Principal investigator
Name:
Beili WuDistinguished Adjunct Professor from CAS , PhD, Distinguished Adjunct Professor from CAS
Position:
Affiliation:
School of Life Science and Technology, Shanghai Institute of Materia Medica, CAS
Honor:
Group Introduction
Research Area:
G Protein-coupled Receptor Structural Biology
Research Interests:
Prof. WU Beili's research is focused on structural biology studies of GPCRs by solving high-resolution crystal structures of different GPCRs to study structure-function relations of GPCRs and perform structure-based drug design and discovery. Her futureresearch directions include:
1. Structuredetermination of complexes between GPCRs and novel ligands
2. Structure determination of complexes between GPCRs and endogenous protein ligands
3. Structure determination of GPCRs withoutstructural information
Representative Publications (*First Author, # Corresponding Author)
- 1. Wu, Beili*; Chien, Ellen Y. T.; Mol, Clifford D.; Fenalti, Gustavo; Liu, Wei; Katritch, Vsevolod; Abagyan, Ruben; Brooun, Alexei; Wells, Peter; Bi, F. Christopher; Hamel, Damon J.; Kuhn, Peter; Handel, Tracy M.; Cherezov, Vadim; Stevens, Raymond C.#.Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists.SCIENCE. 2010. 330(6007):166-171.
- 2. Wu, Beili*; Liu, Yuanfeng; Zhao, Qiang; Liao, Shuang; Zhang, Jun; Bartlam, Mark; Chen, Weifeng#; Rao, Zihe#.Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis.JOURNAL OF MOLECULAR BIOLOGY. 2007. 367(5):145-1412.
- 3. Zhao, Qiang*; Qin, Lipeng; Jiang, Fuguo; Wui, Beili; Yue, Wen; Xu, Feng; Rong, Zhili; Yuan, Hongfeng; Xie, Xiaoyan; Gao, Yanhong; Bai, Cixian; Bartlam, Mark; Pei, Xuetao#; Rao, Zihe#.Structure of human Spindlin1 - Tandemm tudor-like domains for cell cycle regulation.JOURNAL OF BIOLOGICAL CHEMISTRY. 2007. 282(1):647-656.
- 4. Zhao, Qiang#*; Wu, Bei-li.Ice breaking in GPCR structural biology.ACTA PHARMACOLOGICA SINICA. 2012. 33(3):324-334.
- 5. Tan, Qiuxiang*; Zhu, Ya; Li, Jian; Chen, Zhuxi; Han, Gye Won; Kufareva, Irina; Li, Tingting; Ma, Limin; Fenalti, Gustavo; Li, Jing; Zhang, Wenru; Xie, Xin; Yang, Huaiyu; Jiang, Hualiang; Cherezov, Vadim; Liu, Hong; Stevens, Raymond C.; Zhao, Qiang; Wu, Beili#.Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex.SCIENCE. 20 Sep 2013. 341(6152):1387-1390.
- 6. Zhang, Haonan*; Qiao, Anna; Yang, Dehua; Yang, Linlin; Dai, Antao; De Graaf, Chris; Reedtz-Runge, Steffen; Dharmarajan, Venkatasubramanian; Zhang, Hui; Han, Gye Won; Grant, Thomas D.; Sierra, Raymond G.; Weierstall, Uwe; Nelson, Garrett; Liu, Wei; Wu, Yanhong; Ma, Limin; Cai, Xiaoqing; Lin, Guangyao; Wu, Xiaoai; Geng, Zhi; Dong, Yuhui; Song, Gaojie; Griffin, Patrick R.; Lau, Jesper; Chrezov, Vadim; Yang, Huaiyu; Hanson, Michael A.; Stevens, Raymond C.; Zhao, Qiang; Jiang, Hualiang#; Wang, Ming-Wei#; Wu, Beili#.Structure of the full-length glucagon class B G-protein-coupled receptor.NATURE. 08 Jun 2017. 546(7657):259-+.
- 7. Chen, Shuanghong*; Lu, Mengjie; Liu, Dongsheng; Yang, Lingyun; Yi, Cuiying; Ma, Limin; Zhang, Hui; Liu, Qing; Frimurer, Thomas M.; Wang, Ming-Wei; Schwartz, Thue W.; Stevens, Raymond C.; Wu, Beili#; Wuthrich, Kurt#; Zhao, Qiang#.Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.NATURE COMMUNICATIONS. 07 Feb 2019. 10.
- 8. de Graaf, Chris*; Song, Gaojie; Cao, Can; Zhao, Qiang; Wang, Ming-Wei; Wu, Beili; Stevens, Raymond C.#.Extending the Structural View of Class B GPCRs.TRENDS IN BIOCHEMICAL SCIENCES. Dec 2017. 42(12):946-960.
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