Principal investigator
Name:
Zhijie LiuChair Professor , PhD, Chair Professor
Position:
Executive Director of iHuman Institute
Affiliation:
School of Life Science and Technology, iHuman Institute
Honor:
Education Background:
- 1980-1984, Tianjin Normal University, B.Sc.
- 1985-1987, Tianjin University, M.Sc.
- 1988-1994, Institute of Biophysics, Chinese Academy of Sciences, Ph.D.
Working Experience:
- 1995-1995, Department of Crystallography, University of Pittsburgh, Postdoctoral Fellow
- 1995-1997, Department of Biochemistry & Molecular Biology, University of Georgia, Postdoctoral Fellow
- 1997-2002, Department of Biochemistry & Molecular Biology, University of Georgia, Assistant Research Scientist
- 2002-2005, Southeast Collaboratory for Structural Genomics (SECSG), Department of Biochemistry & Molecular Biology, University of Georgia, Associate Research Scientist
- 2005-2013, Institute of Biophysics, Chinese Academy of Sciences, Professor
- 2013-2024, iHuman Institute, ShanghaiTech University, Professor, Executive Director
- 2024/12-Present, iHuman Institute, ShanghaiTech University, Chair Professor, Executive Director
Group Introduction
Research Area:
Structural Biology
Research Interests:
(1) Structural and functional analysis of proteins and multi-protein complexes in innate immune signaling pathway; (2) Structural proteomics of human liver disease related proteins and structure based drug design; (3) Development of new methods and new technologies in protein X-ray crystallography.
Representative Publications (*First Author, # Corresponding Author)
- 1. Xiaolong Hu*#; Weizhen Ao*#; Mingxin Gao*#; Lijie Wu*#; Yuan Pei; Shenhui Liu; Yiran Wu; Fei Zhao; Qianqian Sun; Junlin Liu; Longquan Jiang; Xin Wang; Yan Li; Qiwen Tan; Jie Cheng; Fan Yang; Chi Yang#*; Jinpeng Sun#*; Tian Hua#*; Zhi-Jie Liu#*.Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.Nature. 2024.
- 2. Yuxia Wang*; Lijie Wu*; Tian Wang*; Junlin Liu; Fei Li; Longquan Jiang; Zhongbo Fan; Yanan Yu; Na Chen; Qianqian Sun; Qiwen Tan; Tian Hua#; Zhi-Jie Liu#.Cryo-EM structure of cannabinoid receptor CB1-β- arrestin complex.PROTEIN & CELL. 2024. 15(3): 230-234.
- 3. Yang Yang*; Hye Jin Kang*; Ruogu Gao*; Jingjing Wang; Gye Won Han; Jeffrey F. DiBerto; Lijie Wu; Jiahui Tong; Lu Qu; Yiran Wu; Ryan Pileski; Xuemei Li; Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin; Quan Wang; Raymond C. Stevens; Wei Peng; Bryan L. Roth#; Zihe Rao#; Zhi-Jie Liu#.Structural insights into the human niacin receptor HCA2-Gi signalling complex.NATURE COMMUNICATIONS. 2023. 14(1): 1692.
- 4. Li, Xiaoting*; Chang, Hao*; Bouma, Jara*; de Paus, Laura V.; Mukhopadhyay, Partha; Paloczi, Janos; Mustafa, Mohammed; van der Horst, Cas; Kumar, Sanjay Sunil; Wu, Lijie; Yu, Yanan; van den Berg, Richard J. B. H. N.; Janssen, Antonius P. A.; Lichtman, Aron; Liu, Zhi-Jie#; Pacher, Pal#; van der Stelt, Mario#; Heitman, Laura H.#; Hua, Tian#; .Structural basis of selective cannabinoid CB2 receptor activation.NATURE COMMUNICATIONS. 15 Mar 2023. 14(1).
- 5. Li, Hao*; Zhang, Jinyi; Yu, Yanan; Luo, Feng; Wu, Lijie; Liu, Junlin; Chen, Na; Liu, Zhijie#; Hua, Tian; .Structural insight into the constitutive activity of human orphan receptor GPR12.SCIENCE BULLETIN. 15 Jan 2023. 68(1):95-104.
- 6. Xu, Weixiu*; Wu, Lijie; Liu, Shenhui; Liu, Xiao; Cao, Xiaoling; Zhou, Cui; Zhang, Jinyi; Fu, You; Guo, Yu; Wu, Yiran; Tan, Qiwen; Wang, Ling; Liu, Junlin; Jiang, Longquan; Fan, Zhongbo; Pei, Yuan; Yu, Jingyi; Cheng, Jianjun; Zhao, Suwen; Hao, Xiaojiang; Liu, Zhi-Jie#; Hua, Tian#; .Structural basis for strychnine activation of human bitter taste receptor TAS2R46.SCIENCE. 16 Sep 2022. 377(6612).
- 7. Zhou, Yali*; Daver, Henrik; Trapkov, Boris; Wu, Lijie; Wu, Meng; Harpsoe, Kasper; Gentry, Patrick R.; Liu, Kaiwen; Larionova, Marina; Liu, Junlin; Chen, Na; Brauner-Osborne, Hans#; Gloriam, David E.#; Hua, Tian#; Liu, Zhi-Jie#; .Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139.CELL RESEARCH. Feb 2022.
- 8. Liu, Kaiwen*; Shen, Ling*; Wu, Meng; Liu, Zhi-Jie#; Hua, Tian#; .Structural insights into the activation of chemokine receptor CXCR2.FEBS JOURNAL. Jan 2022.
- 9. Zhang, Jinyi*; Qu, Lu; Wu, Lijie; Tang, Xiaomeng; Luo, Feng; Xu, Weixiu; Xu, Yueming; Liu, Zhi-Jie#; Hua, Tian#; .Structural insights into the activation initiation of full-length mGlu1.PROTEIN & CELL. Aug 2021.
- 10. Li, Xiaoting*; Shen, Ling; Hua, Tian#; Liu, Zhi-Jie#; .Structural and Functional Insights into Cannabinoid Receptors.TRENDS IN PHARMACOLOGICAL SCIENCES. Sep 2020. 41(9):665-677.
- 11. Liu, Kaiwen*; Wu, Lijie; Yuan, Shuguang; Wu, Meng; Xu, Yueming; Sun, Qianqian; Li, Shu; Zhao, Suwen; Hua, Tian#; Liu, Zhi-Jie#; .Structural basis of CXC chemokine receptor 2 activation and signalling.NATURE. 03 Sep 2020.
- 12. Wang, Jingjing*; Hua, Tian#; Liu, Zhi-Jie#; .Structural features of activated GPCR signaling complexes.CURRENT OPINION IN STRUCTURAL BIOLOGY. Aug 2020. 63:82-89.
- 13. Hua, Tian#*; Li, Xiaoting; Wu, Lijie; Iliopoulos-Tsoutsouvas, Christos; Wang, Yuxia; Wu, Meng; Shen, Ling; Johnston, Christina A.; Nikas, Spyros P.; Song, Feng; Song, Xiyong; Yuan, Shuguang; Sun, Qianqian; Wu, Yiran; Jiang, Shan; Grim, Travis W.; Benchama, Othman; Stahl, Edward L.; Zvonok, Nikolai; Zhao, Suwen; Bohn, Laura M.; Makriyannis, Alexandros; Liu, Zhi-Jie#; .Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G(i) Complex Structures.CELL. 20 Feb 2020. 180(4):655-+.
- 14. Li, Xiaoting*; Hua, Tian; Vemuri, Kiran; Ho, Jo-Hao; Wu, Yiran; Wu, Lijie; Popov, Petr; Benchama, Othman; Zvonok, Nikolai; Locke, K'ara; Qu, Lu; Han, Gye Won; Iyer, Malliga R.; Cinar, Resat; Coffey, Nathan J.; Wang, Jingjing; Wu, Meng; Katritch, Vsevolod; Zhao, Suwen; Kunos, George; Bohn, Laura M.; Makriyannis, Alexandros; Stevens, Raymond C.; Liu, Zhi-Jie#; .Crystal Structure of the Human Cannabinoid Receptor CB2.CELL. 24 Jan 2019. 176(3):459-+.
- 15. Peng, Yao*; McCorvy, John D.; Harpsoe, Kasper; Lansu, Katherine; Yuan, Shuguang; Popov, Petr; Qu, Lu; Pu, Mengchen; Che, Tao; Nikolajsen, Louise F.; Huang, Xi-Ping; Wu, Yiran; Shen, Ling; Bjorn-Yoshimoto, Walden E.; Ding, Kang; Wacker, Daniel; Han, Gye Won; Cheng, Jianjun; Katritch, Vsevolod; Jensen, Anders A.; Hanson, Michael A.; Zhao, Suwen; Gloriam, David E.; Roth, Bryan L.#; Stevens, Raymond C.#; Liu, Zhi-Jie#; .5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.CELL. 08 Feb 2018. 172(4):719-+.
- 16. Hua, Tian*; Vemuri, Kiran; Nikas, Spyros P.; Laprairie, Robert B.; Wu, Yiran; Qu, Lu; Pu, Mengchen; Korde, Anisha; Jiang, Shan; Ho, Jo-Hao; Han, Gye Won; Ding, Kang; Li, Xuanxuan; Liu, Haiguang; Hanson, Michael A.; Zhao, Suwen#; Bohn, Laura M.#; Makriyannis, Alexandros#; Stevens, Raymond C.; Liu, Zhi-Jie#; .Crystal structures of agonist-bound human cannabinoid receptor CB1.NATURE. 27 Jul 2017. 547(7664):468-+.
- 17. Song, Gaojie*; Yang, Dehua; Wang, Yuxia; de Graaf, Chris; Zhou, Qingtong; Jiang, Shanshan; Liu, Kaiwen; Cai, Xiaoqing; Dai, Antao; Lin, Guangyao; Liu, Dongsheng; Wu, Fan; Wu, Yiran; Zhao, Suwen; Ye, Li; Han, Gye Won; Lau, Jesper; Wu, Beili; Hanson, Michael A.; Liu, Zhi-Jie#; Wang, Ming-Wei#; Stevens, Raymond C.#; .Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.NATURE. 08 Jun 2017. 546(7657):312-+.
- 18. Hua, Tian*; Vemuri, Kiran; Pu, Mengchen; Qu, Lu; Han, Gye Won; Wu, Yiran; Zhao, Suwen; Shui, Wenqing; Li, Shanshan; Korde, Anisha; Laprairie, Robert B.; Stahl, Edward L.; Ho, Jo-Hao; Zvonok, Nikolai; Zhou, Han; Kufareva, Irina; Wu, Beili; Zhao, Qiang; Hanson, Michael A.; Bohn, Laura M.; Makriyannis, Alexandros; Stevens, Raymond C.; Liu, Zhi-Jie#; .Crystal Structure of the Human Cannabinoid Receptor CB1.CELL. 2016. 167(3):750-762.
- 19. Liu, Bing*; Ouyang, Songying; Makarova, Kira S.; Xia, Qiu; Zhu, Yanping; Li, Zhimeng; Guo, Li; Koonin, Eugene V.; Liu, Zhi-Jie; Huang, Li; .A primase subunit essential for efficient primer synthesis by an archaeal eukaryotic-type primase.NATURE COMMUNICATIONS. 2015. 6:-.
- 20. Zhao, Lixia*; Hua, Tian; Crowley, Christopher; Ru, Heng; Ni, Xiangmin; Shaw, Neil; Jiao, Lianying; Ding, Wei; Qu, Lu; Hung, Li-Wei; Huang, Wei; Liu, Lei; Ye, Keqiang; Ouyang, Songying; Cheng, Genhong; Liu, Zhi-Jie#; .Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.CELL RESEARCH. Mar 2014. 24(3):344-358.
- 21. Niu, Fengfeng*; Shaw, Neil; Wang, Yao E.; Jiao, Lianying; Ding, Wei; Li, Xiaomin; Zhu, Ping; Upur, Halmurat; Ouyang, Songying; Cheng, Genhong; Liu, Zhi-jie; .Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013. 110(22):9054-9059.
- 22. Ru, Heng*; Ni, Xiangmin; Zhao, Lixia; Crowley, Christopher; Ding, Wei; Hung, Li-Wei; Shaw, Neil; Cheng, Genhong; Liu, Zhi-Jie; .Structural basis for termination of AIM2-mediated signaling by p202.CELL RESEARCH. 2013. 23(6):855-858.
- 23. Ouyang, Songying*; Song, Xianqiang; Wang, Yaya; Ru, Heng; Shaw, Neil; Jiang, Yan; Niu, Fengfeng; Zhu, Yanping; Qiu, Weicheng; Parvatiyar, Kislay; Li, Yang; Zhang, Rongguang; Cheng, Genhong; Liu, Zhi-Jie; .Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding.IMMUNITY. 2012. 36(6):1073-1086.
- 24. Wu, Dong*; Li, Yang; Song, Gaojie; Cheng, Chongyun; Zhang, Rongguang; Joachimiak, Andrzej; Shaw, Neil#; Liu, Zhi-Jie#; .Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues.CANCER RESEARCH. 2009. 69(18):7294-7301.
- 25. Shaw, Neil*; Zhao, Min; Cheng, Chongyun; Xu, Hao; Saarikettu, Juha; Li, Yang; Da, Yurong; Yao, Zhi; Silvennoinen, Olli; Yang, Jie; Liu, Zhi-Jie; Wang, Bi-Cheng; Rao, Zihe; .The multifunctional human p100 protein 'hooks' methylated ligands.NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2007. 14(8):779-784.
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