课题组长
姓名：
徐国良中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院分子细胞科学卓越创新中心
荣誉称号：
中国科学院院士
课题组简介
研究内容：
实验室致力于探索：DNA甲基化谱式是如何在胚胎发育早期建立起来的？是否存在新的碱基修饰形式？胚胎干细胞与成体干细胞自我更新与分化是如何达到平衡的？哪些因素导致了 这一平衡的改变而导致肿瘤和疾病发生？对表观遗传信息调控的研究将有助于了解生长发育与疾病发生发展的分子机理，为维护人类健康尤其是再生医学的技术开发提供理论依据。
代表性论文（*第一作者，#通讯作者）
- 1. Yang, Hui*; Shi, Linyu; Wang, Bang-An; Liang, Dan; Zhong, Cuiqing; Liu, Wei; Nie, Yongzhan; Liu, Jie; Zhao, Jing; Gao, Xiang; Li, Dangsheng; Xu, Guo-Liang#; Li, Jinsong#.Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells.CELL. 2012. 149(3):65-617.
- 2. Gu, Tian-Peng*; Guo, Fan; Yang, Hui; Wu, Hai-Ping; Xu, Gui-Fang; Liu, Wei; Xie, Zhi-Guo; Shi, Linyu; He, Xinyi; Jin, Seung-gi; Iqbal, Khursheed; Shi, Yujiang Geno; Deng, Zixin; Szabo, Piroska E.; Pfeifer, Gerd P.; Li, Jinsong#; Xu, Guo-Liang#.The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.NATURE. 2011. 477(7366):606-U136.
- 3. He, Yu-Fei*; Li, Bin-Zhong; Li, Zheng; Liu, Peng; Wang, Yang; Tang, Qingyu; Ding, Jianping; Jia, Yingying; Chen, Zhangcheng; Li, Lin; Sun, Yan; Li, Xiuxue; Dai, Qing; Song, Chun-Xiao; Zhang, Kangling; He, Chuan; Xu, Guo-Liang#.Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA.SCIENCE. 2011. 333(6047):133-137.
- 4. Wang, Yang*; Chen, Jiekai*; Hu, Jia-Lei; Wei, Xi-Xiao; Qin, Dajiang; Gao, Juan; Zhang, Lei; Jiang, Jing; Li, Jin-Song; Liu, Jing; Lai, Ke-Yu; Kuang, Xia; Zhang, Jian; Pei, Duanqing#; Xu, Guo-Liang#.Reprogramming of mouse and human somatic cells by high-performance engineered factors.EMBO REPORTS. 2011. 12(5):478-478.
- 5. Hu, Jia-Lei*; Zhou, Bo O.; Zhang, Run-Rui; Zhang, Kang-Ling; Zhou, Jin-Qiu#; Xu, Guo-Liang#.The N-terminus of histone H3 is required for de novo DNA methylation in chromatin.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009. 106(52):22187-22192.
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