Xiajun LiAssociate Professor , PhD, Associate Professor
School of Life Science and Technology
Genetics and Epigenetics, Developmental and Stem Cell Biology
Genomic imprinting is absolutely essential for mammalian development. Dysregulation of genomic imprinting causes a variety of human diseases including cancer, diabetes, cardiovascular diseases and neurological disorders. Dr. Li’s previous study has shown Zfp57 as a master regulator in genomic imprinting. His lab is interested in modeling major human diseases by utilizing Zfp57 mutant mice. Zfp57 is a maternal-zygotic effect gene and loss of Zfp57 causes maternal-zygotic embryonic lethality, the first one identified in mammals. Recently, his lab demonstrated that both maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development, with partially redundant functions. His current research centers on NOTCH signaling and genomic imprinting in cardiac and neural development as well as related heart and brain diseases including dilated cardiomyopathy (DCM) and Alzheimer’s disease.
Another major research interest of his lab is epigenetic regulation, in particular genomic imprinting, in ES and iPS cells. Indeed, Zfp57 is critical for the maintenance of genomic imprinting in these stem cells, whereas ntES and iPS cells are promising candidates for cell-based therapies for various degenerative diseases including Alzheimer’s disease. Genomic imprinting is commonlydysregulated in reprogrammed ntES and iPS cells, and loss of genomic imprinting may cause cancer and other human diseases. Therefore,his lab is interested in identifying possible strategies for derivation of iPS cells that are suitable for future therapeutic applications.
Representative Publications (*First Author, # Corresponding Author)
- 1. Jiang, Weijun*; Shi, Jiajia; Zhao, Jingjie; Wang, Qiu; Cong, Dan; Chen, Fenghua; Zhang, Yu; Liu, Yuhan; Zhao, Junzheng; Chen, Qian; Gu, Linhao; Zhou, Wenjia; Wang, Chenhang; Fang, Zhaoyuan; Geng, Shuhui; Xie, Wei; Chen, Luo-Nan; Yang, Yang; Bai, Yun#; Lin, Haodong#; Li, Xiajun#.ZFP57 dictates allelic expression switch of target imprinted genes.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Feb 2021. 118(5):e2005377118.
- 2. Li, Albert Jiarui*; Li, Xiajun#.Sex-dependent immune response and lethality of COVID-19.STEM CELL RESEARCH. Jan 2021. 50:102116.
- 3. Li, Xiajun#*; Li, Max Jiahua; Yang, Yang; Bai, Yun.Effects of reprogramming on genomic imprinting and the application of pluripotent stem cells.STEM CELL RESEARCH. Dec 2019. 41.
- 4. Li, Max Jiahua*; Li, Xiajun#.Three paternally imprinted regions are sequentially required in prenatal and postnatal mouse development.SCIENCE CHINA-LIFE SCIENCES. 06 Nov 2019.
- 5. Huang, Shisheng*; Liao, Zhaodi*; Li, Xiangyang*; Liu, Zhen; Li, Guanglei; Li, Jianan; Lu, Zongyang; Zhang, Yu; Li, Xiajun; Ma, Xu#; Sun, Qiang#; Huang, Xingxu#.Developing ABEmax-NG with Precise Targeting and Expanded Editing Scope to Model Pathogenic Splice Site Mutations In Vivo.ISCIENCE. 31 May 2019. 15:640-+.
- 6. Yang, Guang*; Zhou, Changyang*; Wang, Ran*; Huang, Shisheng; Wei, Yu; Yang, Xianfa; Liu, Yajing; Li, Jianan; Lu, Zongyang; Ying, Wenqin; Li, Xiajun; Jing, Naihe; Huang, Xingxu#; Yang, Hui#; Qiao, Yunbo#.Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development.CELL REPORTS. 08 Jan 2019. 26(2):302-+.
- 7. Liu, Junlai*; Hu, Xiao; Chen, Jie; Li, Xinqi; Wang, Lu; Wang, Binbin; Peng, Wenbo; Yang, Cuiwei; Li, Zhijie; Chen, Yan; Wang, Yue J.; Li, Chuanjiang; Li, Xiajun; Yan, Fang; Wang, Yunfang; Shang, Changzhen; Wang, Xin; Chen, Tao#; Huang, Pengyu#.Pericentral Hepatocytes Produce Insulin-Like Growth Factor-2 to Promote Liver Regeneration During Selected Injuries in Mice.HEPATOLOGY. Dec 2017. 66(6):2002-2015.
- 8. Lau, Ho-Tak*; Liu, Lizhi; Li, Xiajun#.Zfp57 mutant ES cell lines directly derived from blastocysts.STEM CELL RESEARCH. 2016. 16(2):282-286.
- 9. Liu, Lizhi*; Mao, Shi-Qing; Ray, Chelsea; Zhang, Yu; Bell, Fong T.; Ng, Sheau-Fang; Xu, Guo-Liang; Li, Xiajun#.Differential regulation of genomic imprinting by TET proteins in embryonic stem cells.STEM CELL RESEARCH. 2015. 15(2):435-443.
- 10. Shamis, Yulia*; Cullen, Dana E.; Liu, Lizhi; Yang, Guan; Ng, Sheau-Fang; Xiao, Lijuan; Bell, Fong T.; Ray, Chelsea; Takikawa, Sachiko; Moskowitz, Ivan P.; Cai, Chen-Leng; Yang, Xiao; Li, Xiajun#.Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015. 112(16):E2020-E2029.
- 11. Li, Xiajun#*.Genomic Imprinting Is a Parental Effect Established in Mammalian Germ Cells.CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY. 2013. 102:35-59.
- 12. Takikawa, Sachiko*; Ray, Chelsea; Wang, Xin; Shamis, Yulia; Wu, Tien-Yuan; Li, Xiajun#.Genomic imprinting is variably lost during reprogramming of mouse iPS cells.STEM CELL RESEARCH. 2013. 11(2):861-873.
- 13. Zuo, Xiaopan*; Sheng, Jipo; Lau, Ho-Tak; McDonald, Carol M.; Andrade, Monica; Cullen, Dana E.; Bell, Fong T.; Iacovino, Michelina; Kyba, Michael; Xu, Guoliang; Li, Xiajun#.Zinc Finger Protein ZFP57 Requires Its Co-factor to Recruit DNA Methyltransferases and Maintains DNA Methylation Imprint in Embryonic Stem Cells via Its Transcriptional Repression Domain.JOURNAL OF BIOLOGICAL CHEMISTRY. 2012. 287(3):2107-2118.
- 14. Li, Xiajun#*; Ito, Mitsuteru; Zhou, Fen; Youngson, Neil; Zuo, Xiaopan; Leder, Philip; Ferguson-Smith, Anne C..A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints.DEVELOPMENTAL CELL. 2008. 15(4):547-557.
- 15. McDonald, Carol M.*; Liu, Lizhi; Xiao, Lijuan; Schaniel, Christoph; Li, Xiajun#.Genomic imprinting defect in Zfp57 mutant iPS cell lines.STEM CELL RESEARCH. 2016. 16(2):259-263.
- 16. Li, XJ#*; Greenwald, I#.Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998. 95(12):7109-7114.
- 17. Li, XJ#*; Greenwald, I.HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997. 94(22):12204-12209.
- 18. Li, XJ#*; Greenwald, I.Membrane topology of the C-elegans SEL-12 presenilin.NEURON. 1996. 17(5):1015-1021.
- 1. 2010-2013, Associate Editor, Molecular Human Reproduction
- 2. 2019-present, Editorial Board Member, Current Stem Cell Reports
- 3. 2020-present, Editorial Board Member, Stem Cell Research
- 4. 2020-present, Associate Editor, Frontiers in Cell and Developmental Biology
- 5. , Reviewer for NIH, MRC, French National Research Agency, American Heart Association (AHA), Alzheimer’s Association, NASA Space Biology
- 6. , Annual meeting reviewer for European Society of Human Reproduction and Embryology (ESHRE)
- 7. , Annual meeting reviewer for International Society for Stem Cell Research (ISSCR)