Principal investigatorName: Quan WangAssistant Professor , PhD, Assistant Professor
Position: Affiliation: School of Life Science and Technology, Shanghai Institute for Advanced Immunochemical Studies
Honor: Education Background:
Working Experience:
Group Introduction Research Area:
Composition, Structure and Mechanism of Energy Metabolism System and Gene Transcription & Replication System in Pathogenic Microorganisms
Research Interests:
We are committed to studying the molecular composition, structure and functional mechanisms of the energy metabolism systems and gene transcription and replication systems of pathogenic microorganisms such as Mycobacterium tuberculosis and Helicobacter pylori at multiple scales by using cryo-electron microscopy and other imaging techniques. At the same time, we carry out the screening and development of drug-resistant bacteria and antiviral drugs through interfering with the biological energy metabolism system and gene transcription and replication system. Research AchievementProfessor Quan Wang is mainly engaged in the research on the structure and function of biomolecular complexes in the energy metabolism of microbial pathogens and gene transcription and replication systems, as well as the research and development of innovative drugs. In recent years, he has made breakthroughs in the study of the oxidative phosphorylation system supercomplex of Mycobacterium tuberculosis (Gong et al., Science, 2018) and the arabinosyltransferase complex in the cell wall synthesis process (Zhang et al., Science, 2020). At the same time, the COVID-19 virus RNA polymerase complex (Gao et al., Science, 2020) and its complex structure with the drug candidate Remdesivir (Wang et al., Cell, 2020) were analyzed in collaboration with professor Zihe Rao et al., providing an important scientific basis for understanding the mechanism of virus replication and the development of antiviral drugs. Representative Publications (*First Author, # Corresponding Author)
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