Principal investigator
Name:
Chao-Po LinAssociate Professor , PhD, Associate Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 1994.9-1998.6, Department of Zoology, National Taiwan University, B.S.
- 2000.9-2002.6, Institute of Genetics, National Yang-Ming University, M.S.
- 2003.9-2010.1, Department of Pharmacology, Rutgers University, USA, Ph.D.
Working Experience:
- 2002.9-2003.8, Institute of Microbiology, National Taiwan University College of Medicine, Research assistant
- 2010.4-2017.3, University of California at Berkeley, USA, Postdoctoral fellow
- 2017.6-Present, ShanghaiTech Uninversity, China, Assistant Professor (TENURE-TRACK)
Group Introduction
Research Area:
Stem Cell Biology; RNA Biology
Research Interests:
Our group is interested in the function(s) of microRNAs in pluripotent stem cells, as well as the function(s) of retrotransposons in mammalian development. First, we explore the importance of the p53-microRNA axis in somatic reprogramming, or the generation of induced pluripotent stem cells (iPSCs). Second, we study the roles of microRNAs in modulating the totipotent-like cell fate potential in pluripotent stem cells, a novel potency state of pluripotent stem cells we identified recently (Science, 2017). Finally, we investigate the functional roles of retrotransposons during mammalian pre-implantation and post-implantation development.
Representative Publications (*First Author, # Corresponding Author)
- 1. Mao, Qian*; Ye, Qinying; Xu, Yiwen; Jiang, Jingwei; Fan, Yunhao; Zhuang, Lili; Liu, Guohui; Wang, Tengfei; Zhang, Zhenwu; Feng, Teng; Kong, Shuangbo; Lu, Jinhua; Zhang, Hui; Wang, Haopeng#; Lin, Chao-Po#; .Murine trophoblast organoids as a model for trophoblast development and CRISPR-Cas9 screening.DEVELOPMENTAL CELL. 18 Dec 2023. 58(24).
- 2. Wang, Tengfei*; Shi, Shuxiang*; Shi, Yuanyuan; Jiang, Peipei; Hu, Ganlu; Ye, Qinying; Shi, Zhan; Yu, Kexin; Wang, Chenguang; Fan, Guoping; Zhao, Suwen; Ma, Hanhui; Chang, Alex C. Y.; Li, Zhi; Bian, Qian#; Lin, Chao-Po#; .Chemical-induced phase transition and global conformational reorganization of chromatin.NATURE COMMUNICATIONS. 09 Sep 2023. 14(1).
- 3. Zhao, Xiaoya*; Zhang, Zhenwu; Zhu, Qian; Luo, Yurui; Ye, Qinying; Shi, Shuxiang; He, Xueyang; Zhu, Jing; Zhang, Duo; Xia, Wei; Zhang, Yiqin; Jiang, Linlin; Cui, Long; Ye, Yinghui; Xiang, Yangfei; Hu, Junhao; Zhang, Jian#; Lin, Chao-Po#; .Modeling human ectopic pregnancies with trophoblast and vascular organoids.CELL REPORTS. 27 Jun 2023. 42(6).
- 4. Zhang, Zhenwu*; Tao, Wanyu; Huang, Shisheng; Sun, Wenjun; Wang, Yue; Jiang, Wen; Huang, Xingxu#; Lin, Chao-Po#; .Engineering an adenine base editor in human embryonic stem cells with minimal DNA and RNA off-target activities.MOLECULAR THERAPY: NUCLEIC ACIDS. 13 Sep 2022. 29.
- 5. Huang, Shisheng*; Zhang, Zhenwu*; Tao, Wanyu*; Liu, Yao; Li, Xiangyang; Wang, Xiaolong; Harati, Javad; Wang, Peng-Yuan; Huang, Xingxu#; Lin, Chao -Po#; .Broadening prime editing toolkits using RNA-Pol-II-driven engineered pegRNA.MOLECULAR THERAPY. 07 Sep 2022. 30(9).
- 6. Zhang, Zhenwu*; Bao, Xinyu; Lin, Chao-Po#; .Progress and Prospects of Gene Editing in Pluripotent Stem Cells.BIOMEDICINES. 01 Aug 2023. 11(8).
- 7. Zhang, Zhenwu*; Zhuang, Lili; Lin, Chao-Po#; .Roles of MicroRNAs in Establishing and Modulating Stem Cell Potential.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Aug 2019. 20(15).
- 8. Liu, Bo*; Jing, Zhengyu; Zhang, Xiaoming; Chen, Yuxin; Mao, Shaoshuai; Kaundal, Ravinder; Zou, Yan; Wei, Ge; Zang, Ying; Wang, Xinxin; Lin, Wenyang; Di, Minghui; Sun, Yiwen; Chen, Qin; Li, Yongqin; Xia, Jing; Sun, Jianlong; Lin, Chao-Po; Huang, Xingxu; Chi, Tian#; .Large-scale multiplexed mosaic CRISPR perturbation in the whole organism.CELL. 04 Aug 2022. 185(16):3008-3024.e16.
- 9. Gao, Kaixuan*; Zhang, Xuedi; Zhang, Zhenwu; Wu, Xiangyu; Guo, Yan; Fu, Pengchong; Sun, Angyang; Peng, Ju; Zheng, Jie; Yu, Pengfei; Wang, Tengfei; Ye, Qinying; Jiang, Jingwei; Wang, Haopeng; Lin, Chao-Po; Gao, Guanjun#; .Transcription-coupled donor DNA expression increases homologous recombination for efficient genome editing.NUCLEIC ACIDS RESEARCH. Aug 2022.
- 10. Tu, Tianxiang*; Song, Zongming; Liu, Xiaoyu; Wang, Shengxing; He, Xiaoxue; Xi, Haitao; Wang, Jiahua; Yan, Tong; Chen, Haoran; Zhang, Zhenwu; Lv, Xiujuan; Lv, Jineng; Huang, Xiu-Feng; Zhao, Junzhao; Lin, Chao-Po; Gao, Caixia#; Zhang, Jinwei#; Gu, Feng#; .A precise and efficient adenine base editor.MOLECULAR THERAPY. 07 Sep 2022. 30(9).
- 11. Lu, Zhengkai*; Jiang, Zhen; Tang, Juan#; Lin, Chao-Po#; Zhang, Hui#; .Functions and origins of cardiac fat.FEBS JOURNAL. 2023. 290(7):1705-1718.
- 12. Huang, Xinyan*; Yan, Lei*; Meng, Jufeng; Liu, Nanbo; Zhu, Shuoji; Jiang, Zhen; Kou, Shan; Feng, Teng; Lin, Chao-Po; Zhou, Bin; Tang, Juan#; Zhu, Ping#; Zhang, Hui#; .Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model.SCIENCE CHINA LIFE SCIENCES. 2023. 66(1):51-66.
- 13. Gao, Zibei*; Lu, Zhengkai*; Meng, Jinyan; Lin, Chao-Po; Zhang, Hui#; Tang, Juan#; .Identification of mesenchymal-to-epithelial transition during heart regeneration through genetic lineage tracing.STEM CELL RESEARCH & THERAPY. 2023. 14(161).
- 14. Huang, Xinyan*; Yan, Lei*; Kou, Shan; Meng, Jufeng; Lu, Zhengkai; Lin, Chao-Po; Liu, Chen#; Zhang, Hui#; .Generation and characterization of a Myh6-driven Cre knockin mouse line.TRANSGENIC RESEARCH. 2021. 30(6):821-835.
- 15. Jiang, Zhen*; Feng, Teng; Lu, Zhengkai; Wei, Yuanxin; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Liu, Chen#; Zhang, Hui#; .PDGFRb+ mesenchymal cells, but not NG2+ mural cells, contribute to cardiac fat.CELL REPORTS. 2021. 34(5):108697.
- 16. Du,Ping*; Tao,Xuelian; Liu,Kun; Lin,Jiao; Shi,Yue; Park,Kwideok; Chen,Hsien Yeh; Lin,Chao Po; Chang,Junlei; Wong,Raymond CB; Pan,Haobo; Wang,Peng Yuan; .Human platelet lysate (hPL) alters the lineage commitment and paracrine functions of human mesenchymal stem cells via mitochondrial metabolism.APPLIED MATERIALS TODAY. Mar 2022. 26.
- 17. Cui, Long*; Fang, Li; Zhuang, Lili; Shi, Biwei; Lin, Chao-Po; Ye, Yinghui#; .Sperm-borne microRNA-34c regulates maternal mRNA degradation and preimplantation embryonic development in mice.REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY. 26 Apr 2023. 21(1).
- 18. Jiang, Zhen*; Lu, Zhengkai; Kou, Shan; Feng, Teng; Wei, Yuanxin; Gao, Zibei; Deng, Defang; Meng, Jufeng; Lin, Chao-Po; Zhou, Bin; Zhang, Hui#; .Overexpression of Kdr in adult endocardium induces endocardial neovascularization and improves heart function after myocardial infarction.CELL RESEARCH. 2021. 31:485-487.
- 19. Li, Hui*; Yang, Jie; Tian, Cuiping; Diao, Min; Wang, Quan; Zhao, Simeng; Li, Shanshan; Tan, Fangzhi; Hua, Tian; Qin, Ya; Lin, Chao-Po; Deska-Gauthier, Dylan; Thompson, Garth J.; Zhang, Ying; Shui, Wenqing; Liu, Zhi-Jie; Wang, Tong; Zhong, Guisheng#; .Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging.NATURE COMMUNICATIONS. 2020. 11(1):5699.
- 20. Feng, Teng*; Gao, Zibei*; Kou, Shan; Huang, Xinyan; Jiang, Zhen; Lu, Zhengkai; Meng, Jufeng; Lin, Chao-Po; Zhang, Hui#; .No Evidence for Erythro-Myeloid Progenitor-Derived Vascular Endothelial Cells in Multiple Organs.CIRCULATION RESEARCH. 2020. 127(10):1221-1232.
- 21. Lan, Yiyang*; Tao, Yong; Wang, Yunfeng; Ke, Junzi; Yang, Qiuxiang; Liu, Xiaoyi; Su, Bing; Wu, Yiling; Lin, Chao-Po; Zhong, Guisheng#; .Recent development of AAV-based gene therapies for inner ear disorders.GENE THERAPY. Aug 2020.
- 22. Huang, Xinyan*; Feng, Teng; Jiang, Zhen; Meng, Jufeng; Kou, Shan; Lu, Zhengkai; Chen, Weize; Lin, Chao-Po; Zhou, Bin; Zhang, Hui#; .Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes.JOURNAL OF BIOLOGICAL CHEMISTRY. 2019. 294(22):8894-8906.
- 23. Lin, Chao-Po*; He, Lin#; .Noncoding RNAs in Cancer Development.ANNUAL REVIEW OF CANCER BIOLOGY-SERIES. 2017. 1:163-184.
- 24. Choi, Yong Jin*; Lin, Chao-Po#; Risso, Davide; Chen, Sean; Kim, Thomas Aquinas; Tan, Meng How; Li, Jin Billy; Wu, Yalei; Chen, Caifu; Xuan, Zhenyu; Macfarlan, Todd; Peng, Weiqun; Lloyd, K. C. Kent; Kim, Sang Yong; Speed, Terence P.; He, Lin#; .Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells.SCIENCE. 2017. 355(6325).
- 25. Okada, Nobuhiro*; Lin, Chao-Po; Ribeiro, Marcelo C.; Biton, Anne; Lai, Gregory; He, Xingyue; Bu, Pengcheng; Vogel, Hannes; Jablons, David M.; Keller, Andreas C.; Wilkinson, J. Erby; He, Biao; Speed, Terry P.; He, Lin#; .A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.GENES & DEVELOPMENT. 2014. 28(5):438-450.
- 26. Lin, Chao-Po*; Choi, Yong Jin; Hicks, Geoffrey G.; He, Lin#; .The emerging functions of the p53-miRNA network in stem cell biology.CELL CYCLE. 2012. 11(11):2063-2072.
- 27. Choi, Yong Jin*; Lin, Chao-Po; Ho, Jaclyn J.; He, Xingyue; Okada, Nobuhiro; Bu, Pengcheng; Zhong, Yingchao; Kim, Sang Yong; Bennett, Margaux J.; Chen, Caifu; Ozturk, Arzu; Hicks, Geoffrey G.; Hannon, Greg J.; He, Lin#; .miR-34 miRNAs provide a barrier for somatic cell reprogramming.NATURE CELL BIOLOGY. 2011. 13(11):1353.
- 28. Lin, Chao-Po*; Ban, Yi; Lyu, Yi Lisa; Liu, Leroy F.#; .Proteasome-dependent Processing of Topoisomerase I-DNA Adducts into DNA Double Strand Breaks at Arrested Replication Forks.JOURNAL OF BIOLOGICAL CHEMISTRY. 2009. 284(41):28084-28092.
- 29. Tsai, Yuan-Chin*; Qi, Haiyan; Lin, Chao-Po; Lin, Ren-Kuo; Kerrigan, John E.; Rzuczek, Suzanne G.; LaVoie, Edmond J.; Rice, Joseph E.; Pilch, Daniel S.; Lyu, Yi Lisa; Liu, Leroy F.#; .A G-quadruplex Stabilizer Induces M-phase Cell Cycle Arrest.JOURNAL OF BIOLOGICAL CHEMISTRY. 2009. 284(34):22535-22543.
- 30. Lin, Chao-Po*; Ban, Yi; Lyu, Yi Lisa; Desai, Shyamal D.; Liu, Leroy F.#; .A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes.JOURNAL OF BIOLOGICAL CHEMISTRY. 2008. 283(30):21074-21083.
- 31. Lyu, Yi Lisa#*; Kerrigan, John E.; Lin, Chao-Po; Azarova, Anna M.; Tsai, Yuan-Chin; Ban, Yi; Liu, Leroy F.#; .Topoisomerase II beta-Mediated DNA double-strand breaks: Implications in doxorubicin cardiotoxicity and prevention by dexrazoxane.CANCER RESEARCH. 2007. 67(18):8839-8846.
- 32. Azarova, Anna M.*; Lyu, Yi Lisa; Lin, Chao-Po; Tsai, Yuan-Chin; Lau, Johnson Yiu-Nam; Wang, James C.#; Liu, Leroy F.#; .Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007. 104(26):11014-11019.
- 33. Zhang, Ailing*; Lyu, Yi Lisa; Lin, Chao-Po; Zhou, Nai; Azarova, Anna M.; Wood, Laurence M.; Liu, Leroy F.#; .A protease pathway for the repair of topoisomerase II-DNA covalent complexes.JOURNAL OF BIOLOGICAL CHEMISTRY. 2006. 281(47):35997-36003.
- 34. Qi, Haiyan#*; Lin, Chao-Po; Fu, Xuan; Wood, Laurence M.; Liu, Angela A.; Tsai, Yuan-Chin; Chen, Yongjie; Barbieri, Christopher M.; Pilch, Daniel S.; Liu, Leroy F.; .G-quadruplexes induce apoptosis in tumor cells.CANCER RESEARCH. 2006. 66(24):11808-11816.
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