Principal investigator
Name:
Yadong SunAssistant Professor , PhD, Assistant Professor
Position:
School of Life Science and Technology
Affiliation:
Honor:
Education Background:
- 2006/09-2010/07, Jilin University, Bachelor
- 2010/09-2015/07, Tsinghua University, Ph.D.
Working Experience:
- 2015/10-2021/02, Columbia University, Postdoctoral Associate
- 2021/03-Present, ShanghaiTech University, Tenure-track Assistant Professor
Group Introduction
Research Area:
Structural and functional studies on protein machinery/RNA-protein complex
Research Interests:
The regulation of RNA maturation and degradation is a crucial step in gene expression, which has close relationship with human diseases like many cancers. The research in Sun lab will use biochemical and structural approaches (Cryo-EM and X-ray crystallography) to investigate molecular mechanism of the important protein complexes/machinery and RNA-protein complexes in 1）RNA metabolism and regulation; 2) the important macromolecules in antiviral immune defense.
Representative Publications (*First Author, # Corresponding Author)
- 1. Yang, Hao*; Song, Xiaoxuan*; Zhao, Jiazheng*; Zhang, Yuting; Ren, Zhiyun; Bao, Yanling; Chen, Lishuang; Hu, Meng; Cheng, Bingkai; Wu, Shaojuan; Zhao, Yi; Liu, Cong; Sun, Yadong#; Feng, Yan#; Sun, Bo#.The DdmDE defense system eradicates plasmids by target-centered bidirectional ssDNA loop extrusion and site-specific cleavage.MOLECULAR CELL. 29 May 2026. 86(12):1-15.
- 2. Wang, Xiaojie*; Bai, Zhongjian; Wallis, Ciara; Wang, Huanchen; Han, Yaoyao; Jin, Ruitao; Lei, Mingguang; Yang, Tian; Gu, Chunfang; Jessen, Henning; Shears, Stephen#; Sun, Yadong#; Corry, Ben#; Zhang, Yixiao#.KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1.MOLECULAR CELL. 04 Sep 2025. 85(17):3209-3224.e8.
- 3. Yuan, Ling*; Han, Yaoyao; Zhao, Jiazheng; Zhang, Yixiao#; Sun, Yadong#.Recognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex.NATURE COMMUNICATIONS. 28 Sep 2023. 14(1).
- 4. Huang, Ji*; Liu, Xiangyang*; Sun, Yadong*; Li, Zhuang; Lin, Min-Han; Hamilton, Keith; Mandel, Corey R.; Sandmeir, Felix; Conti, Elena; Oyala, Paul H.; Tong, Liang#.An examination of the metal ion content in the active sites of human endonucleases CPSF73 and INTS11.JOURNAL OF BIOLOGICAL CHEMISTRY. 01 Apr 2023. 299(4).
- 5. Liu, Junjie*; Lu, Xubing; Zhang, Siyu; Yuan, Ling; Sun, Yadong#.Molecular Insights into mRNA Polyadenylation and Deadenylation.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Oct 2022. 23(19).
- 6. Sun, Yadong*; Aik, Wei Shen; Yang, Xiao-Cui; Marzluff, William F.; Dominski, Zbigniew#; Tong, Liang#.Reconstitution and biochemical assays of an active human histone pre-mRNA 3 '-end processing machinery.METHODS IN ENZYMOLOGY. 2021. 655:291-324.
- 7. Sun, Yadong*; Zhang, Yixiao; Aik, Wei Shen; Yang, Xiao-Cui; Marzluff, William F.; Walz, Thomas#; Dominski, Zbigniew; Tong, Liang.Structure of an active human histone pre-mRNA 3′-end processing machinery.SCIENCE. 07 Feb 2020. 367(6478):700-703.
- 8. Yixiao Zhang*; Yadong Sun*; Yongsheng Shi; Thomas Walz#; Liang Tong#.Structural Insights into the Human Pre-mRNA 3′-End Processing Machinery.MOLECULAR CELL. 20 Feb 2020. 77(4).
- 9. Yadong Sun*; Keith Hamilton; Liang Tong#.Recent molecular insights into canonical pre-mRNA 3'-end processing.TRANSCRIPTION. Apr 2020. 11(2):83-96.
- 10. Xiao-Cui Yang*; Yadong Sun*; Wei Shen Aik; William F Marzluff; Liang Tong#; Zbigniew Dominski#.Analysis of the nucleolytic activities of CPSF73 using recombinant U7 snRNP.RNA. Oct 2020.
- 11. Keith Hamilton*; Yadong Sun; Liang Tong#.Biophysical characterizations of the recognition of the AAUAAA polyadenylation signal.RNA. Aug 2019.
- 12. Yadong Sun*; Yixiao Zhang*; Keith Hamilton; James L. Manley; Yongsheng Shi; Thomas Walz#; Liang Tong#.Molecular basis for the recognition of the human AAUAAA polyadenylation signal.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Feb 2018.
- 13. Yadong Sun*; Lei Li*; Alberto P. Macho; Zhifu Han#; Zehan Hu; Cyril Zipfel; Jian-Min Zhou#; Jijie Chai#.Structural Basis for flg22-Induced Activation of the Arabidopsis FLS2-BAK1 Immune Complex..SCIENCE. Nov 2013.
- 14. Yadong Sun*; Zhifu Han*; Jiao Tang; Zehan Hu; Chengliang Chai; Bin Zhou; Jijie Chai#.Structure reveals that BAK1 as a co-receptor recognizes the BRI1-bound brassinolide..CELL RESEARCH. Nov 2013.
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