Principal investigator
Name:
Chao-Po LinAssistant Professor , PhD, Assistant Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 1994.9-1998.6, Department of Zoology, National Taiwan University, B.S.
- 2000.9-2002.6, Institute of Genetics, National Yang-Ming University, M.S.
- 2003.9-2010.1, Department of Pharmacology, Rutgers University, USA, Ph.D.
Working Experience:
- 2002.9-2003.8, Institute of Microbiology, National Taiwan University College of Medicine, Research assistant
- 2010.4-2017.3, University of California at Berkeley, USA, Postdoctoral fellow
- 2017.6-Present, ShanghaiTech Uninversity, China, Assistant Professor (TENURE-TRACK)
Group Introduction
Research Area:
Stem Cell Biology; RNA Biology
Research Interests:
Our group is interested in the function(s) of microRNAs in pluripotent stem cells, as well as the function(s) of retrotransposons in mammalian development. First, we explore the importance of the p53-microRNA axis in somatic reprogramming, or the generation of induced pluripotent stem cells (iPSCs). Second, we study the roles of microRNAs in modulating the totipotent-like cell fate potential in pluripotent stem cells, a novel potency state of pluripotent stem cells we identified recently (Science, 2017). Finally, we investigate the functional roles of retrotransposons during mammalian pre-implantation and post-implantation development.
Representative Publications (*First Author, # Corresponding Author)
- 1. Huang, Xinyan*; Yan, Lei*; Kou, Shan; Meng, Jufeng; Lu, Zhengkai; Lin, Chao-Po; Liu, Chen#; Zhang, Hui#.Generation and characterization of a Myh6-driven Cre knockin mouse line.TRANSGENIC RESEARCH. 20 Sep 2021. 30(6):821-835.
- 2. Jiang, Zhen*; Feng, Teng; Lu, Zhengkai; Wei, Yuanxin; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Liu, Chen#; Zhang, Hui#.PDGFRb+ mesenchymal cells, but not NG2+ mural cells, contribute to cardiac fat.CELL REPORTS. 02 Feb 2021. 34:108697.
- 3. Jiang, Zhen*; Lu, Zhengkai; Kou, Shan; Feng, Teng; Wei, Yuanxin; Gao, Zibei; Deng, Defang; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Zhang, Hui#.Overexpression of Kdr in adult endocardium induces endocardial neovascularization and improves heart function after myocardial infarction.CELL RESEARCH. 20 Nov 2020. 31:485-487.
- 4. Li, Hui*; Yang, Jie; Tian, Cuiping; Diao, Min; Wang, Quan; Zhao, Simeng; Li, Shanshan; Tan, Fangzhi; Hua, Tian; Qin, Ya; Lin, Chao-Po; Deska-Gauthier, Dylan; Thompson, Garth J.; Zhang, Ying; Shui, Wenqing; Liu, Zhi-Jie; Wang, Tong; Zhong, Guisheng#.Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging.NATURE COMMUNICATIONS. 2020. 11(1).
- 5. Feng, Teng*; Gao, Zibei*; Kou, shan; Huang, Xinyan; Jiang, Zhen; Lu, Zhengkai; Meng, Jufeng; Lin, Chao-Po; Zhang, Hui#.No Evidence for Erythro-Myeloid Progenitor-Derived Vascular Endothelial Cells in Multiple Organs.CIRCULATION RESEARCH. 23 Oct 2020. 127(10):1221-1232.
- 6. Lan, Yiyang*; Tao, Yong; Wang, Yunfeng; Ke, Junzi; Yang, Qiuxiang; Liu, Xiaoyi; Su, Bing; Wu, Yiling; Lin, Chao-Po; Zhong, Guisheng#.Recent development of AAV-based gene therapies for inner ear disorders.GENE THERAPY. 18 May 2020.
- 7. Zhang, Zhenwu*; Zhuang, Lili; Lin, Chao-Po#.Roles of MicroRNAs in Establishing and Modulating Stem Cell Potential.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Aug 2019. 20(15).
- 8. Huang, Xinyan*; Feng, Teng; Jiang, Zhen; Meng, Jufeng; Kou, Shan; Lu, Zhengkai; Chen, Weize; Lin, Chao-Po; Zhou, Bin; Zhang, Hui#.Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes.JOURNAL OF BIOLOGICAL CHEMISTRY. 31 May 2019. 294(22):8894-8906.
- 9. Lin, Chao-Po*; He, Lin#.Noncoding RNAs in Cancer Development.ANNUAL REVIEW OF CANCER BIOLOGY-SERIES. 2017. 1:163-184.
- 10. Choi, Yong Jin*; Lin, Chao-Po#; Risso, Davide; Chen, Sean; Kim, Thomas Aquinas; Tan, Meng How; Li, Jin Billy; Wu, Yalei; Chen, Caifu; Xuan, Zhenyu; Macfarlan, Todd; Peng, Weiqun; Lloyd, K. C. Kent; Kim, Sang Yong; Speed, Terence P.; He, Lin#.Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells.SCIENCE. 2017. 355(6325).
- 11. Okada, Nobuhiro*; Lin, Chao-Po; Ribeiro, Marcelo C.; Biton, Anne; Lai, Gregory; He, Xingyue; Bu, Pengcheng; Vogel, Hannes; Jablons, David M.; Keller, Andreas C.; Wilkinson, J. Erby; He, Biao; Speed, Terry P.; He, Lin#.A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.GENES & DEVELOPMENT. 2014. 28(5):438-450.
- 12. Lin, Chao-Po*; Choi, Yong Jin; Hicks, Geoffrey G.; He, Lin#.The emerging functions of the p53-miRNA network in stem cell biology.CELL CYCLE. 2012. 11(11):2063-2072.
- 13. Choi, Yong Jin*; Lin, Chao-Po; Ho, Jaclyn J.; He, Xingyue; Okada, Nobuhiro; Bu, Pengcheng; Zhong, Yingchao; Kim, Sang Yong; Bennett, Margaux J.; Chen, Caifu; Ozturk, Arzu; Hicks, Geoffrey G.; Hannon, Greg J.; He, Lin#.miR-34 miRNAs provide a barrier for somatic cell reprogramming.NATURE CELL BIOLOGY. 2011. 13(11):1353.
- 14. Lin, Chao-Po*; Ban, Yi; Lyu, Yi Lisa; Liu, Leroy F.#.Proteasome-dependent Processing of Topoisomerase I-DNA Adducts into DNA Double Strand Breaks at Arrested Replication Forks.JOURNAL OF BIOLOGICAL CHEMISTRY. 2009. 284(41):28084-28092.
- 15. Tsai, Yuan-Chin*; Qi, Haiyan; Lin, Chao-Po; Lin, Ren-Kuo; Kerrigan, John E.; Rzuczek, Suzanne G.; LaVoie, Edmond J.; Rice, Joseph E.; Pilch, Daniel S.; Lyu, Yi Lisa; Liu, Leroy F.#.A G-quadruplex Stabilizer Induces M-phase Cell Cycle Arrest.JOURNAL OF BIOLOGICAL CHEMISTRY. 2009. 284(34):22535-22543.
- 16. Lin, Chao-Po*; Ban, Yi; Lyu, Yi Lisa; Desai, Shyamal D.; Liu, Leroy F.#.A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes.JOURNAL OF BIOLOGICAL CHEMISTRY. 2008. 283(30):21074-21083.
- 17. Lyu, Yi Lisa#*; Kerrigan, John E.; Lin, Chao-Po; Azarova, Anna M.; Tsai, Yuan-Chin; Ban, Yi; Liu, Leroy F.#.Topoisomerase II beta-Mediated DNA double-strand breaks: Implications in doxorubicin cardiotoxicity and prevention by dexrazoxane.CANCER RESEARCH. 2007. 67(18):8839-8846.
- 18. Azarova, Anna M.*; Lyu, Yi Lisa; Lin, Chao-Po; Tsai, Yuan-Chin; Lau, Johnson Yiu-Nam; Wang, James C.#; Liu, Leroy F.#.Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007. 104(26):11014-11019.
- 19. Zhang, Ailing*; Lyu, Yi Lisa; Lin, Chao-Po; Zhou, Nai; Azarova, Anna M.; Wood, Laurence M.; Liu, Leroy F.#.A protease pathway for the repair of topoisomerase II-DNA covalent complexes.JOURNAL OF BIOLOGICAL CHEMISTRY. 2006. 281(47):35997-36003.
- 20. Qi, Haiyan#*; Lin, Chao-Po; Fu, Xuan; Wood, Laurence M.; Liu, Angela A.; Tsai, Yuan-Chin; Chen, Yongjie; Barbieri, Christopher M.; Pilch, Daniel S.; Liu, Leroy F..G-quadruplexes induce apoptosis in tumor cells.CANCER RESEARCH. 2006. 66(24):11808-11816.
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