李剑峰, PhD助理教授研究员博士生导师

电话： 86-21-20684569

邮箱： lijf1@@shanghaitech.edu.cn

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地址：上海市浦东新区华夏中路393号

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中文信息English

药物递送与疾病诊疗

课题组长

姓名：

李剑峰助理教授研究员博士生导师, PhD, 助理教授

职务：

所在院所：

生命科学与技术学院

荣誉称号：

教育经历：

2005/09—2009/06，复旦大学，学士
2009/09—2015/01，复旦大学，博士

博士后及工作经历：

2015/07—2018/11，美国斯坦福大学，博士后
2018/11—至今，上海科技大学，生命科学与技术学院，助理教授（TENURE-TRACK）

课题组简介

研究方向：

核酸药物递送

研究内容：

1）设计合成新型非病毒类纳米载体，安全有效地递送功能性核酸（siRNA、mRNA和pDNA等），实现目标基因沉默、蛋白表达和基因编辑，为疾病（如肿瘤等）的基因治疗提供有力工具。

2）开发基于近红外二区（1000-1700 nm）的智能荧光探针，实现高灵敏度的体内生物学过程成像。

课题组网站：

研究成果展示

6. Qimingxing Chen*, Yan Chang*, Xiaoyan He, Yan Ding, Runyuan Wang, Ran Luo, Jialu Yuan, Jiabei Chen, Guisheng Zhong, Huiying Yang, Jia Chen^#, and Jianfeng Li^#. Targeted Delivery of mRNA with Polymer-Lipid Nanoparticles for in vivo Base Editing. ACS Nano. 2025; 19(8):7835-7850.

5. Xiaoyan He*, Runyuan Wang*, Yan Cao*, Yan Ding, Yan Chang, Haoru Dong, Rong Xie, Guisheng Zhong, Huiying Yang, and Jianfeng Li^#. Lung-Specific mRNA Delivery by Ionizable Lipids with Defined Structure-Function Relationship and Unique Protein Corona Feature. Advanced Science. 2025; 12(14):e2416525.

4. Jinwei Li*, Tongtong Xu*, Jiabei Chen*, Xiaoyan He, Renwei Ma, Xiuhong Lu, Jialu Yuan, Minghua Yao^#, Yaohui Tang^#, Jianfeng Li^#. A Small-Molecule NIR-II Probe for the Diagnosis of Hemorrhagic Diseases. Advanced Healthcare Materials. 2024;13(31):e2402333.

3. Jinwei Li*; Ruihua Pu*; Xiaoyan He; Qimingxing Chen; Suhong Liu; Weimin Liu#; Jianfeng Li#. A Precipitation-Enhanced Emission (PEE) Strategy for Increasing the Brightness and Reducing the Liver Retention of NIR-II Fluorophores. Small. 2022,18(49):e2204153. (BACK COVER)

2. Yan Cao*; Zongxing He*; Qimingxing Chen; Xiaoyan He; Lili Su; Wenxia Yu; Mingming Zhang; Huiying Yang; Xingxu Huang; and Jianfeng Li#. Helper-Polymer Based Five-Element Nanoparticles (FNPs) for Lung-Specific mRNA Delivery with Long-Term Stability after Lyophilization. Nano Letters. 2022,22(16):6580-6589.

1. Qimingxing Chen*; Lili Su; Xiaoyan He; Jinwei Li; Yan Cao; Qingxia Wu; Jianchao Qin; Zongxing He; Xingxu Huang, Huiying Yang#; and Jianfeng Li#. Poly(beta-amino ester)-Based Nanoparticles Enable Nonviral Delivery of Base Editors for Targeted Tumor Gene Editing. Biomacrolecules. 2022,23(5):2116-2125.

代表性论文（*第一作者，#通讯作者）

1. Ma,Rong*; Chang,Yan*; Chen,Qimingxing; Li,Jianfeng^#; Qiao,Bo^#; .Precise PBAEs: A Highly Efficient Single-Molecularly Defined Gene-Delivery System.ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2025.
2. Chen, Qimingxing*; Chang, Yan*; He, Xiaoyan; Ding, Yan; Wang, Runyuan; Luo, Ran; Yuan, Jialu; Chen, Jiabei; Zhong, Guisheng; Yang, Huiying; Chen, Jia^#; Li, Jianfeng^#; .Targeted Delivery of mRNA with Polymer-Lipid Nanoparticles for In Vivo Base Editing.ACS NANO. 2025. 19(8).
3. He, Xiaoyan*; Wang, Runyuan; Cao, Yan; Ding, Yan; Chang, Yan; Dong, Haoru; Xie, Rong; Zhong, Guisheng; Yang, Huiying; Li, Jianfeng^#; .Lung-Specific mRNA Delivery by Ionizable Lipids with Defined Structure-Function Relationship and Unique Protein Corona Feature.ADVANCED SCIENCE. 01 Feb 2025.
4. Li, Jinwei*; Xu, Tongtong*; Chen, Jiabei*; He, Xiaoyan; Ma, Renwei; Lu, Xiuhong; Yuan, Jialu; Yao, Minghua^#; Tang, Yaohui^#; Li, Jianfeng^#; .A Small-Molecule NIR-II Probe for the Diagnosis of Hemorrhagic Diseases.ADVANCED HEALTHCARE MATERIALS. 2024. 13(31).
5. Dong, Haoru*; He, Zongxing; Cai, Shiyi; Ma, Haiqiang; Su, Lili; Li, Jianfeng^#; Yang, Huiying^#; Xie, Rong^#; .Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury.JOURNAL OF NANOBIOTECHNOLOGY. 08 Feb 2025. 23(1).
6. Liu YX*; Wang RX*; Chen QMX; Chang Y; Chen Q; Fukumoto Kodai; Wang BX; Yu JC; Luo ZF; Ma JY; Chen XX; Murayama Yuko; Umeda Kenichi; Kodera Noriyuki; Harada Yoshie; Sekine Shun-ichi; Li JF^#; Tadakuma Hisashi^#; .Organ-specific gene expression control using DNA origami-based nanodevices.NANO LETTERS. 26 Jun 2024. 24(27):8410–8417.
7. Han, Wenyan*; Gao, Bao-Qing*; Zhu, Junjie*; He, Zongxing*; Li, Jianfeng^#; Yang, Li^#; Chen, Jia^#; .Design and application of the transformer base editor in mammalian cells and mice.NATURE PROTOCOLS. 04 Oct 2023.
8. Li, Haoyuan*; Cao, Yan; Ye, Jingjing; Yang, Zhipeng; Chen, Qimingxing; Liu, Xiaoqin; Zhang, Bohan; Qiao, Jingwen; Tang, Qisheng; Yang, Huiying; Li, Jianfeng; Shi, Zhifeng^#; Mao, Ying^#; .Engineering brain-derived neurotrophic factor mRNA delivery for the treatment of Alzheimer's disease.CHEMICAL ENGINEERING JOURNAL. 15 Jun 2023. 466.
9. Zhang, Jieying*; Li, Fang; Su, Lili; Hu, Qian; Li, Jianfeng^#; Zhu, Xingjun^#; .An erythrocyte membrane-modified biomimetic synergistic nanosystem for cancer anti-vascular therapy and initial efficacy monitoring.JOURNAL OF MATERIALS CHEMISTRY B. 2023. 11(30):7160-7168.
10. Yang, Huiying*; Wu, Qingxia; Li, Jinwei^#; Chen, Qimingxing; Su, Lili; He, Xiaoyan; Li, Jianfeng^#; Qiu, Xiaoyan^#; .In Vivo Fate of CXCR2-Overexpressing Mesenchymal Stromal/Stem Cells in Pulmonary Diseases Monitored by Near-Infrared Region 2 Imaging.ACS APPLIED MATERIALS & INTERFACES. Apr 2023. 15(17):20742-20752.
11. Gaofei Jin*; Hui Zhu; Daohuai Jiang; Jinwei Li; Lili Su; Jianfeng Li; Fei Gao; Xiran Cai; .A Signal-Domain Object Segmentation Method for Ultrasound and Photoacoustic Computed Tomography.IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL. 01 Mar 2023. 70(3):253 - 265.
12. Li, Jinwei*; Pu, Ruihua*; He, Xiaoyan; Chen, Qimingxing; Liu, Suhong; Liu, Weimin^#; Li, Jianfeng^#; .A Precipitation-Enhanced Emission (PEE) Strategy for Increasing the Brightness and Reducing the Liver Retention of NIR-II Fluorophores.SMALL. 08 Dec 2022.
13. Cao, Yan*; He, Zongxing*; Chen, Qimingxing; He, Xiaoyan; Su, Lili; Yu, Wenxia; Zhang, Mingming; Yang, Huiying; Huang, Xingxu; Li, Jianfeng^#; .Helper-Polymer Based Five-Element Nanoparticles (FNPs) for Lung-Specific mRNA Delivery with Long-Term Stability after Lyophilization.NANO LETTERS. 24 Aug 2022. 22(16):6580-6589.
14. Chen, Qimingxing*; Su, Lili; He, Xiaoyan; Li, Jinwei; Cao, Yan; Wu, Qingxia; Qin, Jianchao; He, Zongxing; Huang, Xingxu; Yang, Huiying^#; Li, Jianfeng^#; .Poly(beta-amino ester)-Based Nanoparticles Enable Nonviral Delivery of Base Editors for Targeted Tumor Gene Editing.BIOMACROMOLECULES. 2022. 23(5):2116–2125.
15. Yongjian Zhao*; Shaohui Yu; Luyao Zhu; Jinwei Li; Hengrong Lan; Daohuai Jiang; Feng Gao; Jianfeng Li; Fei Gao; .A Light-Adjustable Hand-Held Probe for Photoacoustic Tomography in vivo.IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS. 01 Aug 2021. 27(4).
16. Zhu, Xingjun*; Li, Jianfeng*; Peng, Peng; Nassab, Niloufar Hosseini; Smith, Bryan Ronain^#; .Quantitative Drug Release Monitoring in Tumors of Living Subjects by Magnetic Particle Imaging Nanocomposite.NANO LETTERS. 2019. 19(10):6725-6733.
17. Wang, Christine*; Li, Jianfeng*; Sinha, Sauradeep; Peterson, Addie; Grant, Gerald A.; Yang, Fan^#; .Mimicking brain tumor-vasculature microanatomical architecture via co-culture of brain tumor and endothelial cells in 3D hydrogels.BIOMATERIALS. 2019. 202:35-44.
18. Li, Jianfeng*; Yang, Huiying; Zhang, Yujie; Jiang, Xutao; Guo, Yubo; An, Sai; Ma, Haojun; He, Xi; Jiang, Chen^#; .Choline Derivate-Modified Doxorubicin Loaded Micelle for Glioma Therapy.ACS APPLIED MATERIALS & INTERFACES. 2015. 7(38):21589-21601.
19. Li, Jianfeng*; Jiang, Xutao; Guo, Yubo; An, Sai; Kuang, Yuyang; Ma, Haojun; He, Xi; Jiang, Chen^#; .Linear-Dendritic Copolymer Composed of Polyethylene Glycol and All-trans-Retinoic Acid as Drug Delivery Platform for Paclitaxel against Breast Cancer.BIOCONJUGATE CHEMISTRY. 2015. 26(3):418-426.
20. Li, Jianfeng*; Guo, Yubo; Kuang, Yuyang; An, Sai; Ma, Haojun; Jiang, Chen^#; .Choline transporter-targeting and co-delivery system for glioma therapy.BIOMATERIALS. 2013. 34(36):9142-9148.
21. Li, Jianfeng*; Huang, Shixian; Shao, Kun; Liu, Yang; An, Sai; Kuang, Yuyang; Guo, Yubo; Ma, Haojun; Wang, Xuxia; Jiang, Chen^#; .A choline derivate-modified nanoprobe for glioma diagnosis using MRI.SCIENTIFIC REPORTS. 2013. 3.
22. Li, Jianfeng*; Zhou, Lu; Ye, Deyong; Huang, Shixian; Shao, Kun; Huang, Rongqin; Han, Liang; Liu, Yang; Liu, Shuhuan; Ye, Liya; Lou, Jinning; Jiang, Chen^#; .Choline-Derivate-Modified Nanoparticles for Brain-Targeting Gene Delivery.ADVANCED MATERIALS. 2011. 23(39):4516.

专著

专利

1. 李剑峰、曹燕、何宗兴，一种五元脂质纳米颗粒及其制备方法和应用，中国，ZL202210114678.7，发明专利
2. 李剑峰、李金蔚，荧光分子、其磷酸钙纳米粒以及它们的制备方法和用途，中国，202210685502.7，发明专利
3. 朱幸俊、李剑峰、张洁颖，一种细胞膜包覆的纳米复合材料及其制备方法与应用，中国，CN202210575961.X，发明专利

项目

1. 可实现碱基编辑器体内高效递送的类脂质聚合物载体的设计、合成与应用，上海市科学技术委员，项目负责人
2. 构建双级分子靶向药物递送系统综合治疗儿童弥散性脑桥胶质瘤，上海市科学技术委员，项目负责人

奖励

1. 2020，上海市浦江人才
2. 2023，上海市东方英才青年项目（教育平台）

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课题组成员及合影

姓名：何小燕

身份：助理研究员

在组时间：2021-11至今

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身份：硕士研究生

在组时间：2023/09-至今

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邮箱：yangping2024@shanghaitech.edu.cn