课题组长
姓名：
李佳中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院上海药物研究所
荣誉称号：
课题组简介
研究内容：
针对能量代谢调控的关键分子及相关信号网络进行活性调控机制研究；围绕糖尿病、神经退行性疾病、肿瘤等重大疾病，系统化克隆、表达、纯化和基因转染相关分子靶点，建立分子家族筛选平台和疾病靶向组合筛选模型平台；通过高通量筛选发现先导化合物；研究先导化合物和靶标相互作用模式；研究活性化合物作用机制、发现新靶点。
代表性论文（*第一作者，#通讯作者）
- 1. Zhang, Li-Na*; Zhou, Hua-Yong; Fu, Yan-Yun; Li, Yuan-Yuan; Wu, Fang; Gu, Min; Wu, Ling-Yan; Xia, Chun-Mei; Dong, Tian-Cheng; Li, Jing-Ya#; Shen, Jing-Kang#; Li, Jia#.Novel Small-Molecule PGC-1 alpha Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice.DIABETES. 2013. 62(4):1297-137.
- 2. Qiu, Bei-Ying*; Turner, Nigel; Li, Yuan-Yuan; Gu, Min; Huang, Meng-Wei; Wu, Fang; Pang, Tao; Nan, Fa-Jun; Ye, Ji-Ming; Li, Jing-Ya#; Li, Jia#.High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice.DIABETES. 2010. 59(1):256-265.
- 3. Zang, Yi*; Yu, Li-Fang; Nan, Fa-Jun; Feng, Lin-Yin; Li, Jia#.AMP-activated Protein Kinase Is Involved in Neural Stem Cell Growth Suppression and Cell Cycle Arrest by 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and Glucose Deprivation by Down-regulating Phospho-retinoblastoma Protein and Cyclin D.JOURNAL OF BIOLOGICAL CHEMISTRY. 2009. 284(10):6175-6184.
- 4. Pang, Tao*; Zhang, Zhen-Shan; Gu, Min; Qiu, Bei-Ying; Yu, Li-Fang; Cao, Peng-Rong; Shao, Wei; Su, Ming-Bo; Li, Jing-Ya; Nan, Fa-Jun#; Li, Jia#.Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.JOURNAL OF BIOLOGICAL CHEMISTRY. 2008. 283(23):1651-166.
- 5. Turner, Nigel*; Li, Jing-Ya; Gosby, Alison; To, Sabrina W. C.; Cheng, Zhe; Miyoshi, Hiroyuki; Taketo, Makoto M.; Cooney, Gregory J.; Kraegen, Edward W.; James, David E.; Hu, Li-Hong; Li, Jia#; Ye, Ji-Ming#.Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-Activated protein kinase and improve insulin action.DIABETES. 2008. 57(5):1414-1418.
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