Principal investigator
Name:
Lei LiAssociate Professor , PhD, Associate Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Group Introduction
Research Area:
Synapse Formation
Research Interests:
Synapses are fundamental units of neural circuitry that enable communications between neurons and between a neuron and its target cell. Synaptic transmission and plasticity are critical for brain functions, including sensation, cognition, memory, and motor control. The long-term goal of our lab is to understand molecular mechanisms of synapse formation and maintenance. Currently, we are interested in 1) understanding the molecular mechanisms of neuromuscular junction (NMJ) formation during development; 2) investigating the mechanisms underlying NMJ decline in aging and neurological disorders. Our studies may contribute to new diagnostic and therapeutic strategies for these neurological disorders.
Representative Publications (*First Author, # Corresponding Author)
- 1. Xinyi Tan*; Shuangshuang Sun*; Yuqing Yan*; Wei Li; Ning Ding; Lin Xu; Liying He; Yuhao Zhang; Wenbing Chen#; Yongjun Zheng#; Lei Li#.C9orf72-associated poly-GR in skeletal muscle leads to neuromuscular junction deficits and muscle atrophy.Molecular Therapy. 09 Jul 2026. 34(9):1-16.
- 2. Ding Ning*; Song Yijie*; Zhang Yuhang; Yu Wei; Li Xinnan; Li Wei; Li Lei#.Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux.AUTOPHAGY. 03 Jun 2025. 21(6):1298-1315.
- 3. Shuangshuang Sun*; Zhe Xu*; Liying He; Yihui Shen; Yuqing Yan; Xubing Lv; Xujing Zhu; Wei Li; Wei-Ya Tian; Yongjun Zheng; Sen Lin; Yadong Sun; Lei Li#.Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation.NATURE COMMUNICATIONS. 27 Sep 2024. 15(1).
- 4. Shuangshuang Sun*; Yihui Shen*; Xu Zhang; Ning Ding; Zhe Xu; Qijie Zhang#; Lei Li#.The MuSK agonist antibody protects the neuromuscular junction and extends the lifespan in C9orf72-ALS mice.MOLECULAR THERAPY. 03 Jul 2024. 32(7):2176-2189.
- 5. Yao, Shan*; Xu, Min-Dong; Wang, Ying; Zhao, Shen-Ting; Wang, Jin; Chen, Gui-Fu; Chen, Wen-Bing; Liu, Jian; Huang, Guo-Bin; Sun, Wen-Juan; Zhang, Yan-Yan; Hou, Huan-Li; Li, Lei; Sun, Xiang-Dong#.Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice.NATURE COMMUNICATIONS. 09 Feb 2023. 14(1).
- 6. Lin, Dong*; Li, Luhui; Chen, Wen-Bing; Chen, Jiang; Ren, Dongyan; Zheng, Zhi-Heng; Zhao, Changqin; Zhong, Yanzi; Luo, Bin; Jing, Hongyang; Chen, Peng; Zou, Suqi; Lai, Xinsheng; Zhou, Tian; Ding, Ning; Li, Lei; Pan, Bing-Xing#; Fei, Erkang#.LHPP expression in neurons.MOLECULAR PSYCHIATRY. Feb 2023. 28(2):517-517.
- 7. He, Liying*; Liang, Jiaqi; Chen, Chaonan; Chen, Jijun; Shen, Yihui; Sun, Shuangshuang; Li, Lei#.C9orf72 functions in the nucleus to regulate DNA damage repair.CELL DEATH & DIFFERENTIATION. Mar 2023. 30(3):716-730.
- 8. Hu, Jin-Xia*#; Ma, Wei-Jing*; He, Li-Ying*; Zhang, Cong-Hui*; Zhang, Cheng; Wang, Yan; Chen, Chao-Nan; Shen, Da-Yong; Gao, Hui-Min; Guo, Rui-Ru; Ning, Qian-Qian; Ye, Xin-Chun; Cui, Gui-Yun#; Li, Lei#.Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury.CELL DEATH & DISEASE. 18 May 2022. 13(5).
- 9. Chen, Wenbing*; Luo, Bin*; Gao, Nannan*; Li, Haiwen; Wang, Hongsheng; Li, Lei; Cui, Wanpeng; Zhang, Lei; Sun, Dong; Liu, Fang; Dong, Zhaoqi; Ren, Xiao; Zhang, Hongsheng; Su, Huabo; Xiong, Wen-Cheng; Mei, Lin#.Neddylation stabilizes Na(v)1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models.JOURNAL OF CLINICAL INVESTIGATION. 15 Apr 2021. 131(8).
- 10. Li, Lei*; Xiong, Wen-Cheng; Mei, Lin#.Neuromuscular Junction Formation, Aging, and Disorders.ANNUAL REVIEW OF PHYSIOLOGY. 2018. 80:159-188.
- 11. Li, Lei*; Cao, Yu*; Wu, Haitao; Ye, Xinchun; Zhu, Zhihui; Xing, Guanglin; Shen, Chengyong; Barik, Arnab; Zhang, Bin; Xie, Xiaoling; Zhi, Wenbo; Gan, Lin; Su, Huabo; Xiong, Wen-Cheng; Mei, Lin#.Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation.NEURON. 2016. 92(5):1007-1019.
- 12. Sun, Xiang-Dong*#; Li, Lei*; Liu, Fang; Huang, Zhi-Hui; Bean, Jonathan C.; Jiao, Hui-Feng; Barik, Arnab; Kim, Seon-Myung; Wu, Haitao; Shen, Chengyong; Tian, Yun; Lin, Thiri W.; Bates, Ryan; Sathyamurthy, Anupama; Chen, Yong-Jun; Yin, Dong-Min; Xiong, Lei; Lin, Hui-Ping; Hu, Jin-Xia; Li, Bao-Ming; Gao, Tian-Ming; Xiong, Wen-Cheng; Mei, Lin#.Lrp4 in astrocytes modulates glutamatergic transmission.NATURE NEUROSCIENCE. 2016. 19(8):1010.
- 13. Barik, Arnab*; Li, Lei*; Sathyamurthy, Anupama; Xiong, Wen-Cheng; Mei, Lin#.Schwann Cells in Neuromuscular Junction Formation and Maintenance.JOURNAL OF NEUROSCIENCE. 2016. 36(38):9770-9781.
- 14. Li, Lei*; Wei, Dan; Wang, Qiong; Pan, Jing; Liu, Rong; Zhang, Xu; Bao, Lan#.MEC-17 Deficiency Leads to Reduced alpha-Tubulin Acetylation and Impaired Migration of Cortical Neurons.JOURNAL OF NEUROSCIENCE. 2012. 32(37):12673-12683.
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