课题组长
姓名：
谭丹助理教授 研究员 博士生导师, PhD, 助理教授
职务：
所在院所：
生命科学与技术学院
荣誉称号：
教育经历：
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2005/09—2009/06，湖南师范大学，学士
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2009/09—2014/07，协和医学院/北京生命科学研究所，博士
博士后及工作经历：
- 2014/08—2016/12，北京生命科学研究所，博士后
- 2017/01—2023/01，美国Salk研究所，博士后
- 2023/01—2024/07，美国Salk研究所，Senior Research Associate
- 2024/07—至今，上海科技大学，助理教授
课题组简介
研究内容：
我们课题组致力于使用前沿的质谱技术，并结合细胞生物学、动物模型、化学生物学、生物信息学等交叉学科手段，深入研究脂质代谢在人类疾病中的作用。脂质作为重要的代谢分子，不仅是细胞能量的来源和生物膜的基本组成部分，还作为信号分子参与调控多种生物过程。脂质组学旨在系统性地鉴定和定量细胞、组织或机体中的所有脂质。质谱技术因其高灵敏度、高通量和精准的定量能力，已成为脂质组学研究的核心工具。
我们将重点开展以下几个研究方向： 1. 开发基于质谱的脂质代谢组学分析方法及数据分析工具，提高脂质代谢物的鉴定率和定量的准确度； 2. 将脂质组学与蛋白质组学、转录组学等多组学相结合，探索脂质代谢在神经系统疾病等人类疾病中的作用，力求为疾病的发病机制、诊断与治疗提供理论基础； 3. 研究脂质代谢物的合成、降解及其他代谢通路，为调控体内脂质水平提供新策略。
代表性论文（*第一作者，#通讯作者）
- 1. Tan, Dan*; Konduri, Srihari; Erikci Ertunc, Meric; Zhang, Pan; Wang, Justin; Chang, Tina; Pinto, Antonio FM; Rocha, Andrea; Donaldson, Cynthia J; Vaughan, Joan M; Ludwig, Raissa G; Willey, Elizabeth; Iyer, Manasi; Gray, Peter C; Maher, Pamela; Allen, Nicola J; Zuchero, J Bradley; Dillin, Andrew; Mori, Marcelo A; Kohama, Steven G; Siegel, Dionicio; Saghatelian, Alan#.A class of anti-inflammatory lipids decrease with aging in the central nervous system.Nature Chemical Biology. 2023.
- 2. Tan, Dan*; Ertunc, Meric Erikci; Konduri, Srihari; Zhang, Justin; Pinto, Antonio M; Chu, Qian; Kahn, Barbara B; Siegel, Dionicio#; Saghatelian, Alan#.Discovery of FAHFA-containing triacylglycerols and their metabolic regulation. Journal of the American Chemical Society.Journal of the American Chemical Society. 2019.
- 3. Tan, Dan*; Li, Qiang*; Zhang, Mei-Jun; Liu, Chao; Ma, Chengying; Zhang, Pan; Ding, Yue-He; Fan, Sheng-Bo; Tao, Li; Yang, Bing; Li, Xiangke; Ma, Shoucai; Liu, Junjie; Feng, Boya; Liu, Xiaohui; Wang, Hong-Wei; He, Si-Min; Gao, Ning; Ye, Keqiong; Dong, Meng-Qiu#; Lei, Xiaoguang#.Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states.Elife. 2016.
- 4. Patel, Rucha*; Santoro, Anna; Hofer, Peter; Tan, Dan; Oberer, Monika; Nelson, Andrew T; Konduri, Srihari; Siegel, Dionicio; Zechner, Rudolf; Saghatelian, Alan; Kahn, Barbara B#.ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.Nature. 2022.
- 5. Wang, Jian-Hua*; Tang, Yu-Liang*; Gong, Zhou; Jain, Rohit; Xiao, Fan; Zhou, Yu; Tan, Dan; Li, Qiang; Huang, Niu; Liu, Shu-Qun; Ye, Keqiong; Tang, Chun; Dong, Meng-Qiu#; Lei, Xiaoguang#.Characterization of protein unfolding by fast cross-linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers.Nature Communications. 2022.
- 6. Martinez, Thomas F*; Chu, Qian; Donaldson, Cynthia; Tan, Dan; Shokhirev, Maxim N; Saghatelian, Alan#.Accurate annotation of human protein-coding small open reading frames.Nature Chemical Biology. 2020.
- 7. Erikci Ertunc, Meric*; Kok, Bernard P; Parsons, William H; Wang, Justin G; Tan, Dan; Donaldson, Cynthia J; Pinto, Antonio FM; Vaughan, Joan M; Ngo, Nhi; Lum, Kenneth M; Henry, Cassandra L; Coppola, Aundrea R; Niphakis, Micah J; Cravatt, Benjamin F; Saez, Enrique; Saghatelian, Alan#.AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.Journal of Biological Chemistry. 2020.
- 8. Chu, Qian*; Martinez, Thomas F; Novak, Sammy Weiser; Donaldson, Cynthia J; Tan, Dan; Vaughan, Joan M; Chang, Tina; Diedrich, Jolene K; Andrade, Leo; Kim, Andrew; Zhang, Tong; Manor, Uri; Saghatelian, Alan#.Regulation of the ER stress response by a mitochondrial microprotein.Nature Communications. 2019.
- 9. Zhang, Xiaoyun*; Wang, Jian-Hua*; Tan, Dan; Li, Qiang; Li, Maodong; Gong, Zhou; Tang, Chun; Liu, Zhirong; Dong, Meng-Qiu#; Lei, Xiaoguang#.Carboxylate-selective chemical cross-linkers for mass spectrometric analysis of protein structures.Analytical Chemistry. 2018.
专利
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1. 雷晓光，李强，董梦秋，谭丹，一种多功能化学交联剂及其制备方法与应用，中国，CN107129455A[P]，发明专利
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目前课题组正在招聘一位科研助理（详细信息参见学校招聘网页），请有意向者发送简历至tandan@shanghaitech.edu.cn。
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