英文信息

Principal investigator

Name:

Quan WangAssistant Professor , PhD, Assistant Professor

Position:

Affiliation:

School of Life Science and Technology, Shanghai Institute for Advanced Immunochemical Studies

Honor:

Education Background:

2005/09-2009/07, Nankai University, Bachelor
2009/09-2014/07, Nankai University, Doctor

Working Experience:

2014/07-2018/12, Institute of Biophysics, Chinese Academy of Sciences, Research Assistant Professor
2014/09-2015/03, Oxford University, Academic Visitor
2019/01-2019/07, Institute of Biophysics, Chinese Academy of Sciences, Research Associate Professor
2019/07-2020/01, Institute of Biophysics, Chinese Academy of Sciences, Research Professor, Principal Investigator (IBP Fellow)
2020/02-Now, ShanghaiTech University, Assistant Professor（TENURE-TRACK）

Group Introduction

Research Area:

Composition, Structure and Mechanism of Energy Metabolism System and Gene Transcription & Replication System in Pathogenic Microorganisms

Research Interests:

We are committed to studying the molecular composition, structure and functional mechanisms of the energy metabolism systems and gene transcription and replication systems of pathogenic microorganisms such as Mycobacterium tuberculosis and Helicobacter pylori at multiple scales by using cryo-electron microscopy and other imaging techniques. At the same time, we carry out the screening and development of drug-resistant bacteria and antiviral drugs through interfering with the biological energy metabolism system and gene transcription and replication system.

Group Website:

Research Achievement

Professor Quan Wang is mainly engaged in the research on the structure and function of biomolecular complexes in the energy metabolism of microbial pathogens and gene transcription and replication systems, as well as the research and development of innovative drugs. In recent years, he has made breakthroughs in the study of the oxidative phosphorylation system supercomplex of Mycobacterium tuberculosis (Gong et al., Science, 2018) and the arabinosyltransferase complex in the cell wall synthesis process (Zhang et al., Science, 2020). At the same time, the COVID-19 virus RNA polymerase complex (Gao et al., Science, 2020) and its complex structure with the drug candidate Remdesivir (Wang et al., Cell, 2020) were analyzed in collaboration with professor Zihe Rao et al., providing an important scientific basis for understanding the mechanism of virus replication and the development of antiviral drugs.

Representative Publications (*First Author, # Corresponding Author)

1. Wang, Quan*; Wang, Tao; Cao, Lin; Mu, An; Fu, Sheng; Wang, Peipei; Gao, Yan; Ji, Wenxin; Liu, Zhenyu; Du, Zhanqiang; Guddat, Luke W.; Zhang, Wenchi; Li, Shuang; Li, Xuemei; Lou, Zhiyong; Wang, Xiangxi; Hu, Zhongyu^#; Rao, Zihe^#; .Inherent symmetry and flexibility in hepatitis B virus subviral particles.SCIENCE. 13 Sep 2024. 385(6714):1217-1224.
2. Wang, Quan*; Wu, Jiqin*; Wang, Haofeng*; Gao, Yan*; Liu, Qiaojie*; Mu, An; Ji, Wenxin; Yan, Liming; Zhu, Yan; Zhu, Chen; Fang, Xiang; Yang, Xiaobao; Huang, Yucen; Gao, Hailong; Liu, Fengjiang; Ge, Ji; Sun, Qianqian; Yang, Xiuna; Xu, Wenqing; Liu, Zhijie; Yang, Haitao; Lou, Zhiyong; Jiang, Biao; Guddat, Luke W.; Gong, Peng^#; Rao, Zihe^#; .Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.CELL. 23 Jul 2020. 182(2):417.
3. Zhang, Lu*; Zhao, Yao*; Gao, Yan; Wu, Lijie; Gao, Ruogu; Zhang, Qi; Wang, Yinan; Wu, Chengyao; Wu, Fangyu; Gurcha, Sudagar S.; Veerapen, Natacha; Batt, Sarah M.; Zhao, Wei; Qin, Ling; Yang, Xiuna; Wang, Manfu; Zhu, Yan; Zhang, Bing; Bi, Lijun; Zhang, Xian'en; Yang, Haitao; Guddat, Luke W.; Xu, Wenqing; Wang, Quan^#; Li, Jun^#; Besra, Gurdyal S.^#; Rao, Zihe^#; .Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.SCIENCE. 12 Jun 2020. 368(6496):1211.
4. Gao, Yan*; Yan, Liming*; Huang, Yucen*; Liu, Fengjiang*; Zhao, Yao; Cao, Lin; Wang, Tao; Sun, Qianqian; Ming, Zhenhua; Zhang, Lianqi; Ge, Ji; Zheng, Litao; Zhang, Ying; Wang, Haofeng; Zhu, Yan; Zhu, Chen; Hu, Tianyu; Hua, Tian; Zhang, Bing; Yang, Xiuna; Li, Jun; Yang, Haitao; Liu, Zhijie; Xu, Wenqing; Guddat, Luke W.; Wang, Quan^#; Lou, Zhiyong^#; Rao, Zihe^#; .Structure of the RNA-dependent RNA polymerase from COVID-19 virus.SCIENCE. 15 May 2020. 368(6492):779-+.
5. Gong, Hongri*; Li, Jun*; Xu, Ao*; Tang, Yanting; Ji, Wenxin; Gao, Ruogu; Wang, Shuhui; Yu, Lu; Tian, Changlin; Li, Jingwen; Yen, Hsin-Yung; Lam, Sin Man; Shui, Guanghou; Yang, Xiuna; Sun, Yuna; Li, Xuemei; Jia, Minze; Yang, Cheng; Jiang, Biao; Lou, Zhiyong; Robinson, Carol V.; Wong, Luet-Lok; Guddat, Luke W.; Sun, Fei^#; Wang, Quan^#; Rao, Zihe^#; .An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.SCIENCE. 30 Nov 2018. 362(6418):1020-+.

Quan Wang, PhDAssistant Professor

Principal investigator

Group Introduction

Research Achievement

Representative Publications (*First Author, # Corresponding Author)

Monograph

Patent

Funding

Awards

Research Achievement

Group Member and Photo