英文信息

Principal investigator

Name:

Bing SunDistinguished Adjunct Professor from CAS , PhD, Distinguished Adjunct Professor from CAS

Position:

Affiliation:

School of Life Science and Technology, Shanghai Institute of Biochemistry and Cell Biology, CAS

Honor:

Education Background:

Working Experience:

1991/2-1994/1, Shanghai First Medical University, Lecture and associate Professor
1994/2-1998/5, National Institutes of Health (NIH), USA, Postdoctoral training
1998/5-Now, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. Shanghai, P. R. China, Professor, Chief, Lab of Molecular Immunology
2005/5-2016/12, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Chief, Lab of molecular virology
2013/9-Now, ShanghaiTech University, Guest Professor
2019/10-Now, Chinese Society of Immunology, Vice Chairman

Group Introduction

Research Area:

Molecular Immunology, Molecular Virus

Research Interests:

1.We used single-cell RT-PCR technology to prepare fully human antibodies and we have developed antiviral and tumor antibody drugs. The laboratory has successfully generated humanized anti-tumor CD47 antibody, and fully human neutralizing antibodies against Influenza, RSV, HCV and Novel-coronavirus 2019 .

2.The knock out mice with ECM1 gene were used to induce spontaneous liver fibrosis. To study the regulation mechanism of ECM1 on the activation of hepatic stellate cells and develop new anti-liver fibrosis drugs.

Group Website:

Research Achievement

1. Antibody drugs play an important role in tumor treatment and viral infections. The laboratory uses single-cell technology to isolate antigen-activated B cells from human peripheral blood, and generates specific fully human neutralizing antibodies against influenza virus, RSV, HCV and novel coronavirus-2019. It is currently cooperating with companies for translational research and clinical applications.

2. On the basis of nearly 15 years of work in the laboratory, it was innovatively discovered that ECM1 (extracellular matrix protein 1) is secreted by liver parenchymal cells and inhibits the maturation of TGF-b in the liver sinusoids, thereby inhibiting hepatic stellate cells. ECM1 can inhibit the occurrence and development of liver fibrosis, and can be used as a drug target for anti-liver fibrosis.

Representative Publications (*First Author, # Corresponding Author)

1. Yi, Chunyan*; Sun, Xiaoyu; Ye, Jing; Ding, Longfei; Liu, Meiqin; Yang, Zhuo; Lu, Xiao; Zhang, Yaguang; Ma, Liyang; Gu, Wangpeng; Qu, Aidong; Xu, Jianqing; Shi, Zhengli^#; Ling, Zhiyang^#; Sun, Bing^#.Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies.CELLULAR & MOLECULAR IMMUNOLOGY. 15 May 2020.
2. Fan, Weiguo*; Liu, Tianhui; Chen, Wen; Hammad, Seddik; Longerich, Thomas; Hausser, Ingrid; Fu, Yadong; Li, Nan; He, Yajing; Liu, Cui; Zhang, Yaguang; Lian, Qiaoshi; Zhao, Xinhao; Yan, Chenghua; Li, Li; Yi, Chunyan; Ling, Zhiyang; Ma, Liyan; Zhao, Xinyan; Xu, Hufeng; Wang, Ping; Cong, Min; You, Hong; Liu, Zhihong; Wang, Yan; Chen, Jianfeng; Li, Dangsheng; Hui, Lijian; Dooley, Steven^#; Hou, Jinlin^#; Jia, Jidong^#; Sun, Bing^#.ECM1 Prevents Activation of Transforming Growth Factor beta, Hepatic Stellate Cells, and Fibrogenesis in Mice.GASTROENTEROLOGY. Nov 2019. 157(5):1352-+.
3. He, Lan*; Gu, Wangpeng; Wang, Meng; Chang, Xiaoyan; Sun, Xiaoyu; Zhang, Yuan; Lin, Xuan; Yan, Chenghua; Fan, Weiguo; Su, Pan; Wang, Yanming; Yi, Chunyan; Lin, Guomei; Li, Li; Jiang, Yu; Lu, Junxia; Dong, Chen; Wang, Haikun^#; Sun, Bing^#.Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 21 Aug 2018. 115(34):8621-8626.
4. Li, Zhenhu*; Zhang, Yuan; Liu, Zhiduo; Wu, Xiaodong; Zheng, Yuhan; Tao, Zhiyun; Mao, Kairui; Wang, Jie; Lin, Guomei; Tian, Lin; Ji, Yongyong; Qin, Meiling; Sun, Shuhui; Zhu, Xueliang; Sun, Bing^#.ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1).NATURE IMMUNOLOGY. 2011. 12(2):178.
5. Yang, Xuexian O.^#*; Angkasekwinai, Pornpimon; Zhu, Jinfang; Peng, Juan; Liu, Zhiduo; Nurieva, Roza; Liu, Xikui; Chung, Yeonseok; Chang, Seon Hee; Sun, Bing^#; Dong, Chen^#.Requirement for the basic helix-loop-helix transcription factor Dec2 in initial T(H)2 lineage commitment.NATURE IMMUNOLOGY. 2009. 10(12):1260.
6. Shi, Mude*; Deng, Weiwen; Bi, Enguang; Mao, Kairui; Ji, Yongyong; Lin, Guomei; Wu, Xiaodong; Tao, Zhiyun; Li, Zhenhu; Cai, Xinfen; Sun, Shuhui; Xiang, Charlie^#; Sun, Bing^#.TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation.NATURE IMMUNOLOGY. 2008. 9(4):369-377.

Bing Sun, PhDDistinguished Adjunct Professor from CAS

Principal investigator

Group Introduction

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo