Principal investigator
Name:
Zhen-Ge LuoProfessor , PhD, Professor
Position:
Executive Dean of School of Life Science and Technology
Affiliation:
School of Life Science and Technology
Honor:
Group Introduction
Research Area:
Neural Development and Regeneration
Research Interests:
We aim to decipher molecular and cellular mechanisms underlying neural development and brain wiring and develop novel strategies targeting neurodegenerative diseases (NDD) and promoting neuronal repair after injury.
Major topics include: understanding genetic and molecular mechanisms of human cortex development and evolution; dissecting molecular and cellular mechanisms of NDD occurrence and progression; developing molecular and physiological modifiers for NDD and nerve injury. Major approaches include: 2D cultured neuronal cells and 3D cultured human brain organoids, transgenic animal models, biochemical analysis, electrophysiological recording, multi-omics, single-cell technology, bioinformatics, immunohistochemistry, and animal behavior analysis.
Representative Publications (*First Author, # Corresponding Author)
- 1. Cheng, Wei*; Huang, Jing; Fu, Xiu-Qing; Tian, Wei-Ya; Zeng, Peng-Ming; Li, Yang; Luo, Zhen-Ge#.Intrathecal delivery of AAV-NDNF ameliorates disease progression of ALS mice.MOLECULAR THERAPY. 01 Nov 2023. 31(11): 3277-3289.
- 2. Sun, Xin-Yao*; Ju, Xiang-Chun#; Li, Yang; Zeng, Peng-Ming; Wu, Jian; Zhou, Ying-Ying; Shen, Li-Bing; Dong, Jian; Chen, Yue-Jun; Luo, Zhen-Ge#.Generation of Vascularized Brain Organoids to Study Neurovascular Interactions.ELIFE. 04 May 2022. 11:e76707.
- 3. Ou,Min-Yi*; Xiao,Qi*; Ju,Xiang-Chun#*; Zeng,Peng-Ming; Huang,Jing; Sheng,Ai-Li; Luo,Zhen-Ge#.The CTNNBIP1-CLSTN1 fusion transcript regulates human neocortical development.CELL REPORTS. Jun 2021. 35(13):109290.
- 4. Hou, Qiong-Qiong*; Xiao, Qi; Sun, Xin-Yao; Ju, Xiang-Chun; Luo, Zhen-Ge#.TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a.SCIENCE ADVANCES. Jan 2021. 7(3):eaba8053.
- 5. Ou, Min-Yi*; Ju, Xiang-Chun; Cai, Yi-Jun; Sun, Xin-Yao; Wang, Jun-Feng; Fu, Xiu-Qing; Sun, Qiang; Luo, Zhen-Ge#.Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.DEVELOPMENT. May 2020. 147(10).
- 6. Fu, Xiu-Qing*; Peng, Jian; Wang, Ai-Hua; Luo, Zhen-Ge#.Tumor necrosis factor alpha mediates neuromuscular synapse elimination.CELL DISCOVERY. 03 Mar 2020. 6(1).
- 7. Peng, Jian*; Sheng, Ai-li; Xiao, Qi; Shen, Libing; Ju, Xiang-Chun; Zhang, Min; He, Si-Ting; Wu, Chao; Luo, Zhen-Ge#.Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum.JOURNAL OF MOLECULAR CELL BIOLOGY. 2019. 11(8):636-648.
- 8. Wu, Kong-Yan*; Zuo, Guo-Long*; Li, Xiao-Feng*; Ye, Qing; Deng, Yong-Qiang; Huang, Xing-Yao; Cao, Wu-Chun; Qin, Cheng-Feng#; Luo, Zhen-Ge#.Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice.CELL RESEARCH. Jun 2016. 26(6):645-654.
- 9. Ju, Xiang-Chun*; Hou, Qiong-Qiong*; Sheng, Ai-Li; Wu, Kong-Yan; Zhou, Yang; Jin, Ying; Wen, Tieqiao; Yang, Zhengang; Wang, Xiaoqun; Luo, Zhen-Ge#.The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.ELIFE. 09 Aug 2016. 5.
- 10. He, Miao*; Ding, Yue-Tong*; Chu, Chen; Tang, Jing; Xiao, Qi; Luo, Zhen-Ge#.Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016. 113(40):11324-11329.
- 11. Xu, Xiao-Hui*; Deng, Cai-Yun*; Liu, Yang; He, Miao; Peng, Jian; Wang, Tong; Yuan, Lei; Zheng, Zhi-Sheng; Blackshear, Perry J.; Luo, Zhen-Ge#.MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development.CELL RESEARCH. May 2014. 24(5):576-594.
- 12. Wang, Jin-Yuan*; Chen, Fei*; Fu, Xiu-Qing; Ding, Chuang-Shi; Zhou, Li; Zhang, Xiao-Hui; Luo, Zhen-Ge#.Caspase-3 Cleavage of Dishevelled Induces Elimination of Postsynaptic Structures.DEVELOPMENTAL CELL. 31 Mar 2014. 28(6):670-684.
- 13. Wu, Kong-Yan*; He, Miao; Hou, Qiong-Qiong; Sheng, Ai-Li; Yuan, Lei; Liu, Fei; Liu, Wen-Wen; Li, Guangpu; Jiang, Xing-Yu; Luo, Zhen-Ge#.Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections.SCIENCE SIGNALING. 2014. 7(340).
- 14. Deng, Cai-Yun*; Lei, Wen-Liang; Xu, Xiao-Hui; Ju, Xiang-Chun; Liu, Yang; Luo, Zhen-Ge#.JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization.JOURNAL OF NEUROSCIENCE. 2014. 34(5):1710-1723.
- 15. Liu, Yang*; Xu, Xiao-Hui; Chen, Qi; Wang, Tong; Deng, Cai-Yun; Song, Bao-Liang; Du, Jiu-Lin; Luo, Zhen-Ge#.Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development..NATURE COMMUNICATIONS. 2013. 4:2005.
- 16. Lei, Wen-Liang*; Xing, Shi-Ge; Deng, Cai-Yun; Ju, Xiang-Chun; Jiang, Xing-Yu; Luo, Zhen-Ge#.Laminin/beta 1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization.CELL RESEARCH. 2012. 22(6):954-972.
- 17. Yang, Guo-Ying*; Liang, Bin*; Zhu, Ji; Luo, Zhen-Ge#.Calpain Activation by Wingless-type Murine Mammary Tumor Virus Integration Site Family, Member 5A (Wnt5a) Promotes Axonal Growth.JOURNAL OF BIOLOGICAL CHEMISTRY. 2011. 286(8):6566-6576.
- 18. Wang, Tong*; Liu, Yang*; Xu, Xiao-Hui; Deng, Cai-Yun; Wu, Kong-Yan; Zhu, Ji; Fu, Xiu-Qing; He, Miao; Luo, Zhen-Ge#.Lgl1 Activation of rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization.DEVELOPMENTAL CELL. 13 Sep 2011. 21(3):431-44.
- 19. Wang, Jia*; Fu, Xiu-Qing*; Lei, Wen-Liang; Wang, Tong; Sheng, Ai-Li; Luo, Zhen-Ge#.Nuclear Factor Kappa B Controls AChR Clustering by Regulating Rapsyn Expression at the Neuromuscular Junction.JOURNAL OF NEUROSCIENCE. 2010. 30(33):11104-11113.
- 20. Liang, Bin*; Duan, Bao-Yu; Zhou, Xiu-Ping; Gong, Jia-Xin; Luo, Zhen-Ge#.Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease.JOURNAL OF BIOLOGICAL CHEMISTRY. 2010. 285(36):27737-27744.
- 21. Zhou, Xiu-Ping*; Wu, Kong-Yan; Liang, Bin; Fu, Xiu-Qing; Luo, Zhen-Ge#.TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008. 105(44):17181-17186.
- 22. Wang, Jia*; Ruan, Nan-Jie; Qian, Lei; Lei, Wen-Liang; Chen, Fei; Luo, Zhen-Ge#.Wnt/beta-catenin signaling suppresses Rapsyn expression and inhibits acetylcholine receptor clustering at the neuromuscular junction.JOURNAL OF BIOLOGICAL CHEMISTRY. 2008. 283(31):21668-21675.
- 23. Zhang, Xian*; Zhu, Ji*; Yang, Guo-Ying*; Wang, Qing-Jie*; Qian, Lei; Chen, Yan-Min; Chen, Fei; Tao, Yu; Hu, Han-Song; Wang, Tong; Luo, Zhen-Ge#.Dishevelled promotes axon differentiation by regulating atypical protein kinase C.NATURE CELL BIOLOGY. 2007. 9(7):743.
- 24. Chen, Fei*; Qian, Lei*; Yang, Zhi-Hua; Huang, Ying; Ngo, Shyuan T.; Ruan, Nan-Jie; Wang, Jia; Schneider, Claudio; Noakes, Peter G.; Ding, Yu-Qiang; Mei, Lin; Luo, Zhen-Ge#.Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction.NEURON. 2007. 55(2):247-260.
- 25. Chen, Y. M.*; Wang, Q. J.; Hu, H. S.; Yu, P. C.; Zhu, J.; Drewes, G.; Piwnica-Worms, H.; Luo, Z. G.#.Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006. 103(22):8534-8539.
- 26. Luo, Z.G.*; Wang, Q.*; Zhou, J.Z.; Wang, J.; Luo, Z.; Liu, M.; He, X.; Wynshaw-Boris, A.; Xiong, W. C.,; Lu, B.; Mei, L.#.Regulation of AchR clustering by Dishevelled Interacting with MuSK and PAK1.NEURON. 2002. 35(3):489-505.
- 27. Luo, Z.G.*; Je, H.S.; Wang, Q.; Yang, F.; Clem Dobbins, G.; Yang, Z.H.; Xiong, W.C.; Lu, B.; Mei, L.#.Implication of Geranylgeranyltransferase in Synapse Formation.NEURON. 2003. 40(4):703-717.
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