英文信息

Principal investigator

Name:

Enduo WangDistinguished Adjunct Professor from CAS , PhD, Distinguished Adjunct Professor from CAS

Position:

Affiliation:

School of Life Science and Technology, Shanghai Institute of Biochemistry and Cell Biology, CAS

Honor:

Education Background:

Working Experience:

Group Introduction

Research Area:

The Interaction of Proteins and Nucleic Acids

Research Interests:

The fidelity of protein synthesis is dependent on accurate substrate recognition by the aminoacyl-tRNA synthetase (aaRS) which catalyzes the first step reaction of protein biosynthesis, aminoacylation of tRNA. Each recognizes a single cognate amino acid and covalently attaches it to the correct tRNA. Some aaRSs misactivate incorrect amino acids, but have evolved mechanisms to proofread their errors and edit their mistakes. I am interested in understanding the mechanistic details and molecular interactions that govern aaRS aminoacylation and editing activities. Results from these investigations address basic research questions and also target long-term applications such as antibiotic development. My lab has focused on leucyl-, arginyl- and methionyl- tRNA synthetases to carry out the investigation.

Group Website:

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

1. Huang, Qian*; Yao, Peng; Eriani, Gilbert; Wang, En-Duo^#.In vivo identification of essential nucleotides in tRNA(Leu) to its functions by using a constructed yeast tRNA(Leu) knockout strain.NUCLEIC ACIDS RESEARCH. 2012. 40(20):1463-1477.
2. Zhou, Xiao-Long*; Ruan, Zhi-Rong; Huang, Qian; Tan, Min; Wang, En-Duo^#.Translational fidelity maintenance preventing Ser mis-incorporation at Thr codon in protein from eukaryote.NUCLEIC ACIDS RESEARCH. 2013. 41(1):32-314.
3. Hu, Qing-Hua*; Huang, Qian; Wang, En-Duo^#.Crucial role of the C-terminal domain of Mycobacterium tuberculosis leucyl-tRNA synthetase in aminoacylation and editing.NUCLEIC ACIDS RESEARCH. 2013. 41(3):1859-1872.
4. Chen, Xin*; Ma, Jing-Jing; Tan, Min; Yao, Peng; Hu, Qing-Hua; Eriani, Gilbert; Wang, En-Duo^#.Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase.NUCLEIC ACIDS RESEARCH. 2011. 39(1):235-247.
5. Zhou, Xiao-Long*; Du, Dao-Hai; Tan, Min; Lei, Hui-Yan; Ruan, Liang-Liang; Eriani, Gilbert; Wang, En-Duo^#.Role of tRNA amino acid-accepting end in aminoacylation and its quality control.NUCLEIC ACIDS RESEARCH. 2011. 39(20):8857-8868.

Enduo Wang, PhDDistinguished Adjunct Professor from CAS

Principal investigator

Group Introduction

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo