Principal investigator
Name:
Zhen-Ge LuoChair Professor , PhD, Chair Professor
Position:
Dean of School of Life Science and Technology
Affiliation:
School of Life Science and Technology
Honor:
Group Introduction
Research Area:
Neural Development and Regeneration
Research Interests:
We aim to decipher molecular and cellular mechanisms underlying neural development and brain wiring and develop novel strategies targeting neurodegenerative diseases (NDD) and promoting neuronal repair after injury.
Major topics include: understanding genetic and molecular mechanisms of human cortex development and evolution; dissecting molecular and cellular mechanisms of NDD occurrence and progression; developing molecular and physiological modifiers for NDD and nerve injury. Major approaches include: 2D cultured neuronal cells and 3D cultured human brain organoids, transgenic animal models, biochemical analysis, electrophysiological recording, multi-omics, single-cell technology, bioinformatics, immunohistochemistry, and animal behavior analysis.
Representative Publications (*First Author, # Corresponding Author)
- 1. Peng-Ming Zeng*; Xin-Yao Sun; Yang Li; Wen-di Wu; Jing Huang; Dong-Dong Cao; Pin-jue Qian; Xiang-Chun Ju; Zhen-Ge Luo.Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids.Stem Cell Reports. 14 Aug 2025.
- 2. Li, Yang*; Sun, Xin-Yao; Zeng, Peng-Ming; Luo, Zhen-Ge.Neural Responses to Hypoxic Injury in a Vascularized Cerebral Organoid Model.NEUROSCIENCE BULLETIN. 22 Apr 2025.
- 3. Fu, Xiu-Qing#*#*#*; Zhan, Wen-Rong*; Tian, Wei-Ya*; Zeng, Peng-Ming; Luo, Zhen-Ge#.Comparative transcriptomic profiling reveals a role for Olig1 in promoting axon regeneration.CELL REPORTS. 12 July 2024. 43(7): 114514.
- 4. Dong, Jian*; Zhu, Xiao-Na*; Zeng, Peng-Ming; Cao, Dong-Dong; Yang, Yang; Hu, Ji; Luo, Zhen-Ge#.A hominoid-specific signaling axis regulating the tempo of synaptic maturation.CELL REPORTS. 24 July 2024. 43(8), 114548.
- 5. Xu, Peibo*; Peng, Jian*; Yuan, Tingli*; Chen, Zhaoqin*; He, Hui*; Wu, Ziyan; Li, Ting; Li, Xiaodong; Wang, Luyue; Gao, Le; Yan, Jun; Wei, Wu; Li, Chengyu#; Luo, Zhen-Ge#; Chen, Yuejun#.High-throughput mapping of single-neuron projection and molecular features by retrograde barcoded labeling.ELIFE. 23 Feb 2024. 13:e85419.
- 6. Cheng, Wei*; Huang, Jing; Fu, Xiu-Qing; Tian, Wei-Ya; Zeng, Peng-Ming; Li, Yang; Luo, Zhen-Ge#.Intrathecal delivery of AAV-NDNF ameliorates disease progression of ALS mice.MOLECULAR THERAPY. 01 Nov 2023. 31(11): 3277-3289.
- 7. Sun, Xin-Yao*; Ju, Xiang-Chun; Li, Yang; Zeng, Peng-Ming; Wu, Jian; Zhou, Ying-Ying; Shen, Li-Bing; Dong, Jian; Chen, Yue-Jun; Luo, Zhen-Ge.Generation of Vascularized Brain Organoids to Study Neurovascular Interactions.ELIFE. 04 May 2022. 11:e76707.
- 8. Ou,Min-Yi*; Xiao,Qi*; Ju,Xiang-Chun*; Zeng,Peng-Ming; Huang,Jing; Sheng,Ai-Li; Luo,Zhen-Ge.The CTNNBIP1-CLSTN1 fusion transcript regulates human neocortical development.CELL REPORTS. Jun 2021. 35(13):109290.
- 9. Hou, Qiong-Qiong*; Xiao, Qi; Sun, Xin-Yao; Ju, Xiang-Chun; Luo, Zhen-Ge.TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a.SCIENCE ADVANCES. Jan 2021. 7(3):eaba8053.
- 10. Ou, Min-Yi*; Ju, Xiang-Chun; Cai, Yi-Jun; Sun, Xin-Yao; Wang, Jun-Feng; Fu, Xiu-Qing; Sun, Qiang; Luo, Zhen-Ge.Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.DEVELOPMENT. May 2020. 147(10).
- 11. Fu, Xiu-Qing*; Peng, Jian; Wang, Ai-Hua; Luo, Zhen-Ge.Tumor necrosis factor alpha mediates neuromuscular synapse elimination.CELL DISCOVERY. 03 Mar 2020. 6(1).
- 12. Peng, Jian*; Sheng, Ai-li; Xiao, Qi; Shen, Libing; Ju, Xiang-Chun; Zhang, Min; He, Si-Ting; Wu, Chao; Luo, Zhen-Ge.Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum.JOURNAL OF MOLECULAR CELL BIOLOGY. 2019. 11(8):636-648.
- 13. Wu, Kong-Yan*; Zuo, Guo-Long*; Li, Xiao-Feng*; Ye, Qing; Deng, Yong-Qiang; Huang, Xing-Yao; Cao, Wu-Chun; Qin, Cheng-Feng; Luo, Zhen-Ge.Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice.CELL RESEARCH. Jun 2016. 26(6):645-654.
- 14. Ju, Xiang-Chun*; Hou, Qiong-Qiong*; Sheng, Ai-Li; Wu, Kong-Yan; Zhou, Yang; Jin, Ying; Wen, Tieqiao; Yang, Zhengang; Wang, Xiaoqun; Luo, Zhen-Ge.The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.ELIFE. 09 Aug 2016. 5.
- 15. He, Miao*; Ding, Yue-Tong*; Chu, Chen; Tang, Jing; Xiao, Qi; Luo, Zhen-Ge.Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016. 113(40):11324-11329.
- 16. Wang, Jin-Yuan*; Chen, Fei*; Fu, Xiu-Qing; Ding, Chuang-Shi; Zhou, Li; Zhang, Xiao-Hui; Luo, Zhen-Ge.Caspase-3 Cleavage of Dishevelled Induces Elimination of Postsynaptic Structures.DEVELOPMENTAL CELL. 31 Mar 2014. 28(6):670-684.
- 17. Wu, Kong-Yan*; He, Miao; Hou, Qiong-Qiong; Sheng, Ai-Li; Yuan, Lei; Liu, Fei; Liu, Wen-Wen; Li, Guangpu; Jiang, Xing-Yu; Luo, Zhen-Ge.Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections.SCIENCE SIGNALING. 2014. 7(340).
- 18. Deng, Cai-Yun*; Lei, Wen-Liang; Xu, Xiao-Hui; Ju, Xiang-Chun; Liu, Yang; Luo, Zhen-Ge.JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization.JOURNAL OF NEUROSCIENCE. 2014. 34(5):1710-1723.
- 19. Lei, Wen-Liang*; Xing, Shi-Ge; Deng, Cai-Yun; Ju, Xiang-Chun; Jiang, Xing-Yu; Luo, Zhen-Ge.Laminin/beta 1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization.CELL RESEARCH. 2012. 22(6):954-972.
- 20. Liang, Bin*; Duan, Bao-Yu; Zhou, Xiu-Ping; Gong, Jia-Xin; Luo, Zhen-Ge.Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease.JOURNAL OF BIOLOGICAL CHEMISTRY. 2010. 285(36):27737-27744.
- 21. Zhang, Xian*; Zhu, Ji*; Yang, Guo-Ying*; Wang, Qing-Jie*; Qian, Lei; Chen, Yan-Min; Chen, Fei; Tao, Yu; Hu, Han-Song; Wang, Tong; Luo, Zhen-Ge.Dishevelled promotes axon differentiation by regulating atypical protein kinase C.NATURE CELL BIOLOGY. 2007. 9(7):743.
- 22. Chen, Fei*; Qian, Lei*; Yang, Zhi-Hua; Huang, Ying; Ngo, Shyuan T.; Ruan, Nan-Jie; Wang, Jia; Schneider, Claudio; Noakes, Peter G.; Ding, Yu-Qiang; Mei, Lin; Luo, Zhen-Ge.Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction.NEURON. 2007. 55(2):247-260.
- 23. Chen, Y. M.*; Wang, Q. J.; Hu, H. S.; Yu, P. C.; Zhu, J.; Drewes, G.; Piwnica-Worms, H.; Luo, Z. G..Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006. 103(22):8534-8539.
- 24. Luo, Z.G.*; Wang, Q.*; Zhou, J.Z.; Wang, J.; Luo, Z.; Liu, M.; He, X.; Wynshaw-Boris, A.; Xiong, W. C.,; Lu, B.; Mei, L..Regulation of AchR clustering by Dishevelled Interacting with MuSK and PAK1.NEURON. 2002. 35(3):489-505.
- 25. Luo, Z.G.*; Je, H.S.; Wang, Q.; Yang, F.; Clem Dobbins, G.; Yang, Z.H.; Xiong, W.C.; Lu, B.; Mei, L..Implication of Geranylgeranyltransferase in Synapse Formation.NEURON. 2003. 40(4):703-717.
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