Principal investigator
Name:
Quan WangAssistant Professor , PhD, Assistant Professor
Position:
Affiliation:
School of Life Science and Technology, Shanghai Institute for Advanced Immunochemical Studies
Honor:
Education Background:
- 2005/09-2009/07, Nankai University, Bachelor
- 2009/09-2014/07, Nankai University, Doctor
Working Experience:
- 2014/07-2018/12, Institute of Biophysics, Chinese Academy of Sciences, Research Assistant Professor
- 2014/09-2015/03, Oxford University, Academic Visitor
- 2019/01-2019/07, Institute of Biophysics, Chinese Academy of Sciences, Research Associate Professor
- 2019/07-2020/01, Institute of Biophysics, Chinese Academy of Sciences, Research Professor, Principal Investigator (IBP Fellow)
- 2020/02-Now, ShanghaiTech University, Assistant Professor（TENURE-TRACK）
Group Introduction
Research Area:
Composition, Structure and Mechanism of Energy Metabolism System and Gene Transcription & Replication System in Pathogenic Microorganisms
Research Interests:
We are committed to studying the molecular composition, structure and functional mechanisms of the energy metabolism systems and gene transcription and replication systems of pathogenic microorganisms such as Mycobacterium tuberculosis and Helicobacter pylori at multiple scales by using cryo-electron microscopy and other imaging techniques. At the same time, we carry out the screening and development of drug-resistant bacteria and antiviral drugs through interfering with the biological energy metabolism system and gene transcription and replication system.
Research Achievement
Professor Quan Wang is mainly engaged in the research on the structure and function of biomolecular complexes in the energy metabolism of microbial pathogens and gene transcription and replication systems, as well as the research and development of innovative drugs. In recent years, he has made breakthroughs in the study of the oxidative phosphorylation system supercomplex of Mycobacterium tuberculosis (Gong et al., Science, 2018) and the arabinosyltransferase complex in the cell wall synthesis process (Zhang et al., Science, 2020). At the same time, the COVID-19 virus RNA polymerase complex (Gao et al., Science, 2020) and its complex structure with the drug candidate Remdesivir (Wang et al., Cell, 2020) were analyzed in collaboration with professor Zihe Rao et al., providing an important scientific basis for understanding the mechanism of virus replication and the development of antiviral drugs.
Representative Publications (*First Author, # Corresponding Author)
- 1. Wang, Weiwei*; Gao, Yan*; Tang, Yanting; Zhou, Xiaoting; Lai, Yuezheng; Zhou, Shan; Zhang, Yuying; Yang, Xiuna; Liu, Fengjiang; Guddat, Luke W.; Wang, Quan#; Rao, Zihe#; Gong, Hongri#.Cryo-EM structure of mycobacterial cytochrome bd reveals two oxygen access channels.NATURE COMMUNICATIONS. Jul 2021. 12(1).
- 2. Wu, Jiqin*; Wang, Haofeng; Liu, Qiaojie; Li, Rui; Gao, Yan; Fang, Xiang; Zhong, Yao; Wang, Meihua; Wang, Quan; Rao, Zihe; Gong, Peng.Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex.CELL REPORTS. 2021. 37(4).
- 3. Tang, Yanting*; Mu, An*; Zhang, Yuying; Zhou, Shan; Wang, Weiwei; Lai, Yuezheng; Zhou, Xiaoting; Liu, Fengjiang; Yang, Xiuna; Gong, Hongri#; Wang, Quan#; Rao, Zihe.Cryo-EM structure of Mycobacterium smegmatis DyP-loaded encapsulin.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 14 Apr 2021. 118(16).
- 4. Zhou, Xiaoting*; Gao, Yan*; Wang, Weiwei; Yang, Xiaolin; Yang, Xiuna; Liu, Fengjiang; Tang, Yanting; Lam, Sin Man; Shui, Guanghou; Yu, Lu; Tian, Changlin; Guddat, Luke W.; Wang, Quan#; Rao, Zihe#; Gong, Hongri#.Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded Rieske FeS cluster.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 05 Apr 2021.
- 5. Zhang, Lu*; Zhao, Yao*; Gao, Yan; Wu, Lijie; Gao, Ruogu; Zhang, Qi; Wang, Yinan; Wu, Chengyao; Wu, Fangyu; Gurcha, Sudagar S.; Veerapen, Natacha; Batt, Sarah M.; Zhao, Wei; Qin, Ling; Yang, Xiuna; Wang, Manfu; Zhu, Yan; Zhang, Bing; Bi, Lijun; Zhang, Xian'en; Yang, Haitao; Guddat, Luke W.; Xu, Wenqing; Wang, Quan#; Li, Jun#; Besra, Gurdyal S.#; Rao, Zihe#.Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.SCIENCE. 12 Jun 2020. 368(6496):1211.
- 6. Wang, Quan#*; Wu, Jiqin*; Wang, Haofeng*; Gao, Yan*; Liu, Qiaojie*; Mu, An; Ji, Wenxin; Yan, Liming; Zhu, Yan; Zhu, Chen; Fang, Xiang; Yang, Xiaobao; Huang, Yucen; Gao, Hailong; Liu, Fengjiang; Ge, Ji; Sun, Qianqian; Yang, Xiuna; Xu, Wenqing; Liu, Zhijie; Yang, Haitao; Lou, Zhiyong; Jiang, Biao; Guddat, Luke W.; Gong, Peng#; Rao, Zihe#.Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.CELL. 23 Jul 2020. 182(2):417.
- 7. Gao, Yan*; Yan, Liming*; Huang, Yucen*; Liu, Fengjiang*; Zhao, Yao; Cao, Lin; Wang, Tao; Sun, Qianqian; Ming, Zhenhua; Zhang, Lianqi; Ge, Ji; Zheng, Litao; Zhang, Ying; Wang, Haofeng; Zhu, Yan; Zhu, Chen; Hu, Tianyu; Hua, Tian; Zhang, Bing; Yang, Xiuna; Li, Jun; Yang, Haitao; Liu, Zhijie; Xu, Wenqing; Guddat, Luke W.; Wang, Quan#; Lou, Zhiyong#; Rao, Zihe#.Structure of the RNA-dependent RNA polymerase from COVID-19 virus.SCIENCE. 15 May 2020. 368(6492):779-+.
- 8. Zhang, Lu*; Zhao, Yao*; Gao, Ruogu*; Li, Jun; Yang, Xiuna; Gao, Yan; Zhao, Wei; Gurcha, Sudagar S.; Veerapen, Natacha; Batt, Sarah M.; Besra, Kajelle Kaur; Xu, Wenqing; Bi, Lijun; Zhang, Xian'en; Guddat, Luke W.; Yang, Haitao; Wang, Quan#; Besra, Gurdyal S.#; Rao, Zihe#.Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB(2)-AcpM(2).PROTEIN & CELL. 03 May 2020. 11(7):505-517.
- 9. Gong, Hongri#*; Gao, Yan*; Zhou, Xiaoting; Wang, Weiwei; Tang, Yanting; Zhou, Shan; Zhang, Yuying; Ji, Wenxin; Yu, Lu; Tian, Changlin; Lam, Sin Man; Shui, Guanghou; Guddat, Luke W.; Wong, Luet-Lok; Wang, Quan#; Rao, Zihe#.Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF.NATURE COMMUNICATIONS. 25 Aug 2020.
- 10. Gong, Hongri*; Li, Jun*; Xu, Ao*; Tang, Yanting; Ji, Wenxin; Gao, Ruogu; Wang, Shuhui; Yu, Lu; Tian, Changlin; Li, Jingwen; Yen, Hsin-Yung; Lam, Sin Man; Shui, Guanghou; Yang, Xiuna; Sun, Yuna; Li, Xuemei; Jia, Minze; Yang, Cheng; Jiang, Biao; Lou, Zhiyong; Robinson, Carol V.; Wong, Luet-Lok; Guddat, Luke W.; Sun, Fei#; Wang, Quan#; Rao, Zihe#.An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.SCIENCE. 30 Nov 2018. 362(6418):1020-+.
- 11. Li, Baobin*; Wang, Quan*; Pan, Xijiang; Fernandez de Castro, Isabel; Sun, Yuna; Guo, Yu; Tao, Xinwei; Risco, Cristina; Sui, Sen-Fang; Lou, Zhiyong#.Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013. 110(22):9048-9053.
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