课题组长
姓名：
孙兵中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院分子细胞科学卓越创新中心
荣誉称号：
博士后及工作经历：
- 1991/02—1994/01，上海第一医科大学，任讲师和副教授
- 1994/2—1998/5，美国国立卫生研究院，博士后和高级访问学者
- 1998/5—至今，中国科学院上海细胞所和生化所，课题组长
- 2006/4—2016/12，中科院上海巴斯德研究所，中方所长和分子病毒课题组长
- 2013/9—至今，上海科技大学，特聘教授
- 2019/10—至今，中国免疫学学会，副理事长
课题组简介
研究内容：
1.实验室用单细胞RT-PCR技术制备全人抗体，发展抗病毒和肿瘤抗体药物。实验室已成功制备了全人广谱抗流感抗体、全人抗RSV、HCV和新冠病毒中和抗体，以及抗肿瘤CD47抗体。 2.利用ECM1基因剔除小鼠，诱发自发性肝纤维化。重点关注于ECM1对肝星状细胞活化的调控机制和发展抗肝纤维化新的药物。
代表性论文（*第一作者，#通讯作者）
- 1. Yi, Chunyan*; Sun, Xiaoyu; Ye, Jing; Ding, Longfei; Liu, Meiqin; Yang, Zhuo; Lu, Xiao; Zhang, Yaguang; Ma, Liyang; Gu, Wangpeng; Qu, Aidong; Xu, Jianqing; Shi, Zhengli#; Ling, Zhiyang#; Sun, Bing#.Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies.CELLULAR & MOLECULAR IMMUNOLOGY. 15 May 2020.
- 2. Fan, Weiguo*; Liu, Tianhui; Chen, Wen; Hammad, Seddik; Longerich, Thomas; Hausser, Ingrid; Fu, Yadong; Li, Nan; He, Yajing; Liu, Cui; Zhang, Yaguang; Lian, Qiaoshi; Zhao, Xinhao; Yan, Chenghua; Li, Li; Yi, Chunyan; Ling, Zhiyang; Ma, Liyan; Zhao, Xinyan; Xu, Hufeng; Wang, Ping; Cong, Min; You, Hong; Liu, Zhihong; Wang, Yan; Chen, Jianfeng; Li, Dangsheng; Hui, Lijian; Dooley, Steven#; Hou, Jinlin#; Jia, Jidong#; Sun, Bing#.ECM1 Prevents Activation of Transforming Growth Factor beta, Hepatic Stellate Cells, and Fibrogenesis in Mice.GASTROENTEROLOGY. Nov 2019. 157(5):1352-+.
- 3. He, Lan*; Gu, Wangpeng; Wang, Meng; Chang, Xiaoyan; Sun, Xiaoyu; Zhang, Yuan; Lin, Xuan; Yan, Chenghua; Fan, Weiguo; Su, Pan; Wang, Yanming; Yi, Chunyan; Lin, Guomei; Li, Li; Jiang, Yu; Lu, Junxia; Dong, Chen; Wang, Haikun#; Sun, Bing#.Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 21 Aug 2018. 115(34):8621-8626.
- 4. Li, Zhenhu*; Zhang, Yuan; Liu, Zhiduo; Wu, Xiaodong; Zheng, Yuhan; Tao, Zhiyun; Mao, Kairui; Wang, Jie; Lin, Guomei; Tian, Lin; Ji, Yongyong; Qin, Meiling; Sun, Shuhui; Zhu, Xueliang; Sun, Bing#.ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1).NATURE IMMUNOLOGY. 2011. 12(2):178.
- 5. Yang, Xuexian O.#*; Angkasekwinai, Pornpimon; Zhu, Jinfang; Peng, Juan; Liu, Zhiduo; Nurieva, Roza; Liu, Xikui; Chung, Yeonseok; Chang, Seon Hee; Sun, Bing#; Dong, Chen#.Requirement for the basic helix-loop-helix transcription factor Dec2 in initial T(H)2 lineage commitment.NATURE IMMUNOLOGY. 2009. 10(12):1260.
- 6. Shi, Mude*; Deng, Weiwen; Bi, Enguang; Mao, Kairui; Ji, Yongyong; Lin, Guomei; Wu, Xiaodong; Tao, Zhiyun; Li, Zhenhu; Cai, Xinfen; Sun, Shuhui; Xiang, Charlie#; Sun, Bing#.TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation.NATURE IMMUNOLOGY. 2008. 9(4):369-377.
奖励
- 1. 2012，上海市自然科学二等奖
- 2. 2013，国家自然科学二等奖
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