Cell signaling transduction
Principal investigator
Name:
Tian HuaAssistant Professor , PhD, Assistant Professor
Position:
Affiliation:
School of life science and technology, iHuman Institute
Honor:
Education Background:
- 2007/09-2011/07, University of Science and Technology Beijing, B.S.
- 2011/09-2017/07, Institute of Biophysics, Chinese Academy of Science, Ph.D.
Working Experience:
- 2017/07-2020/03, iHuman institute, ShanghaiTech University, Research associate professor
- 2020/03-Now, iHuman institute, ShanghaiTech University, PI
- 2020/07--Now, School of Life Science and Technology, ShanghaiTech University, Assistant Professor (TENURE-TRACK)
Group Introduction
Research Area:
Structural and Functional Study of Membrane Protein
Research Interests:
The research in our group will focus on the molecular dissection and mechanistic understanding of taste receptors, and also the investigation into the neurological related orphan GPCRs from pharmacology perspective.
Research Achievement
1. Structural and functional studies of proteins and multi-protein complexes in innate immune and metabolism signaling pathway. 2. Structural and functional studies of class A G protein-coupled receptors (GPCRs) using X-ray crystallography. 3. Structural and functional studies of GPCR-downstream signaling complexes using cryo-EM technology.
Representative Publications (*First Author, # Corresponding Author)
- 1. Xiaolong Hu*; Weizhen Ao*; Mingxin Gao*; Lijie Wu*; Yuan Pei; Shenhui Liu; Yiran Wu; Fei Zhao; Qianqian Sun; Junlin Liu; Longquan Jiang; Xin Wang; Yan Li; Qiwen Tan; Jie Cheng; Fan Yang; Chi Yang#; Jinpeng Sun#; Tian Hua#; Zhi-Jie Liu#.Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.Nature. 2024.
- 2. Yuxia Wang*; Lijie Wu*; Tian Wang*; Junlin Liu; Fei Li; Longquan Jiang; Zhongbo Fan; Yanan Yu; Na Chen; Qianqian Sun; Qiwen Tan; Tian Hua#; Zhi-Jie Liu#.Cryo-EM structure of cannabinoid receptor CB1-β- arrestin complex.PROTEIN & CELL. March 2024. 15(3): 230–234.
- 3. Li, Xiaoting*; Chang, Hao*; Bouma, Jara*; de Paus, Laura V.; Mukhopadhyay, Partha; Paloczi, Janos; Mustafa, Mohammed; van der Horst, Cas; Kumar, Sanjay Sunil; Wu, Lijie; Yu, Yanan; van den Berg, Richard J. B. H. N.; Janssen, Antonius P. A.; Lichtman, Aron; Liu, Zhi-Jie#; Pacher, Pal#; van der Stelt, Mario#; Heitman, Laura H.#; Hua, Tian#; .Structural basis of selective cannabinoid CB2 receptor activation.NATURE COMMUNICATIONS. 15 Mar 2023. 14(1).
- 4. Li, Hao*; Zhang, Jinyi; Yu, Yanan; Luo, Feng; Wu, Lijie; Liu, Junlin; Chen, Na; Liu, Zhijie#; Hua, Tian; .Structural insight into the constitutive activity of human orphan receptor GPR12.SCIENCE BULLETIN. 15 Jan 2023. 68(1):95-104.
- 5. Zhou, Yali*; Daver, Henrik; Trapkov, Boris; Wu, Lijie; Wu, Meng; Harpsoe, Kasper; Gentry, Patrick R.; Liu, Kaiwen; Larionova, Marina; Liu, Junlin; Chen, Na; Brauner-Osborne, Hans#; Gloriam, David E.#; Hua, Tian#; Liu, Zhi-Jie#; .Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139.CELL RESEARCH. Feb 2022.
- 6. Xu, Weixiu*; Wu, Lijie; Liu, Shenhui; Liu, Xiao; Cao, Xiaoling; Zhou, Cui; Zhang, Jinyi; Fu, You; Guo, Yu; Wu, Yiran; Tan, Qiwen; Wang, Ling; Liu, Junlin; Jiang, Longquan; Fan, Zhongbo; Pei, Yuan; Yu, Jingyi; Cheng, Jianjun; Zhao, Suwen; Hao, Xiaojiang; Liu, Zhi-Jie#; Hua, Tian#; .Structural basis for strychnine activation of human bitter taste receptor TAS2R46.SCIENCE. 16 Sep 2022. 377(6612).
- 7. Wang, Jingjing*; Wu, Meng; Chen, Zhangcheng; Wu, Lijie; Wang, Tian; Cao, Dongmei; Wang, Huan; Liu, Shenhui; Xu, Yueming; Li, Fei; Liu, Junlin; Chen, Na; Zhao, Suwen; Cheng, Jianjun#; Wang, Sheng#; Hua, Tian#; .The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.NATURE COMMUNICATIONS. 23 May 2022. 13(1).
- 8. Liu, Kaiwen*; Shen, Ling*; Wu, Meng; Liu, Zhi-Jie#; Hua, Tian#; .Structural insights into the activation of chemokine receptor CXCR2.FEBS JOURNAL. Jan 2022.
- 9. Wang, Xiaoyan*; Liu, Dongsheng; Shen, Ling; Li, Fahui; Li, Yongze; Yang, Lingyun; Xu, Tiandan; Tao, Houchao; Yao, Deqiang; Wu, Lijie; Hirata, Kunio; Bohn, Laura M.; Makriyannis, Alexandros; Liu, Xiaohong; Hua, Tian#; Liu, Zhi-Jie#; Wang, Jiangyun#; .A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2021. 143(40):16320-16325.
- 10. Zhang, Jinyi*; Qu, Lu; Wu, Lijie; Tang, Xiaomeng; Luo, Feng; Xu, Weixiu; Xu, Yueming; Liu, Zhi-Jie#; Hua, Tian#; .Structural insights into the activation initiation of full-length mGlu1.PROTEIN & CELL. Aug 2021.
- 11. Hua, Tian#*; Li, Xiaoting; Wu, Lijie; Iliopoulos-Tsoutsouvas, Christos; Wang, Yuxia; Wu, Meng; Shen, Ling; Johnston, Christina A.; Nikas, Spyros P.; Song, Feng; Song, Xiyong; Yuan, Shuguang; Sun, Qianqian; Wu, Yiran; Jiang, Shan; Grim, Travis W.; Benchama, Othman; Stahl, Edward L.; Zvonok, Nikolai; Zhao, Suwen; Bohn, Laura M.; Makriyannis, Alexandros; Liu, Zhi-Jie#; .Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G(i) Complex Structures.CELL. 20 Feb 2020. 180(4):655-+.
- 12. Wang, Jingjing*; Wu, Meng; Wu, Lijie; Xu, Yueming; Li, Fei; Wu, Yiran; Popov, Petr; Wang, Lin; Bai, Fang; Zhao, Suwen; Liu, Zhi-Jie; Hua, Tian#; .The structural study of mutation-induced inactivation of human muscarinic receptor M4.IUCRJ. Mar 2020. 7:294-305.
- 13. Li, Xiaoting*; Shen, Ling; Hua, Tian#; Liu, Zhi-Jie#; .Structural and Functional Insights into Cannabinoid Receptors.TRENDS IN PHARMACOLOGICAL SCIENCES. Sep 2020. 41(9):665-677.
- 14. Liu, Kaiwen*; Wu, Lijie; Yuan, Shuguang; Wu, Meng; Xu, Yueming; Sun, Qianqian; Li, Shu; Zhao, Suwen; Hua, Tian#; Liu, Zhi-Jie#; .Structural basis of CXC chemokine receptor 2 activation and signalling.NATURE. 03 Sep 2020.
- 15. Wang, Jingjing*; Hua, Tian#; Liu, Zhi-Jie#; .Structural features of activated GPCR signaling complexes.CURRENT OPINION IN STRUCTURAL BIOLOGY. Aug 2020. 63:82-89.
- 16. Li, Xiaoting*; Hua, Tian; Vemuri, Kiran; Ho, Jo-Hao; Wu, Yiran; Wu, Lijie; Popov, Petr; Benchama, Othman; Zvonok, Nikolai; Locke, K'ara; Qu, Lu; Han, Gye Won; Iyer, Malliga R.; Cinar, Resat; Coffey, Nathan J.; Wang, Jingjing; Wu, Meng; Katritch, Vsevolod; Zhao, Suwen; Kunos, George; Bohn, Laura M.; Makriyannis, Alexandros; Stevens, Raymond C.; Liu, Zhi-Jie#; .Crystal Structure of the Human Cannabinoid Receptor CB2.CELL. 24 Jan 2019. 176(3):459-+.
- 17. Wang, J.*; Hua, T.; Liu, Z-J; .Activation and allosteric modulation of muscarinic acetylcholine M4 receptor.JOURNAL OF BIOENERGETICS AND BIOMEMBRANES. Dec 2018. 50(6):510-510.
- 18. Hua, Tian*; Vemuri, Kiran; Nikas, Spyros P.; Laprairie, Robert B.; Wu, Yiran; Qu, Lu; Pu, Mengchen; Korde, Anisha; Jiang, Shan; Ho, Jo-Hao; Han, Gye Won; Ding, Kang; Li, Xuanxuan; Liu, Haiguang; Hanson, Michael A.; Zhao, Suwen#; Bohn, Laura M.#; Makriyannis, Alexandros#; Stevens, Raymond C.; Liu, Zhi-Jie#; .Crystal structures of agonist-bound human cannabinoid receptor CB1.NATURE. 27 Jul 2017. 547(7664):468-+.
- 19. Hua, Tian*; Vemuri, Kiran; Pu, Mengchen; Qu, Lu; Han, Gye Won; Wu, Yiran; Zhao, Suwen; Shui, Wenqing; Li, Shanshan; Korde, Anisha; Laprairie, Robert B.; Stahl, Edward L.; Ho, Jo-Hao; Zvonok, Nikolai; Zhou, Han; Kufareva, Irina; Wu, Beili; Zhao, Qiang; Hanson, Michael A.; Bohn, Laura M.; Makriyannis, Alexandros; Stevens, Raymond C.; Liu, Zhi-Jie#; .Crystal Structure of the Human Cannabinoid Receptor CB1.CELL. 2016. 167(3):750-762.
Awards
- 1. 2019, “30 under 30 China 2019” by Forbes
- 2. 2018, The outstanding PhD thesis award of CAS
- 3. 2017, “President special award” of CAS
Group Member and Photo
-
Name：Kaiwen Liu
Position：Postdoct
Duration：2020/08-至今
Email：liukw@shanghaitech.edu.cn
-
Name：Wu Meng
Position：Postdoct
Duration：2020/08-至今
Email：wumeng@shanghaitech.edu.cn
-
Name：Jingjing Wang
Position：Visiting Student
Duration：2020/07-至今
Email：wangjj@shanghaitech.edu.cn
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