Principal investigator
Name:
Yanfen LiuAssociate Professor , PhD, Associate Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 1998/09-2002/07, Zhejiang University, B.A.
- 2002/09-2008/06, Peking Union Medical College / NIBS, Ph.D.
Working Experience:
- 2009/06-2015/01, National Institutes of Health (NIH)/NIDDK, Postdoctoral Fellow
- 2015/01-2015/09, ShanghaiTech University, School of Life Science and Technology, Assistant Professor (TENURE-TRACK)
- 2023/10-present, ShanghaiTech University, School of Life Science and Technology, Associated Professor (TENURED)
Group Introduction
Research Area:
Protein Quality Control and Neurodegenerative Diseases
Research Interests:
We are interested in understanding how eukaryotic cells deal with protein misfolding. Removal of unwanted proteins by Ubiquitin-Proteasome System (UPS) is an integral component of the cellular quality control program that offers an essential protective mechanism to maintain protein homeostasis. Impairment in protein quality control results in protein aggregates associated with various diseases from neurodegenerative disorders to cancers. In short term, we want to study how the ubiquitin-proteasome system (UPS) and autophagy is regulated to maintain protein and organelle homeostasis with an emphasis on ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs). In long term, we wish to elucidate the functional interplays between UPS and other degradation pathways such as autophagy in human development and diseases.
Representative Publications (*First Author, # Corresponding Author)
- 1. Man Zhang*, Zhangshun Wang, Qing Zhao, Qian Yang, Jieyun Bai, Cuiwei Yang, Zai-Rong Zhang, Yanfen Liu#.USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy.Autophagy. 12 May 2024.
- 2. Yanfen Liu*, Zhangshun Wang, Yong Cang.Mini PROTACs: N-end rule-mediated degradation on the horizon.Trends in Biochemical Sciences. 2 Nov 2023. S0968-0004(23)00256-6..
- 3. Shuyao Hu#*; Yufeng Zhang; Qianqian Yi; Cuiwei Yang; Yanfen Liu#; Yun Bai#; .Time-resolved proteomic profiling reveals compositional and functional transitions across the stress granule life cycle.NATURE COMMUNICATIONS. 2023. 14(1):7782.
- 4. Wang, Zhangshun*; Zhang, Chen'ang; Fan, Chengyu; Liu, Yanfen#; .Post-translational modifications in stress granule and their implications in neurodegenerative diseases.BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS. 01 Dec 2023. 1866(4).
- 5. Wang, Xinjian*; Fan, Chengyu; Liu, Yanfen#; Zou, Yan#; .The interconnection of endoplasmic reticulum and microtubule and its implication in Hereditary Spastic Paraplegia.COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. Jan 2023. 21:1670-1677.
- 6. Yang, Cuiwei*; Wang, Zhangshun*; Kang, Yingjin*; Yi, Qianqian; Wang, Tong; Bai, Yun#; Liu, Yanfen#; .Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.AUTOPHAGY. 2023. 19(7):1934-1951.
- 7. Klionsky, DJ#*; Abdel-Aziz, AK; Abdelfatah, S; Abdellatif, M; Abdoli, A; Abel, S; Abeliovich, H; Abildgaard, MH; Abudu, YP; Acevedo-Arozena, A; Adamopoulos, IE; Adeli, K; Adolph, TE; Adornetto, A; Liu, YF; Liu, Y; .Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).AUTOPHAGY. 2021. 17(1):1-382.
- 8. Chu, Yuanyuan*; Kang, Yingjin*; Yan, Cong*; Yang Cuiwei; Zhang, Tao; Huo, Huanhuan; Liu, Yanfen#; .LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.AUTOPHAGY. 03 Jul 2021. 10.1080/15548627.2020.1781393.
- 9. Chu, Yuanyuan*; Dong, Xingqi; Kang, Yingjin; Liu, Jingnan; Zhang, Tao; Yang, Cuiwei; Wang, Zhangshun; Shen, Wangchen; Huo, Huanhuan; Zhuang, Min; Lu, Junxia#; Liu, Yanfen#; .The Chaperone BAG6 Regulates Cellular Homeostasis between Autophagy and Apoptosis by Holding LC3B.ISCIENCE. 20 Nov 2020. 23(11).
- 10. Zhao, Yupeng*; Feng, Zhigang*; Zou, Yan#; Liu, Yanfen#; .The E3 Ubiquitin Ligase SYVN1 Ubiquitinates Atlastins to Remodel the Endoplasmic Reticulum Network.ISCIENCE. 25 Sep 2020. 23(9).
- 11. Yan, Cong*; Huo, Huanhuan; Yang, Cuiwei; Zhang, Tao; Chu, Yuanyuan; Liu, Yanfen#; .Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 04 Mar 2018. 497(2):726-733.
- 12. Zhao, Yupeng*; Zhang, Ting; Huo, Huanhuan; Ye, Yihong#; Liu, Yanfen#; .Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions.JOURNAL OF BIOLOGICAL CHEMISTRY. 26 Aug 2016. 291(35):18252-18262.
- 13. Zhang, Ting*; Xu, Yue; Liu, Yanfen; Ye, Yihong#; .gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.MOLECULAR BIOLOGY OF THE CELL. 2015. 26(24):4438-4450.
- 14. Liu, Yanfen*; Soetandyo, Nia; Lee, Jin-gu; Liu, Liping; Xu, Yue; Clemons, William M., Jr.; Ye, Yihong#; .USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.ELIFE. 2014. 3.
- 15. Xu, Yue*; Liu, Yanfen; Lee, Jin-Gu; Ye, Yihong#; .A Ubiquitin-like Domain Recruits an Oligomeric Chaperone to a Retrotranslocation Complex in Endoplasmic Reticulum-associated Degradation.JOURNAL OF BIOLOGICAL CHEMISTRY. 2013. 288(25):18068-18076.
- 16. Liu, Yanfen*; Ye, Yihong#; .Roles of p97-Associated Deubiquitinases in Protein Quality Control at the Endoplasmic Reticulum.CURRENT PROTEIN & PEPTIDE SCIENCE. 2012. 13(5):436-446.
- 17. Wang, Qiuyan*; Liu, Yanfen*; Soetandyo, Nia; Baek, Kheewoong; Hegde, Ramanujan; Ye, Yihong#; .A Ubiquitin Ligase-Associated Chaperone Holdase Maintains Polypeptides in Soluble States for Proteasome Degradation.MOLECULAR CELL. 2011. 42(6):758-770.
- 18. Liu, Yanfen*; Ye, Yihong#; .Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy.CELL RESEARCH. 2011. 21(6):867-883.
- 19. Liu, Yanfen*; Wang, Feng; Zhang, Huiyong; He, Hang; Ma, Ligeng; Deng, Xing Wang#; .Functional characterization of the Arabidopsis ubiquitin-specific protease gene family reveals specific role and redundancy of individual members in development.PLANT JOURNAL. 2008. 55(5):844-856.
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