Principal investigator
Name:
Chenhui WangAssistant Professor , PhD, Assistant Professor
Position:
Affiliation:
Honor:
Education Background:
- 2004/09-2008/07, Beijing Normal University, B.S.
- 2008/09-2013/07, Beijing Normal University& NIBS, Ph.D.
Working Experience:
- 2013/07-2015/08, National Institute of Biological Sciences, Beijing, postdoc associate
- 2015/08-2019/08, HHMI/Carnegie Institution for Science, postdoc associate
- 2019/08-2021/11, HHMI/Carnegie Institution for Science, research specialist
- 2021/12-Now, ShanghaiTech University, Assistant professor (tenure-track)
Group Introduction
Research Area:
Adult stem cell and kidney repair
Research Interests:
The kidneys are an essential organ which is responsible for the excretion of body waste and harmful chemicals into the urine. It has been estimated that millions of people worldwide die from kidney failure and acute kidney injury each year.Moreover, a couple of million people depend on dialysis to survive. Kidney diseases have been a tremendous economic burden globally. Unfortunately, kidney diseases have not received enough attention and are described to be the most neglected chronic diseases. Our laboratory employs the classic model organism Drosophila melanogaster as a model to investigate the regulatory mechanisms of renal stem cells and kidney damage repair, with emphases on uncovering mechanisms regulating renal stem cell quiescence and establishing Drosophila disease models to study kidney diseases such as kidney stone and renal cancer. My long-term vision is to apply knowledge gained from our work into mammals with the hope to better understand homeostasis maintenance of kidney and identify novel therapeutic strategies for kidney conditions.
Representative Publications (*First Author, # Corresponding Author)
- 1. Guo, Xingting*; Wang, Chenhui#; Zhang, Yongchao; Wei, Ruxue; Xi, Rongwen#; .Cell-fate conversion of intestinal cells in adult Drosophila midgut by depleting a single transcription factor.NATURE COMMUNICATIONS. 26 Mar 2024. 15(1).
- 2. Wang, Chenhui*; Spradling, Allan C.#; .Drosophila renal stem cells enhance fitness by delayed remodeling of adult Malpighian tubules.SCIENCE ADVANCES. 20 May 2022. 8(20).
- 3. Wang, Chenhui*; Spradling, Allan C#; .An abundant quiescent stem cell population in Drosophila Malpighian tubules protects principal cells from kidney stones.ELIFE. 16 Mar 2020.
- 4. Li, Zhaohui*; Guo, Xingting; Huang, Huanwei; Wang, Chenhui; Yang, Fu; Zhang, Yongchao; Wang, Jiawen; Han, Lu; Jin, Zhen; Cai, Tao; Xi, Rongwen#; .A Switch in Tissue Stem Cell Identity Causes Neuroendocrine Tumors in Drosophila Gut.CELL REPORTS. 11 Feb 2020.
- 5. Chen, Jun*; Xu, Na; Wang, Chenhui; Huang, Pin; Huang, Huanwei; Jin, Zhen; Yu, Zhongsheng; Cai, Tao; Jiao, Renjie; Xi, Rongwen#; .Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.NATURE CELL BIOLOGY. Feb 2018.
- 6. Li, Yumei#*; Pang, Zhimin; Huang, Huanwei; Wang, Chenhui; Cai, Tao; Xi, Rongwen#; .Transcription Factor Antagonism Controls Enteroendocrine Cell Specification from Intestinal Stem Cells.SCI REP. 20 Apr 2017.
- 7. Wang, Chenhui*; Guo, Xingting; Dou, Kun; Chen, Hongyan; Xi, Rongwen#; .Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages.DEVELOPMENT. 01 Oct 2015. 142(19):3321-3331.
- 8. Wang, Chenhui*; Guo, Xingting; Xi, Rongwen#; .EGFR and Notch signaling respectively regulate proliferative activity and multiple cell lineage differentiation of Drosophila gastric stem cells.CELL RESEARCH. May 2014.
- 9. Wang, Chenhui*; Xi, Rongwen#; .Keeping intestinal stem cell differentiation on the Tramtrack.FLY. Dec 2015.
- 10. Wang, Chenhui*; Zhao, Rui; Huang, Pin; Yang, Fu; Quan, Zhenghui; Xu, Na; Xi, Rongwen#; .APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.DEVELOPMENTAL BIOLOGY. 15 Jun 2013.
- 11. Lin, Guonan*; Zhang, Xi; Ren, Juan; Pang, Zhimin; Wang, Chenhui; Xu, Na; Xi, Rongwen#; .Integrin signaling is required for maintenance and proliferation of intestinal stem cells in Drosophila.DEVELOPMENTAL BIOLOGY. 01 May 2013.
- 12. Dodge,Ren*; Jones,Eric W; Zhu,Haolong; Obadia,Benjamin; Martinez,Daniel J; Wang, Chenhui; Aranda-Diaz,Andres; Aumiller,Kevin; Liu,Zhexian; Voltolini,Marco; Brodie,Eoin L; Huang,Kerwyn Casey; Carlson,Jean M; Sivak,David A; Spradling, Allan C; Ludington,William B#; .A gut commensal niche regulates stable association of a multispecies microbiota.BIORXIV. 30 Sep 2021.
Group Member and Photo
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Name：Hui Chen
Position：Doctoral Student
Duration：2021/12 - Now
Email：
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Name：Zhen Yang
Position：Doctoral Student
Duration：2021/12 - Now
Email：
-
Name：Yunfeng Cao
Position：Doctoral Student
Duration：2022/1 - Now
Email：
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Name：Hanzhang Dai
Position：Postgraduate Student
Duration：2022/12- Now
Email：
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Name：Yunlong Wang
Position：Postgraduate Student
Duration：2022/12- Now
Email：
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Name：Dai Zhang
Position：Postgraduate Student
Duration：2022/9- Now
Email：
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Name：Ruiyang Zeng
Position：Undergraduate Student
Duration：2023/3-Now
Email：
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Name：Xinyue Zhou
Position：Postgraduate Student
Duration：2024/01-Now
Email：
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Name：Jiacheng Long
Position：Postgraduate Student
Duration：2024/01- Now
Email：
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Name：Tong Yan
Position：Undergraduate Student
Duration：2023/11- Now
Email：
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Name：Pengcheng Wang
Position：Undergraduate Student
Duration：2023/11- Now
Email：
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Name：Pucheng Cai
Position：Undergraduate Student
Duration：2024/03-Now
Email：
-
Name：jize Sui
Position：Undergraduate Student
Duration：2023/2-2023/6
Email：
2023/4
2022/3
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