; Horng, Tiffany##; .The TSC-mTOR pathway regulates macrophage polarization.NATURE COMMUNICATIONS. 2013. 4.
- 5. Horng, Tiffany#*; .Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome.TRENDS IN IMMUNOLOGY. 2014. 35(6):253-261.
- 6. Yu, Jiujiu**; Nagasu, Hajime**; Murakami, Tomohiko; Hoang, Hai; Broderick, Lori; Hoffman, Hal M.; Horng, Tiffany##; .Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. 111(43):15514-15519.
- 7. Covarrubias, Anthony J.*; Aksoylar, H. Ibrahim; Horng, Tiffany##; .Control of macrophage metabolism and activation by mTOR and Akt signaling.SEMINARS IN IMMUNOLOGY. 2015. 27(4):286-296.
- 8. Covarrubias, Anthony J.*; Aksoylar, Halil Ibrahim; Yu, Jiujiu; Snyder, Nathaniel W.; Worth, Andrew J.; Iyer, Shankar S.; Wang, Jiawei; Ben-Sahra, Issam; Byles, Vanessa; Polynne-Stapornkul, Tiffany; Espinosa, Erika C.; Lamming, Dudley; Manning, Brendan D.; Zhang, Yijing; Blair, Ian A.; Horng, Tiffany##; .Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation.ELIFE. 2016. 5.
- 9. Langston, P. Kent*; Shibata, Munehiko; Horng, Tiffany##; .Metabolism Supports Macrophage Activation.FRONTIERS IN IMMUNOLOGY. 2017. 8.
- 10. Jung, Jonathan*; Zeng, Hu#; Horng, Tiffany##; .Metabolism as a guiding force for immunity.NATURE CELL BIOLOGY. Jan 2019. 21(1):85-93.
- 11. Yan, Jiawei*; Wang, Ruoning#; Horng, Tiffany##; .mTOR Is Key to T Cell Transdifferentiation.CELL METABOLISM. 05 Feb 2019. 29(2):241-242.
- 12. Langston, P. Kent*; Nambu, Aya; Jung, Jonathan; Shibata, Munehiko; Aksoylar, H. Ibrahim; Lei, Jiahui; Xu, Peining; Doan, Mary T.; Jiang, Helen; MacArthur, Michael R.; Gao, Xia; Kong, Yong; Chouchani, Edward T.; Locasale, Jason W.; Synder, Nathaniel W.; Horng, Tiffany##; .Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.NATURE IMMUNOLOGY. Sep 2019. 20(9):1186-+.
- 13. Yan, Jiawei*; Horng, Tiffany##; .Lipid Metabolism in Regulation of Macrophage Functions.TRENDS IN CELL BIOLOGY. Dec 2020. 30(12):979-989.
- 14. Luan, Haoming*; Horng, Tiffany#; .Dynamic changes in macrophage metabolism modulate induction and suppression of Type I inflammatory responses.CURRENT OPINION IN IMMUNOLOGY. Dec 2021. 73.
- 15. Olzmann, James A.#*; Fendt, Sarah-Maria; Shah, Yatrik; Vousden, Karen; Chandel, Navdeep; Horng, Tiffany; Danial, Nika; Tu, Benjamin; Christofk, Heather; Vander Heiden, Matthew G.; Wellen, Kathryn; .More Metabolism!.MOLECULAR CELL. 2021. 81(18):3659-3664.
- 16. Sun Yulong*; Jiang Wenjiao*; Horng T#.Circadian metabolism regulates the macrophage inflammatory response.Life Metabolism. 2022.
- 17. Jiawei Yan*, Xin Zhang*, Huiying Wang*, Xinglong Jia, Ruohong Wang, Shuangyang Wu, Zheng-Jiang Zhu, Minjia Tan, Tiffany Horng#.Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation.Cell Reports. 22 October 2024.
Awards
- 1. 2017-2018, Associate Editor, The Journal of Immunology
- 2. 2018-2020, Section Editor, The Journal of Immunology
- 3. 2019, Organizer of Keystone Symposium: Myeloid Cells
- 4. 2019-Now, Reviewing Editor, eLife
- 5. 2020-Now, Advisory Board, Cell Metabolism
- 6. 2020-Now, Associate Editor, Life Metabolism
Group Member and Photo
-
Name：Yan Jiawei
Position：Postdoct
Duration：2019/03-Now
Email：yanjw1@@shanghaitech.edu.cn
-
Name：Jiang Wenjiao
Position：Postdoct
Duration：2020/10-Now
Email：jiangwj1@@shanghaitech.edu.cn
-
Name：Li Na
Position：Doctoral Student
Duration：2018/09-Now
Email：lina2@@shanghaitech.edu.cn
-
Name：Zhang Xin
Position：Doctoral Student
Duration：2018/09-Now
Email：zhangxin1@@shanghaitech.edu.cn
-
Name：Luan Haoming
Position：Doctoral Student
Duration：2020/01-Now
Email：luanhm@shanghaitech.edu.cn
-
Name：Sun Yulong
Position：Doctoral Student
Duration：2020/01-Now
Email：sunyl2@@shanghaitech.edu.cn
-
Name：Zhou Dongzhe
Position：Doctoral Student
Duration：2020/01-Now
Email：zhoudzh@@shanghaitech.edu.cn
-
Name：Li Jiakun
Position：Visiting Student
Duration：2020/10-Now
Email：kenleeljk@@163.com
-
Name：Wang Huiying
Position：Postgraduate Student
Duration：2021/01-Now
Email：wanghy8@@shanghaitech.edu.cn
-
Name：Li Junying
Position：Postgraduate Student
Duration：2022/01-Now
Email：lijy4@@shanghaitech.edu.cn
-
Name：Tong Zhizi
Position：Postgraduate Student
Duration：2022/01-Now
Email：tongzhz@@shanghaitech.edu.cn
-
Name：Wu Boyu
Position：Postgraduate Student
Duration：2023/02-Now
Email：wuby2022@@shanghaitech.edu.cn
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