Principal investigator
Name:
Xiajing TongAssociate Professor , PhD, Associate Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 2001/09-2005/07, University of Science and Technology of China, Bachelor
- 2005/09-2010/07, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Ph.D.
Working Experience:
- 2010/08-2011/08, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Research Assistant
- 2011/09-2016/05, Harvard Medical School/Mass General Hospital, Postdoc
- 2016/06-2017/07, Harvard Medical School/Mass General Hospital, Research Associate
- 2017/08-2023/10, ShanghaiTech University, Assistant Professor
- 2023/10-Now, ShanghaiTech University, Associate Professor
Group Introduction
Research Area:
neurobiology, sexual dimorphism, synaptic transmission
Research Interests:
Brain has high complexity and capacity. On the one hand, it stabilizes neuronal function. On the other hand, it can adjust neuronal activity according to external changes through plasticity. Disturbance of brain stability and plasticity will cause lots of neurological and psychiatric diseases, such as autism and schizophrenia. Synapse is the basic structure in the brain that mediates neuronal connections and functions. In the Tong lab, we use C. elegans as our model organism combined with studies in mammals to elucidate the molecular mechanisms of synapse homeostasis and plasticity. We deploy a collection of tools to study synapse function, including biochemistry, imaging, electrophysiology, genetics, optogenetics, and animal behaviors. Our characterization of synapse structure and function that are highly conserved from nematodes to mammals will provide insights into mechanistic understanding of human disorders related to synapse dysfunction and therapy design.
Representative Publications (*First Author, # Corresponding Author)
- 1. Ming-Han Wang*; Yue Hao*; Xia-Jing Tong#; .Targeting the intracellular neurexin interactome by in vivo proximity ligation.TRENDS IN NEUROSCIENCES. 06 Mar 2024.
- 2. Hankui Cheng*; Du Chen*; Xiao Li*; Umar Al-Sheikh; Duo Duan; Yuedan Fan; Linhui Zhu; Wanxin Zeng; Zhitao Hu; Xiajing Tong; Guohua Zhao; Yongming Zhang; Wenjuan Zou; Shumin Duan; Lijun Kang#; .Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging.NEURON. 01 May 2024.
- 3. Wan-Xin Zeng*, Haowen Liu*, Yue Hao*, Kang-Ying Qian, Fu-Min Tian, Lei Li, Bin Yu, Xian-Ting Zeng, Shangbang Gao, Zhitao Hu#, and Xia-Jing Tong#.CaMKII mediates sexually dimorphic synaptic transmission at neuromuscular junctions in C. elegans.JOURNAL OF CELL BIOLOGY. Aug 2023. 222(11).
- 4. Peng, Jing-Yi*; Liu, Xuqing*; Zeng, Xian-Ting; Hao, Yue; Zhang, Jia-Hui; Li, Qian; Tong, Xia-Jing#.Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans.CELL REPORTS. 27 June 2023. 42(6):112598.
- 5. Hao, Yue*; Liu, Haowen*; Zeng, Xian-Ting; Wang, Ya; Zeng, Wan-Xin; Qian, Kang-Ying; Li, Lei; Chi, Ming-Xuan; Gao, Shangbang; Hu, Zhitao; Tong, Xia-Jing#.UNC-43/CaMKII-triggered anterograde signals recruit GABAARs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs.NATURE COMMUNICATIONS. 15 Mar 2023. 14(1):1436.
- 6. Li, Lei*; Liu, Haowen*; Qian, Kang-Ying*; Nurrish, Stephen*; Zeng, Xian-Ting; Zeng, Wan-Xin; Wang, Jiafan; Kaplan, Joshua M.#; Tong, Xia-Jing#; Hu, Zhitao#; .CASK and FARP localize two classes of post-synaptic ACh receptors thereby promoting cholinergic transmission.PLOS GENETICS. 24 Oct 2022. 18(10).
- 7. Song, Chun-Xue*; Zeng, Xian-Ting; Zeng, Wan-Xin; Liu, Rong; Tong, Xia-Jing#; Li, Qian#; .A WDR47 homolog facilitates ciliogenesis by modulating intraflagellar transport.JOURNAL OF CELL SCIENCE. 01 Dec 2022. 135(24).
- 8. Qian, Kang-Ying*; Zeng, Wan-Xin; Hao, Yue; Zeng, Xian-Ting; Liu, Haowen; Li, Lei; Chen, Lili; Tian, Fu-Min; Chang, Cindy; Hall, Qi; Song, Chun-Xue; Gao, Shangbang; Hu, Zhitao; Kaplan, Joshua M; Li, Qian#; Tong, Xia-Jing#; .Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner.ELIFE. 31 Mar 2021. 10.
- 9. Tong, Xia-Jing*; Lopez-Soto, Eduardo Javier; Li, Lei; Liu, Haowen; Nedelcu, Daniel; Lipscombe, Diane; Hu, Zhitao; Kaplan, Joshua M.#; .Retrograde Synaptic Inhibition Is Mediated by alpha-Neurexin Binding to the alpha 2 delta Subunits of N-Type Calcium Channels.NEURON. 2017. 95(2):326.
- 10. Tong, Xia-Jing*; Hu, Zhitao*; Liu, Yu; Anderson, Dorian; Kaplan, Joshua M.#; .A network of autism linked genes stabilizes two pools of synaptic GABA(A) receptors.ELIFE. 2015. 4.
- 11. Hu, Zhitao*; Tong, Xia-Jing; Kaplan, Joshua M.#; .UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans.ELIFE. 2013. 2.
- 12. Hu, Zhitao*; Hom, Sabrina; Kudze, Tambudzai; Tong, Xia-Jing; Choi, Seungwon; Aramuni, Gayane; Zhang, Weiqi; Kaplan, Joshua M.#; .Neurexin and Neuroligin Mediate Retrograde Synaptic Inhibition in C. elegans.SCIENCE. 2012. 337(6097):980-984.
- 13. Zhang, Ming-Liang*; Tong, Xia-Jing*; Fu, Xiao-Hong; Zhou, Bo O.; Wang, Jianyong; Liao, Xin-Hua; Li, Qian-Jin; Shen, Ning; Ding, Jianping; Zhou, Jin-Qiu#; .Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongation.NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2010. 17(2):202.
- 14. Tong, Xia-Jing*; Li, Qian-Jin; Duan, Yi-Min; Liu, Ning-Ning; Zhang, Ming-Liang; Zhou, Jin-Qiu#; .Est1 Protects Telomeres and Inhibits Subtelomeric Y '-Element Recombination.MOLECULAR AND CELLULAR BIOLOGY. 2011. 31(6):1263-1274.
- 15. Duan, Yi-Min*; Zhou, Bo-O.; Peng, Jing; Tong, Xia-Jing; Zhang, Qiong-Di; Zhou, Jin-Qiu#; .Molecular dynamics of de novo telomere heterochromatin formation in budding yeast.JOURNAL OF GENETICS AND GENOMICS. 20 Jul 2016. 43(7):451-465.
- 16. Hu, Yan*; Tang, Hong-Bo*; Liu, Ning-Ning*; Tong, Xia-Jing; Dang, Wei; Duan, Yi-Min; Fu, Xiao-Hong; Zhang, Yang; Peng, Jing; Meng, Fei-Long; Zhou, Jin-Qiu#; .Telomerase-Null Survivor Screening Identifies Novel Telomere Recombination Regulators.PLOS GENETICS. 2013. 9(1).
- 17. Li, Qian-Jin*; Tong, Xia-Jing; Duan, Yi-Min; Zhou, Jin-Qiu#; .Characterization of the intramolecular G-quadruplex promoting activity of Est1.FEBS LETTERS. 2013. 587(6):659-665.
- 18. Chang, Yuanyuan*; Wu, Jian; Tong, Xia-Jing; Zhou, Jin-Qiu; Ding, Jianping#; .Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism.BIOCHEMICAL JOURNAL. 2011. 433:295-302.
- 19. Meng, Fei-Long*; Hu, Yan; Shen, Ning; Tong, Xia-Jing; Wang, Jianyong; Ding, Jianping; Zhou, Jin-Qiu#; .Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication.EMBO JOURNAL. 2009. 28(10):1466-1478.
- 20. 童夏静#*; 周金秋; .端粒和端粒酶的发现及其生物学意义.生命科学. Dec 2009. 21(6):760-769.
Awards
- 1. 2024, GENETICS, Associate editor
Group Member and Photo
-
Name:Xianting Zeng
Position:Engineer
Duration:
Email:
-
Name:Wanxin Zeng
Position:Postgraduate Student
Duration:2018/02-Now
Email:
-
Name:Yue Hao
Position:Postgraduate Student
Duration:2019/02-Now
Email:
-
Name:Jingyi Peng
Position:Postgraduate Student
Duration:2020/02-Now
Email:
-
Name:Minghan Wang
Position:Postgraduate Student
Duration:2021/02-Now
Email:
-
Name:Jiahui Zhang
Position:Postgraduate Student
Duration:2021/02-Now
Email:
-
Name:Jian He
Position:Postgraduate Student
Duration:2021/02-Now
Email:
-
Name:Chunxue Song
Position:Visiting Student
Duration:2018/11-Now
Email:
-
Name:Chengxi Li
Position:Postgraduate Student
Duration:2022/02-Now
Email:
-
Name:Guanyu Peng
Position:Postgraduate Student
Duration:2023/02-Now
Email:
-
Name:Kailiang Zhang
Position:Postgraduate Student
Duration:2023/01-Now
Email:
|