Principal investigator
Name:
Dan TanAssistant Professor , PhD, Assistant Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 2009/09-2014/07, Peking Union Medical College / National Institute of Biological Sciences, Beijing (NIBS), Ph.D.
- 2005/09-2009/06, Hunan Normal University, B.S.
Working Experience:
- 2014/08-2016/12, National Institute of Biological Sciences, Beijing (NIBS), Postdoctoral Fellow
- 2017/01-2023/01, Salk Institute for Biological Studies, Research Associate
- 2023/01-2024/07, Salk Institute for Biological Studies, Senior Research Associate
- 2024/07-Now, ShanghaiTech University, Assistant Professor
Group Introduction
Research Area:
Lipidomics, Biological Mass Spectrometry, Chemical Biology
Research Interests:
Our lab leverages cutting-edge mass spectrometry technologiesalongside interdisciplinary approaches, including cell biology, animal models, chemical biology, and bioinformatics, to investigate the role of lipid metabolism in human diseases. Lipids play multifaceted roles in biology, acting as energy sources for cells, integral constituents of membranes, and signaling molecules that regulate diverse biological processes. Lipidomics seeks to systematically identify and quantify the complete set of lipids in cells, tissues, or organisms. Mass spectrometry, with its high sensitivity, throughput, and precision, has become the cornerstone of lipidomics research.
Our research focuses on three areas: 1. Developing mass spectrometry-based lipidomics methods and data analysis tools to improve lipid identification and quantification; 2. Integrating lipidomics with proteomics, transcriptomics, and other omics approaches to investigate the role of lipid metabolism in human diseases, with a particular focus on neurological disorders; 3. Elucidating the biosynthesis and degradation pathways of lipids to identify new strategies for modulating endogenous lipid levels.
Representative Publications (*First Author, # Corresponding Author)
- 1. Tan, Dan*; Saghatelian, Alan#.The measurement, regulation and biological activity of FAHFAs.Nature Chemical Biology. 2025.
- 2. Tan, Dan*; Konduri, Srihari; Erikci Ertunc, Meric; Zhang, Pan; Wang, Justin; Chang, Tina; Pinto, Antonio FM; Rocha, Andrea; Donaldson, Cynthia J; Vaughan, Joan M; Ludwig, Raissa G; Willey, Elizabeth; Iyer, Manasi; Gray, Peter C; Maher, Pamela; Allen, Nicola J; Zuchero, J Bradley; Dillin, Andrew; Mori, Marcelo A; Kohama, Steven G; Siegel, Dionicio; Saghatelian, Alan#.A class of anti-inflammatory lipids decrease with aging in the central nervous system.Nature Chemical Biology. 2023.
- 3. Tan, Dan*; Ertunc, Meric Erikci; Konduri, Srihari; Zhang, Justin; Pinto, Antonio M; Chu, Qian; Kahn, Barbara B; Siegel, Dionicio#; Saghatelian, Alan#.Discovery of FAHFA-containing triacylglycerols and their metabolic regulation. Journal of the American Chemical Society.Journal of the American Chemical Society. 2019.
- 4. Tan, Dan*; Li, Qiang*; Zhang, Mei-Jun; Liu, Chao; Ma, Chengying; Zhang, Pan; Ding, Yue-He; Fan, Sheng-Bo; Tao, Li; Yang, Bing; Li, Xiangke; Ma, Shoucai; Liu, Junjie; Feng, Boya; Liu, Xiaohui; Wang, Hong-Wei; He, Si-Min; Gao, Ning; Ye, Keqiong; Dong, Meng-Qiu#; Lei, Xiaoguang#.Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states.Elife. 2016.
- 5. Patel, Rucha*; Santoro, Anna; Hofer, Peter; Tan, Dan; Oberer, Monika; Nelson, Andrew T; Konduri, Srihari; Siegel, Dionicio; Zechner, Rudolf; Saghatelian, Alan; Kahn, Barbara B#.ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.Nature. 2022.
- 6. Wang, Jian-Hua*; Tang, Yu-Liang*; Gong, Zhou; Jain, Rohit; Xiao, Fan; Zhou, Yu; Tan, Dan; Li, Qiang; Huang, Niu; Liu, Shu-Qun; Ye, Keqiong; Tang, Chun; Dong, Meng-Qiu#; Lei, Xiaoguang#.Characterization of protein unfolding by fast cross-linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers.Nature Communications. 2022.
- 7. Martinez, Thomas F*; Chu, Qian; Donaldson, Cynthia; Tan, Dan; Shokhirev, Maxim N; Saghatelian, Alan#.Accurate annotation of human protein-coding small open reading frames.Nature Chemical Biology. 2020.
- 8. Erikci Ertunc, Meric*; Kok, Bernard P; Parsons, William H; Wang, Justin G; Tan, Dan; Donaldson, Cynthia J; Pinto, Antonio FM; Vaughan, Joan M; Ngo, Nhi; Lum, Kenneth M; Henry, Cassandra L; Coppola, Aundrea R; Niphakis, Micah J; Cravatt, Benjamin F; Saez, Enrique; Saghatelian, Alan#.AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.Journal of Biological Chemistry. 2020.
- 9. Chu, Qian*; Martinez, Thomas F; Novak, Sammy Weiser; Donaldson, Cynthia J; Tan, Dan; Vaughan, Joan M; Chang, Tina; Diedrich, Jolene K; Andrade, Leo; Kim, Andrew; Zhang, Tong; Manor, Uri; Saghatelian, Alan#.Regulation of the ER stress response by a mitochondrial microprotein.Nature Communications. 2019.
- 10. Zhang, Xiaoyun*; Wang, Jian-Hua*; Tan, Dan; Li, Qiang; Li, Maodong; Gong, Zhou; Tang, Chun; Liu, Zhirong; Dong, Meng-Qiu#; Lei, Xiaoguang#.Carboxylate-selective chemical cross-linkers for mass spectrometric analysis of protein structures.Analytical Chemistry. 2018.
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