课题组长
姓名：
吴蓓丽中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院上海药物研究所
荣誉称号：
课题组简介
研究内容：
主要从事G蛋白偶联受体（GPCR）的结构生物学研究，研究工作集中在以下几个方面：1.GPCR高分辨率晶体结构解析； 2.GPCR三维结构与功能关系的研究； 3.基于GPCR结构的药物设计与研发。
代表性论文（*第一作者，#通讯作者）
- 1. Wu, Beili*; Chien, Ellen Y. T.; Mol, Clifford D.; Fenalti, Gustavo; Liu, Wei; Katritch, Vsevolod; Abagyan, Ruben; Brooun, Alexei; Wells, Peter; Bi, F. Christopher; Hamel, Damon J.; Kuhn, Peter; Handel, Tracy M.; Cherezov, Vadim; Stevens, Raymond C.#.Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists.SCIENCE. 2010. 330(6007):166-171.
- 2. Wu, Beili*; Liu, Yuanfeng; Zhao, Qiang; Liao, Shuang; Zhang, Jun; Bartlam, Mark; Chen, Weifeng#; Rao, Zihe#.Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis.JOURNAL OF MOLECULAR BIOLOGY. 2007. 367(5):145-1412.
- 3. Zhao, Qiang*; Qin, Lipeng; Jiang, Fuguo; Wui, Beili; Yue, Wen; Xu, Feng; Rong, Zhili; Yuan, Hongfeng; Xie, Xiaoyan; Gao, Yanhong; Bai, Cixian; Bartlam, Mark; Pei, Xuetao#; Rao, Zihe#.Structure of human Spindlin1 - Tandemm tudor-like domains for cell cycle regulation.JOURNAL OF BIOLOGICAL CHEMISTRY. 2007. 282(1):647-656.
- 4. Zhao, Qiang#*; Wu, Bei-li.Ice breaking in GPCR structural biology.ACTA PHARMACOLOGICA SINICA. 2012. 33(3):324-334.
- 5. Tan, Qiuxiang*; Zhu, Ya; Li, Jian; Chen, Zhuxi; Han, Gye Won; Kufareva, Irina; Li, Tingting; Ma, Limin; Fenalti, Gustavo; Li, Jing; Zhang, Wenru; Xie, Xin; Yang, Huaiyu; Jiang, Hualiang; Cherezov, Vadim; Liu, Hong; Stevens, Raymond C.; Zhao, Qiang; Wu, Beili#.Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex.SCIENCE. 20 Sep 2013. 341(6152):1387-1390.
- 6. Zhang, Haonan*; Qiao, Anna; Yang, Dehua; Yang, Linlin; Dai, Antao; De Graaf, Chris; Reedtz-Runge, Steffen; Dharmarajan, Venkatasubramanian; Zhang, Hui; Han, Gye Won; Grant, Thomas D.; Sierra, Raymond G.; Weierstall, Uwe; Nelson, Garrett; Liu, Wei; Wu, Yanhong; Ma, Limin; Cai, Xiaoqing; Lin, Guangyao; Wu, Xiaoai; Geng, Zhi; Dong, Yuhui; Song, Gaojie; Griffin, Patrick R.; Lau, Jesper; Chrezov, Vadim; Yang, Huaiyu; Hanson, Michael A.; Stevens, Raymond C.; Zhao, Qiang; Jiang, Hualiang#; Wang, Ming-Wei#; Wu, Beili#.Structure of the full-length glucagon class B G-protein-coupled receptor.NATURE. 08 Jun 2017. 546(7657):259-+.
- 7. Chen, Shuanghong*; Lu, Mengjie; Liu, Dongsheng; Yang, Lingyun; Yi, Cuiying; Ma, Limin; Zhang, Hui; Liu, Qing; Frimurer, Thomas M.; Wang, Ming-Wei; Schwartz, Thue W.; Stevens, Raymond C.; Wu, Beili#; Wuthrich, Kurt#; Zhao, Qiang#.Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.NATURE COMMUNICATIONS. 07 Feb 2019. 10.
- 8. de Graaf, Chris*; Song, Gaojie; Cao, Can; Zhao, Qiang; Wang, Ming-Wei; Wu, Beili; Stevens, Raymond C.#.Extending the Structural View of Class B GPCRs.TRENDS IN BIOCHEMICAL SCIENCES. Dec 2017. 42(12):946-960.
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