Principal investigator
Name:
Jun LiAssistant Professor , PhD, Assistant Professor
Position:
Affiliation:
School of Life Science and Technology, Shanghai Institute for Advanced Immunochemical Studies
Honor:
Education Background:
- 2004/09-2008/07, Zhejiang University, B.S.
- 2008/09-2013/07, Institute of Biophysics, Chinese Academy of Sciences, Ph.D.
Working Experience:
- 2013/08-2016/07, Institute of Biophysics, Chinese Academy of Sciences, Research Assistant Professor
- 2016/07-2018/07, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Research Assistant Professor
- 2018/08-2021/01, ShanghaiTech University, Research Associate Professor
- 2021/02-Now, ShanghaiTech University, Assistant Professor (TENURE-TRACK)
Group Introduction
Research Area:
Structural biology of pathogens, membrane protein studies, drug design
Representative Publications (*First Author, # Corresponding Author)
- 1. Liang, Lihong*; Liu, Zhiyong; Chen, Jie; Zha, Qin; Zhou, Yihuan; Li, Jun; Hu, Yangbo; Chen, Xinwen; Zhang, Tianyu#; Zhang, Niuniu#; .Design and synthesis of Thieno[3, 2-b]pyridinone derivatives exhibiting potent activities against Mycobacterium tuberculosis in vivo by targeting Enoyl-ACP reductase.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 05 Dec 2024. 279.
- 2. Zhu, Chen*; Shi, Yanfeng; Yu, Jing; Zhao, Wenhao; Li, Lingqiao; Liang, Jingxi; Yang, Xiaolin; Zhang, Bing; Zhao, Yao; Gao, Yan; Chen, Xiaobo; Yang, Xiuna; Zhang, Lu; Guddat, Luke W.; Liu, Lei; Yang, Haitao#; Rao, Zihe#; Li, Jun#; .Cryo-EM structures of a prokaryotic heme transporter CydDC.PROTEIN & CELL. 01 May 2023.
- 3. Wang, Haofeng*; Xiao, Yunjie; Chen, Xia; Zhang, Mengwen; Sun, Guangxin; Wang, Feng; Wang, Lin; Zhang, Hanxiao; Zhang, Xiaoyu; Yang, Xin; Li, Wenling; Wei, Yi; Yao, Deqiang; Zhang, Bing; Li, Jun; Cui, Wen; Wang, Fenghua; Chen, Cheng; Shen, Wei; Su, Dan; Bai, Fang; Huang, Jinhai; Ye, Sheng; Zhang, Lei; Ji, Xiaoyun; Wang, Wei#; Wang, Zefang#; Hochstrasser, Mark#; Yang, Haitao#; .Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue.NATURE COMMUNICATIONS. 25 Mar 2022. 13(1):1608.
- 4. Zhang, Lu*; Zhao, Yao*; Gao, Yan; Wu, Lijie; Gao, Ruogu; Zhang, Qi; Wang, Yinan; Wu, Chengyao; Wu, Fangyu; Gurcha, Sudagar S.; Veerapen, Natacha; Batt, Sarah M.; Zhao, Wei; Qin, Ling; Yang, Xiuna; Wang, Manfu; Zhu, Yan; Zhang, Bing; Bi, Lijun; Zhang, Xian'en; Yang, Haitao; Guddat, Luke W.; Xu, Wenqing; Wang, Quan#; Li, Jun#; Besra, Gurdyal S.#; Rao, Zihe#; .Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.SCIENCE. 12 Jun 2020. 368(6496):1211.
- 5. Gao, Yan*; Yan, Liming*; Huang, Yucen*; Liu, Fengjiang*; Zhao, Yao; Cao, Lin; Wang, Tao; Sun, Qianqian; Ming, Zhenhua; Zhang, Lianqi; Ge, Ji; Zheng, Litao; Zhang, Ying; Wang, Haofeng; Zhu, Yan; Zhu, Chen; Hu, Tianyu; Hua, Tian; Zhang, Bing; Yang, Xiuna; Li, Jun; Yang, Haitao; Liu, Zhijie; Xu, Wenqing; Guddat, Luke W.; Wang, Quan#; Lou, Zhiyong#; Rao, Zihe#; .Structure of the RNA-dependent RNA polymerase from COVID-19 virus.SCIENCE. 15 May 2020. 368(6492):779-+.
- 6. Zhang, Lu*; Zhao, Yao*; Gao, Ruogu*; Li, Jun; Yang, Xiuna; Gao, Yan; Zhao, Wei; Gurcha, Sudagar S.; Veerapen, Natacha; Batt, Sarah M.; Besra, Kajelle Kaur; Xu, Wenqing; Bi, Lijun; Zhang, Xian'en; Guddat, Luke W.; Yang, Haitao; Wang, Quan#; Besra, Gurdyal S.#; Rao, Zihe#; .Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB(2)-AcpM(2).PROTEIN & CELL. 03 May 2020. 11(7):505-517.
- 7. Wang, Lin*; Wu, Juehui*; Li, Jun*; Yang, Hua; Tang, Tianqi; Liang, Haijiao; Zuo, Mianyong; Wang, Jie; Liu, Haipeng; Liu, Feng; Chen, Jianxia; Liu, Zhonghua; Wang, Yang; Peng, Cheng; Wu, Xiangyang; Zheng, Ruijuan; Huang, Xiaochen; Ran, Yajun; Rao, Zihe#; Ge, Baoxue#; .Host-mediated ubiquitination of a mycobacterial protein suppresses immunity.NATURE. 30 Jan 2020. 577(7792):682-+.
- 8. Wang, Shuhui*; Zhou, Kaixuan; Yang, Xiaolin; Zhang, Bing; Zhao, Yao; Xiao, Yu; Yang, Xiuna; Yang, Haitao; Guddat, Luke W.; Li, Jun#; Rao, Zihe#; .Structural insights into substrate recognition by the type VII secretion system.PROTEIN & CELL. 23 Nov 2019.
- 9. Wang, Manfu*; Guo, Xiangyang*; Yang, Xiuna; Zhang, Bing; Ren, Jie; Liu, Aijun; Ran, Yajun; Yan, Bing; Chen, Fang; Guddat, Luke W.; Hu, Junjie#; Li, Jun#; Rao, Zihe; .Mycobacterial dynamin-like protein IniA mediates membrane fission.NATURE COMMUNICATIONS. 29 Aug 2019. 10.
- 10. Zhang, Bing*; Li, Jun*; Yang, Xiaolin; Wu, Lijie; Zhang, Jia; Yang, Yang; Zhao, Yao; Zhang, Lu; Yang, Xiuna; Yang, Xiaobao; Cheng, Xi; Liu, Zhijie; Jiang, Biao; Jiang, Hualiang; Guddat, Luke W.; Yang, Haitao#; Rao, Zihe#; .Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.CELL. 24 Jan 2019. 176(3):636-+.
- 11. Gong, Hongri*; Li, Jun*; Xu, Ao*; Tang, Yanting; Ji, Wenxin; Gao, Ruogu; Wang, Shuhui; Yu, Lu; Tian, Changlin; Li, Jingwen; Yen, Hsin-Yung; Lam, Sin Man; Shui, Guanghou; Yang, Xiuna; Sun, Yuna; Li, Xuemei; Jia, Minze; Yang, Cheng; Jiang, Biao; Lou, Zhiyong; Robinson, Carol V.; Wong, Luet-Lok; Guddat, Luke W.; Sun, Fei#; Wang, Quan#; Rao, Zihe#; .An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.SCIENCE. 30 Nov 2018. 362(6418):1020-+.
- 12. Zhang, Jia*; Zhang, Bing; Zhao, Yao; Yang, Xiuna; Huang, Min; Cui, Peng; Zhang, Wenhong; Li, Jun#; Zhang, Ying#; .Snapshots of catalysis: Structure of covalently bound substrate trapped in Mycobacterium tuberculosis thiazole synthase (ThiG).BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 26 Feb 2018. 497(1):214-219.
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