Principal investigator
Name:
Mofang LiuDistinguished Adjunct Professor from CAS , PhD, Distinguished Adjunct Professor from CAS
Position:
Affiliation:
School of Life Science and Technology/ Shanghai Institute of Biochemistry and Cell Biology,CAS
Honor:
Group Introduction
Research Area:
The Functional Mechanism of Noncoding RNA
Research Interests:
The major research interests in Liu’s group are the roles and mechanisms of noncoding RNAs. The group is focusing on the studies of two important types of small noncoding RNAs, PIWI-interacting RNAs (piRNAs) and microRNAs (miRNAs). The goal of ongoing projects in the laboratory is to gain new insights into the function and mechanism of PIWI/piRNAs in mammal spermatogenesis and human male infertility as well as the function and mechanism of miRNAs in human cancers, especially in inflammation-associated tumorigenesis and cancer cell metabolism.
Representative Publications (*First Author, # Corresponding Author)
- 1. Jiang, Shuai*; Zhang, Hong-Wei; Lu, Ming-Hua; He, Xiao-Hong; Li, Yong; Gu, Hua; Liu, Mo-Fang#; Wang, En-Duo.MicroRNA-155 Functions as an OncomiR in Breast Cancer by Targeting the Suppressor of Cytokine Signaling 1 Gene.CANCER RESEARCH. 2010. 70(8):3119-3127.
- 2. Jiang, Shuai*; Zhang, Ling-Fei; Zhang, Hong-Wei; Hu, Song; Lu, Ming-Hua; Liang, Sheng; Li, Biao; Li, Yong; Li, Dangsheng; Wang, En-Duo; Liu, Mo-Fang#.A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells.EMBO JOURNAL. 2012. 31(8):1985-1998.
- 3. Zhao, Shuang*; Gou, Lan-Tao; Zhang, Man; Zu, Li-Dong; Hua, Min-Min; Hua, Ye; Shi, Hui-Juan; Li, Yong; Li, Jinsong; Li, Dangsheng; Wang, En-Duo#; Liu, Mo-Fang#.piRNA-Triggered MIWI Ubiquitination and Removal by APC/C in Late Spermatogenesis.DEVELOPMENTAL CELL. 2013. 24(1):13-25.
- 4. Wang, Lin*; Zhang, Ling-Fei; Wu, Jing; Xu, Shu-Jun; Xu, Yang-Yang; Li, Dangsheng; Lou, Jia-Tao#; Liu, Mo-Fang#.IL-1 beta-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis.CANCER RESEARCH. 2014. 74(17):472-473.
- 5. Gou, Lan-Tao*; Dai, Peng; Yang, Jian-Hua; Xue, Yuanchao; Hu, Yun-Ping; Zhou, Yu; Kang, Jun-Yan; Wang, Xin; Li, Hairi; Hua, Min-Min; Zhao, Shuang; Hu, Si-Da; Wu, Li-Gang; Shi, Hui-Juan; Li, Yong; Fu, Xiang-Dong; Qu, Liang-Hu; Wang, En-Duo; Liu, Mo-Fang#.Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis.CELL RESEARCH. 2014. 24(6):68-7.
- 6. He, X-H*; Zhu, W.; Yuan, P.; Jiang, S.; Li, D.; Zhang, H-W; Liu, M-F#.miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells.ONCOGENE. 17 Nov 2016. 35(46):6015-6025.
- 7. Gou, Lan-Tao*; Kang, Jun-Yan; Dai, Peng; Wang, Xin; Li, Feng; Zhao, Shuang; Zhang, Man; Hua, Min-Min; Lu, Yi; Zhu, Yong; Li, Zheng; Chen, Hong; Wu, Li-Gang; Li, Dangsheng; Fu, Xiang-Dong; Li, Jinsong; Shi, Hui-Juan#; Liu, Mo-Fang#.Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange During Spermiogenesis.CELL. 01 Jun 2017. 72(9):540-541.
- 8. Yuan, Peng*; He, Xiao-Hong; Rong, Ye-Fei; Cao, Jing; Li, Yong; Hu, Yun-Ping; Liu, Yingbin; Li, Dangsheng; Lou, Wenhui#; Liu, Mo-Fang#.KRAS/NF-kappa B/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis.CANCER RESEARCH. Jan 2017. 77(1):100-111.
- 9. Dai, Peng*; Wang, Xin; Gou, Lan-Tao; Li, Zhi-Tong; Wen, Ze; Chen, Zong-Gui; Hua, Min-Min; Zhong, Ai; Wang, Lingbo; Su, Haiyang; Wan, Huida; Qian, Kun; Liao, Lujian; Li, Jinsong; Tian, Bin; Li, Dangsheng; Fu, Xiang-Dong; Shi, Hui-Juan#; Zhou, Yu#; Liu, Mo-Fang#.A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis.CELL. 12 Dec 2019. 179(7):1566-+.
- 10. Li, Feng*; Yuan, Peng; Rao, Ming; Jin, Chun-Hui; Tang, Wei; Rong, Ye-Fei; Hu, Yun-Ping; Zhang, Fengjuan; Wei, Tao; Yin, Qi; Liang, Tingbo; Wu, Ligang; Li, Jinsong; Li, Dangsheng; Liu, Yingbin; Lou, Wenhui; Zhao, Shuang#; Liu, Mo-Fang#.piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis.NATURE CELL BIOLOGY. 16 Mar 2020.
- 11. Wang, Xin*; Li, Zhi-Tong; Yan, Yue; Lin, Penghui; Tang, Wei; Hasler, Daniele; Meduri, Rajyalakshmi; Li, Ye; Hua, Min-Min; Qi, Hui-Tao; Lin, Di-Hang; Shi, Hui-Juan; Hui, Jingyi; Li, Jinsong; Li, Dangsheng; Yang, Jian-Hua; Lin, Jinzhong; Meister, Gunter; Fischer, Utz; Liu, Mo-Fang#.LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice.MOLECULAR CELL. 05 Mar 2020. 77(5):999-+.
|
