Principal investigator
Name:
Jianfeng LiAssistant Professor , PhD, Assistant Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Group Introduction
Research Area:
Biomaterials and Stem Cell-based Therapeutics for Tissue Regeneration and Tumor Therapy
Research Interests:
Our research is highly interdisciplinary and spans from fundamental science to translational research. We are particularly interested in the following areas: (1) engineering 3D scaffolds to elucidate the influence of cell-cell and cell-matrix interactions on stem cell fate, (2) developing novel biomaterials to enhance the in vivo therapeutic outcome of stem cells, (3) developing non-viral vector for CRISPR/CAS9 gene delivery into stem cells, (4) developing optical and magnetic particle imaging based multi-module imaging contrast agent for in vivo tumor cell tracking.
Highly motivated research assistant or postdoctoral applicants with relevant background are welcome to join our team. |
Representative Publications (*First Author, # Corresponding Author)
- 1. Ma,Rong*; Chang,Yan*; Chen,Qimingxing; Li,Jianfeng#; Qiao,Bo#; .Precise PBAEs: A Highly Efficient Single-Molecularly Defined Gene-Delivery System.ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2025.
- 2. Chen, Qimingxing*; Chang, Yan*; He, Xiaoyan; Ding, Yan; Wang, Runyuan; Luo, Ran; Yuan, Jialu; Chen, Jiabei; Zhong, Guisheng; Yang, Huiying; Chen, Jia#; Li, Jianfeng#; .Targeted Delivery of mRNA with Polymer-Lipid Nanoparticles for In Vivo Base Editing.ACS NANO. 2025. 19(8).
- 3. He, Xiaoyan*; Wang, Runyuan; Cao, Yan; Ding, Yan; Chang, Yan; Dong, Haoru; Xie, Rong; Zhong, Guisheng; Yang, Huiying; Li, Jianfeng#; .Lung-Specific mRNA Delivery by Ionizable Lipids with Defined Structure-Function Relationship and Unique Protein Corona Feature.ADVANCED SCIENCE. 01 Feb 2025.
- 4. Li, Jinwei*; Xu, Tongtong*; Chen, Jiabei*; He, Xiaoyan; Ma, Renwei; Lu, Xiuhong; Yuan, Jialu; Yao, Minghua#; Tang, Yaohui#; Li, Jianfeng#; .A Small-Molecule NIR-II Probe for the Diagnosis of Hemorrhagic Diseases.ADVANCED HEALTHCARE MATERIALS. 2024. 13(31).
- 5. Dong, Haoru*; He, Zongxing; Cai, Shiyi; Ma, Haiqiang; Su, Lili; Li, Jianfeng#; Yang, Huiying#; Xie, Rong#; .Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury.JOURNAL OF NANOBIOTECHNOLOGY. 08 Feb 2025. 23(1).
- 6. Liu YX*; Wang RX*; Chen QMX; Chang Y; Chen Q; Fukumoto Kodai; Wang BX; Yu JC; Luo ZF; Ma JY; Chen XX; Murayama Yuko; Umeda Kenichi; Kodera Noriyuki; Harada Yoshie; Sekine Shun-ichi; Li JF#; Tadakuma Hisashi#; .Organ-specific gene expression control using DNA origami-based nanodevices.NANO LETTERS. 26 Jun 2024. 24(27):8410–8417.
- 7. Han, Wenyan*; Gao, Bao-Qing*; Zhu, Junjie*; He, Zongxing*; Li, Jianfeng#; Yang, Li#; Chen, Jia#; .Design and application of the transformer base editor in mammalian cells and mice.NATURE PROTOCOLS. 04 Oct 2023.
- 8. Li, Haoyuan*; Cao, Yan; Ye, Jingjing; Yang, Zhipeng; Chen, Qimingxing; Liu, Xiaoqin; Zhang, Bohan; Qiao, Jingwen; Tang, Qisheng; Yang, Huiying; Li, Jianfeng; Shi, Zhifeng#; Mao, Ying#; .Engineering brain-derived neurotrophic factor mRNA delivery for the treatment of Alzheimer's disease.CHEMICAL ENGINEERING JOURNAL. 15 Jun 2023. 466.
- 9. Zhang, Jieying*; Li, Fang; Su, Lili; Hu, Qian; Li, Jianfeng#; Zhu, Xingjun#; .An erythrocyte membrane-modified biomimetic synergistic nanosystem for cancer anti-vascular therapy and initial efficacy monitoring.JOURNAL OF MATERIALS CHEMISTRY B. 2023. 11(30):7160-7168.
- 10. Yang, Huiying*; Wu, Qingxia; Li, Jinwei#; Chen, Qimingxing; Su, Lili; He, Xiaoyan; Li, Jianfeng#; Qiu, Xiaoyan#; .In Vivo Fate of CXCR2-Overexpressing Mesenchymal Stromal/Stem Cells in Pulmonary Diseases Monitored by Near-Infrared Region 2 Imaging.ACS APPLIED MATERIALS & INTERFACES. Apr 2023. 15(17):20742-20752.
- 11. Gaofei Jin*; Hui Zhu; Daohuai Jiang; Jinwei Li; Lili Su; Jianfeng Li; Fei Gao; Xiran Cai; .A Signal-Domain Object Segmentation Method for Ultrasound and Photoacoustic Computed Tomography.IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL. 01 Mar 2023. 70(3):253 - 265.
- 12. Li, Jinwei*; Pu, Ruihua*; He, Xiaoyan; Chen, Qimingxing; Liu, Suhong; Liu, Weimin#; Li, Jianfeng#; .A Precipitation-Enhanced Emission (PEE) Strategy for Increasing the Brightness and Reducing the Liver Retention of NIR-II Fluorophores.SMALL. 08 Dec 2022.
- 13. Cao, Yan*; He, Zongxing*; Chen, Qimingxing; He, Xiaoyan; Su, Lili; Yu, Wenxia; Zhang, Mingming; Yang, Huiying; Huang, Xingxu; Li, Jianfeng#; .Helper-Polymer Based Five-Element Nanoparticles (FNPs) for Lung-Specific mRNA Delivery with Long-Term Stability after Lyophilization.NANO LETTERS. 24 Aug 2022. 22(16):6580-6589.
- 14. Chen, Qimingxing*; Su, Lili; He, Xiaoyan; Li, Jinwei; Cao, Yan; Wu, Qingxia; Qin, Jianchao; He, Zongxing; Huang, Xingxu; Yang, Huiying#; Li, Jianfeng#; .Poly(beta-amino ester)-Based Nanoparticles Enable Nonviral Delivery of Base Editors for Targeted Tumor Gene Editing.BIOMACROMOLECULES. 2022. 23(5):2116–2125.
- 15. Yongjian Zhao*; Shaohui Yu; Luyao Zhu; Jinwei Li; Hengrong Lan; Daohuai Jiang; Feng Gao; Jianfeng Li; Fei Gao; .A Light-Adjustable Hand-Held Probe for Photoacoustic Tomography in vivo.IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS. 01 Aug 2021. 27(4).
- 16. Zhu, Xingjun*; Li, Jianfeng*; Peng, Peng; Nassab, Niloufar Hosseini; Smith, Bryan Ronain#; .Quantitative Drug Release Monitoring in Tumors of Living Subjects by Magnetic Particle Imaging Nanocomposite.NANO LETTERS. 2019. 19(10):6725-6733.
- 17. Wang, Christine*; Li, Jianfeng*; Sinha, Sauradeep; Peterson, Addie; Grant, Gerald A.; Yang, Fan#; .Mimicking brain tumor-vasculature microanatomical architecture via co-culture of brain tumor and endothelial cells in 3D hydrogels.BIOMATERIALS. 2019. 202:35-44.
- 18. Li, Jianfeng*; Yang, Huiying; Zhang, Yujie; Jiang, Xutao; Guo, Yubo; An, Sai; Ma, Haojun; He, Xi; Jiang, Chen#; .Choline Derivate-Modified Doxorubicin Loaded Micelle for Glioma Therapy.ACS APPLIED MATERIALS & INTERFACES. 2015. 7(38):21589-21601.
- 19. Li, Jianfeng*; Jiang, Xutao; Guo, Yubo; An, Sai; Kuang, Yuyang; Ma, Haojun; He, Xi; Jiang, Chen#; .Linear-Dendritic Copolymer Composed of Polyethylene Glycol and All-trans-Retinoic Acid as Drug Delivery Platform for Paclitaxel against Breast Cancer.BIOCONJUGATE CHEMISTRY. 2015. 26(3):418-426.
- 20. Li, Jianfeng*; Guo, Yubo; Kuang, Yuyang; An, Sai; Ma, Haojun; Jiang, Chen#; .Choline transporter-targeting and co-delivery system for glioma therapy.BIOMATERIALS. 2013. 34(36):9142-9148.
- 21. Li, Jianfeng*; Huang, Shixian; Shao, Kun; Liu, Yang; An, Sai; Kuang, Yuyang; Guo, Yubo; Ma, Haojun; Wang, Xuxia; Jiang, Chen#; .A choline derivate-modified nanoprobe for glioma diagnosis using MRI.SCIENTIFIC REPORTS. 2013. 3.
- 22. Li, Jianfeng*; Zhou, Lu; Ye, Deyong; Huang, Shixian; Shao, Kun; Huang, Rongqin; Han, Liang; Liu, Yang; Liu, Shuhuan; Ye, Liya; Lou, Jinning; Jiang, Chen#; .Choline-Derivate-Modified Nanoparticles for Brain-Targeting Gene Delivery.ADVANCED MATERIALS. 2011. 23(39):4516.
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