课题组长
姓名：
许琛琦中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院分子细胞科学卓越创新中心
荣誉称号：
课题组简介
研究内容：
T淋巴细胞(简称T细胞)是适应性免疫系统的主要功能细胞，在清除病原体和肿瘤细胞过程中发挥着至关重要的作用。本研究组交叉利用免疫学、生物化学、生物物理学前沿手段，着力于T细胞活性调控的分子机制研究，揭示了T细胞发挥免疫功能的分子基础，并且发展了新的肿瘤免疫治疗方法。
研究成果展示
许琛琦从2009年度开始建立独立课题组研究T细胞生物学。一方面，许琛琦对T细胞表面受体的活化机制做了系统的研究，提出了“膜脂及钙离子静电调控”的新理论。另一方面，许琛琦从胆固醇代谢方面提出了肿瘤免疫治疗新理论和策略，他也发展了一种可以提高细胞的抗肿瘤功能新型CAR-T治疗技术。代表性论文包括Cell 2020, Nature 2018，Nature 2016，Nature 2013等，两项成果入选2016年度中国科学十大进展及以及2016年度和2020年度中国生命科学十大进展，其发明专利已成功进入转化
代表性论文（*第一作者，#通讯作者）
- 1. Shi, Xiaoshan*; Bi, Yunchen; Yang, Wei; Guo, Xingdong; Jiang, Yan; Wan, Chanjuan; Li, Lunyi; Bai, Yibing; Guo, Jun; Wang, Yujuan; Chen, Xiangjun; Wu, Bo; Sun, Hongbin; Liu, Wanli; Wang, Junfeng#; Xu, Chenqi#.Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids.NATURE. 2013. 493(7430):111.
- 2. Wang, Ye*; Gao, Jing; Guo, Xingdong; Tong, Ti; Shi, Xiaoshan; Li, Lunyi; Qi, Miao; Wang, Yajie; Cai, Mingjun; Jiang, Junguang; Xu, Chenqi#; Ji, Hongbin#; Wang, Hongda#.Regulation of EGFR nanocluster formation by ionic protein-lipid interaction.CELL RESEARCH. 2014. 24(8):959-976.
- 3. Wertek, Felix*; Xu, Chenqi#.Digital response in T cells: to be or not to be.CELL RESEARCH. 2014. 24(3):265-266.
- 4. Wu, Wei*; Yan, Chengsong; Shi, Xiaoshan; Li, Lunyi; Liu, Wanli; Xu, Chenqi#.Lipid in T-cell receptor transmembrane signaling.PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY. Sep 2015. 118(3):130-138.
- 5. Chen, Xiangjun*; Pan, Weiling; Sui, Yinqiang; Li, Hua; Shi, Xiaoshan; Guo, Xingdong; Qi, Hai; Xu, Chenqi#; Liu, Wanli.Acidic phospholipids govern the enhanced activation of IgG-B cell receptor.NATURE COMMUNICATIONS. Oct 2015. 6.
- 6. Liu, Wanli#*; Wang, Haopeng; Xu, Chenqi#.Antigen Receptor Nanoclusters: Small Units with Big Functions.TRENDS IN IMMUNOLOGY. Oct 2016. 37(10):680-689.
- 7. Xu, Liling*; Xia, Mengdie; Guo, Jun; Sun, Xiaolin; Li, Hua; Xu, Chenguang; Gu, Xiaomei; Zhang, Haowen; Yi, Junyang; Fang, Yan; Xie, Hengyi; Wang, Jing; Shen, Zhixun; Xue, Boxin; Sun, Yujie; Meckel, Tobias; Chen, Ying-Hua; Hu, Zhibin; Li, Zhanguo#; Xu, Chenqi#; Gong, Haipeng#; Liu, Wanli#.Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism Fc gamma RIIB-T232.JOURNAL OF EXPERIMENTAL MEDICINE. Nov 2016. 213(12):2707-2727.
- 8. Yang, Wei*; Pan, Weiling; Chen, Shuokai; Trendel, Nicola; Jiang, Shutan; Xiao, Feng; Xue, Manman; Wu, Wei; Peng, Zeli; Li, Xiaoxi; Ji, Hongbin; Liu, Xiaolong; Jiang, Hai; Wang, Haopeng; Shen, Hongbin; Dushek, Omer#; Li, Hua#; Xu, Chenqi#.Dynamic regulation of CD28 conformation and signaling by charged lipids and ions.NATURE STRUCTURAL & MOLECULAR BIOLOGY. Dec 2017. 24(12):1081-+.
- 9. Bietz, Andreas*; Zhu, Hengyu; Xue, Manman; Xu, Chenqi#.Cholesterol Metabolism in T Cells.FRONTIERS IN IMMUNOLOGY. 27 Nov 2017. 8.
- 10. Xu, Chenguang*; Xie, Hengyi; Guo, Xingdong; Gong, Haipeng; Liu, Lei; Qi, Hai; Xu, Chenqi; Liu, Wanli#.A PIP2-derived amplification loop fuels the sustained initiation of B cell activation.SCIENCE IMMUNOLOGY. Nov 2017. 2(17).
- 11. Guo, Xingdong*; Yan, Chengsong; Li, Hua; Huang, Wenmao; Shi, Xiaoshan; Huang, Min; Wang, Yingfang; Pan, Weiling; Cai, Mingjun; Li, Lunyi; Wu, Wei; Bai, Yibing; Zhang, Chi; Liu, Zhijun; Wang, Xinyan; Zhang, Xiaohui F.; Tang, Chun; Wang, Hongda; Liu, Wanli; Ouyang, Bo; Wong, Catherine C.; Cao, Yi#; Xu, Chenqi#.Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor.CELL RESEARCH. Apr 2017. 27(4):505-525.
- 12. Li, Lunyi*; Guo, Xingdong; Shi, Xiaoshan; Li, Changting; Wu, Wei; Yan, Chengsong; Wang, Haopeng; Li, Hua; Xu, Chenqi#.Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 18 Jul 2017. 114(29):E5891-E5899.
- 13. Meng, Xiangbo*; Liu, Xiwei; Guo, Xingdong; Jiang, Shutan; Chen, Tingting; Hu, Zhiqiang; Liu, Haifeng; Bai, Yibing; Xue, Manman; Hu, Ronggui; Sun, Shao-cong; Liu, Xiaolong; Zhou, Penghui; Huang, Xiaowu; Wei, Lai; Yang, Wei; Xu, Chenqi#.FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.NATURE. 06 Dec 2018. 564(7734):130-+.
- 14. Guo, Jun*; Zhang, Youhua; Li, Hua; Chu, Huiying; Wang, Qinshu; Jiang, Shutan; Li, Yan; Shen, Hongbin; Li, Guohui#; Chen, Jianfeng#; Xu, Chenqi#.Intramembrane ionic protein-lipid interaction regulates integrin structure and function.PLOS BIOLOGY. Nov 2018. 16(11).
- 15. Xu, Xinyi*; Li, Hua; Xu, Chenqi#.Structural understanding of T cell receptor triggering.CELLULAR & MOLECULAR IMMUNOLOGY. 11 Feb 2020.
- 16. He, Xing*; Xu, Chenqi#.Immune checkpoint signaling and cancer immunotherapy.CELL RESEARCH. Aug 2020. 30(8):660-669.
- 17. Xu, Chenqi#*; Li, Hua-Bing#; Flavell, Richard A.#.A special collection of reviews on frontiers in immunology.CELL RESEARCH. 28 Aug 2020.
- 18. Wu, Wei*; Zhou, Qiuping; Masubuchi, Takeya; Shi, Xiaoshan; Li, Hua; Xu, Xinyi; Huang, Min; Meng, Li; He, Xing; Zhu, Hengyu; Gao, Shuaixin; Zhang, Nan; Jing, Ruirui; Sun, Jie; Wang, Haopeng; Hui, Enfu#; Wong, Catherine Chiulan#; Xu, Chenqi#.Multiple Signaling Roles of CD3 epsilon and Its Application in CAR-T Cell Therapy.CELL. 20 Aug 2020. 182(4):855-+.
- 19. Xu, Yu*; Ma, Junwei; Luo, Haorui; Shi, Yaohuang; Liu, Haifeng; Sun, Ao; Xu, Chenqi; Ji, Hongbin; Liu, Xiaolong.Chromatin assembly factor 1B critically controls the early development but not function acquisition of invariant natural killer T cells in mice.EUROPEAN JOURNAL OF IMMUNOLOGY. 2021.
奖励
- 1. 2021年，药明康德生命化学研究奖杰出成就奖
- 2. 2021年，2020年度中国生命科学领域十大进展
- 3. 2021年，中国2020年度重要医学进展
- 4. 2020年，上海市青年科技杰出贡献奖
- 5. 2018年，树兰基金，树兰医学青年奖
- 6. 2018年，十五届中国青年科技奖
- 7. 2018年，普洛麦格生物化学奖
- 8. 2018年，中青年科技创新领军人才
- 9. 2017年，2016年度中国科学十大进展
- 10. 2017年，2016年度中国生命科学领域十大进展
- 11. 2016年，谈家桢生命科学奖创新奖
- 12. 2016年，第七届全国优秀科技工作者
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